Objective:To investigate the changes and clinical implications of T cell subsets, immunoglobulins and tumor necrosis factor - ? (TNF- ?) of serum in schizophrenia. Methods: APAAP was used to detect T cell subsets and single immunodiffusion was used to detect immunoglobulins and ELISA was used to detect TNF- ?. Results :In 41 patients, CD3+ T cell,CD4+ T cell and CD4+CD8+T cell rates were significantly lower than normal controls(P