1.Effect of substance P and Tetrodotoxin in motility of isolated perfused human colon.
Byoung yoon RYU ; Soon Kang LEE ; Hea Wan LEE ; Hong Ki KIM ; Chang Sig CHOI
Journal of the Korean Surgical Society 1993;45(4):471-478
No abstract available.
Colon*
;
Humans*
;
Substance P*
;
Tetrodotoxin*
2.A Case of Systemic Lupus Erythematosus Presented with Clinical Feature Resembling Multiple Sclerosis.
Chang Wan HAN ; Hoon Suk CHA ; Seong Wook KANG ; Yoon Jong LEE ; Yeong Wook SONG
The Journal of the Korean Rheumatism Association 1997;4(2):180-184
Systemic lupus erythematosus is a connective tissue disease which can affect every organ system. Neurologic abnormalities are common, occuring in approximately half of all patients at some time during the course of their illness. But symptoms of nervous system as the sole presenting symptoms occur in less than 1% of lupus patients. In patients initially presenting with neurologic symptoms and signs, differential diagnosis is difficult and sometimes it may be misdiagnosed. Therefore extensive laboratory investigations should be carried out in all patients with unusual neurological symptoms, since early diagnosis of lupus can help in providing effective treatment. We report a patient with systemic lupus erythematosus who presented with dysarthria and dysphagia resembling multiple sclerosis.
Connective Tissue Diseases
;
Deglutition Disorders
;
Diagnosis, Differential
;
Dysarthria
;
Early Diagnosis
;
Humans
;
Lupus Erythematosus, Systemic*
;
Multiple Sclerosis*
;
Nervous System
;
Neurologic Manifestations
3.Histochemical and Immunohistochemical Stain of Helicobacter pylori from the Gastric Mucosa.
Jong Cheul BAEK ; Heon Seok KANG ; Soong LEE ; Jae Il MYUNG ; Wan KIM ; Chang Soo PARK
Korean Journal of Medicine 1997;53(5):645-653
No abstract available.
Gastric Mucosa*
;
Helicobacter pylori*
;
Helicobacter*
4.Fracture Dislocation of the interphalangeal Joint of Great Toe: Report of Three Cases
Jun Seop JAHNG ; Hui Wan PARK ; Kyu Hyun YANG ; Kang Soo CHANG
The Journal of the Korean Orthopaedic Association 1994;29(5):1424-1427
We experienced two cases of irreducible fracture dislocation and one case of neglected dislocation of the interphalangeal joint of great toe. The cause of irreducibility of fracture dislocation were an interposition of the flexor hallucis longus tendon entrapped within undisplaced longitudinal fracture of the condyle of proximal phalanx and an entrapment of the osteochondral fragment which was avulsed from the distal insertion of lateral collateral ligament.
Dislocations
;
Joints
;
Lateral Ligament, Ankle
;
Tendons
;
Toes
5.Treatment of Tibial Pilon Fractures: Ilizarov Method vs Conventional Methods
Dae Yong HAN ; Soo Bong HAHN ; Hui Wan PARK ; Soo Chang KANG
The Journal of the Korean Orthopaedic Association 1995;30(3):717-724
The tibial pilon fracture has been described as difficult fracture to manage. We have reviewed 23 cases of tibial pilon fractures from Mar. 1987 to Feb. 1993 at our hospital. 1. The fractures were classified into five types according to the system of Ovadia and Beals and the methods of treatment were divided into two groups; 9 cases were treated with Ilizarov device(Group I). 6 cases out of Group I were type 3, 4 and 5. Other methods were performed in 14 cases(Group II). 8 cases out of Group II were type 3, 4, and 5. 2. In type 3, 4 and 5 fractures, there were 86 per cent good and fair radiographic results in Group I and 63 per cent good and fair results in Group II. 3. Satisfactory results were obtained by the treatment of Ilizarov method especially in type 3, 4 and 5 fractures. The advantages of Ilizarov device were its primary reduction with ligamentotaxis, easy open reduction due to proximal and distal stabilization, minimal soft tissue injury and minimal internal fixation.
Ilizarov Technique
;
Methods
;
Soft Tissue Injuries
6.Effects of histamine H|2-receptor stimulation on Mg2+ efflux in perfused guinea pig heart.
Hyung Sub KANG ; Sung Eun CHANG ; Chang Won KANG ; Soo Wan CHAE ; Jin Sang KIM
The Korean Journal of Physiology and Pharmacology 1998;2(1):49-54
Mg2+ is an important regulator of many cardiac functions. However, regulation of intracellular Mg2+ activity in the heart is not well characterized. To assess the effect of histamine H2-receptor stimulation on intracellular Mg2+ regulation, changes in extracellular Mg2+ concentration were examined under a variety of conditions in perfused guinea pig hearts. Mg2+ in the cardiac perfusate was measured by atomic absorbance spectrophotometry. The histamine (10(-6) M induced a marked Mg2+ efflux from the heart. The H2-receptor antagonists, cimetidine (10(-5) M), ranitidine (10(-5) ND, but not a H1-receptor antagonist, diphenhydramine (3 X 10(-6) M), completely blocked the histamine-induced Mg2+ efflux. The Mg2+ efflux could also be induced by forskolin (3 X 10(-6) M), 8-Cl-cAMP (2 X 10(-4) M), permeable cAMP analogue, or dimaprit, (10(-5) M). However, the carbachol (10(-5) M) considerably decreased the efflux of Mg2+. In the presence of papaverine (10(-5) M), a phosphodiesterase inhibitor, dimaprit-induced Mg2+ efflux was potentiated. These results suggest that a significant Mg2+ efflux from perfused guinea pig heart by histamine can be induced by the histamine H2-receptor stimulation and it is suggested that cytosolic cAMP may be linked.
Animals
;
Carbachol
;
Cimetidine
;
Colforsin
;
Cytosol
;
Dimaprit
;
Diphenhydramine
;
Guinea Pigs*
;
Guinea*
;
Heart*
;
Histamine*
;
Magnesium
;
Papaverine
;
Ranitidine
;
Spectrophotometry
7.Comparison of the effect of dexmedetomidine and midazolam under spinal anesthesia for cesarean delivery: a randomized controlled trial, single center study in South Korea
Hyoseok KANG ; Taeha LIM ; Hyun jeong LEE ; Tae Wan KIM ; Wan KIM ; Hae Wone CHANG
Anesthesia and Pain Medicine 2023;18(2):159-168
Background:
Cesarean section under spinal anesthesia may cause anxiety and hypotension. Administration of sedative drugs after delivery can diminish these side-effects, but may increase hemodynamic instability. We evaluated the effect of the administration of 0.7 μg/kg dexmedetomidine and compared it with that of 0.03 mg/kg midazolam for usefulness of sedation of the parturient after delivery during cesarean section.
Methods:
After obtaining written consent and the ethics board approval, 60 parturients aged 20–43 years who underwent elective cesarean delivery under spinal anesthesia were recruited. A total of 0.5% hyperbaric bupivacaine (8–10 mg) and intrathecal fentanyl (10 μg) was given to induce anesthesia. Parturients were then randomly allocated to receive either midazolam (0.03 mg/kg; group M) or dexmedetomidine 0.7 (μg/kg; group D) after delivery. The primary outcome measure was patient satisfaction score. Secondary outcomes included vital signs; vasopressor dosage; incidence of shivering, nausea, and vomiting; incidence of bradycardia; time to sensory and motor recovery; postoperative nausea and vomiting score; and postoperative pain visual analog scale at 6, 24, and 48 h.
Results:
Satisfaction scores for sedation were similar between the two groups. The systolic blood pressure, heart rate, oximetry saturation, and tympanic temperature were comparable between the two groups. The predicted mean systolic blood pressure of group D was 106.3 mmHg and that of group M was 107.5 mmHg. Both groups showed comparable adverse intraoperative and postoperative outcomes.
Conclusions
Dexmedetomidine and midazolam showed similar hemodynamic effects and patient satisfaction in parturients under spinal anesthesia.
8.The Management and Characteristics of Posterior Cerebral Artery Aneurysms.
Dong Wan KANG ; Byung Kwan CHOI ; Chang Hwa CHOI
Korean Journal of Cerebrovascular Surgery 2006;8(2):107-113
Posterior cerebral artery (PCA) aneurysm is a rare disease, and has some distinctive features compared with aneurysms located elsewhere. This study is to investigate results of the management and characteristics of posterior cerebral artery aneurysm. Between 1996 and 2005, we treated 8 patients (4 male, 4 female) via endovascular or surgical approach. Six patients underwent endovascular treatment and two were treated with open surgery. The Glasgow Outcome Scale (GOS) was used for estimating the results. Five patients had ruptured PCA aneurysms and three had unruptured aneurysms. The locations were one case of P1 branch, two cases of P1-P2 junction, four cases of P2-P3 junction and one case of distal P4 branch. Among 8 patients, five had good recovery, two had a moderate disability and another one was expired due to rebleeding. Optimal treatment of PCA aneurysms is able to perform via surgical or endovascular approach. Endovascular treatment is effective and an alternative method for PCA aneurysm because of the difficulty and several complications of surgical approach.
Aneurysm
;
Glasgow Outcome Scale
;
Humans
;
Intracranial Aneurysm*
;
Male
;
Passive Cutaneous Anaphylaxis
;
Posterior Cerebral Artery*
;
Rare Diseases
9.A Case of Calvarial Hemangioma in Cranioplasty Site.
Dong Wan KANG ; Chang Hwa CHOI
Journal of Korean Neurosurgical Society 2009;46(5):484-487
It is not uncommon for hemangiomas to occur in the calvarium, accounting for about 10% of the benign skull tumors. A 46-year-old man was presented with a palpable scalp mass on the left parietal region. Past medical history indicated that he had undergone cranioplasty 25 years prior due to a depressed skull fracture suffered from a traffic accident. Magnetic resonance imaging revealed mixed signal intensity mass on T1 -and T2-weighted images pushing a linear signal void lesion outward in the left parietal region. After total surgical removal along with cranioplasty, he was discharged without neurological deficits. Histological examination of the surgical specimen revealed a cavernous hemangioma. A skull hemangioma occurring at the site of a cranioplasty has not yet been reported. Therefore, authors report this case in combination with a pertinent literature review.
Accidents, Traffic
;
Accounting
;
Hemangioma
;
Hemangioma, Cavernous
;
Humans
;
Magnetic Resonance Imaging
;
Middle Aged
;
Scalp
;
Skull
;
Skull Fracture, Depressed
10.Clinical study on placental abruption.
Wan Suk CHO ; Geon O KIM ; Chang Yeon KIM ; Won Shik SHIN ; Sang Dae KANG ; Seung Bo PARK
Korean Journal of Obstetrics and Gynecology 1993;36(7):2304-2312
No abstract available.
Abruptio Placentae*
;
Female
;
Pregnancy