1.Vitamin D Resistant Rickets
Chang Ju LEE ; Ik Yeol CHANG ; Won Chang PARK
The Journal of the Korean Orthopaedic Association 1978;13(1):67-73
The discovery and synthesis of vitamin D and the elucidation of the role of sunlight in the activation of the vitamin D precursors changed the syndromes of rickets from a therapeutic enigma to a socioeconomic and public health problem. Since Albright in 1937 first described vitamin D resistsnt rickets, which did not respond to treatment with the usual dose of vitamin D, it has progressively become a common form of rickets in practice. In addition, as the result of increasing understanding of renal physiology and careful investigation, a spectrum of renal tubular abnormalities have been identified which cause clinical rickets and which in many cases are insensitive to even large doses of vitamin D. We have reported a case of an unusual form of vitamin D resistant rickets which did not easily respond to treatment with high doses of vitamin D and was associated with hypocalcemia in multiple pathologic fractures in the lower extremities of the patient.
Familial Hypophosphatemic Rickets
;
Fractures, Spontaneous
;
Humans
;
Hypocalcemia
;
Lower Extremity
;
Physiology
;
Public Health
;
Rickets
;
Sunlight
;
Vitamin D
;
Vitamins
2.Clinical Implications of Methylenetetrahydrofolate Reductase Mutations and Plasma Homocysteine Levels in Patients with Thromboembolic Occlusion.
Won Cheol PARK ; Jeong Hwan CHANG
Vascular Specialist International 2014;30(4):113-119
PURPOSE: Hyperhomocysteinemia has been identified as an independent risk factor in arterial and venous thrombosis. Mutations in genes encoding methylenetetrahydrofolate reductase (MTHFR), involved in the metabolism of homocysteine, may account for reduced enzyme activity and elevated plasma homocysteine levels. In this study, we investigated the interrelation of MTHFR C677T genotype and level of homocysteine in patients with arterial and venous thrombosis. MATERIALS AND METHODS: We retrospectively reviewed the medical records of 146 patients who were diagnosed as having arterial and venous thrombosis. We excluded patients diagnosed with atrial fibrillation. We examined routinely the plasma concentration of total homocysteine level and MTHFR C677T polymorphism for evaluation of thrombotic tendency in all patients. Screening processes of MTHFR C677T polymorphism were performed by real-time polymerase chain reaction. RESULTS: Investigated groups consisted of thrombotic arterial occlusion in 48 patients and venous occlusion in 63 patients. The distribution of the three genotypes was as follows: homozygous normal (CC) genotype in 29 (26.1%), heterozygous (CT) genotype in 57 (51.4%), and homozygous mutant (TT) genotype in 25 (22.5%) patients. There were no significant differences among individuals between each genotype group for baseline characteristics. Plasma concentration of homocysteine in patients with the TT genotype was significantly increased compared to the CC genotype (P<0.05). CONCLUSION: We observed a significant interaction between TT genotypes and homocysteine levels in our results. The results might reflect the complex interaction between candidate genes and external factors responsible for thrombosis.
Atrial Fibrillation
;
Genotype
;
Homocysteine*
;
Humans
;
Hyperhomocysteinemia
;
Mass Screening
;
Medical Records
;
Metabolism
;
Methylenetetrahydrofolate Reductase (NADPH2)*
;
Plasma*
;
Real-Time Polymerase Chain Reaction
;
Retrospective Studies
;
Risk Factors
;
Thrombosis
;
Venous Thrombosis
3.A Study on Serum Glucose, Insulin, and hGH Levels of Cord Blood in Newborn.
Journal of the Korean Pediatric Society 1984;27(10):945-957
No abstract available.
Blood Glucose*
;
Fetal Blood*
;
Humans
;
Infant, Newborn*
;
Insulin*
5.A Study on the Sourcees of Postoperative Wound Infection in Patients with Open Fracture
Ik Yeol CHANG ; Chang Ju LEE ; Sae Yoon KANG ; Won Chang PARK
The Journal of the Korean Orthopaedic Association 1977;12(2):179-186
The purpose of this paper is to define the bacterial sources of wound infection after surgery including debridement for open fractures. Total number of patients were 123 during surgery July 1975 to Oct. 1976 at Hangang Sacred Heart Hospital. Out of 123 cases 17 were infected postoperatively. Serial bacterial cultures were performed for specimens taken from the contaminated wound in emergency room and by exposing the Petri-dishes in the operating room. Additional cultures were carried out for 17 specimens taken from the infected wounds postoperatively. Positive bacterial cultures from the initial wounds were obtained in 71 cases (57.7%) out of 123 contaminated wounds in emergency room. Setting monitoring of air contamination in conventional operating room, 51 colonies of bacterial growth per 1 hour exposure were noted and common organisms were colliform bacilli, streptococci and staphylococci in order. Postoperative wound infection rate was 13. 8%. Common pathogens were staphylococcus aureus, coliform bacilli and pseudomonas and kanamycin was most effective antibiotics. The retrospective bacteriological studies for 17 infected cases elucidated following results: 1) Organisms of same species; from initial wound and infected wound postoperatively 7 cases 2) Organisms of same species; from air contamination in the operating room and infectected wound postoperatiyely 5 cases 3) Organism of same species; from air contamination in the operating room, initial wound and infected wound postoperatively 1 case 4) Others (contagious or endogenous origin) 4 cases The results reveal that the initial contaminated open fracture and air contamination during surgery are the main sources of postoperative infection. Four cases which the infectious sources were not determined included in contagious origin dogmaticaIly.
Anti-Bacterial Agents
;
Debridement
;
Emergency Service, Hospital
;
Enterobacteriaceae
;
Fractures, Open
;
Heart
;
Humans
;
Kanamycin
;
Operating Rooms
;
Pseudomonas
;
Retrospective Studies
;
Staphylococcus aureus
;
Surgical Wound Infection
;
Wound Infection
;
Wounds and Injuries
6.A Case Report of Clear Cell Sarcoma in Thigh
Yung Khee CHUNG ; Won Chang PARK ; Ik Yull CHANG ; Chang Rock OH
The Journal of the Korean Orthopaedic Association 1982;17(1):158-160
Malignant tumors arising from tendon and aponeurosis are very rare. Among those reported most have been interpreted as synovial sarcoma or fibrosarcoma until Enzinger in 1965 described a new type which he called “Clear Cell Sarcoma of Tendon and Aponeurosis”. The tumor has a uniform and distinctive clinical and morphological pattern which distinguishes it from other groups of tenosynovial tumors. The problem of its histogenesis remains, especially its relation to synovial sarcoma. In this paper, we reported one case which is believed to be “Clear Sarcoma in the thigh”.
Clothing
;
Fibrosarcoma
;
Sarcoma
;
Sarcoma, Clear Cell
;
Sarcoma, Synovial
;
Tendons
;
Thigh
7.Mechanical ventilator care in the newborn infants.
Young Pyo CHANG ; Yong Won PARK ; Won Soon PARK ; Jung Hwan CHOI ; Chong Ku YUN
Journal of the Korean Pediatric Society 1991;34(11):1526-1533
No abstract available.
Humans
;
Infant, Newborn*
;
Respiration, Artificial
;
Survival Rate
;
Ventilators, Mechanical*
8.A Clinical Study of the Fractures of the Femoral Neck in Children
Yung Khee CHUNG ; Jung Soo PARK ; Won Chang PARK ; Ik Yull CHANG ; In Ho HWANG
The Journal of the Korean Orthopaedic Association 1984;19(5):925-933
Fractures of the femoral neck in children are rare and usually occur as a result of severe trauma. They are one of the most challenging injuries to treat. Their complication rate is high and their anatomic and physiologic characteristics make treatment difficult. The commonly encountered complications are avascular necrosis, nonunion, coxa vara and premature fusion of epiphyseal plate. Treatment of these fractures remains an unsolved problem but accurate reduction held with adequate internal fixation would appear to offer the best chance for succesful results. We report our observations in the treatment of eighteen cases of fracture of the femoral neck in children. Included is a review of references. The results obtained are as follows: 1. Among 18 patients, 11 were boys and 7 were girls. the highest incidence was between the ages of 5 and 7 years. 2. The main causes of fractures were traffic accidents in 10 cases (55.5%), falling from a height, and slipping down. 3. The commonest type of fracture was the cervicotrochanteric type (47.4%). Twelve cases were displaced fractures (66.7 %). 4. The range of Pauwels angle varied from 20° to 70°. 5. The commonly associated injuries were pelvic bone fractures, extremity fractures, skull fractures and soft tissue injuries. 6. Nine cases were treated by skin traction and plaster cast. Five cases ere treated by closed reduction and internal fixation with K-wires or knowles pins. 7. In 13 of the 18 cases, follow-up studies were done for an average period of 18 months. 8. The results were analyzed according to the Ratliffs assessment. Among the 13 cases, 10 cases showed good results, two fair and one poor. 9. All cases treated by closed reduction and internal fixation showed good results without complications. 10. Complications developed in five cases (38.5%), three cases of avascular necrosis and two cases of coxa vara. Among these five cases, one case of avascular necrosis developed as a result of neglect of the fracture and the others as a result of too conservative a treatment. 11. Secondary treatment of trochanteric arthroplasty was required in only one neglected case. This was further by avascular necrosis and the results were poor. 12. As a result, we recommond closed reduction and internal fixation as the most favorable method of treatment for the fracture of the femoral neck in children.
Accidental Falls
;
Accidents, Traffic
;
Arthroplasty
;
Casts, Surgical
;
Child
;
Clinical Study
;
Coxa Vara
;
Extremities
;
Female
;
Femur
;
Femur Neck
;
Follow-Up Studies
;
Growth Plate
;
Humans
;
Incidence
;
Methods
;
Necrosis
;
Pelvic Bones
;
Skin
;
Skull Fractures
;
Soft Tissue Injuries
;
Traction
9.The relationship among insight, psychopathology and drug compliance in the schizophrenic patient.
Bo Yeon KIM ; Chang Wook LEE ; Chong Won PARK
Journal of Korean Neuropsychiatric Association 1993;32(3):373-380
No abstract available.
Compliance*
;
Humans
;
Psychopathology*
10.Bullous Necrotizing Vasculitis of the Skin.
Pyung Won PARK ; Chang Woo LEE ; Jae Hong KIM
Annals of Dermatology 1993;5(2):113-116
Three cases of necrotizing vasculitis clinically showing bullous skin lesions and histopathologically confirmed as leukocytoclastic vasculitis are reported. Compared with those of skin -limited non-bullous forms of cutaneous vasculitis, these cases showed relatively frequent abnormalities in urinalysis and required more aggresive corticosteriod therapy. Clinicians should be aware of the possible systemic involvements when the skin lesions are bullous in cutaneous necrotizing vasculitis.
Skin*
;
Urinalysis
;
Vasculitis*