1.Analysis of Urinary Flow Rates in 577 Normal Children.
Korean Journal of Urology 2000;41(7):850-855
2.Two Cases of Seckel Syndrome.
Kyu Chang PARK ; Phil Soo OH ; Jeh Hoon SHIN
Journal of Korean Society of Pediatric Endocrinology 1998;3(2):228-230
Seckel syndrome is a rare, autosomal recessive disorder of severe growth retardation and distinct craniofacial, orodental, and skeletal anomalies. We report hereby the first two Korean cases of typical Seckel syndrome who had characteristic symptoms of intrauterine growth retardation, small head, large eyes, sharp facial features (beaked nose, dysplastic ears and narrow face) with underdeveloped chin, dwarfism, severe mental retardation, and other malformation. We report two cases of Seckel syndrome with a brief review of related literatures.
Chin
;
Dwarfism
;
Ear
;
Fetal Growth Retardation
;
Head
;
Intellectual Disability
;
Nose
3.The Study of p53 Expression and DNA Ploidy in Colorectal Carcinoma.
Ji Shin LEE ; Kwang Soo CHEON ; Chang Soo PARK
Korean Journal of Pathology 1996;30(9):775-783
Mutation of the p53 gene frequently results in overexpression of the p53 protein and loss of its tumor-suppressing properties. The overexpression of the p53 gene could be an indicator of rapid proliferation, poor differentiation, advanced stages, or poor prognosis. The prognostic value of the overexpression of the p53 gene in colorectal carcinoma is equivocal. The presence of DNA aneuploidy has been described as a powerful adverse prognostic indicator in relation to survival. To investigate the prognostic significance of p53 expression, and the relationship with DNA ploidy, 92 cases of colorectal carcinomas were analyzed. The overexpression of p53 gene product was present in 50(54.4%) of 92 cases. p53 expression only correlated with recurrence or metastasis during the follow-up periods (p=0.045). DNA aneuploidy was observed in 32(39.1%) of 82 cases. DNA ploidy was strongly associated with lymph node invasion(p=0.005), Dukes' stage(p=0.003), TNM classification (p=0.003), and recurrence or metastasis during the follow-up periods (p=0.045). The frequency of DNA aneuploidy was higher in the p53-positive colorectal carcinomas(58.3%) than in the p53-negative colorectal carcinomas (21.6%) (p=0.003). p53-positive colorectal carcinomas had a higher rate of cell proliferation than p53-negative cases(p<0.001). These results suggest that checking the p53 expression and DNA ploidy could be useful prognostic indicators of colorectal carcinoma.
Neoplasm Metastasis
;
Genes, p53
4.Tumor Angiogenesis in Renal Cell Carcinoma.
Ji Shin LEE ; Jong Jae JUNG ; Chang Soo PARK
Korean Journal of Pathology 1999;33(11):1055-1060
Angiogenesis is essential for the growth of solid tumors. Microvessel counts, which represent a measure of tumor angiogenesis, have been correlated with the overall survival of patients with a variety of malignancies. However, the significance of angiogenesis in renal cell carcinoma remains controversial. To determine whether angiogenesis correlates with prognosis of patients with renal cell carcinoma, we counted the microvessels within the primary tumors and compared their numbers with patients' prognosis. Tumor specimens from 42 patients were investigated. Microvessels were stained with anti-CD34 and anti-factor VIII-related antigen monoclonal antibodies. Significant correlation between microvessel counts for two antibodies was observed (r=0.875, p<0.01), although microvessel counts for CD34 were approximately two times higher. Microvessel counts were higher in clear cell than in non-clear cell carcinoma (p<0.05). These results suggest that immunostaining with anti-CD34 antibody may provide a more sensitive and accurate measure of tumor angiogenesis. There was no correlation between microvessel counts and nuclear grade, or TNM stage. In univariate analyses, nuclear grade and TNM stage were significantly associated with patient survival (p<0.01). But further studies on tumor angiogenesis of renal cell carcinoma are needed before it can be adopted as a prognostic marker.
Antibodies
;
Antibodies, Monoclonal
;
Carcinoma, Renal Cell*
;
Humans
;
Microvessels
;
Prognosis
;
von Willebrand Factor
5.Tumor Angiogenesis in Renal Cell Carcinoma.
Ji Shin LEE ; Jong Jae JUNG ; Chang Soo PARK
Korean Journal of Pathology 1999;33(11):1055-1060
Angiogenesis is essential for the growth of solid tumors. Microvessel counts, which represent a measure of tumor angiogenesis, have been correlated with the overall survival of patients with a variety of malignancies. However, the significance of angiogenesis in renal cell carcinoma remains controversial. To determine whether angiogenesis correlates with prognosis of patients with renal cell carcinoma, we counted the microvessels within the primary tumors and compared their numbers with patients' prognosis. Tumor specimens from 42 patients were investigated. Microvessels were stained with anti-CD34 and anti-factor VIII-related antigen monoclonal antibodies. Significant correlation between microvessel counts for two antibodies was observed (r=0.875, p<0.01), although microvessel counts for CD34 were approximately two times higher. Microvessel counts were higher in clear cell than in non-clear cell carcinoma (p<0.05). These results suggest that immunostaining with anti-CD34 antibody may provide a more sensitive and accurate measure of tumor angiogenesis. There was no correlation between microvessel counts and nuclear grade, or TNM stage. In univariate analyses, nuclear grade and TNM stage were significantly associated with patient survival (p<0.01). But further studies on tumor angiogenesis of renal cell carcinoma are needed before it can be adopted as a prognostic marker.
Antibodies
;
Antibodies, Monoclonal
;
Carcinoma, Renal Cell*
;
Humans
;
Microvessels
;
Prognosis
;
von Willebrand Factor
6.Surgical treatment of pulmonary atresia with intact ventricular septum without extracorporeal circulation: report of one case.
Chul Hyun PARK ; Shin Yeong LEE ; Chang Ho KIM
The Korean Journal of Thoracic and Cardiovascular Surgery 1991;24(7):719-724
No abstract available.
Extracorporeal Circulation*
;
Pulmonary Atresia*
;
Ventricular Septum*
7.A new culture system for in situ observation of the growth and development of Eucyclops serrulatus (Copepoda: Cyclopoida) .
Sung Hee PARK ; Cheon Young CHANG ; Sung Shik SHIN
The Korean Journal of Parasitology 2005;43(4):141-147
A practical and convenient method of rearing Eucyclops serrulatus in a microculture environment is described. A complete life cycle of E. serrulatus was maintained in a narrow space on a microscope slide glass on which a cover glass of 22 x 40 mm in size was mounted at a height of 0.8 mm. The culture medium was constituted by bottled mineral water boiled with grains of Glycine max (soybean). Chilomonas paramecium, a free-living protozoan organism, was provided as live food. Growth of nauplii hatched from eggs to the first stage of copepodite took an average of 7.7 days, and the growth of copepodite 1 to the egg-bearing adult female took an average of 20.1 days in the microculture cell with an average life time of 44.7 days. Continuous passage of copepods was successfully maintained as long as sufficient medium and food were provided. The microculture method enables an in situ microscopic observation on the growth and developmental process of helminth larvae experimentally infected to copepods as well as of copepod itself. Furthermore, it does not require anesthetization and, therefore, minimize the amount of stress exposed to copepods during the handling process.
Protozoa
;
Male
;
Female
;
Culture Techniques/*methods
;
Culture Media
;
Copepoda/*growth & development
;
Animals
8.The use of seclusion room in a milieu therapeutic psychiatric ward.
Sang Il LEE ; Ki Chang PARK ; Jongho SHIN
Journal of Korean Neuropsychiatric Association 1991;30(2):312-321
No abstract available.
9.A Clinical Study of the Popliteal Cyst: An Analysis of 90 Cases
Chang Dong HAN ; Sung Il SHIN ; Byeong Mun PARK
The Journal of the Korean Orthopaedic Association 1986;21(3):433-438
We reviewed 90 cases of popliteal cyst in 88 patients, managed at Department of Orthopedic Surgery, Severance Hospital from January 1976 to June 1985 and the following results were obtained. 1. The average age of the 88 patients was 42 years. There were 23 males and 65 females. Of the all patients, 47 were occured in right side and 39 the left. Two patients were both sides. 2. Of the all cysts, 62 were found to be bursa between the semimembranosus and the medial head of the gastrocnemius muscles(68.8%). 3. Associated adnormalities of the knee joint were apparent in 29(33%) and the most common abnormalities were osteoarthritis. 3. Associated adnormalities of the knee joint were apparent in 29(33%) and the most common abnormalities were osteoarthritis. 4. Communication of the cyst with the joint was apparent in 44 cases(49%). 5. Twelve patients were recurred and associated abnormality of the knee joint was osteoarthritis. Three patients were children and they had no abnormality of the knee joint. 6. Recurrence after primary operation was rare when the stalk of the cyst had been opened.
Child
;
Clinical Study
;
Female
;
Head
;
Humans
;
Joints
;
Knee Joint
;
Male
;
Orthopedics
;
Osteoarthritis
;
Popliteal Cyst
;
Recurrence
10.Axial Fixation on Calcaneal Fractures
Chang Uk CHOI ; Byung Joon SHIN ; Jong Seok PARK
The Journal of the Korean Orthopaedic Association 1990;25(1):54-60
Calcaneus is the largest tarsal bone and serves weight bearing of the body. The calcaneus has a pattern of cancellous bone enclosed with a very thin cortical shell. It is difficult to reduce the bony fragments accurately when there are comminution and displacement on the calcaneal fractures. Retrospective study was carried out of 18 patients(21 feet) of calcaneus fractures after axial fixation in Soonchunhyang University Hospital from July, 1982 to July, 1988. Minimum follow up period was 8 months(average 2 years 6 months). The clinical analysis of them are reported with a review of the literature and the results are follows:l. According to the Rowe's unit system, the results of treatment were excellent or good in 9 cases of 13 tongue types and 5 cases of 8 joint depression types. 2. The results were satisfactory in the calcaneal fractures of well reestablished Bohler angle to 21-30 degrees. 3. The results were excellent or good in 5 cases operated within post-trauma 1 week and in 9 cases operated from 1 week to 2 weeks. 4. The results were poor in the 2 joint depression type with severe comminution. And subtalar joint fusion was performed on the previous 2 cases. Then pain on the lateral malleolar area was subsided.
Calcaneus
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Depression
;
Follow-Up Studies
;
Joints
;
Retrospective Studies
;
Subtalar Joint
;
Tarsal Bones
;
Tongue
;
Weight-Bearing