1.Relationship Between Plasma Level of B-type Natriuretic Peptide and Prognosis in Patients of Sudden Cardiac Arrest With Successful Cardiopulmonary Resuscitation
Zhimin CAO ; Haixia YU ; Liduan TAN ; Changan REN ; Qiaoli LIU ; Ruinian CHENG
Chinese Circulation Journal 2015;(9):859-862
Objective: To explore the relationship between plasma level of B-type natriuretic peptide (BNP) and short term prognosis in patients of sudden cardiac arrest with successful cardiopulmonary resuscitation (CPR). Methods:A total of 60 relevant patients were divided into 3 groups based on their plasma levels of BNP. Group A, the patients with plasma level of BNP < 200 pg/ml at immediately, 3 hours and 12-24 hours after CPR,n=16. Group B, the patients with consistently increased BNP and at 3 hours, 12-24 hours after CPR and the BNP level > 200 pg/ml , n=22. Group C, the patients with obviously increased BNP at 3 hours after CPR, while at 12-24 hours after CPR, BNP level decreased to lower than 3 hours level,n=22. All patients were followed-up for 6 months to compare the mortality incidence among different groups. Results: There was no patient died in Group A, the mortality incidence in Group B was 11 and in Group C was 3. The 6 months survival rate in Group A was higher than that in Group B (χ2 = 11.337,P=0.001), the survival rates were similar between Group A and Group C (χ2 = 2.330,P=0.127), and the survival rate in Group B was lower than that in Group C (χ2=7.435,P= 0.006). Conclusion: Consistently increased plasma level of BNP may imply heart failure in patients of sudden cardiac arrest with successful CPR, those patients could have poor short term prognosis. It is critical to improve the cardiac function and increase the important organ infusion to make better recent clinical prognosis.
2.Role of enteric glial cells in maintaining intestinal health
Yiru YIN ; Wei ZHANG ; Shengxi YANG ; Zhuojia TIAN ; Feiyu YUAN ; Changan CHENG ; Jianyun WU
Chinese Journal of Veterinary Science 2024;44(9):2081-2086
As an important part of the enteric nervous system(ENS),enteric glial cells(EGCs)play an important role in regulating intestinal homeostasis and maintaining intestinal health in hu-mans and animals.This review focuses on the role of EGCs in maintaining intestinal barrier homeo-stasis,maintaining gastrointestinal transit and motor function,regulating the niche of intestinal cells,and the role in the occurrence and development of intestinal diseases,hoping to provide new ideas for further research on the function and mechanism of EGCs in the intestine and the occur-rence,development and treatment of related intestinal diseases.
3.New guaiane-type sesquiterpenoid dimers from
Lihua SU ; Xintian ZHANG ; Yunbao MA ; Changan GENG ; Xiaoyan HUANG ; Jing HU ; Tianze LI ; Shuang TANG ; Cheng SHEN ; Zhen GAO ; Xuemei ZHANG ; Ji-Jun CHEN
Acta Pharmaceutica Sinica B 2021;11(6):1648-1666
Leading by cytotoxicity against HepG2 cells, bioactivity-guided fractionation of the EtOAc fraction from