No abstract available.
Humans ; Orthognathic Surgery*

Segmentally distributed cutaneous eruptions and neuralgia are common manifestations of herpes zoster. However, motor loss is another aspect of this manifestation, which is less well known and considered a rare finding. In many cases the loss of motor function may be easily overlooked because the pain is the more prominent feature and the weakness probably goes unrecognized with only a mild impairment of the motor function. We experienced a 71-year-old male patient with a herpes zoster-related motor paralysis of right arm whose clinical features of a weak limb mimicked other spinal motor diseases and confirmed motor involvement using electromyographic (EMG) and motor nerve conduction velocity (MNCV) studies.
Aged ; Arm ; Extremities* ; Herpes Zoster* ; Humans ; Male ; Neural Conduction ; Neuralgia ; Paralysis*

Eosinophilic folliculitis (EF) is regarded as a variant of eosinophilic pustular folliculitis (EPF), because it has a few distinctive clinical features different from those of EPF. EF is generally associated with systemic disorders, such as acquired immunodeficiency syndrome (AIDS) and hematologic malignancies. We have recently experienced a case of EF occurring in a 40 year-old male patient treated with allogenic bone marrow transplantation (BMT) for acute myelogenous leukemia(AML) and achieved a good clinical outcome after a short course of systemic corticosteroid therapy. The immunologic aberration resulting from systemic diseases may play a role in the development of EF.
Acquired Immunodeficiency Syndrome ; Bone Marrow Transplantation ; Bone Marrow* ; Eosinophils* ; Folliculitis* ; Hematologic Neoplasms ; Humans ; Leukemia, Myeloid, Acute* ; Male

Generalized plane xanthoma is a group of plane xanthomas that appear as yellow to yellow-brown flat patches or slightly elevated plaques with a wide-spread distribution. The disease is frequently associated with multiple myeloma or other reticulo-endothelial malignancies and monoclonal gammopathy with unknown significance, and when accompanied by these hematologic malignancies, normolipoproteinemia is invariably associated. We present a case of generalized plane xanthoma associated with multiple myeloma and type III hyperlipoproteinemia in a 48 year-old woman, and this is the first report in Korean literature.
Female ; Hematologic Neoplasms ; Humans ; Hyperlipoproteinemia Type III ; Hyperlipoproteinemias* ; Middle Aged ; Multiple Myeloma* ; Paraproteinemias ; Xanthomatosis*

A 51-year-old Korean woman presented with a non-tender, well-demarcated, reddish, edematous patch on the right anterior chest where a previous mastectomy and radiation therapy had been performed. She had been diagnosed as having infiltrating ductal carcinoma of the right breast about 1 year ago. Histopathological findings of the skin lesions were consistent with inflammatory metastatic carcinoma of the breast. Inflammatory carcinoma or carcinoma erysipeloides is a well-established entity most frequently associated with carcinoma of the breast. It is characterized by dermal lymphatic invasion by malignancy and clinically should be distinguished from erysipelas or cellulitis. We describe a case of inflammatory metastatic carcinoma derived from an infiltrating ductal carcinoma of the breast which can be clinically confused with radiation dermatitis.
Breast* ; Carcinoma, Ductal ; Cellulitis ; Dermatitis ; Erysipelas ; Erysipeloid ; Female ; Humans ; Mastectomy ; Middle Aged ; Skin ; Thorax

BACKGROUND: Impairment of the DNA repair system after UVB irradiation is the key factor in transformation of normal keratinocytes to squamous cancer cells (SCC). Among anti-proliferative genes (APRO), BTG1, BTG2, and TOB genes are involved in the repairing of DNA damage and, BTG3 and TOB 2 are involved in differentiation and cell cycle arrest in human cells, respectively. However, the expressions of APRO genes in SCC and human keratinocytes after UVB irradiation are largely unknown. OBJECTIVE: The purpose of this study was to investigate the expression levels of APRO genes in UVB-irradiated HaCaT keratinocyte lines and SCC cell lines. METHODS: Cells were irradiated with UVB at various doses (0, 100, 200, 300 mJ/cm2), then total RNA was extracted from the cells. The expression of genes were confirmed by RT-PCR analysis using specific primers. The results were obtained from two independent experiments. RESULTS: The expression of BTG1, BTG2, and TOB2, but not BTG3 and TOB, were markedly increased in UVB-irradiated HaCaT cells, compared to UVB-irradiated SCC. To confirm the expression levels of BTG1, BTG2, and TOB2 genes correlated with extent of DNA damage or susceptibility to cell death by UVB, we carried out staining of surviving UVB-irradiated HaCaT and SCC cell lines. Interestingly, it was found that the number of surviving HaCaT colonies was higher than SCC cell lines. CONCLUSION: The number of surviving colonies, as well as the expression of BTG1, BTG2, and TOB2 after UVB irradiation were higher in HaCaT cells than the SCC cell lines, suggesting that the gene expression of BTG1, BTG2, and TOB2 in HaCaT cells might be involved in reducing the death of UVB-irradiated cells by repairing DNA damage.
Cell Cycle Checkpoints ; Cell Death ; Cell Line* ; DNA Damage ; DNA Repair ; Gene Expression ; Humans ; Keratinocytes* ; RNA

No abstract available.
Drug Therapy*

PURPOSE: To evaluate the efficacy and long-term prognosis of pars plana vitrectomy and Ahmed valve implantation for intractable glaucoma comorbid with retinal disorders. METHODS: A retrospective review of 34 eyes of 30 patients receiving pars plana vitrectomy and Ahmed valve implantation for intractable glaucoma comorbid with retinal disorders was performed. Preoperative and postoperative intraocular pressure (IOP) and visual acuity, the usage of IOP-lowering medications and postoperative complications, and surgical success rate were evaluated. RESULTS: IOP and the number of IOP-lowering medications showed a significant decrease after pars plana vitrectomy and Ahmed valve implantation, as compared to before surgery (p < 0.001). The success rate was 88%, 88%, 84% and 85% postoperatively at 1 month, 6 months, 1 year and 3 years respectively. The mean follow up period was 24.21 +/- 14.99 months. Complications related to surgery included hyphema in 2 eyes, recurrent corneal epithelial erosion and defect in 2 eyes, corneal ulcer in 2 eyes and vitreous hemorrhage in 4 eyes. Visual acuity improved in 14 eyes (41.1%), no changes in 13 eyes (38.2%) and decreased in 7 eyes (20.6%). CONCLUSIONS: Pars plana vitrectomy and Ahmed valve implantation for intractable glaucoma comorbid with retinal disorders show long-term efficacy in lowering IOP.
Corneal Ulcer ; Eye ; Follow-Up Studies ; Glaucoma ; Humans ; Hyphema ; Intraocular Pressure ; Postoperative Complications ; Prognosis ; Retinaldehyde ; Retrospective Studies ; Visual Acuity ; Vitrectomy ; Vitreous Hemorrhage