No abstract available.
Hyphema*

The regeneration of the injured articular cartilage has been controversial subject among many authors. However, there is not detailed report pertaining to the effect of hydrocortisone on the repair of injured articular cartilage. The author, therefore, has undertaken an experimental study in order to observe effect of hydrocortisone on the repair of intra-articular cartilage in young growing rabbits. Forty rabbits weighting 1000 to 1500 gm were selected and the articular cartilage including at the distal end of femur in the knee was sosteotomised about 1.5X1.5 cm extending 5.0mm depth through the subchondral bone layer and replaced immediately into the original site, then each rabbit of experimental group was injected 1 mg hydrocortisone into the knee joint. After entire procedure, 5 animals from each group were sacrificed at 1st, 2nd, 4th and 8th week and the gross and microscopic examination of the specimen of transplanted articular cartilage was done through the longitudinal section. The result are obtained as following: 1. Articular surface revealed fragile fibrous tissue appearing later than control group. 2. Degenerative change was noted on the articular cartilage. 3. Necrosis and regeneration were delayed on both articular cartilage. 4. Bone regeneration in subchondral bone layer was inhibited. 5. Decreased fibroblastic proliferation was noted in subchondral bone layer. 6. Complete regeneration was noted at the postoperative 8 th week.
Animals ; Bone Regeneration ; Cartilage ; Cartilage, Articular ; Femur ; Fibroblasts ; Hydrocortisone ; Knee ; Knee Joint ; Necrosis ; Rabbits ; Regeneration

No abstract available.
Fetal Blood* ; Glucose* ; Humans ; Infant, Newborn*

No abstract available.
Complement System Proteins* ; Humans ; Infant, Newborn*

No abstract available.
Humans ; Infant* ; Infant, Low Birth Weight* ; Infant, Newborn* ; Parathyroid Hormone*

No abstract available.
Angiogenesis Inhibitors*

OBJECTIVE: In muscle and neuronal cells, calcium channels have been classified by electrophysiological and pharmacological properties into (1) voltage-dependent Ca2+-channel(1) P/Q-type Ca2+-channel (2) N-type Ca2+-channel R(3) L-type Ca2+-channel (4) T-type Ca2+-channel (5)R-type Ca2+-channel. The present study was done in order to investigate whether there is any difference in Ca2+-channel distribution between activated and normally fertilized embryos. METHODS: The immunocytochemical method was used to identify the existence of voltage-dependent Ca2+-channels in parthenogenetically activated 2-cell embryos by ethanol and SrCl2 treatment. These 2-cell embryos were obtained by exposure to 6% ethanol for 6 min and to 10 mM SrCl2 for 2h. RESULTS: P/Q-type Ca2+ channels and L-type Ca2+-channels have been identified. Whereas, three type of Ca2+-channel P/Q-type, N-type, L-type have been identified in 2-cell embryos fertilized in vivo. CONCLUSION: Activation by ethanol was faster than those by SrCl2. However, there was difference in DAB staining of the embryos between ethanol and SrCl2 treatment (87.7% and 54.1%). Intensity of staining was also different between ethanol- and SrCl2-treated group. However, it has not been known why there was some difference in DAB staining and staining intensity in the present study.
Mice ; Animals

No abstract available.
Osteotomy ; Syphilis, Congenital

Pyuria, pain and hematuria are the predominant symptoms in urologic diseases. Among them hematuria is the most important complaint referable to the urinary tract in both children and adults Accordingly, hematuria should never be ignored, and no matter how trivial the bleeding a complete urologic investigation into itscause is mandatory. A statistical survey was made on hematuria of the in-patientsin the Department of Urology at ST. Mary's Hospital, during the two years from August 1966 to July 1968 and the following results were obtained. 1. During that period. out of 437 cases who were hospitalized, 246 cases(179 males and 67 females) had hematuria, giving a rate of 5t percent (gross: 24 percent, micro-hematuria: 30 percent) 2. More than 70 percent of all the cases of hematuria processed were found to be calculus, tumor and tuberculosis of the genitourinary tract. 3. Most frequent incidences of hematuria 'were shown to be trauma in children, while calculus, tuberculosis and tumor in young and middle aged group, and tumor in old aged group as well. 4. Among 141 cases of micro-hematuria, grade I showed 78 cases(55 percent) 5. The location of bleeding in 1O5 cases of gross hematuria was in the kidney by 40 percent, bladder, ureter and urethra in that order of frequency.
Adult ; Calculi ; Child ; Hematuria* ; Hemorrhage ; Humans ; Incidence ; Kidney ; Male ; Middle Aged ; Pyuria ; Tuberculosis ; Ureter ; Urethra ; Urinary Bladder ; Urinary Tract ; Urolithiasis ; Urologic Diseases* ; Urology

PURPOSE: Platinum coordination complex (cisplatin) has been currently used as one of the most effective compound in the treatment of various solid tumors. However, its use has been limited by severe side effects such as renal toxicity. Our platinum-based drug discovery program has been aimed at developing drugs capable of diminishing toxicity and selective cytotoxicity. MATERIALS AND METHODS: A new series of highly water soluble platinum (II) complexes Pt (II) [1,3-Bis (phenylthio) propane) (trans-l-1,2-diaminocyclohexane) (PC-1) and Pt (II) [1,3-Bis-(phenylthio) (propane)]-1,2-diaminocyclohexane (PC-2) were synthesized and characterized by their elemental analysis and by various spectroscopic techniques [infrared (.IR), ""C-nuclear magnetic resonance (NMR)]. In vitro antitumor activity and nephrotoxi -cities of new Pt (II) complexes were tested against MKN-45 human gastric cancer cell- lines and normal kidney cells using colorimetric MTT[3-(4,5-dimethyl thiazol-2-yl)-2,5- diphenyl tetrazolium bromide] assay for cell survival and proliferation. RESULTS: PC-1 showed activity against MKN-45/P and MKN-45/CDDP human gastric adenocarcinoma cells, and the antitumor activity of this compound was comparable or superior to that of PC-2 and cisplatin. The nephrotoxicity of PC-1 and PC-2 were found quite less than that of cisplatin using MTT, [H] thymidine uptake and glucose consumption tests in rabbit proximal tubule cells, human kidney cortical cells and human renal cortical tissues. CONCLUSION: Based on these results, this novel platinum (II) complex compound (PC-1) represent a valuable lead in the development of a new anticancer chemotherapeutic agent capable of improving antitumor activity and low nephrotoxicity.
Adenocarcinoma ; Cell Survival ; Cisplatin ; Drug Discovery ; Glucose ; Humans* ; Kidney* ; Platinum ; Stomach Neoplasms* ; Thymidine