No abstract available.
Intracranial Arteriovenous Malformations* ; Risk Factors*

No abstract available.
Bacteroides fragilis* ; Bacteroides*

OBJECTIVES: Stroke is leading cause of death and more importantly it is cause of serious disability. The effective treatment of acute ischemic stroke still remains a challenge to modern medicine. Recent clinical trials have shown that carotid endareterctomy(CEA) provide overwhelming benefits compared with medical therapy in preventing subsequent stroke for symptomatic carotid stenosis. For the asymptomatic ones, the data are less compelling, but highly suggestive that CEA do have benefits in properly selected patients. MATERIALS AND METHODS: To investigate the clinical manifestations of carotid stenosis and results of CEAs, authors analyzed retrospectively 19 CEAs in 16 patients from June 1986 to June 1999. Age of patients ranged from 55 to 76 years(median, 66) and male to female ratio was 14 to 2. The duration of follow-up was 1 to 144 months (median, 26). All of CEAs were done on the side of stenosis more than 80% and bilateral CEAs were done in three. Six CEAs were performed in asymptomatic patients. RESULTS: Seventeen of 19 CEAs showed excellent results and complication rate was low although ipsilateral ischemic stroke occurred in two. CONCLUSION: CEA may be a valuable surgical treatment for ischemic stroke caused by carotid stenosis and also for prevention of stroke of asymptomatic patients with carotid stenosis.
Carotid Stenosis* ; Cause of Death ; Constriction, Pathologic ; Endarterectomy, Carotid* ; Female ; Follow-Up Studies ; History, Modern 1601- ; Humans ; Male ; Retrospective Studies ; Stroke

Intracranial dural arteriovenous malformation(AVM) is an uncommon neurosurgical condition; in particular, it has been infrequently reported in Korea. To understand the general clinical characteristics of dural AVMs, the authors reviewed 41 cases and analysed the factors affecting hemorrhage of dural AVMs. Since 1980 we have encountered 320 pial and 41 dural AVM, a ratio of 7.8 to 1. The age of these patients ranged from 3 months to 70 years, the most common being the 6th decade, and female exceeded males by a ratio of 1.56 to 1. All lesions except one was single, and symptoms were related to it's location and the venous drainage pattern. The most common location was the cavernous sinus, accounting for about 70% of cases, so the most common clinical symptoms of dural AVMs were ocular, namely-proptosis and chemosis. The next was tinnitus found in transverse/sigmoid sinus dural AVMs. Intracranial hemorrhage was seen in six cases(14.6%), the primary cause of hemorrhage was retrograde intracranial venous drainage(p=0.001), and no hemorrhage was observed in cases with no intracranial venous drainage. And intracranial hemorrhage was more frequent in transverse/sigmoid than cavernous sinus dural AVMs, and this was so even where there was intracranial venous drainage(p<0.001). However two of 28 patients with cavernous dural AVMs became blind in one eye, demonstrating that in such patients, the clinical course could be aggressvie. The majority of cases were treated by endovascular therapy: surgical excision was performed in only one patient with tentorial dural AVM. Eight patients were treated conservatively. Three died of hemorrhage, 3 who had had fixed deficit had neurologic deficits even after a definite treatment, and 35(85%) showed clinical improvement. During intervention, there was one hemorrhagic complication, due to obstruction of venous outflow with embolic materials.
Arteriovenous Malformations* ; Cavernous Sinus ; Drainage ; Female ; Hemorrhage ; Humans ; Intracranial Hemorrhages ; Korea ; Male ; Neurologic Manifestations ; Tinnitus

Two Years Reports of "Journal of Korean Neuropychiatric Association" during 2001 to 2003 were evaluated by 17 Editorial Board of Korean Neuropsychiatric Association. We investigated the articles to specific fields and rejection rate etc. by different section chiefs. Although several problems concerning review time duration and rejection guideline issues indicated but generally all reviewer processes proved relatively clear and concise criteria. Through these objective and systematic evaluation processes, "Journal of Korean Neuropychiatric Association" will develope a good journal.
Evaluation Studies as Topic*

Four Years Reports of "Journal of Korean Neuropsychiatric Association" during 2001 to 2005 were evaluated by 18 Editorial Board of Korean Neuropsychiatric Association. We investigated the articles to specific fields and rejection rate etc. by different section chiefs. Although several problems concerning review time duration and rejection guideline issues indicated but generally all reviewer processes proved relatively clear and concise criteria. Through these objective and systematic evaluation processes, "Journal of Korean Neuropsychiatric Association" will develop a good journal.
Evaluation Studies as Topic*

Four Years Reports of "Journal of Korean Neuropsychiatric Association" during 2001 to 2005 were evaluated by 18 Editorial Board of Korean Neuropsychiatric Association. We investigated the articles to specific fields and rejection rate etc. by different section chiefs. Although several problems concerning review time duration and rejection guideline issues indicated but generally all reviewer processes proved relatively clear and concise criteria. Through these objective and systematic evaluation processes, "Journal of Korean Neuropsychiatric Association" will develop a good journal.
Evaluation Studies as Topic*

OBJECTIVE: Post-craniotomy seizure (PCS) is reported only rarely. However, our department noted a 433% increase in PCS for a year beginning September 2010, especially after cerebrovascular surgery. Our goal was to identify the cause of our unusual outbreak of PCS. METHODS: For almost one year after September 2010, cases of PCS increased significantly in our department. We analyzed 973 patients who had received a major craniotomy between January 2009 and November 2011. We included seizures that occurred only in the first 24 postoperative hours, which we defined as early PCS. After verifying the presence of PCS, we analyzed multiple seizure-provoking factors and their relation to the duration and character of seizure activity. RESULTS: Overall PCS incidence was 7.2% (70/973). Cefazolin (2 g/L saline) was the antibiotic drug used for intraoperative irrigation in 88.4% of the operations, and no PCS occurred without intraoperative cefazolin irrigation. When analyzed by operation type, clipping surgery for unruptured aneurysms was the most frequently associated with PCS (80%). Using logistic regression, only 2 g cefazolin intraoperative irrigation (p=0.024) and unruptured aneurysm clipping surgery (p<0.001) were associated with early PCS. The seizure rate of unruptured aneurysm clipping surgery using 2 g cefazolin intraoperative irrigation was 32.9%. CONCLUSION: Intraoperative cefazolin irrigation must be avoided in patients undergoing craniotomy, especially for clipping of unruptured aneurysms, because of the increased risk of early PCS.
Aneurysm ; Anti-Bacterial Agents* ; Cefazolin ; Craniotomy ; Humans ; Incidence ; Logistic Models ; Seizures*

PURPOSE: We developed and validated a fetal trisomy detection method for use as a noninvasive prenatal test (NIPT) including a Clinical Laboratory Improvement Amendments (CLIA)-certified bioinformatics pipeline on a cloud-based computing system using both Illumina and Life Technology sequencing platforms for 221 Korean clinical samples. We determined the necessary proportions of the fetal fraction in the cell-free DNA (cfDNA) sample for NIPT of trisomies 13, 18, and 21 through a limit of quantification (LOQ) test. MATERIALS AND METHODS: Next-generation sequencing libraries from 221 clinical samples and three positive controls were generated using Illumina and Life Technology chemistries. Sequencing results were uploaded to a cloud and mapped on the human reference genome (GRCh37/hg19) using bioinformatics tools. Based on Z-scores calculated by normalization of the mapped read counts, final aneuploidy reports were automatically generated for fetal aneuploidy determination. RESULTS: We identified in total 29 aneuploid samples, and additional analytical methods performed to confirm the results showed that one of these was a false-positive. The LOQ test showed that the proportion of fetal fraction in the cfDNA sample would affect the interpretation of the aneuploidy results. CONCLUSION: Noninvasive chromosome examination (NICE), a CLIA-certified NIPT with a cloud-based bioinformatics platform, showed unambiguous success in fetus aneuploidy detection.
Aneuploidy* ; Computational Biology ; DNA ; Fetus* ; Genome ; High-Throughput Nucleotide Sequencing ; Humans ; Prenatal Diagnosis ; Trisomy

Carcinoid heart disease is characterized by heart valve dysfunction as well as carcinoid symptomatology. We report a case of carcinoid heart disease associated with a primary ovarian tumor. A 60-year-old woman presented for dyspnea evaluation with a history of facial flushing, telangiectatic skin changes, and pitting edema of both lower extremities. Chest radiography showed cardiomegaly, and echocardiography revealed an isolated, severe tricuspid regurgitation without left-sided valvular dysfunction. The tricuspid leaflets were severely retracted and shortened, resulting in poor coaptation. Furthermore, mild pulmonary valve stenosis and moderate regurgitation were found along with this deformation. The 24-hour urine analysis revealed an increased level of 5-hydroxyindoleacetic acid, and an ovarian tumor was apparent on computed tomography images. The mass was surgically removed, and the patient was diagnosed as having a primary ovarian carcinoid tumor. She was treated with chemotherapy and regularly followed-up with supportive treatments, deferring surgical correction.
Carcinoid Heart Disease ; Carcinoid Tumor ; Cardiomegaly ; Dyspnea ; Echocardiography ; Edema ; Female ; Flushing ; Heart Valves ; Humans ; Lower Extremity ; Middle Aged ; Pulmonary Valve Stenosis ; Skin ; Thorax ; Tricuspid Valve Insufficiency