PURPOSE: The purpose of this study was to analyze the results of treatment and prognosis of Marjolin's ulcer compared with primary squamous cell carcinoma. MATERIALS AND METHODS: Fourteen patients treated for Marjolin's ulcer were analyzed. Twenty patients with primary squamous cell carcinoma treated during the same time period was the control group. Mean age was 61.2 years. There were 24 males and 10 females. The locations, TNM stages, histological grades, recurrence, metastasis, and survival rate were analyzed and compared between two groups. RESULTS: The mean follow-up period was 54.8 months (range, 12-168 months). Local recurrences were found in 6 cases, 5 ones in Marjolin's ulcer patients, and one case in primary squamous cell carcinoma patients. The mean time interval between the initial presentation and occurrence of local recurrences was 9 months (range, 2-20 months). There were 6 metastases. 2 (14.3%) metastases were found in Marjolin's ulcer patients, and 4 (20.0%) metastases in primary squamous cell carcinoma patients. Total events (metastasis or local recurrence) were found in 10 pateients, 6 of them in Marjolin's ulcer group, and the remaining four in primary group. 5-year disease-free survival rate was 64.3% in Marjolin's ulcer group and 95.0% in primary squamous cell carcinoma group. CONCLUSION: Squamous cell carcinomas originating as Marjolin's ulcers revealed higher recurrence rate and lower survival rate despite of aggressive treatment. Therefore, new treatment modalities should be developed for improving outcomes.
Carcinoma, Squamous Cell ; Disease-Free Survival ; Female ; Follow-Up Studies ; Humans ; Male ; Neoplasm Metastasis ; Prognosis ; Recurrence ; Survival Rate ; Ulcer

No abstract available.
Diagnosis* ; Growth Hormone* ; Humans*

PURPOSE: Matriderm(R) is a highly porous dermal substitute consisting of a collagen matrix (collagen type I, III, and V) cross-linked to an elastin hydrolysate. The 1 mm thickness Matriderm(R) is used in a one-stage procedure. On the other hand, 2 mm thickness Matriderm(R) has been used in two-stage procedures in combination with split thickness skin grafts (STSG) for reconstruction as dermal substitute. To the best our knowledge, there is no case that reports the single stage procedure with 2 mm thickness Matriderm(R). There are many expected advantages if a two-stage surgery could be performed by one-stage procedure as long as the result is guaranteed. The purpose of this study is to present capacity of 2 mm thickness Matriderm(R) as a dermal substitute in single stage skin grafting by the successful results of six cases. METHODS: We performed this one-stage procedure in five patients instead of soft tissue reconstruction. Those patients were required soft tissue reconstruction after trauma injuries or radial forearm harvest as a donor site in the period between 2011 and 2012. Five Patients were treated with a combination of STSG and 2 mm thickness Matriderm(R) solely. Three out of five patients who were injured by trauma got transplanted splint thickness skin that were range from 4/1000~8/1000 inches (Table 1). Patients' data were analyzed retrospectively by chart review and patients interviews. Each patient's chart was reviewed for age, gender, type of injury, complications, final outcome and successful rates. RESULTS: The patient group consisted of 4 men and 1 woman between ages of 5 and 70. The clinical results of these five treated patients concerning skin-quality and coverage of exposed soft tissue were very good. Using 2 mm thickness Matriderm(R) the wound could gain more dermal substitute compare to 1 mm thickness Matriderm(R). CONCLUSION: Matriderm(R) is a single-use three-dimensional matrix composed of native, structurally intact collagen fibrils and elastin for supporting dermal regeneration. In this study five patients with trauma injuries or radial forearm harvest as a donor site were treated with 2 mm thickness Matriderm(R) as a dermal substitute and STSG as a single-stage procedure to cover exposed structures. Compare to 1 mm Matriderm(R), 2 mm thickness Matriderm(R) provide more dermal collagen and enhance skin-elastisity. Achieving single stage STSG with 2 mm thickness Matriderm(R), patient's hospital days were reduced in half and infection chances were also decreased. In conclusion, single skin grafting with 2 mm thickness Matriderm(R) is feasible and it is time-effient and cost effective procedure.
Collagen ; Elastin ; Female ; Forearm ; Hand ; Humans ; Male ; Regeneration ; Retrospective Studies ; Skin Transplantation ; Skin* ; Splints ; Tissue Donors ; Transplants ; Wounds and Injuries

No abstract available.

No abstract available.
Humans ; Infant*

Rotavirus (RV) is the most common cause of severe gastroenteritis and one of the most common causes of hospital infections in infants and young children worldwide. RV vaccines, administered first at 6 weeks of age, have been developed by 2 pharmaceutical companies in the United States and United Kingdom. They were approved for safety and efficacy in 2006 and were recommended by the World Health Organization (WHO) to be included in all national immunization programs in 2009. Since then, the incidence of RV infections has been decreasing. However, RV vaccines are not indicated for newborns, and therefore, the vaccines cannot be used to protect newborns from RV infections. Neonatal RV strains are different from those in other age groups. Although neonatal RV strains primarily cause asymptomatic infections, they can also lead to serious complications such as severe diarrhea, dehydration, metabolic acidosis, necrotizing enterocolitis, and even death. Additionally, they can cause serious outbreaks in newborn nurseries, neonatal intensive care units, and postpartum care facilities. I reviewed the literature, including our own study, on neonatal RV infections to determine the characteristics of neonatal RV infection and its prevention in newborns.
Acidosis ; Asymptomatic Infections ; Child ; Cross Infection ; Dehydration ; Diarrhea ; Disease Outbreaks ; Enterocolitis, Necrotizing ; Gastroenteritis ; Great Britain ; Humans ; Immunization Programs ; Incidence ; Infant ; Infant, Newborn ; Intensive Care Units, Neonatal ; Nurseries ; Postnatal Care ; Rotavirus Infections* ; Rotavirus* ; United States ; Vaccines ; World Health Organization

OBJECTS AND METHODS: In order to evaluate the relationships between drinking habits and biological and psychosocial characteristics, the authors administrated the questionnaires about drinking patterns and acute physiological and psychological responses after drinking, several psychological scales and ethanol patch test to 94 male medical students in Chosun University. RESULTS: 1) Low consumer group had significantly more severe physiological repondents after drinking in family members than high consumer group(p<.005). 2) Low consumer had significantly more severe acute physiological responses(p<.005) and high consumer group revealed more positive psychological responses after drinking(p<.005). But there was no difference in the degree of negative psychological responses between tow groups. 3) High consumer group had significantly more extroversion tedency(p<.01) and recieved more financial support from family than low consumer group(p<.01). 4) In the results of ethanol patch test. low consumer group showed more positive skin reaction in three test occasions than high consumer grou(p<.005). 5) Also the high consumer group revealed higher scores in factor 1,2,4(alpha=0.005), and 3(alpha=0.01) in comparison of factors of Korean Alcohol Use Inventory. 6) In comparison of drinking habits, low consumer group revealed higher incidence of nearly non-drinkers and sublimatory drinkers. But there were more casulal social drinkers, selcontrolled social drinkers, impusive-binge drinkers, and habitual-excessive drinkers in high consumer group(p<.005). And in drinking patterns, the items of dependence and duration of drinking, daily drinking disposition, preferential beverage, average and maximum drinking amount of each liquor, and magnitude of sips taken were higher in high consumer group. Only one item of interval between sips was longer in low consumer group(p<.005). 7) In comparison of sociodemographic variables, there were more students who were smokers(p<.01), from larger cities and small family(p<.05), and whose parents were well educated(p<.05) but had worse marital realtionship(p<.05) in high consumer group. CONCLUSEION: For better explanation of the etiology and characteristics of alcoholism, we investigated the differences in various aspects between low alcohol consumers and high alcohol consumers in college students. The most evident differences lied in the degree of acute physiological reaction and positive rates of ethanol patch test that strongly suggested the relations with the activty of ALDH. Some differences in psychosocial aspects between two groups were noticed but could not appropriately be explained at this time.
Alcoholism ; Beverages ; Drinking* ; Ethanol ; Extraversion (Psychology) ; Financial Support ; Humans ; Incidence ; Male ; Parents ; Patch Tests ; Surveys and Questionnaires ; Skin ; Students, Medical ; Weights and Measures

No abstract available.
Bronchopulmonary Dysplasia ; Humans ; Infant, Newborn

No abstract available.
Prognosis* ; Rubella* ; Syphilis, Congenital*

PURPOSE: We investigated the autonomic nervous and complex modulation of heart rate and peripheral blood volume, and linear and nonlinear coupling between heart rate and peripheral blood volume in full-term and preterm infants. METHODS: In twenty healthy preterm infants and twenty full-term infants at postconceptional age of 30-37 and 38-41 weeks each, we recorded electrocardiogram and photoplethysmogram simultaneously during sleep in the supine position. To evaluate the autonomic and complex modulation, we performed power spectral analysis and analysis of the univariate nonlinear determinism. To quantify degree of linear and nonlinear couple between heart rates and peripheral blood volume, analyses of cross spectrum and bivariate nonlinear determinism were performed respectively. RESULTS: In the analysis of heart rates, preterm infants had significantly lower normalized high-frequency power (20.3+/-7.7% vs 30.7+/-15.1%, P<0.05), higher low-to high-frequency power ratio (3.0+/-2.1 vs 1.9+/-1.6, P<0.05), and significantly lower univariate prediction error (2.9+/-1.3% vs 4.1+/- 2.8%, P<0.05) when compared to full-term infants. In the analysis of peripheral blood volume, they showed no significant differences. Cross spectrum in all frequency ranges showed no significant difference between them. But preterm infants showed a significantly higher bivariate nonlinear prediction error (4.8+/-3.8% vs 3.1+/-2.2%, P<0.05) and a lower statistical coupling index (16.6+/-10.4 vs 22.9+/-9.2, P<0.05) than full-term infants. CONCLUSION: Compared to full-term infants, the heart rates of preterm infants are less modulated by cardiac parasympathetic activity and less complex. Furthermore, their peripheral blood volume was less nonlinearly coupled to heart rate.
Blood Volume* ; Electrocardiography ; Heart Rate* ; Heart* ; Humans ; Infant ; Infant, Newborn ; Infant, Premature* ; Nonlinear Dynamics ; Perfusion ; Supine Position