The increased susceptibility in patients of chronic renal failure to infection has been reported to be attributed to defects in granulocyte and lymphocyte function and proliferative activity of hematopoietic cells. The definite cause of the frequent infection in uremic patients, however, is still controversial. The effect of uremic plasma on the aspect of the hematopoietic cells has been scarcely been studied. In the present study, mouse bone marrow was cultured with uremic plasma, to evaluate the effect of uremic plasma on the proliferative activity and morphological features of CFU-GM. The results obtained were as follows. 1) The number of colonies in group co-cultured with uremic plasma was more reduced than that of normal plasma group. 2) There was no difference between the group cultured with predialytic uremic plasma and that of postdialytic plasma in number of colonies, macroclusters and microclusters. 3) The forms of colony were granulocytic and monocytic forms at 5 day of culture. Electron microscopically, granulocytes disclosed electron dense azurophilic granules and electrolucent specific granules in the cytoplasm, and monocyte showed numerous vesicles and vacuoles in the cytoplasm which had finger-like projections. 4) The molecular weight of inhibitory factor in the uremic plasma was supposed to be less than 50,000 daltons.
Mice ; Animals

No abstract available.
Child* ; Humans ; Obesity*

Supracondylar fractures of the humerus is the most common elbow fractures in children. The fractures so designated are in the supracondylar area of the humerus just proximal to the elbow, and do not directly involve the joint or the distal humeral epiphysis. Unfortunately, it can also be one of the most difficult fractures to treat. And the catastrophic picture of Volkmann's ischemic contracture and nerve injuries associated with these fractures, as after successful reduction, the late complications of loss of elbow motion, the chage in carrying angle, myositis ossifgicans, and delayed ulnar nerve palsy still lie ahead. For the period of 4 years and 10 months from May 1979 to March 1985, 47 patients who had been treated for supracondylar fractures of the humerus at the Department of Orthopaedic Surgery, college of medicine, Soon Chun Hyang University Hospital, are presented, The results obtained are as follows; 1. Supracondylar fractures of the humerus frequently occured between the ages of 4 and 9 years (70.2%) and the sex ratio was 2.1: 1 in male to female. 2. Of all fratures, 89.4% were the extension type and the left side was predominent in 55.3% than right. 3. According to the Holmberg clasification, Group 1 was 6 cases(12.8%), 10 cases(21.3%) in Group 2, 11 cases(23.4%) in Group 3, and 20 cases(42.5%) in Group 4. 4. Closed reduction with percutaneous pinning showed little changes in carrying angle. 5. Limitation of motion was most frequent complication after closed reduction with plaster cast immobilization. 6. By the modified Mitchell and Adams' criteria for grading results, excellent were obtained in 55.3 %, good in 44.7%, and zero in unsatisfactory. 7. In the neurovascular injuries associated with fractue, there were 4 neural injuries, and 2 vascular injuries. In 4 traumatic neuropathies, median nerve was involved most commonly and the were recovered spontaneously within 5 weeks. 8. Average time from injury to reduction was 1.6 day and delayed reduction or operation made worse the prognosis in most cases.
Casts, Surgical ; Child ; Elbow ; Epiphyses ; Female ; Humans ; Humerus ; Immobilization ; Ischemic Contracture ; Joints ; Male ; Median Neuropathy ; Myositis ; Prognosis ; Sex Ratio ; Ulnar Neuropathies ; Vascular System Injuries

Soft tissue coverage of heel defects has long been a difficult problem. In 1982, Iron reported eight cases of heel defects in children using an ipsilateral posterior thigh flap with use of the Hoff-man's skeletal fixation apparatus for immobilization. We report three cases of heel defects treatment in children using ipsilateral posterior thigh flap and detach flap in an average 13 days with aid of single photon emission computed tomography(SPECT) for evaluation of circulation status of flap.
Child ; Fracture Fixation ; Heel ; Humans ; Immobilization ; Iron ; Thigh ; Tomography, Emission-Computed, Single-Photon

No abstract available.
Lymphoma, T-Cell, Cutaneous*

No abstract available.
Encephalitis, Arbovirus*

Fractures in the subtrochanteric region of the femur present more formidable problems in treatment than do other trochanteric fractures, because such severe stresses exit at the fracture site. Therefore, as a rule we prefer to treat subtrochanteric fractures by operative means if possible. Many internal fixation devices have been recommanded for use in subtrochanteric fractures and each of these devices have advantages in certain types of subtrochanteric fractures, and their selection should be based on the individual fracture anatomy. A total of 20 patients with fracture of the subtrochanteric region of the femur, who were treated by internal fixation with Judet plate between January 1982 and December 1988 have been reviewed. Our conclusions were as follows; 1. Average age was 38 years old and most common cause of injury was traffic accident. 2. Cast immobilization was done after Judet plate fixation. Partial weight bearing ambulation was enabled from POD 10 weeks and full weight bearing ambulation was enabled from POD 16 weeks. 3. 18 in 20 cases, primary bony union was happened and the mean duration of radiological bony union was 24 weeks. 4. 3 cases of complications, metal failure with refracture (2 cases) and screw loosening (1 case), were occured due to early weight bearing in the post operative course. 5. Judet plate fixation was gave satisfactory result in uncomminuted subtrochanteric fracture, especially Seinsheimer's type I, II-A,B,C or Fieldings type I, II. 6. From a consideration of these series, Judet plate showed easy to use, perfect adaptation and rigid fixation. We thought Judet plate is one of a good implants for rigid fixation of subtrochanteric fracture without severe medial cortical disruption.
Accidents, Traffic ; Clinical Study ; Femur ; Hip Fractures ; Humans ; Immobilization ; Internal Fixators ; Walking ; Weight-Bearing

BACKGROUND:Acute seizures that increase neuronal activity cause a rapid and transient induction of the immmediate early c-fos in specific brain regions. C-fos gene may mediate long-term changes in cell function, such as growth, differeniation, and development, in response to acute extracellular stimulation. This study is designed to compare the expression of Fos protein in hippocampus after single and repeated injections of kainic acid (KA). METHODS:In KA-single injection model, twelve adult male Sprague-Dawley rats were treated with single intraperitoneal injection of convulsive dose(20-30 mg/kg) of KA, and. in KA-multiple injections model, seven rats received KA by repeated daily intraperitoneal injections for 15 days. Eight control rats received normal saline. Expression of Fos protein was tested in hippocampus by immunohistochemical staining, and was scored by the degree of staining intensity and the ratio of stained cells to tested ones. RESULTS:The scores tended to increase in CA3 and dentate gyrus were significantly higher in KA-single injection model than in control (p<0.05). In comparison with scores in KA-model. CONCLUSION:These results show that repeated seizure produces some blockade of c-fos induction in CA2, CA3 and dentate gyrus. This may be a long-term adaptive response by the nervous system to repated neuronal activation
Adult ; Animals ; Brain ; Dentate Gyrus ; Genes, fos ; Hippocampus* ; Humans ; Injections, Intraperitoneal ; Kainic Acid* ; Male ; Nervous System ; Neurons ; Rats* ; Rats, Sprague-Dawley ; Seizures

No abstract available.
Primary Myelofibrosis*

No abstract available.
Child* ; Epilepsy* ; Humans