No abstract available.
Multiple Myeloma* ; Oncogene Proteins* ; Oncogenes* ; Proliferating Cell Nuclear Antigen*

To observe whether the measurement of enzyme activity has any critical role in assesment of diagnostic value, beta-glucuronidase and lactic dehydrogenase activities in neoplastic tissue of stomach were compared with those in the stomach at the stomach mucosa at the antrum and body which was uninvolved by tumor. And then activities of those enzymes were also compared with differentiated and undifferentiated carcinomas. The stomach tested were obtained by gastrectomy in Pusan National University Hospital during the months from March to June in 1983. The results were summarized as follows: 1) beta-glucuronidase activity in the neoplastic tissue of stomach was higher than that in the antral and body mucosa, and this enzyme activity in the antral mucosa with intestinal metaplasia was higher than that in the body mucosa of stomach. 2) Lactic dehydrogenase activity in the neoplastic tissue of stomach was similar to that in the antral mucosa with intestinal metaplasia, and was higher than that in the body mucosa of stomach. 3) Acitivities of both enzymes in the neoplastic tissue of differentiated carcinoma were slightly higher than that of undifferentiated one, but did not found statistically significant difference. 4) In the neoplastic tissue of the stomach there was no significant correlation between beta-glucuronidase and latic dehydrogenase activities. Above results support that the measurement of gastric juice enzymes is useful in the diagnosis of stomach carcinoma and may be of value in the identification of high-risk groups.

Implant materials, for examples, plaster of Paris, Bone cement and ceramics which are used experimentally to regain shape and function, act as a scaffold for bone growth and contribute to the healing processes at bone defect developed by trauma, infection and other causes. Therefore, the effect of plastei of Paris on the bone defects of adult rabbits may be an interesting subject, particularly in the orthopedic field. The authors carried out an experiment to study the effect of plaster of Paris on the bone defect, using 30 adult rabbits weighing fmm 3000-3500 gm, which were divided into 3 main gmups. (Each group was composed of 10 adult rabbits.). In Group 1, which was the control group, made a defect at the proximal metaphysis of the tibia, 6 mm×6 mm×6 mm in size, using a drill bit and filled by hematoma spontaneously. In Group II and Group IU, a defect was also made by the same method as in Group I and a piece of Gelfoam or plaster of Paris was inserted into the bone defect respectively. Then we studied the healing processes of the bone defect by sacrifying animals of each group at 6th and 12 th week after operation. The results of this experiment were as follows. 1. New bone formarion in the bone defect was poor in group I and Gmup Il, but it was good in Group III. 2. The plaster of Paris, filling into the defect, was absorbed and removed from the site of implantation continuously and stimulated the new bone formation. 3. The Gelfoam in Group II was more rapidly absorbed than plaster of Paris and didn't stimulate the new bone formation.
Adult ; Animals ; Bone Development ; Calcium Sulfate ; Ceramics ; Gelatin Sponge, Absorbable ; Hematoma ; Humans ; Methods ; Orthopedics ; Osteogenesis ; Rabbits ; Tibia

There is room for debate in appropriate diagnosis and treatment due to physiological and anatomical differences in pediatric facial bone fractures from that of adult's. The objectives of this article is to analyze for our clinical cases and to suggest the appropriate management of facial bone fracture in children. The study included 56 children who had treatment for the craniofacial fractures form March, 1990 to February, 1998. Their ages ranged from 3 to 15. There were 38 males and 18 females. Physical examination, simple x-rays, ultrasonograms and routine CT scans were used for diagnosis. Materials were classified into 28 nasal bone fractures, 4 nasoethmoidal fractures, 6 orbital fractures, 8 mandible fractures, and 10 zygoma fractures. Patients were treated with conservative treatment in 9 cases, with closed reduction in 28 cases and open reduction only, and 14 patients with open reduction and internal fixation using microplates and screws. 3 patients needed autogenous calvarial bone graft. Plates and screws were removed in postoperative 3-6 months. All patients had successful union of fractured bones without no specific complications, and normal bony growths were noticed during the 7 years follow up. We conclude that surgeons should be careful in diagnosis and management for the pediatric facial fracture due to anatomical variations and differences in fracture aspects. First, it is mandatory for surgeous to get accurate diagnosis and identify children's fracture and displacement through routine CT check up along with physical examination. Second, it is important to perform the minimally invasive technique or conservative treatment for the children with mild displacement so that it reduces the incidence of growth retardation which may be caused by extensive operation. However, application of rigid fixation is necessary in case of extensive bony displacement or bony defects because of poor coorporation in postoperative care. Third, plates and screws which were used for the internal fixation should be removed at 3-6 months after the surgery. Fourth, if bone graft is needed, it is better to use autogenous graft than allogeneous graft. Fifth, care for dentition and follow up for growth are necessary for growing children.
Child ; Dentition ; Diagnosis ; Facial Bones* ; Female ; Follow-Up Studies ; Humans ; Incidence ; Male ; Mandible ; Nasal Bone ; Orbital Fractures ; Physical Examination ; Postoperative Care ; Tomography, X-Ray Computed ; Transplants ; Ultrasonography ; Zygoma

The authors studied EBV genome expression in 40 conventionally processed samples of nasopharyngeal carcinomas (NPC), using in situ hybridization for EBERs and immunohistochemistry for LMP, Bcl-2 and p53 proteins. The NPCs consisted of 6 keratinizing squamous cell carcinomas (KSCs), 13 nonkeratinizing carcinomas (NKCs) and 21 undifferentiated carcinomas (UCs). The results were summarized as follows: 1) EBERs were expressed in 80.0% of all the NPCs (32/40). As for the subtypes, they were detected in 92.3% of NKCs (12/13), in 90.5% of the UCs (19/21), and in 16.7% of the KSCs (1/6). In positive cases, the nuclei of tumor cells displayed uniformly strong staining. 2) LMP was expressed in 10.0% of all the NPCs (4/40), all of which were UC. The LMP expression in the UCs was not correlated to the expression of EBERs, Bcl-2 and p53 proteins. 3) Bcl-2 protein was detected in 85.0% of all the NPCs (34/40). As for the subtypes, they were detected in 92.3% of the NKCs (12/13), in 90.5% of the UCs (19/21), and in 50.0% of the KSCs (3/6). 4) p53 protein was detected in 75.0% of all the NPCs (30/40). As for the subtypes, they were detected in 81.0% of the UCs (17/21), in 69.2% of the NKCs (9/13), and in 66.7% of the KSCs (4/6). 5) In the NPCs the expression of EBER showed a significantly positive correlation with that of p53 or Bcl-2 protein. The above results indicate that the association of EBV with NPC is chiefly with poorly differentiated and undifferentiated carcinomas. Additionally, carcinomas commonly display widespread, strong immunoreactivity of Bcl-2 and p53 proteins over tumor cells. In conclusion, these observations indicate that the EBV-association in NPC appears to contribute to the overexpression of tumor-related genes during carcinogenesis.
Carcinogenesis ; Carcinoma ; Carcinoma, Squamous Cell ; Genome ; Herpesvirus 4, Human* ; Immunohistochemistry ; In Situ Hybridization

No abstract available.
Methionine*

We report a 44-year-old female patient with Eosinophilic cellulitis who had developed pruritic erythematous plaque on the right lower abdomen since two months ago. The blood eosinophil count was 2,066/mm at first visit. This lesion responded well to cortieosteroid therapy. However new erythematous swelling reappeared on the left lower abdomen and left inner thigh 3 months after the first treatment. A biopsy specimen taken from an erythematous plaque showed many flame figures and diffuse infiltration of eosinophils and histiocytes in the lower dermis and subcutaneous fat tissue.
Abdomen ; Adult ; Biopsy ; Cellulitis* ; Dermis ; Eosinophils* ; Female ; Histiocytes ; Humans ; Subcutaneous Fat ; Thigh

No abstract available.

No abstract available.
Gastrectomy* ; Stomach Neoplasms* ; Stomach*

This study was performed to apply the submentovertex cephalometric radiograph to mandibular condylar fractures. Because the left and right structures are not overlaped in the submentovertex radiograph, the dimension and position of mandibular condyle can be clearly identified in this view. The subjects consisted of 40 normal adult patients, twenty healthy males and females with no medical and dental histories. Specific angular and linear measurements were made from each submentovertex radiograph and computerized statistic analysis was carried out. The results were as follows. 1. There was no sexual difference in the angular measurements such as intercondylar angle, angle between condylar axis and mandibular line, and angle between condylar axis and TPA. Though no sexual difference was seen in the linear measurements related to the position of the condyle such as L-TSA, L-TPA, and MSP-Pog, measurements related to the dimension of the condyle such as condylar thickness, condylar width, L-MSP, L-Cpp, MSP-Cpp, and L-Pog were lager in male than female. 2. Statistically, significant difference between right and left values was seen only in the value of condylar width and L-Cpp(p<0.05). But the correlation coefficient of the condylar width between right and left side was very high that it could be thought very useful to compare the left and right side value clinically. 3. In the correlation analysis between left and right side condylar width, L-Cpp, and L-Pog were showed high relation. On the other hand the value of L-TSA was showed low relation. The other measurements were showed relatively high relation. 4. The difference between the maximum and minimum value of each measurement was considerable that the individual variation of measurement was relatively high.
Adult* ; Axis, Cervical Vertebra ; Diagnosis* ; Female ; Hand ; Humans ; Male ; Mandibular Condyle ; Prognosis*