No abstract available.
Intracranial Arteriovenous Malformations* ; Risk Factors*

No abstract available.
Bacteroides fragilis* ; Bacteroides*

OBJECTIVES: Stroke is leading cause of death and more importantly it is cause of serious disability. The effective treatment of acute ischemic stroke still remains a challenge to modern medicine. Recent clinical trials have shown that carotid endareterctomy(CEA) provide overwhelming benefits compared with medical therapy in preventing subsequent stroke for symptomatic carotid stenosis. For the asymptomatic ones, the data are less compelling, but highly suggestive that CEA do have benefits in properly selected patients. MATERIALS AND METHODS: To investigate the clinical manifestations of carotid stenosis and results of CEAs, authors analyzed retrospectively 19 CEAs in 16 patients from June 1986 to June 1999. Age of patients ranged from 55 to 76 years(median, 66) and male to female ratio was 14 to 2. The duration of follow-up was 1 to 144 months (median, 26). All of CEAs were done on the side of stenosis more than 80% and bilateral CEAs were done in three. Six CEAs were performed in asymptomatic patients. RESULTS: Seventeen of 19 CEAs showed excellent results and complication rate was low although ipsilateral ischemic stroke occurred in two. CONCLUSION: CEA may be a valuable surgical treatment for ischemic stroke caused by carotid stenosis and also for prevention of stroke of asymptomatic patients with carotid stenosis.
Carotid Stenosis* ; Cause of Death ; Constriction, Pathologic ; Endarterectomy, Carotid* ; Female ; Follow-Up Studies ; History, Modern 1601- ; Humans ; Male ; Retrospective Studies ; Stroke

Intracranial dural arteriovenous malformation(AVM) is an uncommon neurosurgical condition; in particular, it has been infrequently reported in Korea. To understand the general clinical characteristics of dural AVMs, the authors reviewed 41 cases and analysed the factors affecting hemorrhage of dural AVMs. Since 1980 we have encountered 320 pial and 41 dural AVM, a ratio of 7.8 to 1. The age of these patients ranged from 3 months to 70 years, the most common being the 6th decade, and female exceeded males by a ratio of 1.56 to 1. All lesions except one was single, and symptoms were related to it's location and the venous drainage pattern. The most common location was the cavernous sinus, accounting for about 70% of cases, so the most common clinical symptoms of dural AVMs were ocular, namely-proptosis and chemosis. The next was tinnitus found in transverse/sigmoid sinus dural AVMs. Intracranial hemorrhage was seen in six cases(14.6%), the primary cause of hemorrhage was retrograde intracranial venous drainage(p=0.001), and no hemorrhage was observed in cases with no intracranial venous drainage. And intracranial hemorrhage was more frequent in transverse/sigmoid than cavernous sinus dural AVMs, and this was so even where there was intracranial venous drainage(p<0.001). However two of 28 patients with cavernous dural AVMs became blind in one eye, demonstrating that in such patients, the clinical course could be aggressvie. The majority of cases were treated by endovascular therapy: surgical excision was performed in only one patient with tentorial dural AVM. Eight patients were treated conservatively. Three died of hemorrhage, 3 who had had fixed deficit had neurologic deficits even after a definite treatment, and 35(85%) showed clinical improvement. During intervention, there was one hemorrhagic complication, due to obstruction of venous outflow with embolic materials.
Arteriovenous Malformations* ; Cavernous Sinus ; Drainage ; Female ; Hemorrhage ; Humans ; Intracranial Hemorrhages ; Korea ; Male ; Neurologic Manifestations ; Tinnitus

Two Years Reports of "Journal of Korean Neuropychiatric Association" during 2001 to 2003 were evaluated by 17 Editorial Board of Korean Neuropsychiatric Association. We investigated the articles to specific fields and rejection rate etc. by different section chiefs. Although several problems concerning review time duration and rejection guideline issues indicated but generally all reviewer processes proved relatively clear and concise criteria. Through these objective and systematic evaluation processes, "Journal of Korean Neuropychiatric Association" will develope a good journal.
Evaluation Studies as Topic*

Four Years Reports of "Journal of Korean Neuropsychiatric Association" during 2001 to 2005 were evaluated by 18 Editorial Board of Korean Neuropsychiatric Association. We investigated the articles to specific fields and rejection rate etc. by different section chiefs. Although several problems concerning review time duration and rejection guideline issues indicated but generally all reviewer processes proved relatively clear and concise criteria. Through these objective and systematic evaluation processes, "Journal of Korean Neuropsychiatric Association" will develop a good journal.
Evaluation Studies as Topic*

Four Years Reports of "Journal of Korean Neuropsychiatric Association" during 2001 to 2005 were evaluated by 18 Editorial Board of Korean Neuropsychiatric Association. We investigated the articles to specific fields and rejection rate etc. by different section chiefs. Although several problems concerning review time duration and rejection guideline issues indicated but generally all reviewer processes proved relatively clear and concise criteria. Through these objective and systematic evaluation processes, "Journal of Korean Neuropsychiatric Association" will develop a good journal.
Evaluation Studies as Topic*

PURPOSE: The purpose of this study is to determine whether luminacin, a marine microbial extract from the Streptomyces species, has anti-tumor effects on head and neck squamous cell carcinoma (HNSCC) cell lines via autophagic cell death. MATERIALS AND METHODS: Inhibition of cell survival and increased cell death was measured using cell viability, colony forming, and apoptosis assays. Migration and invasion abilities of head and cancer cells were evaluated using wound healing, scattering, and invasion assays. Changes in the signal pathway related to autophagic cell death were investigated. Drug toxicity of luminacin was examined in in vitro HaCaT cells and an in vivo zebrafish model. RESULTS: Luminacin showed potent cytotoxicity in HNSCC cells in cell viability, colony forming, and fluorescence-activated cell sorting analysis. In vitro migration and invasion of HNSCC cells were attenuated by luminacin treatment. Combined with Beclin-1 and LC3B, Luminacin induced autophagic cell death in head and neck cancer cells. In addition, in a zebrafish model and human keratinocyte cell line used for toxicity testing, luminacin treatment with a cytotoxic concentration to HNSCC cells did not cause toxicity. CONCLUSION: Taken together, these results demonstrate that luminacin induces the inhibition of growth and cancer progression via autophagic cell death in HNSCC cell lines, indicating a possible alternative chemotherapeutic approach for treatment of HNSCC.
Apoptosis ; Autophagy* ; Carcinoma, Squamous Cell* ; Cell Death ; Cell Line ; Cell Survival ; Drug-Related Side Effects and Adverse Reactions ; Flow Cytometry ; Head and Neck Neoplasms ; Head* ; Humans ; Keratinocytes ; Neck* ; Signal Transduction ; Streptomyces ; Toxicity Tests ; Wound Healing ; Zebrafish

There has been a mistake, claimed and confirmed by all the authors of Vol 50(1), 2012, p10-20 issue, that first author should have been Chang-Gyu Lee instead of Jang-Hyun Paek.

BACKGROUND/AIMS: Rebleeding after endoscopic therapy for non-variceal upper gastrointestinal hemorrhage (NGIH) is the most important predictive factor of mortality. We evaluated the risk factors of rebleeding in patients undergoing endoscopic therapy for the NGIH. METHODS: Between January 2003 and January 2007, 554 bleeding events in 487 patients who underwent endoscopic therapy for NGIH were retrospectively enrolled. We reviewed the clinicoendoscopical characteristics of patients with rebleeding and compared them with those of patients without rebleeding. RESULTS: The incidence of rebleeding was 21.7% (n=120). In the multivariate analysis, initial hemoglobin level < or =9 g/dL (p=0.002; odds ratio [OR], 2.433), inexperienced endoscopist with less than 2 years of experience in therapeutic endoscopy (p=0.001; OR, 2.418), the need for more 15 cc of epinephrine (p=0.001; OR, 2.570), injection therapy compared to thermal and injection therapy (p=0.001; OR, 2.840), and comorbidity with chronic renal disease (p=0.004; OR, 2.908) or liver cirrhosis (p=0.010; OR, 2.870) were risk factors for rebleeding following endoscopic therapy. CONCLUSIONS: Together with patients with low hemoglobin level at presentation, chronic renal disease, liver cirrhosis, the need for more 15 cc of epinephrine, or therapy done by inexperienced endoscopist were risk factors for the development of rebleeding.
Comorbidity ; Endoscopy ; Epinephrine ; Gastrointestinal Hemorrhage ; Hemoglobins ; Hemorrhage ; Humans ; Incidence ; Liver Cirrhosis ; Multivariate Analysis ; Odds Ratio ; Renal Insufficiency, Chronic ; Retrospective Studies ; Risk Factors