Modified two layer vasovasostomy and modified one layer vasovasostomy with stent under micro- scope were performed in 63 patients from April 1987 to December 1991 in Fatima General Hospital. Among 56 patients who could be followed up post-operatively, modified two layer vasovasostomy under microscope was performed in 26 patients and modified one layer vasovasostomy with stent under microscope was performed in 31 patients. Patients whose vesovasostomy had been performed using modified two layer technique had a 80.0% patency rate and they had a 60% prenenancy rate. Patients whose vasovasostomy had been performed using modified one layer with stent technique had a 77.4 % patency rate and they had a 54.8 % pregnancy rate. In conclusion, we found a little difference in pregnancy rate and patency rate between two technique but we experienced that modified one layer technique with stenting was easier, more time-saving and cost-effective than two layer technique.
Hospitals, General ; Humans ; Pregnancy Rate ; Stents* ; Vasovasostomy*

BACKGROUND: Acyl protein thioesterase-1 (APT1) is a cytosolic protein that may function in the depalmitoylation of numerous proteins, including the Ras family. However, the clinical role of depalmitoyl thioesterase in human cancer is not known. We evaluated the APT1 expression in lung cancer tissue and its clinicopathological findings according APT1 expression pattern. METHODS: APT1 expression was examined by immunohistochemistry in the tumor tissue from 79 patients, who had undergone curative surgical removal of the primary lesion; all patients had been diagnosed with stage I non-small cell lung cancer between 1993 and 2004, at Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. RESULTS: The APT1 expression was seen in 50 out of 79 (63.3%) cases. The positive APT1 expression was significantly related with histologic subtype and T stage, but was not influenced by differentiation. The positive APT1 expression was not significantly related to patient age, gender, or smoking history. The median follow-up duration was 10.0 years; the 5-year survival rate was 71.0%. The positive APT1 expression group showed significantly worse overall survival and worse disease-free survival without statistical significance. CONCLUSION: We conclude that positive APT1 expression in stage I lung cancer after surgery is closely associated with overall survival. To evaluate APT1 as a prognostic marker in lung cancer, comprehensive studies on advanced stage cases are needed.
Biomarkers ; Carcinoma, Non-Small-Cell Lung ; Cytosol ; Disease-Free Survival ; Follow-Up Studies ; Humans ; Immunohistochemistry ; Lung Neoplasms ; Proteins ; Smoke ; Smoking ; Survival Rate