1.Spontaneous rupture of pyometra : a case report.
Chang Hyuk OH ; Soo Nyung KIM ; In Jae CHO ; Doo Ho KIM
Korean Journal of Obstetrics and Gynecology 1993;36(7):1711-1714
No abstract available.
Pyometra*
;
Rupture, Spontaneous*
2.The Assessment of Proliferating Cell Nuclear Antigen (PCNA) in Cervical Tumors.
Soo Nyung KIM ; Tchan Kyu PARK ; Kun Chang SONG ; Ho Guen KIM ; Chan Il PARK
Korean Journal of Gynecologic Oncology and Colposcopy 1994;5(2):1-9
Proliferating cell nuclear ntigen (FCNA) iis a nuclear protein that is syntheaimd in late Gl and S phases of cell cycle and is correlated with the cell proliferative stale. The recent study demonstrated that FCNA functions in 13NA replication. The present study evaluated proliferetive iindices (PI) for the assessment of tumor proliferation and for investigating prognostic significancx, in cervical tumors. lmmunohiatoehemical PCNA staining was perfurmed in formalin-fixed paraffin-embedded cervical tissues via the avidin-biotin-complex immunoperoxidase methad. Mean PI was 36.03+/-5.14% in normaI controls, as compared to 66.19+/-11.36% in cerviml intraepithelial neoplasia. and 63.19+/-10.94% in invasive cervical cancer. Our results showed no significant correlation between Pll and histological type. Among invasive cervical cancer (24 cases), PI waa 64.43+/-10.94% in squamoua cell carcinoma and 59.00+/-4.10% in adenocarcinoma. There was no eipiifiant relationship between Fl and clinical etage, and between PI and lesion size. This study auggeste that Pl may not serve as a new prognostie factor in cervical tumors.
Adenocarcinoma
;
Cell Cycle
;
Nuclear Proteins
;
Proliferating Cell Nuclear Antigen*
;
S Phase
;
Uterine Cervical Neoplasms
3.Studies in serum antithyroglonbulin and antimicrosomal antibodies as screening for postpartum thyroid dysfunction.
Chang Hyuk OH ; Hyung Min CHING ; Soo Nyung KIM ; In Jae CHO ; Doo Ho KIM
Korean Journal of Obstetrics and Gynecology 1993;36(7):1602-1606
No abstract available.
Antibodies*
;
Mass Screening*
;
Postpartum Period*
;
Thyroid Gland*
4.Minilaparotomy for gynecologic surgery.
Soo Nyung KIM ; Chang Hyuk OH ; In Jae CHO ; Doo Ho KIM
Korean Journal of Obstetrics and Gynecology 1991;34(9):1242-1246
No abstract available.
Female
;
Gynecologic Surgical Procedures*
;
Laparotomy*
5.Concurrent chemotherapy and radiotherapy in invasive cervical cancer patients with high risk factors.
Tchan Kyu PARK ; Soo Nyung KIM ; Sang Wun KIM ; Gwi Eon KIM ; Chang Ok SUH
Journal of Korean Medical Science 2000;15(4):436-441
The aim of this study was to evaluate the survival of 395 previously untreated cervical cancer patients with at least one high risk factor following concurrent chemoradiation and to assess the toxicities. Two different chemotherapy regimens were used for concurrent chemoradiation. In the patients with squamous cell carcinoma, 100 mg/m2 of cisplatin was infused intravenously, followed immediately by five consecutive daily administrations of 5-fluorouracil, 1,000 mg/m2/day, each infused intravenously over 24 hr. As for the patients with adenocarcinoma, 70 mg/m2 of cisplatin, 250 mg/m2 of cytoxan and 45 mg/m2 of adriamycin were administered intravenously on days 1, 2, and 3, respectively. The 5-year survival rate was 54.4+ACU- with stage III and IV, 62.6+ACU- with lymph node metastasis on computed tomogram or MRI, 77.9+ACU- with stage I-II disease with lesion size +AD4- or +AD0-4 cm, and 50.3+ACU- with small cell carcinoma or adenocarcinoma. Side effects from concurrent chemoradiation such as nausea, vomiting, and alopecia were present in all 395 cases. Anemia, leukopenia, thrombocytopenia, hepatotoxicity, and nephrotoxicity were observed to varying degrees, but there was no toxic death. This study suggests that cisplatin-based concurrent chemoradiation in treating cervical cancer patients with high risk factors is effective and relatively well tolerated, with acceptable toxicity.
Adenocarcinoma/radiotherapy
;
Adenocarcinoma/mortality
;
Adenocarcinoma/drug therapy
;
Adult
;
Aged
;
Antineoplastic Agents, Combined/therapeutic use+ACo-
;
Antineoplastic Agents, Combined/adverse effects
;
Carboplatin/administration +ACY- dosage
;
Carcinoma, Squamous Cell/radiotherapy
;
Carcinoma, Squamous Cell/mortality
;
Carcinoma, Squamous Cell/drug therapy
;
Cervix Neoplasms/radiotherapy+ACo-
;
Cervix Neoplasms/mortality
;
Cervix Neoplasms/drug therapy
;
Chemotherapy, Adjuvant/adverse effects
;
Cisplatin/administration +ACY- dosage
;
Combined Modality Therapy
;
Comparative Study
;
Cyclophosphamide/administration +ACY- dosage
;
Doxorubicin/administration +ACY- dosage
;
Female
;
Fluorouracil/administration +ACY- dosage
;
Gastrointestinal Diseases/etiology
;
Gastrointestinal Diseases/epidemiology
;
Hematologic Diseases/etiology
;
Hematologic Diseases/epidemiology
;
Hepatitis, Toxic/etiology
;
Hepatitis, Toxic/epidemiology
;
Human
;
Kidney Diseases/epidemiology
;
Kidney Diseases/chemically induced
;
Korea/epidemiology
;
Life Tables
;
Lymphatic Metastasis
;
Middle Age
;
Particle Accelerators
;
Radiotherapy, High-Energy+ACo-/adverse effects
;
Retrospective Studies
;
Risk
;
Survival Analysis
;
Treatment Outcome
6.Concurrent chemotherapy and radiotherapy in invasive cervical cancer patients with high risk factors.
Tchan Kyu PARK ; Soo Nyung KIM ; Sang Wun KIM ; Gwi Eon KIM ; Chang Ok SUH
Journal of Korean Medical Science 2000;15(4):436-441
The aim of this study was to evaluate the survival of 395 previously untreated cervical cancer patients with at least one high risk factor following concurrent chemoradiation and to assess the toxicities. Two different chemotherapy regimens were used for concurrent chemoradiation. In the patients with squamous cell carcinoma, 100 mg/m2 of cisplatin was infused intravenously, followed immediately by five consecutive daily administrations of 5-fluorouracil, 1,000 mg/m2/day, each infused intravenously over 24 hr. As for the patients with adenocarcinoma, 70 mg/m2 of cisplatin, 250 mg/m2 of cytoxan and 45 mg/m2 of adriamycin were administered intravenously on days 1, 2, and 3, respectively. The 5-year survival rate was 54.4+ACU- with stage III and IV, 62.6+ACU- with lymph node metastasis on computed tomogram or MRI, 77.9+ACU- with stage I-II disease with lesion size +AD4- or +AD0-4 cm, and 50.3+ACU- with small cell carcinoma or adenocarcinoma. Side effects from concurrent chemoradiation such as nausea, vomiting, and alopecia were present in all 395 cases. Anemia, leukopenia, thrombocytopenia, hepatotoxicity, and nephrotoxicity were observed to varying degrees, but there was no toxic death. This study suggests that cisplatin-based concurrent chemoradiation in treating cervical cancer patients with high risk factors is effective and relatively well tolerated, with acceptable toxicity.
Adenocarcinoma/radiotherapy
;
Adenocarcinoma/mortality
;
Adenocarcinoma/drug therapy
;
Adult
;
Aged
;
Antineoplastic Agents, Combined/therapeutic use+ACo-
;
Antineoplastic Agents, Combined/adverse effects
;
Carboplatin/administration +ACY- dosage
;
Carcinoma, Squamous Cell/radiotherapy
;
Carcinoma, Squamous Cell/mortality
;
Carcinoma, Squamous Cell/drug therapy
;
Cervix Neoplasms/radiotherapy+ACo-
;
Cervix Neoplasms/mortality
;
Cervix Neoplasms/drug therapy
;
Chemotherapy, Adjuvant/adverse effects
;
Cisplatin/administration +ACY- dosage
;
Combined Modality Therapy
;
Comparative Study
;
Cyclophosphamide/administration +ACY- dosage
;
Doxorubicin/administration +ACY- dosage
;
Female
;
Fluorouracil/administration +ACY- dosage
;
Gastrointestinal Diseases/etiology
;
Gastrointestinal Diseases/epidemiology
;
Hematologic Diseases/etiology
;
Hematologic Diseases/epidemiology
;
Hepatitis, Toxic/etiology
;
Hepatitis, Toxic/epidemiology
;
Human
;
Kidney Diseases/epidemiology
;
Kidney Diseases/chemically induced
;
Korea/epidemiology
;
Life Tables
;
Lymphatic Metastasis
;
Middle Age
;
Particle Accelerators
;
Radiotherapy, High-Energy+ACo-/adverse effects
;
Retrospective Studies
;
Risk
;
Survival Analysis
;
Treatment Outcome
7.The role of chemoradiotherapy in cervical cancer patients with high risk factors for treatment failures.
Tchan Kyu PARK ; Dong Hee CHOI ; Young Tae KIM ; Soo Nyung KIM ; Kwi Yon KIM ; Chang Ook SEO ; Joon Kyu ROH
Korean Journal of Obstetrics and Gynecology 1992;35(4):545-561
No abstract available.
Chemoradiotherapy*
;
Humans
;
Risk Factors*
;
Treatment Failure*
;
Uterine Cervical Neoplasms*
8.A clinical observation on meconium peritonitis.
Ki Soo KIM ; In Koo KIM ; Nyung Nam MOON ; Chang Yee HONG ; Jung Hwan CHOI ; Jeong Kee SEO ; Chong Ku YUN ; Kwi Won PARK ; Woo Ki KIM
Korean Journal of Perinatology 1992;3(1):42-50
No abstract available.
Meconium*
;
Peritonitis*
9.Adjuvant Chemotherapy for Advanced Gastric Cancer in Elderly and Non-elderly Patients: Meta-Analysis of Randomized Controlled Trials.
Seong Hwan CHANG ; Soo Nyung KIM ; Hye Jung CHOI ; Misuk PARK ; Rock Bum KIM ; Se Il GO ; Won Sup LEE
Cancer Research and Treatment 2017;49(1):263-273
PURPOSE: This study evaluated the benefits of adjuvant chemotherapy on elderly patients with advanced gastric cancer (AGC) using meta-analysis of well-designed randomized controlled clinical studies. MATERIALS AND METHODS: PubMed, Embase, and Cochrane were searched to retrieve clinical studies evaluating the benefits of adjuvant chemotherapy in the elderly with AGC. Hazards ratios (HRs) with 95% confidence intervals (CIs) were pooled across studies using a fixed-effects model. RESULTS: Two studies were included in this meta-analysis to estimate HR for the overall survival (OS), and relapse-free survival (RFS) between adjuvant chemotherapy and surgery in elderly and non-elderly patients. HR for OS in the elderly and non-elderly was 0.745 (95% CI, 0.552 to 1.006, p=0.055) and 0.636 (95% CI, 0.522 to 0.776; p < 0.001), respectively, which showed no heterogeneity regarding HR between the two groups (p(interaction)=0.389). HR for RFS in the elderly and non-elderly was 0.613 (95% CI, 0.466 to 0.806; p < 0.001) and 0.633 (95% CI, 0.533 to 0.753; p < 0.001), respectively (p(interaction)=0.846). CONCLUSION: Meta-analysis suggests that the benefit of adjuvant chemotherapy to the elderly is not big enough to reach statistical significance while the HR for OS is less than 1 (0.745) and no heterogeneity are observed regarding the HR between the elderly and non-elderly patients.
Aged*
;
Chemotherapy, Adjuvant*
;
Humans
;
Population Characteristics
;
Stomach Neoplasms*
10.A Study on Risk Factors of Recurrent Otitis Media.
Eun Jin KIM ; Young Ran KWON ; Kang Hoon SONG ; Won Nyung JANG ; Jin LEE ; Jin Keun CHANG ; Sung Ho CHA
Korean Journal of Pediatric Infectious Diseases 2010;17(2):91-100
PURPOSE: Recurrent otitis media (ROM) is usually defined as > or =3 distinct and well-documented episodes within 6 months or > or =4 episodes within 12 months. ROM is sufficiently important to warrant consideration of chemoprophylaxis, tympanostomy tube placement. There also is evidence that children with ROM are at risk for both hearing loss and speech delay. However, studies of ROM have been notably insufficient. In addition, even though environmental, racial, and sociocultural differences can affect risk factors, few studies have been conducted with regard to recurrent otitis media in Korea. METHODS: This study was conducted from July 2009 to January 2010 with infants and children who were younger than 60 months old, who visited the out-patient clinics at Han-Il General Hospital and Kyunghee University Hospital. Data were collected by interview using a pre-formed sheet. Among a total of 892 infants and children, 457 were excluded, and the remaining 435 were allocated to 104 with ROM and 331 as a control group. RESULTS: Attendance at daycare centers (P<0.001, OR=2.85), allergic rhinitis (P=0.026, OR=2.32), past history of bronchiolitis (P=0.003, OR=2.33), and low socioeconomic status (P=0.005, OR=2.00) were found to have a close significant correlation with ROM. Risk factors such as sex, having a sibling, breast-feeding, use of pacifiers, atopy, pneumococcal vaccination, influenza vaccination, smoking of parents, and indoor smoking are not relevant. CONCLUSION: Attendance at daycare centers, allergic rhinitis, past history of bronchiolitis, and low socioeconomic status have been identified as risk factors for ROM.
Bronchiolitis
;
Chemoprevention
;
Child
;
Hearing Loss
;
Hospitals, General
;
Humans
;
Infant
;
Influenza, Human
;
Language Development Disorders
;
Middle Ear Ventilation
;
Otitis
;
Otitis Media
;
Outpatients
;
Pacifiers
;
Parents
;
Rhinitis
;
Rhinitis, Allergic, Perennial
;
Risk Factors
;
Siblings
;
Smoke
;
Smoking
;
Social Class
;
Vaccination