1.Pancreatic cystadenoma: a case report.
Sang Yul CHO ; Chang Woo RHEE ; Sang Hyun KIM
Journal of the Korean Surgical Society 1991;41(3):408-411
No abstract available.
Cystadenoma*
2.Studies on retrobulbar optic neuritis: I. Clinical findimgs.
Chang Shoo CHOI ; Jung Woo YOUN ; Jong Won RHEE
Journal of the Korean Ophthalmological Society 1966;7(2):27-31
Authors experienced 100 cases of retrobulbar optic neuritis among the patients who visited the Chang Shoo Choi Eye Clinic during the last 2 years, from September 1, 1964 to August 31, 1966. The chief complaints are asthenopia, blurring vision, ocular pain, headache and photophobia. Of 100 cases, 46 cases wanted to be refracted. The corrected visual acuities are not always poor, though they are very variable from time to time as the tests are processing. The most cases revealed central relative scotomas instead of cecocentrals as previously believed. Fields are taken with glasses if corrected. In our cases, the age distribution of the patients are very interesting, the most susceptible age groups are 11~13 years.
Age Distribution
;
Asthenopia
;
Eyeglasses
;
Glass
;
Headache
;
Humans
;
Optic Neuritis*
;
Photophobia
;
Scotoma
;
Vision, Ocular
;
Visual Acuity
3.Percutaneous Vertebroplasty in Spinal Metastasis and Myeloma:25 Cases Experience.
Woo Min PARK ; Jee Soo JANG ; Chang Hun RHEE ; Ho Shin GWAK ; Seung Hoon LEE
Journal of Korean Neurosurgical Society 2000;29(11):1484-1490
No abstract available.
Neoplasm Metastasis*
;
Vertebroplasty*
4.Epidural Granulocytic Sarcoma Causing Cord Compression at Thoracic Region in Acute Myelogenous Leukemia: A Case Report.
Woo Min PARK ; Jee Soo JANG ; Chang Hun RHEE ; Ho Shin GWAK ; Seung Hoon LEE
Journal of Korean Neurosurgical Society 2000;29(11):1533-1537
No abstract available.
Leukemia, Myeloid, Acute*
;
Sarcoma, Myeloid*
5.Effects of Dihydrochlorothiazide, Propranolol, and Prazosin on Serum Lipids in Patients with Essential Hypertension.
Seung Bum JIN ; Young Woo RHEE ; Seok Won CHANG ; Ki Cheol KIM ; Soek Pil KIM ; Chang Sup SONG
Korean Circulation Journal 1985;15(2):329-336
Three groups of patients with newely diagnosed hypertension, or with hypertension not optimally controlled by previous treatment, completed a comparative study on the effects of Dihydrochlorothiazide, propranolol, and prazosin on plasma lipids after three months therapy. The drugs showed equipotent antihypertensive effects(P<0.01). Dihydrochlorothiazide administration was associated with a significant elevation of total cholesterol(42%, P<0.05), and triglyceride(8.1%, P<0.01). Changes of HDL-C(5.1%), LDL-C(3.3%), and cholesterol ratio(-4.8%) were not significant. Propranolol administration was associated with significant elevation of total cholesterol(3.8%, P<0.05), triglyceride(14.5%, P<0.005), and LDL-C(5.6%, P<0.005). Reduction of HDL-C(-7.8%, P<0.05) and cholesterol ratio(-14.7%, p<0.005) was also statistically significant. Prazosin administration was associated with significant decrease in total cholesterol(-6.6%, P<0.005), triglycride(-9.6%, P<0.005), and LDL-C(-11.7%, P<0.005), and significant elevation of HDL-C(10.6%,P<0.005) and cholesterol ratio(24.2%, P<0.005) was noted.
Cholesterol
;
Humans
;
Hydrochlorothiazide*
;
Hypertension*
;
Plasma
;
Prazosin*
;
Propranolol*
6.Total anomalous pulmonary venous return(infradiaphragmatic type)
Gwang Woo RHEE ; Suk Cheol JEON ; Chang Kok HAHM ; Seung Lyong HYUN ; Kyu Hwan LEE ; Chang Ho KIM
Journal of the Korean Radiological Society 1986;22(3):355-360
The infradiaphragmatic type of Total Anomalous Pulmonary Venous Return(TAPVR) is a rare congenital cardiacanomaly which usually results in death during the period of early infancy. A two month-old baby boy with cyanosisand respiratory distress was suspected of having a TAPVR clinically and the two-dimensional echocardiographicfindings were compatible with the infradiaphragmetic type of TAPVR. The subsequent cardiac catheterization andcineangiogram revealed the common pulmonary vein connected with portal vein and inferior vena cava in theinfradiaphragmetic area with obvious obstruction. The surgery and the autopsy confiremd the preopeative diagnosis.Among infants presenting pulmonary venous congestion in the newborn period. TAPVR below the diaphragm shold be oneof the important diagnostic cosiderations.
Autopsy
;
Cardiac Catheterization
;
Cardiac Catheters
;
Diaphragm
;
Humans
;
Hyperemia
;
Infant
;
Infant, Newborn
;
Male
;
Portal Vein
;
Pulmonary Veins
;
Scimitar Syndrome
;
Vena Cava, Inferior
7.Effects of Various Growth Factors on the Growth and PSA Secretion of the Androgen-dependent LNCaP Prostate Cancer Cell Line.
Hong Woo RHEE ; Sung Hak KANG ; Chang Hee HAN
Korean Journal of Urology 1999;40(8):979-984
PURPOSE: The growth and PSA secretion of prostate carcinoma is predominantly regulated by androgens. However, locally produced growth factors(GFs) also have been shown to play a crucial role in the proliferation of androgen-dependent prostatic tumor cells. Androgen has been proposed to stimulate the cell proliferation and PSA secretion by modulating the activity of some of these growth factors. The objectives of this study are to determine the effects of various GFs (epidermal growth factor; EGF, basic fibroblast growth factor; bFGF, keratinocyte growth factor; KGF, hepatocyte growth factor; HGF) on the growth and PSA secretion of androgen-dependent LNCaP prostate cancer cell line. MATERIALS AND METHODS: To determine the effects of EGF, bFGF, KGF and HGF on the growth and PSA secretion of LNCaP, LNCaP cells at a concentration of 3 x 103 cells/well, suspended in T-medium containing 2% TCM, were seeded in 96 well plates. Cells were exposed to six different concentrations (0.5, 1, 5, 10, 20 and 40 ng/ml) of GFs. Cell numbers were evaluated by crystal violet assay on day 3, 5 and 7, and PSA concentrations in conditioned medium were determined on day 5. RESULTS: EGF and HGF had minimal, not significant, stimulatory effects on the growth of LNCaP. However, bFGF and KGF had significant growth stimulatory effects (P<0.05). EGF, bFGF, KGF and HGF did not have any stimulatory effects on the PSA secretion of androgen-dependent LNCaP cell line. CONCLUSIONS: bFGF and KGF, not EGF and HGF, directly stimulate the growth of LNCaP cells. However, bFGF and KGF as well as EGF and HGF do not affect the PSA secretion of LNCaP. There seems to be another signal transduction pathway, which is not associated with GFs mentioned above, for PSA secretion of androgen-dependent LNCaP cell line.
Androgens
;
Cell Count
;
Cell Line*
;
Cell Proliferation
;
Culture Media, Conditioned
;
Epidermal Growth Factor
;
Fibroblast Growth Factor 2
;
Fibroblast Growth Factor 7
;
Gentian Violet
;
Hepatocyte Growth Factor
;
Intercellular Signaling Peptides and Proteins*
;
Prostate*
;
Prostatic Neoplasms*
;
Signal Transduction
8.Vertebral compression fractures after spine irradiation using conventional fractionation in patients with metastatic colorectal cancer.
Woo Joong RHEE ; Kyung Hwan KIM ; Jee Suk CHANG ; Hyun Ju KIM ; Seohee CHOI ; Woong Sub KOOM
Radiation Oncology Journal 2014;32(4):221-230
PURPOSE: To evaluate the risk of vertebral compression fracture (VCF) after conventional radiotherapy (RT) for colorectal cancer (CRC) with spine metastasis and to identify risk factors for VCF in metastatic and non-metastatic irradiated spines. MATERIALS AND METHODS: We retrospectively reviewed 68 spinal segments in 16 patients who received conventional RT between 2009 and 2012. Fracture was defined as a newly developed VCF or progression of an existing fracture. The target volume included all metastatic spinal segments and one additional non-metastatic vertebra adjacent to the tumor-involved spines. RESULTS: The median follow-up was 7.8 months. Among all 68 spinal segments, there were six fracture events (8.8%) including three new VCFs and three fracture progressions. Observed VCF rates in vertebral segments with prior irradiation or pre-existing compression fracture were 30.0% and 75.0% respectively, compared with 5.2% and 4.7% for segments without prior irradiation or pre-existing compression fracture, respectively (both p < 0.05). The 1-year fracture-free probability was 87.8% (95% CI, 78.2-97.4). On multivariate analysis, prior irradiation (HR, 7.30; 95% CI, 1.31-40.86) and pre-existing compression fracture (HR, 18.45; 95% CI, 3.42-99.52) were independent risk factors for VCF. CONCLUSION: The incidence of VCF following conventional RT to the spine is not particularly high, regardless of metastatic tumor involvement. Spines that received irradiation and/or have pre-existing compression fracture before RT have an increased risk of VCF and require close observation.
Colorectal Neoplasms*
;
Follow-Up Studies
;
Fractures, Compression*
;
Humans
;
Incidence
;
Multivariate Analysis
;
Neoplasm Metastasis
;
Radiotherapy
;
Retrospective Studies
;
Risk Factors
;
Spinal Fractures
;
Spinal Neoplasms
;
Spine*
9.The Effect of A Potent Calcium Channel Blocker, Nifedipine, on the Castration-induced Apoptosis of the Rat Ventral Prostate.
Chang Hee HAN ; Hong Woo RHEE ; Sung Hak KANG
Korean Journal of Urology 1997;38(9):905-911
The rapid involution of the rat ventral prostate after castration is an active process initiated by removal of the inhibitory effects of androgen on prostatic cell death. The degradation of genomic DNA into nucleosomal-sized fragments if an early event in this process and is catalyzed by Ca2+Mg2+-dependent endonuclease activity which is dependent upon calcium ions. The morphologic correlation of the involution process involves a series of structural changes which are collectively referred to as apoptosis. Since the castration-induced endonuclease is dependent upon calcium ions for maximal activity, a potential involvement of a intracellular calcium in the castration-induced prostatic cell death was investigated. Acute disturbance in intracellular calcium homeostasis within the ventral prostate by means of a potent calcium channel blocker, nifedipine, simultaneous with castration resulted in a significant decrease in prostatic apoptosis. This result points to a potential role intracellular calcium levels in the mechanism of activation of castration-induced death of the androgen-dependent epithelial cells in the ventral prostate.
Animals
;
Apoptosis*
;
Calcium Channels*
;
Calcium*
;
Castration
;
Cell Death
;
Deoxyribonuclease I
;
DNA
;
Epithelial Cells
;
Homeostasis
;
Ions
;
Nifedipine*
;
Prostate*
;
Rats*
10.Usefulness of Automated Biopsy Guns in Image-guided Biopsy.
Sung Moon LEE ; Hong KIM ; Sung Ku WOO ; Soo Jhi SUH ; Jung Hyung LEE ; Chang Soo RHEE
Journal of the Korean Radiological Society 1994;31(6):1127-1132
PURPOSE: To evaluate the usefulness of automated biopsy guns in image-guided biopsy of lung, liver. pancreas and other organs. MATERIALS AND METHODS: Using automated biopsy devices, 160 biopsies of variable anatomic sites were performed:Biopsies were performed under ultrasonographic(US) guidance in 95 and computed tomographic (CT) guidance in 65. We retrospectively analyzed histologic results and complications. RESULTS: Specimens were adequate for histopathologic diagnosis in 143 of the 160 patients(89.4%)-Diagnostic tissue was obtained in 130 (81.3%), suggestive tissue obtained in 13(8.1%), and non-diagnostic tissue was obtained in 14(8.7%). Inadequate tissue was obtained in only 3(1.9%). There was no statistically significant difference between US-guided and CT-guided percutaneous biopsy. There was no occurrence of significant complication. We have experienced mild complications in only 5 patients-2 hematuria & 2 hematochezia in transrectal prostatic biopsy, and 1 minimal pneumothorax in CT-guided percutaneous lung biopsy. All of them were resolved spontaneously. CONCLUSION: The image-guided biopsy using the automated biopsy gun was a simple, safe and accurate method of obtaining adequate specimen for the histopathologic diagnosis.
Biopsy*
;
Diagnosis
;
Firearms*
;
Gastrointestinal Hemorrhage
;
Hematuria
;
Image-Guided Biopsy*
;
Liver
;
Lung
;
Pancreas
;
Pneumothorax
;
Retrospective Studies