Aiming at the current situation of insufficient integration of medical humanities teaching and clinical practice， as well as the need for further research and improvement in the teaching system， guided by the concept of medicine and humanistic literacy integration advocated by the new medical science， this paper deeply discussed the construction of clinical medical humanities teaching system from four aspects， including the selection of clinical medical humanities teachers and team building； the teaching path that combines theoretical education， narrative medicine， and clinical skill training infused with medical humanities content； curriculum ideological and political construction with the goal of establishing the core concept and value orientation of “patient-centered”； the teaching assessment and evaluation method characterized by formative evaluation. The clinical medical humanities teaching system emphasizes the practicality， experiential， and emotional aspects of medical humanities teaching， deeply integrating medical humanities with clinical practice teaching content throughout the clinical internship period of medical education， with a view to enhancing the humanistic practice ability and literacy of medical students.