There are many herbs used in the treatment of dermatophytosis as home medicine and Castanea crenata Flos (C.C.F.) is one of that used in Kyung gi-do district. With that regard we tried to examine in vitro antifungal activity of the C.C.F. with its water extract and alcohol extract as the test materials. Until now many authors have studied the antifungal activity with several plant extracts, as like the alcohol extracts of Zanthoxylum piperatum Fructus and Berberis Korea palibin or Fennel oil, and reported that these plant extrscts or essential oiI have good antifungal activities in vitro and in vivo. On that they said that the principal fractions those have strong fungistatic activity were all alikely the fatty acids chemically similar with the well known undecylenic acid. At this in vitro experiment the extracts of C.C.F. were diluted. serially in the Sabourauds dextrose agar and certain portions of fungi (the strains of Trichophyton (Tr.) mentagrophytes and Tr. rubrum) were transplanted into each medium containing different concentrations of test materials then observed its growth for 2 weeks at room temperature. After that we measured the sizes of colony grown in various conditions and compired with that of the normal medium to determine the fungistatic effectiveness. As the result, in the view of the colony sizes, Tr. mentagrophytes and Tr. rubrum equally revealed marked inhibition of its growth only in the media with water extract over the concentration of 10mg/ml in the mediurn, and the critical fungistatic dilution was 20 mg/ml. We could not identified the principal fraction in the water extract of C.C.F.which exhibited antifungal activity. In the comparison of the critical fungistatic dilution with the alcohol extract of Zanthoxylum piperaturn Fructus and Fennel oil, water extract of C.C.F. required tenfold higher concentration for the same effect. However in regarding the utilizing habits of C.C.F. in horne medicine, as topical wet dressing with water boiled solution, we might expect its effect practically. iVow there are problems to be investigated about the chemical natures and physical properties of the C.C.F. and for the antifungal fractions of it, in addition further in vivo study we thought would be interesting.
Agar ; Animals ; Bandages ; Berberis ; Fatty Acids ; Foeniculum ; Fungi ; Glucose ; Horns ; Korea ; Plant Extracts ; Plants ; Tinea ; Trichophyton ; Water ; Zanthoxylum

BACKGROUND: In patients with systemic lupus erythematosus(SLE), LE-specific cutaneous lesions include malar rashes, widespread/morbilliform erythema, oral ulcer and bullous lesions. OBJECTIVE: Clinical observations were carried out to define cutaneous features of morbilliform erythema and to see possible relevancy of this erythema to disease activity of SLE. METHODS: Examinations were performed on 7 SLE patients with morbilliform erythema regarding the distribution and course of the cutaneous lesions; some SLE-activity related hematologic/immunologic data taken during/around the time of this skin disease were also assessed in each patient. RESULTS: In most of those patients with morbilliform erythema, which covered the trunk and extremities, the skin lesions lasted for about 2 weeks until their disappearance. At or around the time of suffering from this skin disease of acute eutaneous LE, activities of systemic disease were recognized as "in a state of flare-up or aggravation" with hypocomplementemia and high titers of anti-nDNA autoantibodies. CONCLUSION: As with malar rashes, morbilliform erythema of acute cutaneous LE seems to develop more frequently at the time of severe systemic involvement of immunopathological processes of SLE.
Autoantibodies ; Blister ; Erythema* ; Exanthema ; Extremities ; Humans ; Lupus Erythematosus, Systemic* ; Oral Ulcer ; Skin ; Skin Diseases

The prevalence of syphilis was sharply decreased throughout the world since the introduction of penicillin into the treatment of syphilis in 1943, however recent in formations seemed to be increased in incidence of syphilis since about 1960. In Korea, recent trends of syphilis can hardly be assesed because there are few reports of it. In order to know the current incidence of syphilis in Seoul we carried out S.T.S. in 1046 healthy young men living in Seoul. At that we classified the man as syphilitic who has positive serologic test on both VDRL and RPCF and has not recieved regular antisyplulitic treatment in the past. The result reveala that the incidence of syphilitic infection is 1.72%, which is slightiy decreased statistical figure than in 1960s. There are no much differences in incidence between each group of age or educational degree. Among the 653 unmarried men, 62.3% of them had experiences of sexual contact and their sex partners were business girls, students and prostitutes in order of frequency.
Commerce ; Equidae ; Female ; Humans ; Incidence ; Korea ; Male ; Penicillins ; Prevalence ; Seoul* ; Serologic Tests ; Sex Workers ; Single Person ; Syphilis*

Pemphgus vulgaris (PV), Bullus pemphigoid (BP), and Epidermolysis bullous acqusita (EBA) are autoimmune bullous dermatoses, characterized by circulating IgG autoantibodies. These antibodies react with antigens located at the intercellular substance (ICS) of epidermis, basement membrane zone (BMZ), and subepidermal anchoring fibril zone (AFZ), respectively. The subclass distribution of IgG autoantibodies, and the properties and degrees of complement fixing activities of these autoantibodies in each of the above diseases have not been well understood. Indirect immunofluorescence and in vitro complement stainings were performed for the titration of subclasses of IgG antibodies and for the immunofluorescence staining reactivities of complement components C3, C4, C5b-9, H, C4bp, and S. Each serum specimen from five cases of PV, five cases of BP. and three cases of EBA was tested. The findings of multistep technique with monoclonal and polyclonal antibodies are as follows : All four subclasses of IgG antibodies were identified at the antigenic sites in these group, however there were some differences in the antibodies titers. In PV and BP the dominant subclass of highest antibody titer was IgG1 and/or IgG4. In EBA only IgG4 was dominant in all three cases. The results of complement component stainings, in most of the cases of PV, showed positive for C3 and C4 but were negative for the other components or inhibitor proteins at the ICS of epidermis. In BP most of the cases revealed positive staining reactivities at the BMZ for C3, C4, C5b-9, H, and C4bp-9 with no staining reactivities for the inhibitor proteins No significant relevancy was found between the titers of complement fixing IgG subclasses and the numbers of positive complement staining reactivities for complement components. The results suggest that the complement system may contribute more strongly to the formation of bullous lesions in BP and EBA than in PV.
Antibodies ; Autoantibodies ; Basement Membrane ; Blister ; Complement Membrane Attack Complex ; Complement System Proteins ; Epidermis ; Epidermolysis Bullosa Acquisita* ; Epidermolysis Bullosa* ; Fluorescent Antibody Technique ; Fluorescent Antibody Technique, Indirect ; Immunoglobulin G ; Pemphigoid, Bullous* ; Pemphigus* ; Skin Diseases, Vesiculobullous

A retrospective study was made of 10 consecutive patients who underwent mandibular reconstruction with PCBM from December 1994 to July 1996. Free autogenous iliac bone in the from of particulate cancellous bone and marrow was densely packed into the crib that was adapted to bridge the mandibular discontinuity defect. Frozen-treated autogenous mandibular bone, splitted autogenous rib, and titanium mesh(Dumbach, Leibinger) were used as cribs carrying the PCBM. All ten cases underwent successful healing with the formation of a continuous bony union with the remaining mandible. The rate of resorption was assessed by sequential panoramic radiographs. The mean horizontal dimension of the madibular defects was 44mm and the mean vertical dimension of the reconstructed segments was 23mm. The bony height of the reconstructed segments retained about 90% of the bony height of over a 1-year period. We confirmed that PCBM grafts were the most successful and predictable grafts in mandibular discontinuity reconstruction.
Bone Marrow* ; Humans ; Infant Equipment ; Mandible ; Mandibular Reconstruction* ; Retrospective Studies ; Ribs ; Titanium ; Transplants ; Vertical Dimension

Frequent anomalies causing a left-sided appendix are situs inversus and malrotation. The ectopic position of the appendix frequently causes a delay or error in diagnosis because of atypical symptoms. A physical examination is of limited value unless dextrocardia is present. A left-sided appendix is a rare anomaly, but when other diseases are ruled out, it must be considered especially at the emergency department.
Appendicitis* ; Appendix ; Dextrocardia ; Diagnosis ; Emergency Service, Hospital ; Physical Examination ; Situs Inversus

No abstract available.
Chungcheongbuk-do* ; Leptospira interrogans* ; Leptospira*

Three cases of necrotizing vasculitis clinically showing bullous skin lesions and histopathologically confirmed as leukocytoclastic vasculitis are reported. Compared with those of skin -limited non-bullous forms of cutaneous vasculitis, these cases showed relatively frequent abnormalities in urinalysis and required more aggresive corticosteriod therapy. Clinicians should be aware of the possible systemic involvements when the skin lesions are bullous in cutaneous necrotizing vasculitis.
Skin* ; Urinalysis ; Vasculitis*

No abstract available.
Rectovaginal Fistula*

No abstract available.
Depression* ; Humans ; Inpatients*