1.Cord plasma lipid and lipoprotein levels of newborn infants.
Chang Joo KIM ; Hyoung Moo PARK ; Do Hwan BAE
Korean Journal of Perinatology 1993;4(3):285-294
No abstract available.
Humans
;
Infant, Newborn*
;
Lipoproteins*
;
Plasma*
3.Chemoradiotherapy in squamous cell carcinoma of the anal canal: a single institution experience.
Kyung Hwan KIM ; Jee Suk CHANG ; Ki Chang KEUM ; Joong Bae AHN ; Chang Geol LEE ; Woong Sub KOOM
Radiation Oncology Journal 2013;31(1):25-33
PURPOSE: We reviewed the treatment outcomes and prognostic factors for patients with anal canal carcinoma who were treated with curative intent chemoradiotherapy (CRT) at Severance Hospital from 2005 to 2011. MATERIALS AND METHODS: Data for 38 eligible patients treated during this period were reviewed. All patients were treated with curative intent using radiotherapy (RT) with (n = 35) or without concomitant chemotherapy (n = 3). Among 35 patients who received CRT, most of the chemotherapeutic regimens were either 5-fluorouracil (5-FU) plus mitomycin C (23 patients) or 5-FU plus cisplatin (10 patients). Recurrence-free survival (RFS), colostomy-free survival (CFS), overall survival (OS), and locoregional control (LRC) rates were calculated using the Kaplan-Meier method and survival between subgroups were compared using the log-rank test. Cox's proportional hazard model was used for multivariate analysis. RESULTS: Over a median follow-up period of 44 months (range, 11 to 96 months), 3-year RFS, CFS, OS, and LRC were 80%, 79%, 85%, and 92%, respectively. In multivariate analysis, tumor size >4 cm was an independent predicting factor for poorer RFS (hazard ratio [HR], 6.35; 95% confidence interval [CI], 1.42 to 28.5; p = 0.006) and CFS (HR, 6.25; 95% CI, 1.39-28.0; p = 0.017), while the presence of external iliac lymph node metastasis was an independent prognosticator for poorer OS (HR, 9.32; 95% CI, 1.24 to 70.3; p = 0.030). No treatment-related colostomies or deaths occurred during or after treatment. CONCLUSION: Curative intent CRT resulted in excellent outcomes that were comparable to outcomes in previous randomized trials. No severe treatment-related toxicities were observed.
Anal Canal
;
Anus Neoplasms
;
Carcinoma, Squamous Cell
;
Chemoradiotherapy
;
Cisplatin
;
Colostomy
;
Fluorouracil
;
Follow-Up Studies
;
Humans
;
Lymph Nodes
;
Mitomycin
;
Multivariate Analysis
;
Neoplasm Metastasis
;
Proportional Hazards Models
4.Histomorphologic Changes of Small Intestinal Mucosa after Irradiation in Rats.
Chan Hwan KIM ; Eun Sook CHANG ; Keon Young KWON ; Kwan Kyu PARK ; Ok Bae KIM
Korean Journal of Pathology 1999;33(9):639-651
Inadvertent application of ionizing radiation, a valuable tool in diagnostic radiology and radiotherapy, results in injury and death of adjacent normal cells, inducing gene mutations or even producing latent cancers. Captopril, an angiotensin I converting enzyme (ACE) inhibitor, has been reported to prevent the structural and functional changes in variable organs, such as lung and kidney, from radiation injury in different experimental animal models. An experiment was carried out to elucidate the radiation-induced histomorphologic changes of small intestine, especially jejunum, and to determine whether captopril can reduce or prevent the radiation-induced injuries in jejunum. Twenty-six healthy Sprague-Dawley rats were used. Experimental group (n=24) was divided into two large groups: the first one (n=16) was treated with two different single dose (9 Gy, 17 Gy) irradiation only and was sacrificed at 12 hours and at 8 weeks following irradiation; the second one (n=8) received captopril 500 mg/l per oral continuously after same doses of irradiation and was sacrificed at 8 weeks. The control group (n=2) was maintained on a stock diet in a same period of experimental group and sacrificed coincidentally. On light and electron microscopy, the 9 Gy and 17 Gy 12 hours groups revealed frequent apoptosis and necrosis but extremely decreased mitotic figures of the crypt cells. However, the 9 Gy and 17 Gy 8 weeks groups and the combined irradiation with captopril groups showed extremely reduced apoptosis and necrosis with increased mitotic figures. There was good correlation between experimental groups in apoptotic count and mitotic count (p<0.05). In the 9 Gy and 17 Gy 12 hours groups, the mucosal surface was focally or diffusely fragmented and the villi were slightly to moderately distorted. Collagen deposition was very mild and confined to the lower portion of the lamina propria. The 9 Gy and 17 Gy 8 weeks groups showed more severe mucosal surface fragmentation even with foci of erosion, short and distorted villi, and more intense collagen deposition. In contrast, the combined irradiation with captopril groups revealed complete regeneration of the mucosal surface epithelium and absent collagen deposition. These findings suggest that the acute radiation injuries to small intestine occur principally in the mucosal crypt cells. Captopril, the ACE inhibitor, might provide a useful intervention in the radiation injuries of intestinal mucosa.
Animals
;
Apoptosis
;
Captopril
;
Collagen
;
Diet
;
Epithelium
;
Intestinal Mucosa*
;
Intestine, Small
;
Jejunum
;
Kidney
;
Lung
;
Microscopy, Electron
;
Models, Animal
;
Mucous Membrane
;
Necrosis
;
Peptidyl-Dipeptidase A
;
Radiation Injuries
;
Radiation, Ionizing
;
Radiotherapy
;
Rats*
;
Rats, Sprague-Dawley
;
Regeneration
5.Clinical study of pregnancy success on peritoneal oocyte and sperm transfer.
Sang Hoon LEE ; Byung Joon CHEONG ; Hyun Jeong CHANG ; Do Hwan BAE
Korean Journal of Obstetrics and Gynecology 1991;34(11):1535-1543
No abstract available.
Oocytes*
;
Pregnancy*
;
Spermatozoa*
6.A study on the anatomic configuration of bladder and urethra in patients with stress urinary incontinence before and after anterior colporrhaphy: analysis with metallic beaded chain urethrocystography.
Kyung Hun HYUN ; Jae Chang LEE ; Hyoung Moo PARK ; Do Hwan BAE
Korean Journal of Obstetrics and Gynecology 1993;36(4):503-520
No abstract available.
Humans
;
Urethra*
;
Urinary Bladder*
;
Urinary Incontinence*
7.A study on the anatomic configuration of bladder and urethra in patients with stress urinary incontinence before and after anterior colporrhaphy: analysis with metallic beaded chain urethrocystography.
Kyung Hun HYUN ; Jae Chang LEE ; Hyoung Moo PARK ; Do Hwan BAE
Korean Journal of Obstetrics and Gynecology 1993;36(4):503-520
No abstract available.
Humans
;
Urethra*
;
Urinary Bladder*
;
Urinary Incontinence*
8.A case of neonatal hemolytic disease due to anti-c isoimmunization.
Hwan Sup KANG ; Hyo Sup JOO ; Chong Woo BAE ; Suk Chul KANG ; Chang Il AHN
Journal of the Korean Pediatric Society 1982;25(9):945-948
No abstract available.
Primary Myelofibrosis*
9.Massive subcapsular renal hemorrhage in a case of SLE.
Chang Hwan BAE ; Jun YOON ; Kee Hyung LEE ; Moon Jae KIM
Korean Journal of Nephrology 1992;11(1):70-73
No abstract available.
Hemorrhage*
10.Short-term Safety Evaluation of Resident-performed Intravitreal Injection
Young Hwan BAE ; Ha Kyoung KIM ; So Hyun BAE ; Chang Ki YOON ; Dae Joong MA
Journal of the Korean Ophthalmological Society 2021;62(11):1509-1517
Purpose:
This study evaluated the short-term safety of resident-performed intravitreal injections.
Methods:
We retrospectively reviewed the medical records of 503 patients (503 eyes) treated for the first time in our hospital from January 2018 to October 2020 via intravitreal bevacizumab, ranibizumab, aflibercept, or triamcinolone acetonide injections by residents or retina specialists. In terms of short-term ophthalmic complications, patients were followed-up 1 day, 1 week, and 1 month after injection.
Results:
A total of 503 eyes of 503 patients were included. Intravitreal injections were given to 211 and 292 eyes by residents (the resident group) and retina specialists (the retina specialist group), respectively. There were no between-group differences in baseline characteristics except in terms of the indications for injection. Intraocular pressure elevation >5 mmHg occurred in two eyes (0.95%) in the resident group and five (1.71%) in the retina specialist group, but the difference was not statistically significant. Subconjunctival hemorrhage occurred in 29 eyes (13.74%) of the resident group and 32 eyes (10.96%) of the retina specialist group; again, the difference was not statistically significant. No case of noninfectious endophthalmitis occurred in the resident group but two (0.68%) cases occurred in the retina specialist group; again, the difference was not significant. There were two (0.95%) cases of infectious endophthalmitis in the resident group and one (0.34%) case in the retina specialist group; again, the difference was not significant. No corneal erosion, traumatic lens damage, vitreous hemorrhage, or retinal tearing or detachment were noted in either group.
Conclusions
Resident-performed intravitreal injections appear to be safe.