1.Morphological assessment of macular hole surgery by scanning laser tomography
Qing CHANG ; Peiquan ZHAO ; Yin SHEN
Chinese Journal of Ocular Fundus Diseases 1999;0(02):-
Purpose To explore the role of scanning laser tomography in the assessment of macular hole surgery. Methods Fifteen eyes of 14 patients with macular holes underwent scanning of their affected macular area using the Heidelberg retina tomograph (HRT). The significance of topographic changes postoperatively were determined in eleven eyes which received vitrectomy surgery. The scan field was set at 15? of the retina and the depth was set to 1.5 mm or 2.0 mm. All the measurements were taken for 3 times and the average value of the 3 measurements was used. Results The average hole area was (0.499?0.34) mm 2 and the maximal depth of the hole was (0.284?0.11) mm. Topographic difference analysis of the eleven eyes showed a significant reduction in the height of the retina after vitrectomy. The maximal depth of the hole was (0.063?0.04) mm postoperatively. Conclusion Scanning laser tomography provides an objective evaluation of the anatomic outcome of the macular hole surgery.
2.Investigation of Somatic Diseases of Inpatients with Psychosis and Hospitlized a Long-term
Ai-qin XU ; Yong-ping WANG ; Chang-yin ZHAO
Chinese Journal of Rehabilitation Theory and Practice 2006;12(4):349-350
ObjectiveTo investigate the diagnoses of somatic diseases of inpatients with psychosis and hospitalized more then 2 years.MethodsThe material of all 350 inpatients were investigated and analyzed.ResultsThe first three psychiatric diagnoses were schizophrenia (61.32%), Alzheimer's disease (15.26%), mood disorder (4.74%). The first three diagnoses of accompanying somatic diseases were heart disease (8.68%), diabetes mellitus (8.42%), and hypertension (4.47%).ConclusionWith the changes of social environment, the disease pedigree of inpatients with psychosis changes, senile patients become more and more, and the incidence of concurrent somatic diseases gradually increases.
3.Prevalence of diabetic retinopathy and macular edema in type 2 diabetes patients in the endocrinology department of Tianjin
Baocheng CHANG ; Qian ZHAO ; Yinghai XU ; Yin WANG ; Huizhu REN ; Bai CHANG ; Liming CHEN
Chinese Journal of Endocrinology and Metabolism 2011;27(8):664-667
According to the analysis of 9 237 hospitalized type 2 diabetic patients, the prevalence of diabetic retinopathy ( DR )was 32.9% , with the prevalence of mild, moderate, and serious non-proliferative DR and proliferative DR being 10. 1%, 18. 3%, 3.2%, and 1.3% respectively. The prevalence of diabetic macular edema ( DME ) was 3.56% in type 2 diabetics and i 0. 8% in patients with DR. Diabetes duration and proteinuria were the common risk factors of DR and DME.
4.Fibronectin decreases its inhibiting activity on disintegrin and metalloproteinase with thrombospondin motifs-4 by citrullination
Luxu YIN ; Xinfeng YAN ; Xiaotian CHANG ; Ming ZHANG ; Yan ZHAO ; Yuejian WANG ; Enshui ZHANG
Chinese Journal of Rheumatology 2013;17(4):259-263,后插2
Objective To observe the inhibiting activities of fibronectin (FN) and citrullinated fibronectin (cFN) on disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4),and to explore the extracellular regulative mechanisms of ADAMTS-4.Methods FN was incubated with peptidylarginine deaminase type 4 (PADI4).Western blotting analysis was used to verify the citrullination of FN.The binding activity of FN and cFN to ADAMTS-4 were investigated by enzyme-linked immunosorbent assay (ELISA).The proteolytic ability of ADAMTS-4 after binding to FN and cFN were measured with the aggrecanase activity assay kit.One-way ANOVA,LSD-t test and t-test were used for statistical analysis.Results The immunosignal of citrulline was detected in FN after incubated with PADI4,but not in the absence of PADI4.A higher absorbance at 405 nm was detected when the full-length ADAMTS-4 protein was incubated with FN (2.182±0.042) than cFN (0.624±0.033; t=50.522,P<0.01).Additionally,the recombinant ADAMTS-4 protein with a truncation at the C-terminus displayed low absorbance at 405 nm when the enzyme was incubated with both FN(0.971±0.024) and cFN(0.934±0.012; t=2.388,P>0.05).Large amounts of ARGxx peptide were detected with full-length ADAMTS-4 in aggrecanase activity assay [(0.908±0.088) nmol/L],but significantly less when in the presence of FN and ADAMTS-4 [(0.573±0.000) nmol/L,P<0.05].The production of this peptide was more when full-length ADAMTS-4 was incubated with cFN [(0.830±0.020) nmol/L,P<0.05] than with FN.The reaction containing the truncated ADAMTS-4 without FN or cFN yielded the highest concentration of ARGxx peptide [(36.420±3.673) nmol/L],peptide production was not significantly altered when FN [(41.099±0.101) nmol/L] or eFN [(41.064±0.083) nmol/L] were added to the reaction.Conclusion FN could bind to ADAMTS-4 and inhibit its proteolytic activity.After citrullinated by PADI4,the binding activity of cFN is weakened and less inhibition to ADAMTS-4.
5.Comparision of different fixation methods on lower limbs for the treatment of pediatric intussusception with air enema
Chang WANG ; Bin LIU ; Chuangao YIN ; Weimin FEI ; Jing FAN ; Zhen ZHAO ; Yue WANG
Journal of Practical Radiology 2014;(10):1727-1728,1732
Objective To investigate the value of lower limbs fixation methods for the treatment of intussusception in children with air enema with.Methods 2 1 1 pediatric patients with intussusception who had accepted the treatment of air enema with two dif-ferent fixation methods on lower limbs were enrolled.Comparisons of median treatment duration and therapeutic effect between the two methods were investigated.Results In 32 patients with knee-joint fixation method,27 were successful with median treatment duration 4.84 minutes.Meanwhile in other 179 ones with lower limbs fixation method,152 were successful with median duration 7.96 minutes.And the duration difference between two methods was found (P<0.05).Conclusion Knee-joint fixation may help significantly shorten the median treatment duration for the treatment of intussusception with air enema in children.
6.Biomechanical evaluation of C2 transpedicle screw fixation for Hangman fractures
Pingyue LI ; Qingshui YIN ; Hong XIA ; Zenghui WU ; Gengbing CHANG ; Fuzhi AI ; Yu ZHANG ; Weidong ZHAO
Chinese Journal of Tissue Engineering Research 2008;12(17):3381-3384
BACKGROUND:C2 transpedicle screw fixation for Hangman fractures has been paid more attention due to reliability and no loss of physiological function.However,there are lacks of biomechanical evidences for indication treatment because the fixation is single segmental.OBJECTIVE:To investigate the biomechanical stability of C2 transpedicle screw fixation for Hangman fractures.DESIGN,TIME and SEITING:This was a contrast study which was performed at the General Key Laboratory of Biomechanics,First Military Medical University of Chinese PLA from May to August 2004.MATERIALS:AO-universal titanium alloy transpedicle screw of 18 25 mm in length and 3.5 mm in diameter was adopted in this study.Six fresh C1-C4 cervical vetebrae samples were ordiually made into type Ⅰ,ⅡA,and Ⅱ Hangman fracture models.METHODS:After transpedicle screw fixation.Hangman fracture models were measured by non-destroyed style with spinal anterior flexion/posterior extension,left/right lateral curvature,and left/right axial direction.Loading/unlonding circulation was performed three times during each testing.Kinematics indicators were measured on the 3rd circulation.MAIN OUTCOME MEASURES:Spinal motor images at zero load and maximal load were obtained with laser photoscanning(0.1% in precision),and the corresponding systematic software was adopted to calculate 3D range of movement.RESULTS:The relative stability of type Ⅰ Hangman fracture models after C2 transpedicle screw fixation was 100.62%(inflexion),96.91%(posterior extension),99.19%(lateral curvature),and 97.12%(rotation)as compared to control group (P>0.05).The relative stability of type Ⅱ Hangman fracture models after C2 transpedicle screw fixation was 47.84%(inflexion),21.29%(posterior extension),65.98%(lateral curvature),and 41.69%(rotation)as compared to control group (P<0.05).CONCLUSION:Biochemical evaluation suggests that type Ⅰ and Ⅱ A Hangman fractures do fit for C2 transpedicle screw fixation,and the fixation may generate well physiological fixation or stability.However,stability of type Ⅱ Hangman fracture is poor,so it is not suitably adopted single transpedicle screw fixation.
7.Change of Interleukin-2 in Nasopharyngeal Secretion of Children with Acute Respiratory Syncytial Virus Bronchitis
jian, CHANG ; dong, LIANG ; ji-rong, LU ; yin-bo, CHEN ; hong-xia, ZHAO
Journal of Applied Clinical Pediatrics 1994;0(04):-
0.05).Conclusion There is no association between IL-2 levels in NS and RSV bronchitis.The IL-2 levels show a heterogenous behavior.
8.Hyalinizing trabecular tumor of thyroid: a clinicopathologic study.
Bo CHEN ; Chang-shui LI ; Gu ZHANG ; Wen-juan YIN ; Jian-qiang ZHAO ; Jun-ying CHEN ; Wen-yong SUN
Chinese Journal of Pathology 2012;41(8):560-561
Adenoma
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genetics
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metabolism
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pathology
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surgery
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Adult
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Carcinoma, Papillary
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genetics
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metabolism
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pathology
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Diagnosis, Differential
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Exons
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Female
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Follow-Up Studies
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Humans
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Ki-67 Antigen
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metabolism
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Male
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Mutation
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Nuclear Proteins
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metabolism
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Proto-Oncogene Proteins B-raf
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genetics
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Thyroglobulin
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metabolism
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Thyroid Neoplasms
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genetics
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metabolism
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pathology
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surgery
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Thyroid Nuclear Factor 1
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Transcription Factors
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metabolism
9.The Long-term Thromboembolic Event Analysis in Atrial Fibrillat ion Patients With Radiofrequency Catheter Ablation
Guocao LI ; Weijin ZHAO ; Yunlong XIA ; Lianjun GAO ; Shulong ZHANG ; Yanzong YANG ; Yingxue DONG ; Xiaomeng YIN ; Dong CHANG
Chinese Circulation Journal 2014;(7):525-528
The Long-term Thromboembolic Event Analysis in Atrial Fibrillation Patients With Radiofrequency Catheter Ablation
Objective: To observe the thromboembolic event in atrial fibrillation (AF) patients with long-term successful radiofrequency catheter ablation (RFCA), and to study the relationship between thromboembolic event and CHA2DS2-VASC score in order to guide the anticoagulation strategy for AF patients.
Methods: A total of 321 AF patients who received RFCA in our hospital from 2000-01 to 2009-05 were studied. There were 261 patients with paroxysmal AF and 60 with persistent AF, they were followed-up for (66.7±26.9) months. The patients were divided into 2 groups according to AF recurrence condition as Non-recurrence group, n=204 and Recurrence group, n=117. The relationship between thromboembolic event and CHA2DS2-VASC score was studied.
Results: The Non-recurrence group had significantly lower rate of thromboembolism than that in Recurrence group (1.96% vs 7.69%), P=0.017. In both groups, the patients with CHA2DS2-VASC score < 2 had much lower rate of thromboembolism than those with CHA2DS2-VASC score ≥ 2, (0% vs 5%), P=0.023 and (4.45% vs 17.24%), P=0.041. The patients with CHA2DS2-VASC score<2 in Non-recurrence group had lower rate of thromboembolism than those in Recurrence group (0%vs 4.45%), P=0.029. The rate of thromboembolism had no statistic meaning between 2 groups in patients with CHA2DS2-VASC score≥2 (5%vs 17.24%), P=0.054.
Conclusion: The AF patients who received RFCA without AF recurrence in long-term follow-up had the lower rate of thromboembolic event, CHA2DS2-VASC score was important for evaluating such event. The patients with CHA2DS2-VASC score < 2 could consider stopping warfarin anticoagulation, while the patients with CHA2DS2-VASC score ≥ 2 might be beneifted for warfarin anticoagulation.
10.Ultrasound-induced uterine smooth muscle contraction
Shu-Fang CHANG ; Shen-Yin ZHU ; Zhi-Biao WANG ; Kai HU ; Zhi-Long WANG ; Chun-Liang ZHAO ;
Chinese Journal of Physical Medicine and Rehabilitation 2003;0(07):-
Objective To study the influence and dose effect of ultrasound on the contraction of uterine smooth muscle in rats.Methods Estradiol benzoate was injected into rats three days before conducting an in-vitro experiment.Their uteri were resected and irradiated with ultrasound(0.8 MHz,3 W/cm~2,0-40 rain).The contrac- tion frequency and amplitude were recorded using an MS-302 biological experiment system.Results It could be seen that the contraction frequency and amplitude,and general contractile activity were significantly increased during ultrasonic irradiation(P<0.01).The increased contraction frequency and amplitude lasted for ten minutes,and then the normal contraction pattern resumed.The contraction frequency as well as the percentage change in eontraction fre- quency were highest during the first 15 minutes of ultrasonic irradiation;the contraction amplitude as well as the per- centage change in amplitude were highest during 40 minutes of ultrasonic irradiation.Contraction activity was at its highest for 30 minutes,but the percentage change in activity was highest for 20 minutes.Conclusions Ultrasound can induce uterine smooth muscle contraction in rats.This biological effect is related to the irradiation time.