1.Castleman Disease Arising from IVlesentery: A Case Report.
Jae Chun CHANG ; Dong Sug KIM ; Hwa Jin LEE
Journal of the Korean Radiological Society 1995;32(5):775-778
Castleman disease is a benign disorder, usually occurring within mediastinum, characterized by proliferation of lymphold tissue. The authors report a rare case of Castleman disease originating from mesenteric root. The tumor was highly vascular, proved by dynamic CT examination and splanchnic angiography.
Angiography
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Giant Lymph Node Hyperplasia*
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Mediastinum
2.Multiple hepatic adenomatosis: a case report.
You Song CHANG ; Jae Chun CHANG ; Sang Jin LEE ; Bok Whan PARK ; Hong Jin KIM ; Dong Sug KIM
Journal of the Korean Radiological Society 1992;28(4):617-622
We expirenced multiple hepatocellular adenomatosis, which was proved by pathology, in 38 years old man who had no prior history of predisposing factors. The radiologic findings were different by the size of tumor mass and intratumoral hemorrhage. Ultrasound demonstrated inhomogeneous hyperechoic large mass in segment 5 of right lobe and hyperechoic or isoechoic multiple small nodules in right lobe. Computed tomography demonstrated low density mass without contrast enhacement. Central high density is noted in hemorrhagic portion. Magnetic resonance T1-weighted image demonstrated high signal intensity in mass and hemorrhagic portion. T2-weighted image demonstrated slightly high signal intensity in mass portion, high signal intensity in hemorrhagic portionand double-layered peripheral rim. Gradient echo image well demonstrated inhomogenesity of mass.
Causality
;
Hemorrhage
;
Pathology
;
Ultrasonography
3.Richer's Syndrome: Report of a case.
Su Kyeong YEON ; Chang Sug KANG ; Han Jin LEE ; Dong Uk KIM ; Chun Chu KIM ; Sang In SHIM
Korean Journal of Pathology 1994;28(4):420-426
Richer's syndrome is a development of a high grade malignant lymphoma in a patient with preexisting chronic 1ymphocytic leukemia, small lymphocytic lymphoma or Waldenstrom's macroglobulinemia. A rare case of Richer's syndrome arising in the spleen of a 35-year-old-man was studied by morphology, immunohistochemistry and gene rearrangement study. He has had weight loss and night sweat for last 6 months. Hepatosplenomegaly and abdominal lymphadenopathy were noted on CT scanning. Especially an ovoid radiolucent mass was found within the image of splenomegaly. Lymph nodes and liver biopsy, bone marrow aspiration and splenectomy were done. In the lymph nodes, liver and bone marrow, well differentiated small lymphocytic infiltrations were found but, in the spleen, pleomorphic, large cells with occasional multinucleated giant cells formed a nodular mass surrounded by diffuse, extensive infiltration of small well differentiated lymphocytes. The two distinctive areas in the spleen had positive staining for B-cell marker (HLA-DR and L26), negative staining for T-cell marker (UCLH1), and positive staining for IgM heavy chain and kappa light chain by immuohistochemical study. so this case was diagnosed as a diffuse large cell 1ymphoma transformed from small lymphocytic lymphoma. We made an another effort to clarify their clonality. Gene rearrangement method usingcomplementarity.determining region 3(CDR3) of immunoglobulin heavy chain (IgH) gene and T-cell receptor gamma (TCRgamma) gene by polymerase chain reaction (PCR) technique was done. The two lymphomas in the spleen demonstrated the same rearrangement pattern in both IgH and TCRgamma gene. We think these findings strongly suggest that the large cell lymphoma has the same clonality with that of the small lymphocytic lymphoma.
Male
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Humans
4.Stent Fracture after Modified Gianturco Stent Placement in Patients with Malignant Esophageal Stricture: A Case Report.
Sang Hoon LEE ; Young Min HAN ; Jeong Soo SONG ; Chang Sug CHUN ; Chong Soo KIM
Journal of the Korean Radiological Society 1997;37(1):79-81
A silicone-covered modified Gianturco stent in patients with malignant esophageal stricture is an easy, safe, and effective palliative procedure, but reports of complications arising from stent placement in patients with this condition are numerous. There have been no reports of fracture of the modified Gianturco esophageal stent. We report a case of stent fracture in association with gastric migration of modified Gianturco esophageal stent in a patient with malignant esophageal stricture. It appears that the fracture was probably due to oxidation of the stent by gastric juice.
Esophageal Stenosis*
;
Gastric Juice
;
Humans
;
Stents*
5.Postoperative adjuvant CCRT concurrentchemoradiotherapy for selected early stage cervical cancer patients following radical hysterectomy and pelvic lymph node dissection.
Young Ah KIM ; Hee Sug RYU ; Mi Son CHUN ; Ki Hong CHANG ; Young Han PARK ; Kie Suk OH
Korean Journal of Obstetrics and Gynecology 2000;43(10):1725-1730
No abstract available.
Humans
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Hysterectomy*
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Lymph Node Excision*
;
Lymph Nodes*
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Uterine Cervical Neoplasms*
6.A Case of Cervical Cancer in Aplastic Anemia Patient.
Hee Sug RYU ; Ki Hong CHANG ; Kie Suk OH ; Young Han PARK ; Jung Pil LEE ; Sung Chun YANG ; Mi Son CHUN
Korean Journal of Gynecologic Oncology and Colposcopy 2000;11(2):200-204
It is a rare occurrence that cervical cancer and aplastic anemia are combined, but eight cases were reported since Fujiu's report in 1968. There has been no one who have reported the case of like this in Korea. And so, we report this case for the support of idea of treatment in aplastic anemia patient combined with cervical cancer. The knowledges required are early detection of malignancy and the individualization of the treatment according to the status of the patient, the bone marrow function saving procedure and the prevention of the patient from death involved with bleeding and sepsis induced by infection.
Anemia, Aplastic*
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Bone Marrow
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Hemorrhage
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Humans
;
Korea
;
Sepsis
;
Uterine Cervical Neoplasms*
7.Differing prognosis of cervical cancer patients with high risk of treatment failure after radical hysterectomy warrants trial treatment modification.
Woo Young KIM ; Suk Joon CHANG ; Ki Hong CHANG ; Seung Chul YOO ; Mison CHUN ; Hee Sug RYU
Journal of Gynecologic Oncology 2009;20(1):17-21
OBJECTIVE: The aim of this study was to ascertain whether all cervical cancer patients who received adjuvant concurrent chemoradiation (CCRT) for high risk of treatment failure after radical hysterectomy are at the same risk of treatment failure, and if not, to propose trial treatment modification. METHODS: Between January 1999 and December 2007, 58 patients with FIGO stage Ib-IIa cervical cancer received adjuvant CCRT due to high risk factors such as positive lymph nodes or positive parametrium, or positive vaginal resection margins. Patients were divided into two Groups. Group A were patients with negative parametrium, negative vaginal resection margins, and only unilateral lymph node metastasis (involved L/N< or =2). Group B were those with either bilateral pelvic lymph node involvement, or more than 2 lymph node involvement, or positive parametrium with lymph node involvement. RESULTS: During a median follow-up period of 34 months (range, 6 to 102 months), 9 patients (15.5%) experienced recurrence; among whom 2 patients (2/28, 7.1%) were Group A, and 7 patients (7/30, 23.3%) were Group B. At 3 years, the estimated progression-free survival rate of all 58 patients was 78.3%, and the overall survival rate was 89.7%. Patients in Group A had significantly better progression-free survival (88.2% vs. 68.2%, p=0.042) and overall survival rate (100% vs. 78.8%, p=0.034) than Group B. CONCLUSION: Treatment modifications such as consolidation chemotherapy after CCRT may be considered based on the poor prognosis of very high risk patients such as those patients in Group B.
Consolidation Chemotherapy
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Disease-Free Survival
;
Follow-Up Studies
;
Humans
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Hysterectomy
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Lymph Nodes
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Neoplasm Metastasis
;
Prognosis
;
Risk Factors
;
Survival Rate
;
Treatment Failure
;
Uterine Cervical Neoplasms
8.Comparison of Concurrent Chemoradiotherapy Regimen Toxicities in the Treatment of Loco-Regionally Advanced Cervical Cancer.
Hye Jin CHANG ; Hee Sug RYU ; Mi Sun CHUN ; Ki Hong CHANG ; Jung Pil LEE
Korean Journal of Obstetrics and Gynecology 2004;47(5):908-916
OBJECTIVE: Concurrent chemoradiotherapy is the idea where the chemotherapeutic agent acts as a radiosensitizer thus producing a synergistic effect between radiotherapy and chemotherapy. We evaluated the efficacy and toxicity of concurrent chemoradiotherapy (CCRT) in loco-regionally advanced cervical cancer patients. METHODS: The medical records were retrospectively reviewed for 24 patients who underwent CCRT (cisplatin 70 mg/m2 on day 1, 29; 5-FU: 1000 mg/m2 on day 2-5 and 30-33 X 4 cycles), 26 patients who underwent weekly CCRT (cisplatin: 40 mg/m2 X 6 weeks) and 62 patients who had underwent radiation therapy alone for loco-regionally advanced cervical cancer at Ajou University Hospital. Toxicity was assessed according to the Gynecologic Oncology Group toxicity criteria. Statistical analysis was performed with chi- squre test. RESULTS: 2 year overall survival rate of patients only treated with RT was 75.0% (39/52). When this was compaired to CCRT, 83.3% (20/24) with monthly CCRT and 88.5% (23/26) with weekly CCRT of 2 year overall survival rates were attained. Recurrence rates were measured 2 years after each therapy done, they were 30.8% (16/52) with RT, 25.0% (6/24) with weekly CCRT, and 23.1% (6/26) monthly CCRT. During CCRT, grade 3 and 4 acute complication rates of nausea/vomiting (20.8% vs. 3.8%) and leukocytopenia (29.1% vs. 15.4%) was significantly higher in monthly group compared to weekly group (p<0.05). Weekly group had more patients who completed planned therapy compaired to monthly group (70.9% vs. 84.6%). CONCLUSION: CCRT improved overall survival rates and disease-free survival rate, but in some cases increased acute toxicity, and it is suggested that CCRT may be advantageous compared to radiation therapy for loco-regionally advanced cervical cancer. Weekly CCRT does not seem to afford distinct advantages in terms of acute toxicities over monthly CCRT, except for possible better patient compliance. Due to small size sample and short duration of follow up, further study of a large group of patients and the long survival rate is necessary.
Chemoradiotherapy*
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Disease-Free Survival
;
Drug Therapy
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Fluorouracil
;
Follow-Up Studies
;
Humans
;
Leukopenia
;
Medical Records
;
Patient Compliance
;
Radiotherapy
;
Recurrence
;
Retrospective Studies
;
Survival Rate
;
Uterine Cervical Neoplasms*
9.Calcifying Fibrous Pseudotumor of the Retroperitoneum: A Case Report.
Jae Ho CHO ; Mi Soo HWANG ; Jay Chun CHANG ; Bok Hwan PARK ; Dong Sug KIM
Journal of the Korean Radiological Society 1999;40(5):953-956
Calcifying Fibrous Pseudotumor of the Retroperi We report a case of calcifying fibrous pseudotumor in theretroperitoneum. This is a rare soft tissue mass le-sion with specific radiologic and pathologic findings, and itis the first reported case arising in the retroperi-toneum. The CT, MR and angiographic findings are described.
10.Risk group criteria for tailoring adjuvant treatment in patients with endometrial cancer: a validation study of the Gynecologic Oncology Group criteria.
Tae Wook KONG ; Suk Joon CHANG ; Jiheum PAEK ; Yonghee LEE ; Mison CHUN ; Hee Sug RYU
Journal of Gynecologic Oncology 2015;26(1):32-39
OBJECTIVE: The purpose of this study is to validate the Gynecologic Oncology Group (GOG) criteria for adjuvant treatment in a different cohort of patients and to evaluate the simplified risk criteria predicting the prognosis and tailoring adjuvant treatment in patients with surgically staged endometrial cancer. METHODS: We performed a retrospective analysis of 261 consecutive patients with surgically staged endometrial cancer between January 2000 and February 2013. All patients had complete staging procedures and were surgically staged according to the 2009 International Federation of Gynecology and Obstetrics staging system. Clinical and pathologic data were obtained from medical records. We designed the simplified risk criteria for adjuvant treatment according to the risk factors associated with survival. The patients were divided into low and low-intermediate, high-intermediate, and high-risk groups according to the GOG criteria and simplified criteria and their survivals were compared. Receiver-operating characteristic curve analysis was used to evaluate the prognostic significance of both criteria. RESULTS: Median follow-up time was 48 months (range, 10 to 122 months). According to the GOG criteria, we identified 197 low and low-intermediate risk patients, 20 high-intermediate risk patients, and 44 high-risk patients. There were significant differences in disease-free (p<0.001) and overall survival (p<0.001) among the three groups. Using the simplified risk criteria, we identified 189 low and low-intermediate risk patients, 28 high-intermediate risk patients, and 44 high-risk patients. There were significant differences in disease-free (p<0.001) and overall survival (p<0.001) among the three groups. The performance of the simplified criteria (area under the curve [AUC]=0.829 and 0.916 for disease recurrences and deaths, respectively) was as good as the GOG criteria (AUC=0.836 and 0.921 for disease recurrences and deaths, respectively). CONCLUSION: The simplified criteria may be easily applicable and offer useful information for planning strategy of adjuvant treatment in patients with surgically staged endometrial cancer as the GOG criteria.
Adult
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Aged
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Aged, 80 and over
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Chemotherapy, Adjuvant
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Endometrial Neoplasms/pathology/surgery/*therapy
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Female
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Humans
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Middle Aged
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Neoplasm Staging
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Prognosis
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Radiotherapy, Adjuvant
;
Retrospective Studies
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Risk Factors
;
Survival Analysis