Objective To investigate the effects of flurbiprofen axetil for preemptive analgesia on hemodynamics and stress levels in patients undergoing neurosurgery.Methods 60 patients undergoing neturosurgery were enrolled in the study.The patients were randomly divided into the flurbiprofen group (Group F,n =30) or the control group (Group C,n =30).HR,MAP and serum norepinephrine (NE),epinephrine (E) levels were measured at 30min before the end of operation (T0),immediately after the end of operation (T1),immediately after extubation (T2).Results The changes in MAP,HR and serum NE,E levels in Group F at T1 and T2 were less than those of Group C (all P ＜ 0.0 1).Conclusion Flurbiprofen axetil for preemptive analgesia may suppress the stress response during recovery period in neurosurgical patients,and keep the hemodynamic index stable.