No abstract available.
Hyphema*

The regeneration of the injured articular cartilage has been controversial subject among many authors. However, there is not detailed report pertaining to the effect of hydrocortisone on the repair of injured articular cartilage. The author, therefore, has undertaken an experimental study in order to observe effect of hydrocortisone on the repair of intra-articular cartilage in young growing rabbits. Forty rabbits weighting 1000 to 1500 gm were selected and the articular cartilage including at the distal end of femur in the knee was sosteotomised about 1.5X1.5 cm extending 5.0mm depth through the subchondral bone layer and replaced immediately into the original site, then each rabbit of experimental group was injected 1 mg hydrocortisone into the knee joint. After entire procedure, 5 animals from each group were sacrificed at 1st, 2nd, 4th and 8th week and the gross and microscopic examination of the specimen of transplanted articular cartilage was done through the longitudinal section. The result are obtained as following: 1. Articular surface revealed fragile fibrous tissue appearing later than control group. 2. Degenerative change was noted on the articular cartilage. 3. Necrosis and regeneration were delayed on both articular cartilage. 4. Bone regeneration in subchondral bone layer was inhibited. 5. Decreased fibroblastic proliferation was noted in subchondral bone layer. 6. Complete regeneration was noted at the postoperative 8 th week.
Animals ; Bone Regeneration ; Cartilage ; Cartilage, Articular ; Femur ; Fibroblasts ; Hydrocortisone ; Knee ; Knee Joint ; Necrosis ; Rabbits ; Regeneration

No abstract available.
Complement System Proteins* ; Humans ; Infant, Newborn*

No abstract available.
Fetal Blood* ; Glucose* ; Humans ; Infant, Newborn*

OBJECTIVE: In muscle and neuronal cells, calcium channels have been classified by electrophysiological and pharmacological properties into (1) voltage-dependent Ca2+-channel(1) P/Q-type Ca2+-channel (2) N-type Ca2+-channel R(3) L-type Ca2+-channel (4) T-type Ca2+-channel (5)R-type Ca2+-channel. The present study was done in order to investigate whether there is any difference in Ca2+-channel distribution between activated and normally fertilized embryos. METHODS: The immunocytochemical method was used to identify the existence of voltage-dependent Ca2+-channels in parthenogenetically activated 2-cell embryos by ethanol and SrCl2 treatment. These 2-cell embryos were obtained by exposure to 6% ethanol for 6 min and to 10 mM SrCl2 for 2h. RESULTS: P/Q-type Ca2+ channels and L-type Ca2+-channels have been identified. Whereas, three type of Ca2+-channel P/Q-type, N-type, L-type have been identified in 2-cell embryos fertilized in vivo. CONCLUSION: Activation by ethanol was faster than those by SrCl2. However, there was difference in DAB staining of the embryos between ethanol and SrCl2 treatment (87.7% and 54.1%). Intensity of staining was also different between ethanol- and SrCl2-treated group. However, it has not been known why there was some difference in DAB staining and staining intensity in the present study.
Mice ; Animals

No abstract available.
Angiogenesis Inhibitors*

No abstract available.
Humans ; Infant* ; Infant, Low Birth Weight* ; Infant, Newborn* ; Parathyroid Hormone*

No abstract available.
Osteotomy ; Syphilis, Congenital

No abstract available.

Mutation of the p53 gene frequently results in overexpression of the p53 protein and loss of its tumor-suppressing properties. The overexpression of the p53 gene could be an indicator of rapid proliferation, poor differentiation, advanced stages, or poor prognosis. The prognostic value of the overexpression of the p53 gene in colorectal carcinoma is equivocal. The presence of DNA aneuploidy has been described as a powerful adverse prognostic indicator in relation to survival. To investigate the prognostic significance of p53 expression, and the relationship with DNA ploidy, 92 cases of colorectal carcinomas were analyzed. The overexpression of p53 gene product was present in 50(54.4%) of 92 cases. p53 expression only correlated with recurrence or metastasis during the follow-up periods (p=0.045). DNA aneuploidy was observed in 32(39.1%) of 82 cases. DNA ploidy was strongly associated with lymph node invasion(p=0.005), Dukes' stage(p=0.003), TNM classification (p=0.003), and recurrence or metastasis during the follow-up periods (p=0.045). The frequency of DNA aneuploidy was higher in the p53-positive colorectal carcinomas(58.3%) than in the p53-negative colorectal carcinomas (21.6%) (p=0.003). p53-positive colorectal carcinomas had a higher rate of cell proliferation than p53-negative cases(p<0.001). These results suggest that checking the p53 expression and DNA ploidy could be useful prognostic indicators of colorectal carcinoma.
Neoplasm Metastasis ; Genes, p53