The regeneration of the injured articular cartilage has been controversial subject among many authors. However, there is not detailed report pertaining to the effect of hydrocortisone on the repair of injured articular cartilage. The author, therefore, has undertaken an experimental study in order to observe effect of hydrocortisone on the repair of intra-articular cartilage in young growing rabbits. Forty rabbits weighting 1000 to 1500 gm were selected and the articular cartilage including at the distal end of femur in the knee was sosteotomised about 1.5X1.5 cm extending 5.0mm depth through the subchondral bone layer and replaced immediately into the original site, then each rabbit of experimental group was injected 1 mg hydrocortisone into the knee joint. After entire procedure, 5 animals from each group were sacrificed at 1st, 2nd, 4th and 8th week and the gross and microscopic examination of the specimen of transplanted articular cartilage was done through the longitudinal section. The result are obtained as following: 1. Articular surface revealed fragile fibrous tissue appearing later than control group. 2. Degenerative change was noted on the articular cartilage. 3. Necrosis and regeneration were delayed on both articular cartilage. 4. Bone regeneration in subchondral bone layer was inhibited. 5. Decreased fibroblastic proliferation was noted in subchondral bone layer. 6. Complete regeneration was noted at the postoperative 8 th week.
Animals ; Bone Regeneration ; Cartilage ; Cartilage, Articular ; Femur ; Fibroblasts ; Hydrocortisone ; Knee ; Knee Joint ; Necrosis ; Rabbits ; Regeneration

No abstract available.
Osteotomy ; Syphilis, Congenital

Clinical analysis was done on 60 meniscus injuries operated on at Orthopaedic Department of Capital Armed Forces General Hospital from Mar. 1977 to Sept. 1978 with the following results. 1. All cases were military personel aged from 21 to 40, most of them 23 and 24 years old. 2. The fall down accident was the most common cause of injury mechanism. 3. The lateral meniscus was more frequently injured than the medial with 43:17, and the right side knee than left with a ratio of 35:25. 4. The posterior horn tear was the most common type of the injuries involved 23 cases (48.3%). 5. The complete healing after menisectomy ranged from 1 month to about 3 months. 6. It seems resonably certain that habit of exaggerated flexion of the knee in Korean is an important factor in the production of the lesion, combined possibly with medial ratation of the tibia, for subsequent episodes of the exaggerated flexion enlarge the rent untill the popliteus attachment and all peripheral attachments behind the hiatus are torn away, and the posterior half of the lateral meniscus is released from normal control.
Animals ; Arm ; Horns ; Hospitals, General ; Humans ; Knee ; Menisci, Tibial ; Military Personnel ; Tears ; Tibia

The Dowling-Meara type of epidermolysis bullosa simplex(EBS) is genetic disease that is transmitted as an autosomal dominant trait and is charscterized clinically by pherpetiform clustering of blisters and palmo-plantar keratoderma. The disease usually presents at with or in early infancy. Although serious and hemorrhagic Wers may occur on any part of the body, the lesions heal without scaning in general. The disease shows a tendency to improve by progressian of age and it usually follows a relatively benign course. Microecopically, there are intraepidermal bli.ter s forming as a result of cytolysis of basal cells. In addition, the is a highly characteristic clumping of tonofilaments of keratinocytes in the lower epidermis, which is not seen in any other form of EBS. We report a case of Dowling-Meara type of EBS that is first destribed in Korean medical literatures.
Blister ; Epidermis ; Epidermolysis Bullosa Simplex* ; Epidermolysis Bullosa* ; Intermediate Filaments ; Keratinocytes

No abstract available.
Breast* ; Female ; Lactation* ; Milk, Human*

No abstract available.
Oncogenes*

No abstract available.
Calcium* ; Humans ; Infant, Newborn* ; Metabolism*

BACKGROUND: The proportion of patients with subacute cutaneous lupus erythematosus(SCLE) is considered to be 10% among the total LE population in western countries. The morphology of LE-specific skin lesions in SCLE : appear as papulosquamous erythema or annular erythema developing mostly on the exposed areas. Among Korean patients with LE the prevalence and the pattern of cutaneous eruption of SCLE may be different from those patients of western countries. OBJECTIVE: To obtain the prevalence and the morphological characteristics of cutaneous lesions in Korean patients with SCI E v;ere the main objectives. METHODS: With 7 cases of SCLE, clinical dermatologic examinations for the character, the distribution, and the clinical course of those cutaneous lesions, and for the extent of systemic symptoms and LE-related laboratory abnormalities in each patient were performed. Results/Coeclusion. The prevalence of SCLE among Korean patients with LE or latent LE was much lower than those seen in Caucasians. The pattern of cutaneous lesions were papular/ papulosquamous erythemas with no (or rare) cases of annular erytherna among those patients diagnosed as SCLE. ~Other cl~inica! features were similar to Caucasian patients. It seems that there are some racial differences in the cutaneous manifestat.ions of LE, which may be relevant to the dissimilarities in immunogenetic backgrounds between different racial groups.
Erythema ; Humans ; Immunogenetics ; Lupus Erythematosus, Cutaneous* ; Prevalence ; Skin

No abstract available.
Breast* ; Female ; Humans ; Milk, Human*

For determination of reliability and clinical applicability of spinal mineral content assessed by quantitativeCT, the basic experiment was undertaken to assure the correlation of CT numbers of calibration material withinphantom and human vertebral specimen. And the analytical study of mineral contents assessed by whole body CT in 208 normal persons was performed at Pusan Natinal University Hospital for these last two years. The resultsobtained were summarized as follows: 1. The concentration of solution of dipotassium hydrogen phosphate had a highcorrelation with CT number with correlatin coefficient of 0.99. 2. in experimental study, the method fordetermining the mid-vertebral line in lateral scout view showed the precision of 1.4%(coefficient of variation).3. Short term precision test for mineral content of spine specimens showed 1.9%(coefficient of variation) and longterm precision test showed 2.4%(coefficient of variation). 4. Mean mineral content of lumber spines in normal malewas 139.0±35.70mg K2,HPO4/cm3, and the highest value was 167.3±22.96mg K2 HPO4/cm3 in the age range of 20–29years. With increasing age, there was a gradual loss of mineral. so that by age 70 the mineral content was reducedto 85.2±19.95mg K2 HPO4/cm3. 5. Mean minearal content of lumbar spines in normal female was 128.7±41.87mg k2HPO4/cm3. the highest value was 169.5±20.46mg/ K2 HPO4.cm3 in second decade. There was gradual decrease inmineral content to 62.2±25.45mg K2 HPO4/cm3 by 70 years of age. 6. From 40's of age the average mineal content ofspine was decreased by 70's, the mineral content in normal women was reduced by 62%, and that in normal men by 47%. 7. After 40's in women, the mineral content of spine was markedly reduced, and the level of mineral contentin women was lower than in men.
Busan ; Calibration ; Female ; Humans ; Hydrogen ; Male ; Methods ; Miners ; Spine