Objective To investigate the early post-operative nutritional support for kidney transplant recipients.Methods Totally 67 patients who received early post-operative nutrition supports were randomly divided into three groups:group A (n = 24,relatively high nitrogen intake),group B (n = 25,intermediate nitrogen intake) and group C (n = 18,relatively low nitrogen intake).Two weeks after operation,albumin,hemoglobin,the nutrition indieators,serum lipids,and renal function 1 day before operation and 2 weeks after operation were evaluated. Results Body weight was significantly different among three groups;the nitrogen balance in group A was significantly better than those in groups B and C (P ＜0.05);albumin and hemoglobin were not significantly different between group A and group B (P ＞ 0.05),but were significantly higher than those in group C (P ＜ 0.05).The renal function in group C was significantly better than those in group A and group B (P ＜ 0.05).The triglyceride level was not significantly different among three groups,while the cholesterol level in group A was significantly higher than those in group B and group C (P ＜ 0.05),but not between group B and group C.Conclusion Proper nitrogen intake in early post-operative nutrition support can improve the recovery of renal function and nutritional status in kidney transplant recipients.

Objective To analyze the correlation between Uyghur metabolic syndrome and northwest dryness syndrome in Kashgar prefecture, Xinjiang. Methods Case-control design was used to include a total of 120 cases from the First People’s Hospital of Kashgar Prefecture, Xinjiang. They were selected as the case group, and 120 cases without diseases of Western medicine were as the control group. The northwest dryness syndrome was statistically analyzed. Results The total integral of northwest dryness syndrome in case group was (11.49±0.89) and that in control group was (5.84±0.81), and the case group was higher than the control group with statistical significance (P<0.01). By comparing various accompanied symptoms, except for the fire & wind dryness syndrome of lung&heart&spleen as well as lung&stomach yin deficiency syndrome, all the other syndromes in case group were higher than those in control group (P<0.01). The attack rate of northwest dryness syndrome in case group was 24.17% (29/120), higher than that in control group (7.50%, 9/120), with significant difference (P<0.01). In the correlation analysis between the state of TCM syndrome and northwest dryness syndrome in case group, spleen yin deficiency syndrome of metabolic syndrome had the strongest correlation with damp accumulation syndrome of northwest dryness syndrome (P<0.01), followed by liver-qi stasis syndrome and heart&kidney yin deficiency syndrome (P<0.01). Conclusion Metabolic syndrome is often concomitant with northwest dryness syndrome in Kashgar prefecture, Xinjiang. Moreover, the severity of clinical symptoms of metabolic syndrome was associated with the state of northwest dryness syndrome, which provides clinical epidemiology basis for developing prevention and cure strategy of metabolic syndrome in Xinjiang from the perspective of“treating the different diseases with the same therapy”.

[Objective] To observe the clinical effect of TCM diet therapy on type-2 diabetes.[Method] Select the said patients 76 cases,randomly divide them into treatment group and control group with 38 cases in each group,which were administered with routine western medicine,while the treatment one was added with TCM diet medication.[Result] Compare the fasting glucose before medication,showing marked difference(P

Breast cancer, a most common malignant tumor of women, is the leading cause of tumor deaths in women, and the incidence shows a gradually younger trend. Early screening is vital to improve prognosis of the patients. As an important functional imaging method, magnetic resonance imaging (MRI) has been widely used in the diagnosis of breast diseases. This article reviewed the application of MRI in the diagnosis, histological grade and molecular typing of breast cancer and the patient prognosis assessment, providing references for the development of MRI technology in breast cancer diagnosis.

Prostate cancer (PCa) is one of the most common malignant tumors in the male genitourinary system and it increasingly poses a threat to men's health. As a post-transcriptional regulator, microRNAs (miRNAs) play important roles in the evolution and development of life and the occurrence and progress of tumor. Researches have shown that the abnormal expression of miRNAs exerts an indispensable part in the initiation and progression of PCa. In this review we summarized the changes of the miRNAs expression profiling in PCa, the progression of castration resistant PCa, and chemotherapeutic drug resistance and its clinical application.

Aortic disease (AD) consists of a series of life-threatening diseases caused by aortic wall lesions. Up to now little has been known about the etiology of non-hereditary AD. Vascular smooth muscle cells (VSMC) are the major components of the medial aortic wall and can toggle between a contractile phenotype and a synthetic phenotype. The excessive transformation of VSMC from contractile state to synthetic state plays an important role in the development and progression of AD. Although there are many researches on the regulation of VSMS phenotype switch, how these regulatory pathways operate harmoniously and the what relationship between them remain to be elucidated. Here in this paper we reviewed the existing regulatory mechanisms of VSMC phenotype switch.

Acute aortic dissection(AAD) is a medical emergency caused by the destruction of the aortic tunica media and is always fatal. Genetic disorders are known to be responsible for AAD, but little is known about the etiology of other non-genetic cases. Tenascin-C(TnC) is a large extracellular matrix glycoprotein and mechanical stretching can up-regulate TnC expression. TnC knockout (TnC-KO) mice have higher blood pressure in the aortic artery and are liable to develop AAD; and mice with AAD have more inflammatory cells in the aortic tissue. TnC prevents aorta from AAD by regulating ECM structure, regulating vascular smooth muscle cell function and inhibiting inflammatory response in the aorta. In this paper we reviewed the role of TnC in the development and progression of AAD.

Objective To analyze the causes of early bioprosthesis failure(EBF) and to discuss its coping strategy. Methods The clinical data of patients who received bioprosthesis replacement in Changhai Hospital between Jan. 2001 and Jan. 2014 were reviewed. We also searched PubMed for related articles which were published from 1994 to 2014 using “bioprosthesis”, “heart valve prosthesis”, “early failure” and “bioprosthesis failure“ as the keywords. Results Only three EBF cases (0.5%) were found among a total of 650 cases who received bioprosthesis replacement in our hospital, and the reasons for EBF in the 3 cases were: native valve attachment, early calcification caused by metabolic syndrome, and early valve thrombosis. PubMed searched identified 14 EBF case reports, and the reasons for these 14 cases were as follows: native valve attachment in 6(42.9%) cases, metabolic abnormalities in 3(21.4%) cases, early valve thrombosis in 2(14.3%) cases, chronic inflammation in 2(14.3%) cases, and improper operation in 1 (7.1%) case. Conclusion EBF is a rare but serious complication after bioprosthesis replacement, with complicated causes. Appropriate preventive measures should be applied according to the different conditions of patients.

The fusion gene of echinoderm microtubule-associated protein-like 4 (EML4) and anaplastic lymphoma kinase(ALK) has recently been identified as a new molecular target for non-small cell lung cancer (NSCLC). EML4-ALK fusion gene is about 3%-11% in patients with NSCLC, and it has a higher morbidity in NSCLC patients who are young, without or with light smoking history and with adenocarcinomas. EML4-ALK positive NSCLC patients may be treated with ALK inhibitor (crizotinib). This review focuses on the biology, detection method, clinical characteristics and the therapeutic application of EML4-ALK in NSCLC.

Objective To study the effects of scopolamine hydrobromide orally disintegrating tablets (DTs) based nanospheres-particles (NiMS) system on the neurological behaviors in mice, so as to provide evidence for clinical administration. Methods The 3 tests in this study were all divided as following: twenty male and 20 female mice were each randomly divided into 4 groups, with 5 mice in each group. Then a female and a male group were merged into one group, so there were 4 groups, each containing 10 mice. The four groups were subjected to the following treatments: control, high dose (24 mg/kg), moderate dose (15 mg/kg) and low dose DTs (6 mg/kg). To study the effects of DTs on the balance capacity, we selected 40 mice with the ability to climb the bar from 50 mice. (1) The spontaneous activities of mice were observed and recorded 20 min after intragastric administration of DTs in each group. (2) Pentobarbital sodium was intraperitoneally injected in mice 20 min after intragastric administration of DTs to observe the sleep of mice, so as to evaluate the synergistic effect between the two drugs. (3) Mice were put on the top of a stainless bar 20 min after intragastric administration of DTs and the time spent by the mice from top to the bottom of bar was recorded to evaluate the impact of the medication on mouse balance capacity. Results (1) DTs at each dose had no significant influence on the spontaneous activity of mice compared with the controls (P>0. 05). (2) The sleep time of mice increased with the dose of DTs, and there were significant difference between control group with high dose and moderate dose groups (P<0. 05). (3) DTs shortened the time spent by mice from top to the bottom of the bar compared with the control group, with significant differences found in female mice taking three doses of DTs (P< 0. 01) and in male mice taking high and moderate dose of DT (P<0. 01, P < 0. 05). Conclusion Intragastric administration of DTs has no influence on spontaneous activity of mice, and its synergistic effect with pentobarbital sodium increases with dose. DTs can also decrease the balancing capacity of mice.