No abstract available.
Hyphema*

The regeneration of the injured articular cartilage has been controversial subject among many authors. However, there is not detailed report pertaining to the effect of hydrocortisone on the repair of injured articular cartilage. The author, therefore, has undertaken an experimental study in order to observe effect of hydrocortisone on the repair of intra-articular cartilage in young growing rabbits. Forty rabbits weighting 1000 to 1500 gm were selected and the articular cartilage including at the distal end of femur in the knee was sosteotomised about 1.5X1.5 cm extending 5.0mm depth through the subchondral bone layer and replaced immediately into the original site, then each rabbit of experimental group was injected 1 mg hydrocortisone into the knee joint. After entire procedure, 5 animals from each group were sacrificed at 1st, 2nd, 4th and 8th week and the gross and microscopic examination of the specimen of transplanted articular cartilage was done through the longitudinal section. The result are obtained as following: 1. Articular surface revealed fragile fibrous tissue appearing later than control group. 2. Degenerative change was noted on the articular cartilage. 3. Necrosis and regeneration were delayed on both articular cartilage. 4. Bone regeneration in subchondral bone layer was inhibited. 5. Decreased fibroblastic proliferation was noted in subchondral bone layer. 6. Complete regeneration was noted at the postoperative 8 th week.
Animals ; Bone Regeneration ; Cartilage ; Cartilage, Articular ; Femur ; Fibroblasts ; Hydrocortisone ; Knee ; Knee Joint ; Necrosis ; Rabbits ; Regeneration

No abstract available.
Complement System Proteins* ; Humans ; Infant, Newborn*

No abstract available.
Fetal Blood* ; Glucose* ; Humans ; Infant, Newborn*

No abstract available.
Humans ; Infant* ; Infant, Low Birth Weight* ; Infant, Newborn* ; Parathyroid Hormone*

OBJECTIVE: In muscle and neuronal cells, calcium channels have been classified by electrophysiological and pharmacological properties into (1) voltage-dependent Ca2+-channel(1) P/Q-type Ca2+-channel (2) N-type Ca2+-channel R(3) L-type Ca2+-channel (4) T-type Ca2+-channel (5)R-type Ca2+-channel. The present study was done in order to investigate whether there is any difference in Ca2+-channel distribution between activated and normally fertilized embryos. METHODS: The immunocytochemical method was used to identify the existence of voltage-dependent Ca2+-channels in parthenogenetically activated 2-cell embryos by ethanol and SrCl2 treatment. These 2-cell embryos were obtained by exposure to 6% ethanol for 6 min and to 10 mM SrCl2 for 2h. RESULTS: P/Q-type Ca2+ channels and L-type Ca2+-channels have been identified. Whereas, three type of Ca2+-channel P/Q-type, N-type, L-type have been identified in 2-cell embryos fertilized in vivo. CONCLUSION: Activation by ethanol was faster than those by SrCl2. However, there was difference in DAB staining of the embryos between ethanol and SrCl2 treatment (87.7% and 54.1%). Intensity of staining was also different between ethanol- and SrCl2-treated group. However, it has not been known why there was some difference in DAB staining and staining intensity in the present study.
Mice ; Animals

No abstract available.
Angiogenesis Inhibitors*

No abstract available.
Osteotomy ; Syphilis, Congenital

The clinical role of tumor markers to detect the extent of tumor invasion and recurrence in cervical cancer has been debated. To evaluate the chncal significance of SCC, CEA and TPA as tumor markers in cervical, we studied 744 patients weith cervieal cancer from June 1990 to Mey 1994. The cut-off val ues of SCC, CEA and TPA were 1.5 ng/ml, 4.5 ng/mi and 110 U/I respectively. Followings were the results. 1. The serum concentration and positive rates of SCC before therapy(567 cases) were 3,0+/-7.0ng/ml(40.4%) for stage I,8.7+/-13.9 ng/ml(71.6%) for stage II, 10.8+/-14.7 ng/ml(85.7%) for stage III, 23.9+/-24.3 ng/ml(94.7%) for stage IV, and 13.4+/-19.1 ng/ml(75.0%) for recurrent cancer. It was increased with advancing clinical stage(p<0.01). 2. The seum levels and positive rate of CEA before therapy(627cases) were 3.4+/-4.3 ng/ml (18%) for stage I, 7.1+/-12.3 ng/ml(37.2%) for stage II, 8.4+/-9.6 ng/ml(57.9%) for stage III, 15.4+/-22.2 ng/ml(52.6%) for stage IV, and 10.3+/-16.2 ng/ml(46.4%) for recurrent cancer. It was increased with advancing clinical stage from stage Ito stage III(p<0.01). 3. The serum concentration and positiceive rate of TFA before therapy(301cases) were 51.7+/-53.8 U/l(9.5%) for stage I, 105.3+/-108.8 U/l(32.3%) for stage II, 186.3%+/-159.8 U/l(50%) for stage III, 191.3+/-l06.2 U/I(63.6%) for stage IV, and 135.4+/-117.0 U/l(46.4%) for recurrent cancer. It was increased with advencing clinical stage(p<0.01). 4. In 64 patients{24.2%) with lymph node invasion of 265 patients treated by operation, the mean serum levels of SCC, CEA and TPA were higher than lymph node negative group(p<0.05). 5. The serum levels of SCCand CKA after therepy were 82.8% in sensitivity. 94.3% in specificity, 67.9% in positive predictive value, 97.4% in negative predictive value.
Humans ; Lymph Nodes ; Recurrence ; Sensitivity and Specificity ; Biomarkers, Tumor* ; Uterine Cervical Neoplasms*

No abstract available.