No abstract available.
Orbit*

No abstract available.
Cheek*

Primary malignant melanoma of the penis is very rare. No one case has been reported in Korea. A case of malignant melanoma of the glans penis in a 80 year old male is presented with a brief review of the literature.
Aged, 80 and over ; Humans ; Korea ; Male ; Melanoma* ; Penis*

No abstract available.
Granular Cell Tumor* ; Larynx*

No abstract available.

Six cases of lunate dislocation were treated in the departments of orthopaedic surgery, Hangang Sacred Heart Hospital and Kangnam Sacred Heart Hospital, Hallym College during the period from March 1, 1978 to August 31, 1982. The results were as follows; l. Among the total 6 cases, two cases had lunate dislocation only and the other four had associated injuries of the same wrist joints. 2. Marupulative reduction was successful in only one case. Five cases were treated by open reduction, and for four of them internal fixation was tried. 3. Postoperative roentgenograms showed acceptable reductions in all cases except one which redislocation occurred. This case showed lunate dorsiflexion instability and was treated with extensor carpi radialis longus tenodesis. 4. The cases with pure lunate dislocation yielded better functional recovery than those with associated carpal injuries.
Dislocations ; Heart ; Tenodesis ; Wrist Joint

No abstract available.
Fibronectins* ; Granulation Tissue* ; Wound Healing* ; Wounds and Injuries*

We assessed 14 eyes of 14 patients with persisting hypotony due to cyclodialysis by blunt trauma of after secondary intraocular lens implantation. All the 14 eyes showed persistent hypotony and no increment of intraocular pressure(IOP) nor the visual acuity during the follow up period of average 4.6 months before treatment, We treated these eyes with argon laser photocoagulation and/or direct cyclopexy. After treatment, the IOP changed from 3.7+/-1.5mmHg to 13.7+/-5.1mmHg, and posttreatment IOP was greater than 8mmHg in 12 eyes. All 14 eyes showed visual acuity under 0.3 before the treatment and after treatment, the visual acuity improved by 4.2+/-3.3 lines at the last follow up visit. The follow up period was 12.5 months on average. Before treatment, all the 12 eyes that had no medial opacity showed hypotony maculopathy, but after treatment only 4 eyes showed persisting hypotony maculopathy. A-scan axial length measurement was performed on 8 eyes before and after treatment, and the axial lengths were increased by 0.90+/-0.88mm after treatment in 7 eyes in which IOP were increased. The change in refractive errors before and after treatment was possible to be assessed in 9 eyes and among them, 7 eyes showed increment of IOP. Among those 7 eyes, 2 eyes had shallow chambers with anteriorly displaced lens before treatment and showed repositioning of lenses and hyperopic shift by +2.86 Dsph on average after treatment, but the remaining 4 eyes excluding one eye that received lensectomy at the time of surgery for taumatic cataract, showed myopic shift by -2.31 Dsph on average after treatment.
Argon ; Cataract ; Follow-Up Studies ; Humans ; Lens Implantation, Intraocular ; Light Coagulation ; Refractive Errors ; Visual Acuity

In this experiment using 30 rabbits(40 normal eyes), the applicability of ocular adhesive, HISTOACRYL blue, as an implant beneath the scleral and conjunctival flap. Group 1 consisted of 10 left eyes. These eyes had undergone a fornix-based conjunctival flap and a triangular lamellar scleral flap without sclerectomy and served as a control on histologic examination. Group 2 consisted of 10 right eyes of the rabbits used in group 1. The Histoacryl was pasted on the sclera under the lamellar scleral flap and the conjunctiva. The pasted Histoacryl turned into a thin membrane. Group 3 consisted of 10 right eyes which had undergone a conventional trabeculectomy. Group 4 consisted of 10 right eyes. These eyes had undergone a trabeculectomy and placement of a Histoacryl membrane. The adhesive was applied closely to the limbus in 5 eyes and posteriorly away from the limbus in the remaining 5 eyes of group 4. At the eighth week after operation a filtering bleb was observed in all of the eyes in group In contrast to this, only two eyes showed filtering blebs in group 3. Filtering blebs were so confined over the Histoacryl membrane that their size and location was in accordance with the membrane. The vessels of the conjunctiva overlying the Histoacryl membrane were dilated and congested. This vascular congestion lasted long. The light microscopic examinations of the operation site showed a thick layer composed of macrophages, eosinophils, neutrophils, foreign body giant cells, and fibroblasts surrounding the Histoacryl membrane with cystic space between them. At the eight postoperative week, this wall remained thick measuring about 50-70 micro thick. From the result, Histoacryl appeared to be effective in preventing the fibrotic scarring down of the filtering bleb, but postoperative inflammatory changes indicated that the Histoacryl seemed to be rather unsuitable for clinical application.
Adhesives ; Blister* ; Cicatrix ; Conjunctiva ; Enbucrilate ; Eosinophils ; Estrogens, Conjugated (USP) ; Fibroblasts ; Filtration* ; Giant Cells, Foreign-Body ; Macrophages ; Membranes ; Neutrophils ; Rabbits ; Sclera ; Tissue Adhesives* ; Trabeculectomy

Beta-lapachone (beta-Lap; 3,4-dihydro-2, 2-dimethyl-2H-naphthol[1, 2-b]pyran-5,6-dione) is a novel anti-cancer drug under phase I/II clinical trials. beta-Lap has been demonstrated to cause apoptotic and necrotic death in a variety of human cancer cells in vitro and in vivo. The mechanisms underlying the beta-Lap toxicity against cancer cells has been controversial. The most recent view is that beta-Lap, which is a quinone compound, undergoes two-electron reduction to hydroquinone form utilizing NAD(P)H or NADH as electron source. This two-electron reduction of beta-Lap is mediated by NAD(P)H:quinone oxidoreductase (NQO1), which is known to mediate the reduction of many quinone compounds. The hydroquinone forms of beta-Lap then spontaneously oxidizes back to the original oxidized beta-Lap, creating futile cycling between the oxidized and reduced forms of beta-Lap. It is proposed that the futile recycling between oxidized and reduced forms of beta-Lap leads to two distinct cell death pathways. First one is that the two-electron reduced beta-Lap is converted first to one-electron reduced beta-Lap, i.e., semiquinone beta-Lap (SQ).- causing production of reactive oxygen species (ROS), which then causes apoptotic cell death. The second mechanism is that severe depletion of NAD(P)H and NADH as a result of futile cycling between the quinone and hydroquinone forms of beta-Lap causes severe disturbance in cellular metabolism leading to apoptosis and necrosis. The relative importance of the aforementioned two mechanisms, i.e., generation of ROS or depletion of NAD(P)H/NADH, may vary depending on cell type and environment. Importantly, the NQO1 level in cancer cells has been found to be higher than that in normal cells indicating that beta-Lap may be preferentially toxic to cancer cells relative to non-cancer cells. The cellular level of NQO1 has been found to be significantly increased by divergent physical and chemical stresses including ionizing radiation. Recent reports clearly demonstrated that beta-Lap and ionizing radiation kill cancer cells in a synergistic manner. Indications are that irradiation of cancer cells causes long-lasting elevation of NQO1, thereby sensitizing the cells to beta-Lap. In addition, beta-Lap has been shown to inhibit the repair of sublethal radiation damage. Treating experimental tumors growing in the legs of mice with irradiation and intraperitoneal injection of beta-Lap suppressed the growth of the tumors in a manner more than additive. Collectively, beta-Lap is a potentially useful anti-cancer drug, particularly in combination with radiotherapy.
Animals ; Apoptosis ; Benzoquinones ; Cell Death ; Electrons ; Humans ; Hydroquinones ; Injections, Intraperitoneal ; Leg ; Mice ; NAD ; Naphthoquinones ; Necrosis ; Radiation Tolerance ; Radiation, Ionizing ; Reactive Oxygen Species ; Recycling ; Substrate Cycling