The immune pathogenesis of tuberculosis,preparation of Mycobacterium tuberculosis vaccine,diagnosis of latent infection and active tuberculosis as well as the assessment of tuberculosis severity are still major challenges in the field of tuberculosis.In recent years,many studies have explored immune pathogenesis and new diagnostic and treatment targets of tuberculosis, and the high mobility group box-1 protein(HMGB1) receives wide attention for its unique pathophysiological mechanism.This article reviews the research progress on the correlation between HMGB1 and tuberculosis, which would be of help in diagnosis and treatment of tuberculosis.

Objective To investigate the number,distribution and expression intensity of dendritic cells and T lymphocytes in human cervical intraepithelial neoplasia and invasive carcinoma for seeking biotherapeutic evidence of cervical carcinoma. Methods The number,distribution and expression intensity of CD-(1a),S-100,CD-3, CD-8 positive cells were determined in cervical intraepithelial neoplasia and invasive carcinoma and human normal cervix tissue as the control,by using immunohistochemical technique and computerized imaging analysis system. Results Compared with human normal cervical tissue,the number and the expression intensity of CD~+-(1a),S-100~+,CD~+-3,CD~+-8 cells in cervical intraepithelial neoplasia significantly increased(P

Child ; Humans ; Neoplasms ; Quality of Life

Adrenal Cortex Hormones ; administration & dosage ; therapeutic use ; Arthritis, Juvenile ; drug therapy ; Humans ; Injections, Intra-Articular

Prognosis factors of Ⅲ A (N2) phase non-small cell lung cancer are various.The histological molecular markers are mainly about multi-resistant gene,growth factors,mucin 4,insulin-like growth factor-2,Ki-67,PTEN and so on.Different expressions of these genes may divide the N2 non-small-cell lung cancer into different molecular subtypes,which is more effective to guide clinical therapy.

This thesis, with a Class 3A hospital as the research object, aims at analyzing the status quo and causes of its costs of health materials so as to put forward corresponding methods and suggestions of cost management, thus providing scientific guidance on reducing operating costs and improve medical quality in public hospitals.

Purpose:To clarify roles of overexpression of phosphorylated Akt(p-Akt) and loss of phosphatase and tensin homologue deleted on chromosome 10(PTEN) expression in biological behavior of non-small-cell lung cancer(NSCLC). Methods:Immunohistochemical staining was used to determine the expression of p-Akt and PTEN in 20 cases of normal lung tissues and 102 patients with NSCLC.Results:Negative p-Akt expression and positive PTEN expression were found in normal lung tissues, while the positive incidences of p-Akt expresssion and loss of incidences of PTEN expresssion in NSCLC were 41.2% (42/102) and 46.1% (47/102)respectivtly.The overexpression of p-Akt and loss of PTEN expression were correlated to degree of differention of cancer, metastasis(including lymph node), and clinical stages. A significant negative correlation was observed between expression of p-Akt and PTEN(Phi r=-0.425,P

Objective To investigate radiation-induced alternations of phospholipids in epithelial cells,and to provide experimental evidence for understanding the mechanism of radiation-induced intestinal injury.Methods The intestinal epithelial cells(IEC-6)in rats were divided into three groups:normal control group,8 Gy X-ray irradiation group and 12 Gy X-ray irradiation group.Phospholipids were extracted at 6 h or 24 h after radiation and then measured by high-performance liquid chromatography and mass spectrometry(HPLC-MS).Results At 6 h after radiation,the phospholipids in 8 Gy irradiation group didn't vary significantly,while those in 12 Gy irradiation group changed.The PG,PI and Lyso PC were significantly up-regulated(F=5.37,9.60,9.88,P＜0.05).However,at 24 h after radiation,many PE and PG species in both irradiation groups declined(F=5.15-99.77,P＜0.05)and SM species increased in 12 Gy irradiation group(F=4.35-7.92,P＜0.05).Conclusions The ionizing radiation could disorder phospholipid metabolism in IEC-6 cells with a dose-dependent manner.

The length of the muscular branches of the nerves in the upper limb from a fixed point along the nerve and its branches in 40 cadavours was measured.The muscular branches of the median and the radial nerve were measured by Sunderland's method, while for the muscular branches of the musculo-cutaneous nerve,we selected the middle point of the clavicle as a fixed point.The shortest and the longest distances and the numbers of muscular branches to the individual muscles supplied by the nerves were re- corded. The point of origin of the muscular branches of individual muscles in each muscle group followed a definite order,for instance,the shortest of the muscular branches of the median nerve was those to the pronator teres,then next by order were those to the flexor digitorum sublimis,the palmaris longus,the flexor pollicis longus and the pro- nator quadratus.The serial order of branches from the radial nerve was that to the long head of the triceps brachii,the medial head of the same muscle,the brachialis, the extensor carpi radialis longus,and the extensor carpi radialis brevis.Among the muscular branches of the musculo-cutaneous nerve,those to the coracobrachialis came out first,then followed by those to the biceps brachii and the brachialis. The number of the branches to the individual muscles in each muscle group seemed to be proportional to the size of the muscle and to the role played by that muscle in the specific movement.The pronator and supinator muscles,though small in size,received quite a number of branches.It is suggested that the more muscular branches a muscle receives,the greater the importance it has in moving a joint.

Measurement of the length of the muscular branches of the nerves in the lower extremity was made on 40 dissection-room specimens.The muscular branches of sciatic nerve and of its two major divisions were measured according to Sunderland's method. For the femoral nerve,we chose the interspinous line as the fixed point.The results were as follows: A muscle may be innervated by a single or several branches.In most cases,the popliteus was supplied by a single branch,the extensors of the thigh were usually sup- plied by many branches.In each muscle group,the number of the muscular branches to one or two muscles was always larger than that to the others.The largest and most powerful muscle (or muscles) received most nerve supply. The order of origin of the muscular branches to a muscle in each muscle group was usually fixed.The muscle of high origin received earlier branch from the trunk.The muscle of superficial position seemed to enjoy the similar previlege as that of higher origin.Thus in the anterior muscle group of the thigh,the branch to the sartorius came out first,branch to the rectus femoris the next,then followed by that of the vastus inter- medius the vastus lateralis and the vastus medialis;This order corresponds to the se- quence generation of the peripheral nerves after injury.