Objective To analyze the clinical diagnosis and therapeutic effect of primary middle lobe lung cancer,in order to provide evidence for clinical diagnosis and treatment.Methods The clinical data of 45 cases of primary middle lobe lung cancer treated by surgery from January 2002 to January 2007 were ana- lyzed retrospectively.The operation style includes:simple middle lobectomy 12 cases(26.7 %),middle or up- per lobectomy 10 cases(22.2 %),right lung total resection 5 cases(11.1%).Chest exploration was done on 2 cases(4.44 %),palliative resection or vedged resection 2 cases(4.44 %).Results 1 case died from lung in- fection and respiratory failure(2.22 %).15 cases with arrhythmia (33.3 %), 1 case with chylothorax were cured after conservative treatment.The survival rate of 1,3,5 year were 82.1%,64.3 %,32.1% respectively. Conclusion The treatment of primary middle lobe lung cancer is dominated by regular lobectomy. It is difficult to perform middle lobectomy,so double or total lobectomy is done generally.Owing to the more postoperative complications, it should be cautious to perform sleeve resection.It should be avoided to do vedged resection for primary middle lobe lung cancer in order to lessen local recurrence.

Objective: To investigate the epidemiological characteristics of pulmonary tuberculosis in Taizhou City from 2016 to 2021, so as to provide the evidence for formulating the pulmonary tuberculosis control measures. Methods: The epidemiological data of pulmonary tuberculosis cases in Taizhou City from 2016 to 2021 were retrieved from the Tuberculosis Management Information System and Infectious Disease Surveillance System of Chinese Disease Prevention and Control Information System, and the trends in the incidence of pulmonary tuberculosis and regional, population and temporal distributions of pulmonary tuberculosis were analyzed using a descriptive epidemiological method in Taizhou City from 2016 to 2021. Results: A total of 15 621 pulmonary tuberculosis cases were reported in Taizhou City from 2016 to 2021, with annual mean reported incidence of 42.12/105. The incidence of reported pulmonary tuberculosis reduced from 43.74/105 in 2016 to 36.31/105 in 2021, with an annual decline rate of 3.65% (χ2trend=34.172, P<0.001). There were 7 606 cases positive for pathogenic tests (48.69%), and the positive rate of pathogenic tests appeared a tendency towards a rise from 2016 to 2021 (χ2trend =470.906, P<0.001). The reported incidence rates of pulmonary tuberculosis were 57.83/105 and 25.46/105 in men and women, and a high incidence rate was reported in patients at ages of 20 to <25 years (72.80/105) and 65 years and older (84.75/105). Farmer was the predominant type of occupation (8 365 cases, 53.55%), and the cases peaked from March to August, with the greatest seasonal index in May (119.76%). A high annual incidence rate of pulmonary tuberculosis was reported in Xianju County (52.51/105) and Wenling City (49.98/105) from 2016 to 2021, and the a high constituent ratio of patients positive for pathogenic tests was seen in Sanmen County (58.71%) and Luqiao District (53.24%). Conclusions The reported incidence of pulmonary tuberculosis showed a tendency towards a decline, and the proportion of pulmonary tuberculosis patients positive for pathogenic tests showed a remarkable increase in Taizhou City from 2016 to 2021. The number of patients peaked in spring and summer. In addition, high incidence of pulmonary tuberculosis was seen in Xianju County and Wenling City.

Adult ; Choanal Atresia ; etiology ; therapy ; Constriction, Pathologic ; etiology ; Humans ; Male ; Nasopharyngeal Diseases ; etiology ; therapy ; Otorhinolaryngologic Surgical Procedures ; adverse effects ; Palate ; surgery ; Postoperative Complications ; therapy ; Uvula ; surgery

Acquired Immunodeficiency Syndrome ; diagnosis ; Adult ; Female ; Humans ; Larynx ; pathology

Adolescent ; Adult ; Aged ; Case-Control Studies ; Child ; Female ; Flow Cytometry ; Humans ; Male ; Middle Aged ; Platelet Glycoprotein GPIIb-IIIa Complex ; metabolism ; Purpura, Thrombocytopenic ; diagnosis ; metabolism ; Young Adult

Animals ; Cells, Cultured ; Excitatory Postsynaptic Potentials ; Glutamic Acid ; physiology ; Hippocampus ; cytology ; Neurons ; cytology ; physiology ; Patch-Clamp Techniques ; Rats ; Rats, Sprague-Dawley

Objective To analyze the clinical and radiographic characterstics of ureteral polyps with hydronephrosis in children.Methods Thirteen patients with ureteral polyps and hydronephrosis were studied retrospectively.All patients underwent abdominal plain film,intravenous pyelogram(IVP)and ultrasound(US)examinations,contrast-enhanced CT scan was performed in 10 cases.Results Intermittent or recurrent abdominal pain with painless hematuria was presented in most cases.Hydronephrosis was demonstrated in radiographic images.IVP delineated the dilatation of the ureter and filling defects within the ureteral lumen in 5 cases.Computed tomography(CT)showed all abnormal changes of ureter and irregular intraluminal soft tissue masses in 6 cases.Moderate and low echoic structures were showed in ureters by US in 2 cases.Conclusion US and CT,as an important imaging modalities,can improve the diagnostic accuracy for ureteral polyps.

Expression of Ia-antigen on cells in lymphoid dendritic cells (LDCs)-enrt- ched fractions isolated from unstimulated rat spleens was observed with ABC immunoperoxidase and indirect immunofluorescent staining methods. The results appeared that there were three types of cells in stained preparaions: 1. Large cells with dendritic processes on their surfaces showed dark brown in colour with ABC staining method and emitted intense light-green fluorescence with immuno- fluorescent staining technic. 2. Large rounded or ovoid cells without obviously ramifications revealed colourless or light yellow-brown in colour with ABC sta- ining method and emitted no or weak yellow-green fluorescence with immuno- fluorescent staining technic. 3. Spherical lymphocytes of varying in size were similar to type 2 cells in immunoreactivity. The results of SEM and S-100 pro- tein staining confirmed that these three types of cells were LDCs, macrophages and lymphocytes in turn. It is indicated that LDCs consistently expressed Ia- antigen in large amount on their surfaces.

Objective To investigate the characteristics of clinical course and outcome in elderly patients with nonvariceal upper gastrointestinal bleeding (NUGB) Methods The 206 hospitalized patients were devided into elderly group (≥60 yrs, 105 cases) and non elderly growp (

Objective To investigate the expression of pro-inflammatory cytokines in lumbar dorsal root ganglions (DRG) of rats model of high-dose fentanyl induced hyperalgesia. Methods 64 male SD rats were divided into 2 groups (n = 32), fentanyl group and normal saline (NS) group. The rats were injected with fentanyl (60 μg/kg) or NS 4 times in total subcutaneously with a 15-minute interval. Mechanical and thermal nociception were measured via the tail pressure test (tail flick thresholds, TFT) and paw withdrawal test (paw withdrawal latency, PWL) at 1 day before, at 1, 2, 3 and 4 hour and on 1 ~ 7 day after administration. 4 rats were sacrificed and the lumbar DRG were harvested to analyze the expression of PGE2 , IL-1β, IL-6 and TNF-αvia ELISA. Results There were no significant changes of TFT, PWL and the expression of pro-inflammatory cytokines in DRG compared to baseline of rats in NS group. The value of TFT , PWL in fentanyl group were above the baseline at the 1 ~ 4 hour and below the baseline at 1~3 day after fentanyl injections. PGE2 , IL-1β, TNF-α and IL-6 increased on 1,3,5,7 day after fentanyl injections significantly. Conclusions High-dose fentanyl induced significant hyperalgesia and up-regulation of pro-inflammatory cytokines in DRG. The expression pro-inflammatory cytokines peaked later and were more protracted than the change of behavior test and show no direct relationship between the two.