OBJECTIVE:To investigate the correlation of patients with end stage renal disease(ESRD)and antibiotics encepha-lopathy after giving ceftazidime. METHODS:Data of 20 ESRD patients with antibiotics encephalopathy were retrospectively ana-lyzed and included into observation group,and also 20 ESRD patients with no antibiotics encephalopathy were included into con-trol group. Patients with no improved conditions in observation group were given hemodialysis associated with hemoperfusion after 2-5 days of ceftazidime withdrawal. The hemoglobin(Hb),albumin(Alb),serum creatinine(Scr),blood urea nitrogen(BUN), total cholesterol(TC),triglyceride(TG),parathyroid hormone(PTH),use time and cumulative dose of ceftazidime in observa-tion group were detected and compared with control group. RESULTS:The age,use time and cumulative dose of ceftazidime in ob-servation group were significantly higher than control group,Alb level was lower than control group,the differences were statisti-cally significant(P<0.05). 19 patients in remission and 1 died in observation group. CONCLUSIONS:The antibiotic encephalopa-thy in ESRD patients has correlation with elderly,hypoalbuminemia,use time and cumulative dose of ceftazidime.

【Objective】 To investigate the death time of patients with coronavirus disease 2019 (COVID-19). 【Methods】 The death time was calculated and analyzed using individual data and aggregated data through the daily notification of the epidemic situation and the death cases published on the website of the Heath Commission of China and provinces. 【Results】 In the 153 patients who died of COVID-19, the shortest time from onset to death was 4 days and the longest time was 50 days with the mean±standard deviation of (16.7±9.2) days. The median was 14 days and the 95% confidence interval was 4.6-42.9. The shortest time from admission to death was 1 day and the longest time was 50 days with the mean ± standard deviation of (12.1±7.8) days. The median was 11 days and the 95% confidence interval was 2-32.8. The time curve from diagnosis to death was skewed. The death time from diagnosis to death was 0 to 48 days with the mean ± standard deviation of (11.1±8.9) days. The median was 9 days, the interquartile interval was 10.5 days, and the 95% confidence interval was 0-35.4. It took 3 days from onset to admission and 1 day from admission to diagnosis. Aggregated data showed that the time from diagnosis to death of COVID-19 patients in China, China (except Hubei Province), Hubei Province and Wuhan City was 8, 9, 6 and 6 days, respectively. 【Conclusion】 The time from diagnosis to death of COVID-19 patients varied significantly, with the median time of 6-9 days in different regions.