2.Congenital penile curvature: long-term results of operative treatment using the plication procedure.
S-S LEE ; E MENG ; F-P CHUANG ; C-Y YEN ; S-Y CHANG ; D-S YU ; G-H SUN
Asian Journal of Andrology 2004;6(3):273-276
AIMTo determine the long-term outcome, effectiveness and patient satisfaction of congenital penile curvature correction by plication of tunica albuginea.
METHODSFrom January 1992 to January 2002, 106 young patients underwent surgical correction of congenital penile curvature by corporeal plication. Indications for operation were difficult or impossible vaginal penetration and cosmetic problems. The technique of corporeal plication consists of placing longitudinal plication sutures of 2-zero braided polyester on the convex side of the curvature until the curvature is corrected when erection is artificially induced. Results of this procedure were obtained by retrospective chart reviews and questionnaires via mail. Long-term follow-up ranged from 11 to 132 (mean 69.3) months and data were available for 68 patients.
RESULTSPenile straightening was excellent in 62 patients (91 %) and good with less than 15 degree of residual curvature in 6 patients (9 %). Sixty-seven patients reported no change in erectile rigidity or maintenance postoperatively, while 1 described early detumescence. Shortening of the penis without functional problems was noted by 26 patients (38 %). Thirty-Five patients (51 %) reported feeling palpable indurations (suture knots) on the penis. Temporary numbness of glans penis was described in 3 patients. Overall, 60 patients were very satisfied, 6 satisfied, 2 unsatisfied.
CONCLUSIONCorporeal plication is an effective and durable procedure with a high rate of patient satisfaction.
Adolescent ; Adult ; Follow-Up Studies ; Humans ; Male ; Penile Erection ; Penis ; abnormalities ; surgery ; Retrospective Studies ; Surgical Procedures, Operative ; Treatment Outcome
3.The Role of Consolidation Chemoradiotherapy in Locally Advanced Pancreatic Cancer Receiving Chemotherapy: An Updated Systematic Review and Meta-Analysis.
Jeffrey S CHANG ; Yen Feng CHIU ; Jih Chang YU ; Li Tzong CHEN ; Hui Ju CH'ANG
Cancer Research and Treatment 2018;50(2):562-574
PURPOSE: The role of consolidation chemoradiation (CCRT) after systemic chemotherapy in locally advanced pancreatic cancer (LAPC) is still controversial. We aim to evaluate the effectiveness of CCRT in LAPC using systematic review and meta-analysis of prospective studies. MATERIALS AND METHODS: Prospective clinical trials of LAPC receiving chemotherapy with or without subsequent CCRT were included in the analysis. We systematically searched in PubMed, MEDLINE, Embase, and Web of Science. The primary outcome of interest was 1-year survival. Secondary end-points were median overall survival, progression-free survival, toxicity, and resection rate. RESULTS: Forty-one studies with 49 study arms were included with a total of 1,018 patients receiving CCRT after induction chemotherapy (ICT) and 954 patients receiving chemotherapy alone. CCRT after ICT did not improve 1-year survival significantly in LAPC patients compared with chemotherapy alone (58% vs. 52%). ICT lasted for at least 3 months revealed significantly improved survival of additional CCRT to LAPC patients compared to chemotherapy alone (65% vs. 52%). A marginal survival benefit of consolidation CCRT was noted in studies using maintenance chemotherapy (59% vs. 52%), and fluorouracil-based CCRT (64% vs. 52%), as well as in studies conducted after the 2010 (64% vs. 55%). CONCLUSION: The survival benefit of ICT+CCRT over chemotherapy alone in treating LAPC was noted when ICT lasted for at least 3 months. Fluorouracil-based CCRT, and maintenance chemotherapy were associated with improved clinical outcomes.
Adenocarcinoma
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Arm
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Chemoradiotherapy*
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Disease-Free Survival
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Drug Therapy*
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Humans
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Induction Chemotherapy
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Maintenance Chemotherapy
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Pancreatic Neoplasms*
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Prospective Studies
4.Prognostic Factors of Stage II Rectal Cancer.
In J PARK ; Hee C KIM ; Tae W KIM ; Jong H KIM ; Jung S KIM ; Jung R KIM ; Chang S YU ; Jin C KIM
The Korean Journal of Gastroenterology 2004;43(1):23-28
BACKGROUND/AIMS: We aimed to verify the prognostic factors of stage II rectal cancer and the effect of radiation therapy on the survival and local recurrence rate. METHODS: This study was undertaken in 202 patients who underwent curative resection of rectal cancer and confirmed to be stage II between July 1989 and December 1996. Univariate and multivariate (Cox's model) analyses of survival were employed to identify prognostic factors. Statistical significance was assigned by p value of <0.05. RESULTS: Overall recurrence occurred in 32 patients. Four patterns of recurrence were observed: hematogenous recurrence in 17 patients, local recurrence in 11, peritoneal seeding in two and simultaneous hematogenous and local recurrence in two cases. Overall 5-year survival rate was 85.6% and 5 year disease free survival rate was 82.8%. There was no significant difference in local recurrence rate and survival according to radiation therapy or location of cancer. In multivariate analysis, the number of harvested lymph node was only a prognostic factor. CONCLUSIONS: The number of harvested lymph nodes has prognostic value in stage II rectal cancer. Postoperative radiation therapy should be considered for stage II rectal cancer with poor prognostic factors although radiation did not decrease local recurrence rate in present study.
Adolescent
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Adult
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Aged
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Child
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English Abstract
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Female
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Humans
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Male
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Middle Aged
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Neoplasm Metastasis
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Neoplasm Recurrence, Local
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Prognosis
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Rectal Neoplasms/pathology/*surgery
5. Construction and clinical preliminary validation of an automaticbone age assessment model based on deep learning
Juan SONG ; Ping GONG ; Chang GAO ; Qing HAN ; Xiuli LI ; Zongming ZHU ; Hongwei CHEN ; Yizhou YU ; Xiangming FANG
Chinese Journal of Radiology 2019;53(11):974-978
Objective:
To build an automatic bone age assessment system based on China 05 Bone Age Standard and the latest deep learning technology, and preliminary clinical verification was carried out.
Methods:
The left-hand radiographs of 5 000 children with suspected metabolic disorders were acquired from Wuxi Children′s Hospital. Among these cases, 2 351 patients were randomly chosen as training set, and 101 patients were randomly used as validation set. Four professional pediatric radiologists annotated the development stage according to the China 05 RUS-CHN standard with double-blind method. The mean value of the bone age assessed by experts was the reference standard which was used to train and validate the deep learning mothods based artificial intelligence (AI) model. Accuracy, mean absolute error (MAE), root mean squared error (RMSE) and time efficiency of bone age assessment were compared by using Chi-square test and
6.Clinical Features and Prognostic Factors in Primary Adenocarcinoma of the Appendix.
In J PARK ; Chang S YU ; Hee C KIM ; Jin C KIM
The Korean Journal of Gastroenterology 2004;43(1):29-34
BACKGROUND/AIMS: Primary appendiceal adenocarcinoma is a rare neoplasm that constitutes less than 0.5% of all gastrointestinal neoplasm. The aim of this study was to figure out its clinicopathologic characteristics that are not well understood. METHODS: We reviewed the medical records of nineteen patients (9 males and 10 females) with histologically proven appendiceal adenocarcinoma. They had been treated at Asan Medical Center between June 1989 and December 2002. Their median follow-up duration was 72.5 months. RESULTS: Their median age was 56.5 (range, 33~80) years. Thirteen patients had mucinous variants and the other five had adenocarcinoma. Seven patients (36.8%) were diagnosed as acute appendicitis. In fact, none of the patients was diagnosed correctly before surgery. The operative procedure, included right hemicolectomy in 9 patients, appendectomy alone in 2 patients, and debulking of their tumors or a biopsy in 8 patients. The 5-year survival rate was 20.5%. The patients with mucinous type had better prognosis than those with the non-mucinous type (p<0.01). In the patients with mucinous type, the survival rate after debulking operation was similar to that after right hemicolectomy. CONCLUSIONS: The most important prognostic factor of primary appendiceal adenocarcinoma was histology. The outcome of debulking operation is being watched compared with that of right hemicolectomy in mucinous variant.
Adenocarcinoma/*diagnosis/mortality/surgery
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Adult
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Aged
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Appendiceal Neoplasms/*diagnosis/mortality/surgery
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English Abstract
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Female
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Humans
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Male
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Middle Aged
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Prognosis
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Survival Rate
7. Postoperative complications and survival analysis of 1 118 cases of open splenectomy and azygoportal disconnection in the treatment of portal hypertension
Ruizhao QI ; Xin ZHAO ; Shengzhi WANG ; Kun ZHANG ; Zhengyao CHANG ; Xinglong HU ; Minliang WU ; Peirui ZHANG ; Lingxiang YU ; Chaohui XIAO ; Xianjie SHI ; Zhiwei LI
Chinese Journal of Surgery 2018;56(6):436-441
Objective:
To analyze the recent postoperative and long-term postoperative complications of open-splenectomy and disconnection in patients with portal hypertension.
Methods:
There were 1 118 cases with portal hypertension who underwent open splenectomy and azygoportal disconnection from April 2010 to September 2015 at Department of Surgery, People′s Liberation Army 302 Hospital. Retrospective case investigation and telephone follow-up were conducted in October 2016. All patients had history of upper gastrointestinal bleeding before operation. Short-term complications after surgery were recorded including secondary laparotomy of postoperative abdominal hemostasis, severe infection, intake disorders, liver insufficiency, postoperative portal vein thrombosis and perioperative mortality. Long-term data including postoperative upper gastrointestinal rebleeding, postoperative survival rate and incidence of postoperative malignancy were recorded, too. GraphPad Prism 5 software for data survival analysis and charting.
Results:
Postoperative short-term complications in 1 118 patients included secondary laparotomy of postoperative abdominal hemostasis(1.8%, 21/1 118), severe infection(2.9%, 32/1 118), intake disorders(1.0%, 11/1 118), liver dysfunction (1.6%, 18/1 118), postoperative portal vein thrombosis(47.1%, 526/1 118)and perioperative mortality(0.5%, 5/1 118). After phone call following-up, 942 patients′ long-term data were completed including 1, 3, 5 years postoperative upper gastrointestinal rebleeding rate(4.4%, 12.1%, 17.2%), 1, 3, 5-year postoperative survival rate(97.0%, 93.5%, 90.3%); the incidence of postoperative malignant tumors in 1, 3 and 5 years were 1.7%, 4.4% and 6.2%.
Conclusions
Reasonable choosing of surgical indications and timing, proper performing the surgery process, effective conducting perioperative management of portal hypertension are directly related to the patient′s short-term prognosis after portal hypertension. Surgical intervention can reduce the rates of patients with upper gastrointestinal rebleeding, improve survival, and do not increase the incidence of malignant tumors.
8. Advances in intralesional injections for infantile hemangioma
Shiren ZHANG ; Yajing QIU ; Yizuo CAI ; Yifei GU ; Wenxin YU ; Lei CHANG ; Xiaoxi LIN
Chinese Journal of Plastic Surgery 2019;35(2):201-204
Intralesional injection is a common method among various therapeutic choices for the treatment of Infantile Hemangiomas. This article reviews the clinical application of intralesional injections for infantile hemangiomas, discusses indications for intralesional injection treatment and evaluates the safety and efficacy of different injected drugs.
9. Treatment of infantile port-wine stains with pulsed dye laser: split lesion randomized comparative study between three sessions and seven sessions
Jiafang ZHU ; Gang MA ; Wenxin YU ; Tianyou WANG ; Yijie CHEN ; Lei CHANG ; Xiaoxi LIN
Chinese Journal of Plastic Surgery 2018;34(5):332-337
Objective:
To compare the safety and efficacy of pulsed dye laser (PDL) with different sessios for the East Asian infants with port-wine stains(PWS).
Methods:
From September 2016 to September 2017, 24 East Asian infants with untreated PWS, who met the standards of enrollment, received seven treatments by PDL at 2-week intervals and three treatments at 6-week intervals at adjacent locations in each patient 2 months after final treatment. The efficacy outcome was compared with Wilcoxon signed-rank test, while the safety was compared using Fisher′s exact test.
Results:
Of the 24 patients, 20 completed study. Seven patients had multiple sites, given a total of 62 treated PWS sites. Among the patients, 18 had lesions on the face and 2 on the extremities. The average blanching rate was (43.71 ± 27.16) % and (43.29 ± 31.58) % for PDL treatments with 7- and 3- sessions, respectively (
10.Maxillary sinus floor elevation
Journal of Prevention and Treatment for Stomatological Diseases 2017;25(1):8-12
Maxillary sinus floor elevation is a common method to increase the bone height in posterior maxilla. Maxillary sinus floor elevation can be divided into 2 types: sinus floor elevation with lateral window approach and sinus floor elevation with trans-alveolar approach. The present article reported the anatomy, antibiotics choice, indications, grafting, growth factors, complications and the influence of tobacco on maxillary sinus floor elevation.