Search Results

1.The Role of Inducible 70-kDa Heat Shock Protein in Cell Cycle Control, Differentiation, and Apoptotic Cell Death of the Human Myeloid Leukemic HL-60 Cells.

6.Effects of nitric oxide produced by macrophages on the proliferation of murine lymphocytes stimulated by mitogen.

Bok Soo LEE ; Soung Kyung CHO ; Chang Duk JUN ; Byung Soon LEE ; Hun Taeg CHUNG

Korean Journal of Immunology 1993;15(1):69-82

7.Effect of Nitric Oxide on the Viability of Bone Marrow - Derived Cultured Mast Cells.

Hun Taeg CHUNG ; Rae Kil PARK ; Chang Duk JUN ; Byung Min CHOI ; Seog Jae LEE

Korean Journal of Immunology 1997;19(4):595-600

It is well established that mast cell proliferation and maturation are regulated by two principle cytokines, IL-3 and the c-kit ligand stem cell factor (SCF). Previous reports have demonstrated that bone marrow-derived IL-3-dependent mast cells exhibit the characteristic apoptosis on removal of IL-3. To know how the number of mast cells is controlled, we observed the effects of nitric oxide (NO) on the murine bone marrow-derived cultured mast cells (BMCMC). Apoptosis was measured by the analysis of flow cytometric data and electrophoretic evidence of DNA fragmentation. Our data showed that sodiurn nitroprusside (SNP)-a NO releasing substance- induced apoptosis in BMCMC. Cell cycle analysis showed that the number of the G,/G, and S phase decreased markedly, while the percentage of cell in G,/M phase was increased. Also, SNP alone induced cell death, whereas SNP in combination with SCF markedly decreased cell death of BMCMC. SNP-induced apoptosis was partially inhibited by the treatment of BMCMC with SCF. Our results suggest that NO might have sorne role in the regulation of the number of mast cells.
Apoptosis ; Bone Marrow* ; Cell Cycle ; Cell Death ; Cytokines ; DNA Fragmentation ; Interleukin-3 ; Mast Cells* ; Nitric Oxide* ; Nitroprusside ; S Phase ; Stem Cell Factor

1.The Role of Inducible 70-kDa Heat Shock Protein in Cell Cycle Control, Differentiation, and Apoptotic Cell Death of the Human Myeloid Leukemic HL-60 Cells.

2.Pseudohypoparathyroidism and Peudopseudohypoparathyroidism in a Family.

3.A Case of Silver Russel Syndrome.

4.Effects of long-term anticonvulsant therapy of thyroid function.

5.A Case of Infantile Cortical Hyperostosis.

6.Effects of nitric oxide produced by macrophages on the proliferation of murine lymphocytes stimulated by mitogen.

7.Effect of Nitric Oxide on the Viability of Bone Marrow - Derived Cultured Mast Cells.

8.Clinical Obseervation and Changing Patterns of Resistance to Antibiotics in Childhood Shigellosis.

9.Reactive oxygen intermediate production of phagocytes from human cord blood.

10.Neurologic Outcome in Congenital Hypothyroidism.

Display Mode

Output Records

File Type