1.The Study on Microvessel Density of Gastric Cancer with Multi-slice Spiral CT and Pathology
Kai MA ; Changhua WANG ; Yuqing LIANG
Journal of Practical Radiology 1996;0(04):-
Objective To investigate the microvessel density of stomach tumor and the relationship between the microvessel density and CT findings.Methods Conventional contrast-enhanced CT scans were performed in 64 patients with stomach tumor(OMNIPAQUE 100 ml,3.0 ml/s),the images at 45 s were gained.After operation,the specimens with partial normal stomach tissue were dealed with injecting the contrast medium through its feeding arteries(10 ml/100 g,within 30 min),then,the specimens underwent CT scan(delayed time 10 s and 20 s),the nets of blood vessel of the masses were reconstructed by post-processed.The density of masses was evaluated in comparison with the enhanced effect of masses before operation.The pathological examinations of specimens were done and the microvessel density of tumors were measured through immunohistochemical technique.The hemodynamic characteristics of tumors were analysed.Results In tumors,the highest density(D)increased with the tumor rank(beside dead band).The visive vessels of specimen were more than that on conventional contrast-enhanced CT,but the D/d(the highest density in the masses/the density in normal stomach tissue)was basically consistent.Conclusion For gastric carcinoma,the D/d ratio can reflect the microvessel density of the tumors on certainly and the hemodynamic characteristics of tumors.
2.Clinical application of regionai cerebral blood flow SPECT imaging in systemic lupus erythematosus patients complicated with neuropsychiatric disorders
Juan QIU ; Changhua LIANG ; Xiaoxia ZUO ; Haoyu DENG ; Zhengliang TAN
Chinese Journal of Rheumatology 2009;13(3):172-174
Objecfive To observe the changes of regional cerebral blood flow (rCBF) in systemic lupus erythematosus (SLE) patients with neuropsychiatrie disorders and evaluate rCBF SPECT imaging in the detection of neuropsychiatric problems in SLE patients.Methods Twenty neuropsychiatrie SLE patients were enrolled in the study and were performed SPECT rCBF imaging anti CT/MRI scans,respectively.Twenty SLE patients without neuropsychiatrie manifestatiuns (SLE) and 20 healthy volunteers also underwent SPECT rCBF imaging as controls.Semiquantitative analysis was conducted as designed by selecting 3 consecutive crosssections and delineating ROI,which generated HQ and the results were compared between with SLE and controls.Results SPECT rCBF findings were almormal in 20 NPSLE.in which 19 of the 20 with abnormal SPECT findings showed focal uptake defects the other patient showed increased foeal uptake.Four N PSLE patients had ahnormal CT/MRI scans findings.Compared with the methods of rCBF and CT/MRI imaging,the difference was significant (P<0.01).Nineteen SLE patients without neuropsychiatrie manifestations had normal SPECT findings.the other 1 patient showed focal uptake defect.SPECT findings were all normal in 20 healthy volunteers.Temporal cortex was the most commonly involved region,followed by frontal cortex.Specific values generated from semiquantitative analysis (HQ) of temporal and frontal regions in neruopsychiatrie SLE patients were lower than that in SLE patients and healthy volunteers (P<0.01 and P<0.05).Conclusion SPECT rCBF imaging has the potential to be a sensitive tool to detect the neuropsyehiatric disordersin SLE patients,and has important value in helping for early diagnosis and therapy.Hypoperfusion on ECD-SPECT under the territory of the middle cerebral artery (MCA) is the most common observation,and which temporal and frontal regions are the most frequently involved regions in neruopsychiatrie SLE patients.
3.Influencing factors of lateral lymph node metastasis in papillary thyroid carcinoma
Liang WANG ; Changhua WU ; Shujuan ZOU ; Wanjun CHEN
Journal of International Oncology 2016;43(3):207-209
Papillary thyroid carcinoma is the most common pathology type of thyroid carcinoma with the following biological characteristics:low malignancy,slow progress,longer duration,good prognosis,but it is prone to lymph node metastasis.Lateral lymph node metastasis relates with patients' age,sex,tumor size,tumor location,capsular invasion/extra-thyroidal extension,muli-focality and the number of positive central lymph nodes.Understanding the influencing factors of the lateral lymph node metastasis has important clinical significance for determining the lymph node dissection scope and the indications for the patients with thyroid carcinoma.
4.Dignosis of SPECT in lower digestive tract hemorrhage
Hui HU ; Haoyu DENG ; Xinhui LI ; Changhua LIANG
Chinese Journal of General Surgery 2000;0(12):-
Objective To determine the diagnostic value of SPECT in lower digestive tract hemorrhage (LDTH). Methods Of the 24 LDTH cases,16 were tested by gastric mucosa imaging ,4 by 99m Tc PHA imaging,and the other 4 by 99m Tc RBC imaging.All the patients' diagnosis were confirmed by surgery and pathology. Results The sensitivity and the specificity of the gastric mucosa imaging were 100%(16/16) and 93.7%(15/16),respectively. The sensitivity of the 99m Tc PHA imaging and the 99m Tc RBC imaging was 75.0%(3/4) and 75.0 %(3/4), respectively, but had no specificity. Conclusions SPECT has very high sensitivity and specificity in the diagnosis of Meckel's diverticulum. 99m Tc PHA imaging and 99m Tc RBC imaging may help to determine the position of bleeding in unkown causes of LDTH.
5.The management of colorectal cancer with synchronous liver metastases
Wu SONG ; Yulong HE ; Shirong CAI ; Changhua ZHANG ; Chuangqi CHEN ; Liang WANG ; Wenhua ZHAN
Chinese Journal of General Surgery 2009;24(6):492-495
Objective To investigate the clinical pathologic characters of colorectal cancer with simultaneous hepatic metastasis and the prognosis. Methods From Aug. 1994 to Dec. 2006, 2019 cases of colorectal carcinoma were admitted, among them there were 166 patients of colorectal cancer with synchronous liver metastases receiving surgical therapy. Results were analyzed retrospectively using the software of SPSS. Results These 166 patients with synchronous liver metastases from colorectal cancer accounted for 8.1% of all 2019 patients of colorectal cancer admitted. Multivariate analysis demonstrated that CEA level before surgery、depth of invasion、 pathological type and Ducks' stage were the key risk factors predicting simultaneous liver metastasis from colorectal cancer. The survival rates at 1, 3 and 5 years were 69%, 21%, and 9% respectively. There was significant difference among the different liver metastasis group of H1, H2 and H3(X2=23.35, P<0.01). The survival rates of patients undergoing radical resection was higher than those undergoing palliative resection (PR)and by-pass operation or feeding neostomy(BP/ FN)(X2= 21.18,P<0.01). PR improved short-term prognosis but did not improve long-term survival compared with BP/FN group(P=0.13). Conclusion Colorectal cancer with synchronous liver metastases has poor clinic pathological characters. Different degree of liver metastasis result in different prognosis.Radical resection leads to a better prognosis. Palliative resection can improve short-term prognosis and life quality but can't improve long-term survival.
6.Study of flail chest surgery opportunity
Changhua DUAN ; Yuesheng HU ; Jingzhi LIANG ; Guangfia CHEN ; Jie LI ; Wei YANG
Chinese Journal of Primary Medicine and Pharmacy 2009;16(1):28-29
Objective To discuss the flail chest in the rib the fixed surgery opportunity,in fixed spot. Meth-ads Clinical data of 26 flail cheat patients in my courtyard were retrospectively analyzed. Results 26 patients were cured completely,nobody died,no obvious cheat abnormity was observed. Condusion Regarding the flail cheat pa-tient, at the right moment to adopt the fixed surgery in the rib, restore the integrity of the thoracic wall, may reduce the mortality rate, the chest shape normal, the quality of life obtains the enhancement.
7.Feasibility of a novel two-piece nasogastric feeding tube for patients with dysphagia.
Sen-Yung LIU ; Chao-Pin YANG ; Ta-Sen WEI ; Yen-Chun CHEN ; Chih-Hao LIANG ; Ching-Hsuan WU ; Chih-Lin CHEN ; Tsung-Ju WU
Singapore medical journal 2013;54(4):227-230
INTRODUCTIONThe exposed section of a traditional nasogastric (NG) tube can interfere with patients' social activities and thereby result in distress. This study was conducted to evaluate the feasibility and safety of a novel two-piece NG tube for patients with dysphagia.
METHODSTen patients with dysphagia were recruited between November 2011 and May 2012. Patients who were unconscious or in critical condition, had a traditional NG tube < 50 cm or > 60 cm in fixed length, or were unable to follow instructions or sign consent forms were excluded. The two-piece NG tube, which was placed in the patients for one week, comprised a removable external tube that can be joined to an internal tube via a T-connector, which was placed close to the naris. Events related to safety (e.g. nasal pressure sores, number of unplanned extubation, displacement and spontaneous migration of the NG tube, other unpredictable injuries) and effectiveness (e.g. liquid food spills, tube obstruction, perfusion rate, other adverse circumstances) were assessed daily.
RESULTSAll patients received feeding without complication using the two-piece NG tube and none experienced premature removal of the tube. No serious NG tube complications or malfunctions were observed.
CONCLUSIONThe results of this study indicate that the two-piece NG feeding tube is a feasible option for patients with dysphagia. Future improvements to the connector may help enhance its performance. A rigorous randomised controlled trial to examine the effects of the two-piece NG tube on patients' quality of life and quality of medical care is being planned.
Aged ; Aged, 80 and over ; Deglutition Disorders ; therapy ; Enteral Nutrition ; instrumentation ; methods ; Equipment Design ; Female ; Humans ; Intubation, Gastrointestinal ; adverse effects ; methods ; Male ; Middle Aged
8.Total tumor perfusion value of CT in hepatocellular carcinoma with the tumor volume and Child-Pugh classification
Changhua LIANG ; Huajie MAO ; Junyan YUE ; Yanlong HU ; Huijie ZHANG ; Pan LIANG ; Jianbo GAO
Journal of Practical Radiology 2018;34(3):378-381
Objective To investigate the correlation between tumor perfusion parameters and tumor volume and Child-Pugh classification in CT of hepatocellular carcinoma (HCC).Methods Fifty-six patients with hepatocellular carcinoma were selected to perform CT perfusion imaging.The parameters of the total tumor perfusion such as hepatic artery perfusion (HAP),portal vein perfusion (PVP)and hepatic perfusion index (HAPI)were calculated according to the degree of hepatic encephalopathy,albumin,bilirubin, clotting time,ascites for liver Child-Pugh classification.The relationship between the tumor or peritumoral perfusion parameters with tumor volume and Child-Pugh classification were analyzed.Results (1)There was no correlation between tumor or peritumoral perfusion with the tumor volume.(2)The difference of HAP,PVP and HAPI between the different Child-Pugh classification groups was statistically significant (P<0.000 1).(3)With the reduction of Child-Pugh classification,the tumor body HAP and HAPI values gradually decreased, while the PVP value increased gradually.Conclusion There is no correlation between the tumor volume of hepatocellular carcinoma with total tumor perfusion parameters.The differences in perfusion measurements between different Child-Pugh classification can intuitively and quantitatively reflect the reserve function of the liver.
9.Application value of diffusion tensor imaging in the diagnosis and quantitative analysis of parkinson’s disease
Journal of Apoplexy and Nervous Diseases 2020;37(10):900-903
Objective To investigate the application value of diffusion tensor imaging (DTI) in the diagnosis and quantitative analysis of parkinson's disease (PD).Methods Forty five patients with PD in our hospital from December 2017 to October 2019 were selected as the observation group,and 39 healthy people were selected as the control group.Two groups were examined by DTI,and the fractional anisotropy (FA) and apparent diffusion coefficient (ADC) value were measured and analyzed statistically.Results The FA value of thalamus and substantia nigra in the observation group were lower than those of the control group (P<0.05).There was no significant difference in ADC value of thalamus,substantia nigra,pons,superior cerebellar peduncle and middle peduncle between the two groups (P>0.05).The results of ROC curve showed that:the AUC of FA value in thalamus and substantia nigra was 0.704 and 0.798,respectively (P<0.05).The FA value of substantia nigra in PD patients with mid-Hoehn-Yahr stage was lower than that of early stage,and the ADC value of thalamus was higher than that of early stage (P<0.05). Pearson correlation analysis showed that:the FA value of substantia nigra was negatively correlated with Hoehn-Yahr stage of PD patients (r=-0.457,P=0.002);the ADC value of thalamus was positively correlated with Hoehn-Yahr stage of PD patients (r=0.405,P=0.006).Conclusion DTI has a quantitative diagnostic value for PD,and FA value of substantia nigra and ADC value of thalamus were correlated with PD condition.
10.Features of multi-slice spiral CT examination of indirect and direct and femoral inguinal hernia in adults
Zhiping ZHU ; Wenguang DOU ; Junyan YUE ; Juan WANG ; Qingwu WU ; Jie CHEN ; Changhua LIANG
Chinese Journal of Digestive Surgery 2018;17(11):1127-1133
Objective To explore the features of multi-slice spiral computed tomography (MSCT) examination of indirect,direct and femoral inguinal hernia.Methods The retrospective cross-sectional study was conducted.The clinical data of 106 patients with indirect,direct and femoral inguinal hernia who were admitted to the First Affiliated Hospital of Xinxiang Medical University between December 2014 and August 2017 were collected.All the patients were diagnosed as inguinal hernia by MSCT examination and multi-planar reconstruction.Observation indicators:(1) sensitivity,specificity,positive and negative predictive values and diagnostic accordance rate of indirect,direct and femoral inguinal hernia by MSCT;(2) inguinal anatomic presentation in MSCT examination;(3) relationship between hernial sac and surrounding structures in MSCT examination;(4) hernia contents and quadrants of hernial sac in the quadrant partition with " cross intersect" method and complications.Count data were described as absolute number or percentage.Comparison of count data was done using the chi-square test with row multiplied by column.Results (1) Sensitivity,specificity,positive and negative predictive values and diagnostic accordance rate of indirect,direct and femoral inguinal hernia by MSCT:of 106 patients,66,22 and 18 were diagnosed as indirect hernia,direct hernia and femoral hernia with 70,27 and 20 hernial sacs respectively.Sensitivity,specificity,positive and negative predictive values of inguinal hernia by MSCT were respectively 95.7%,96.3%,98.5%,89.7% in indirect hernia patients and 96.3%,95.7%,89.7%,98.5% in direct hernia patients and 100.0%,100.0%,100.0%,100.0% in femoral hernia patients,and diagnostic accordance rate of femoral hernia was also 100.0%.Diagnostic accordance rate of inguinal hernia was 95.9%,and correct index was 0.920.(2) Inguinal anatomic presentation in MSCT examination:transverse,coronal and sagittal imagings of inferior epigastric artery,inguinal ligament,musculus rectus abdominis,femoral vein and other anatomic structures can be identified,and internal ring of inguinal canal of 6 patients cannot be observed clearly.For relationship between internal ring of inguinal canal and inferior epigastric artery,coronal view was the best,transverse view was the next,and sagittal view was rarely observed.For relationship between inguinal ligament and hernial sac,sagittal view was the best,coronal view was also observed clearly by continuous planes,and transverse view was poor.The oblique coronal view was the best for the direct hernial triangle and internal ring of inguinal canal,and coronal view of femoral triangle was the best.The lateral crescent sign and quadrant partition of "ross intersect" method needed to be observed in transverse plane.(3) Relationship between hernial sac and surrounding structures in MSCT examination:indirect hernia entered into the inguinal canal through internal ring of inguinal canal,and hernial sac was located at the outside of inferior epigastric artery;direct hernia was out through triangle hernia,and hernial sac was located at the inside of inferior epigastric artery,92.6% (25/27) patients were accompanied by lateral crescent sign.The indirect hernia and direct hernia went along the upper front of inguinal ligament;femoral hernia was out through femoral triangle hernia,and hernial sac was located at the lower back of inguinal ligament and the outside of the pubic tubercle.(4) The hernia contents and quadrants of hernial sac in the quadrant partition with "cross intersect" method and complications:the most common hernia content was small intestine,including partial patients with hernia content composed of various substances;indirect hernia contents included small intestine (35),mesentery (29),effusion (25),intraabdominal fat (9),colon (8) and ovary (1) in turn;direct hernia contents included small intestine (14),intraabdominal fat (11),effusion (6),mesentery (6),colon (3) and bladder (2) in turn;femoral hernia contents included small intestine (12),intraabdominal fat (8),effusion (3) and mesentery (2) in turn.There was a statistically significant difference in the hernia contents among indirect hernia,direct hernia and femoral hernia (x2=28.389,P<0.05).The main hernial sac located at antero-external quadrant was respectively occurred in 70 hernial sacs of indirect hernia and 27 hernial sacs of direct hernia and 15 hernial sacs of femoral hernia,and 5 hernial sacs of femoral hernia were located at postero-external quadrant.There was a statistically significant difference in comparison of the quadrant partition with "cross intersect" method (x2 =78.904,P < 0.05).The intestinal obstruction was respectively occurred in 8 patients with indirect hernia and 14 patients with direct hernia and 12 patients with femoral hernia,with a statistically significant difference (x2=26.674,P<0.05).Conclusions Indirect hernia,direct hernia and femoral hernia have characteristic signs of imaging.MSCT can display precisely the anatomical details of inguinal region,which plays an important role in diagnosis and differential diagnosis of indirect hernia,direct hernia and femoral hernia,especially in display of hernia contents and diagnosis of complications,thus it can provide important information for evaluating risk and making operation plan.