To investigate the involvement of expression of the Fragile Histidine Triad(FH1T) gene product in the process of carcinogenesis and progression in cervical carcinoma, we examined its expression by immunohistochemical method in 15 cervical invasive carcinomas, 10 low grade cervical intraepithelial neoplasias(CINs) and 30 high grade CINs(CMI and III). We detected expression of FHIT gene product in 4 of 15(27%) of invasive carcinomas, 3 of 10(30%) low grade CIN and 7 of 30(23%) of high grade CIN, while we detected expression of FHIT gene product in 28 of 45(62%) normal and metaplastic epithelium near the tumor. Thesc data indicate that loss of expression of FH1T gene product has some role in the early tumorigenesis of uterine cervical carcinoma, but not the consequence of the pregression of the tumor.
Carcinogenesis ; Epithelium ; Histidine* ; Immunohistochemistry

No abstract available.
Neurology*

No abstract available.
Reproduction*

The authors present a case of spontaneous discitis in a 1-year-old female who presented with fever and limping gait. The erythrocyte sediment rate was increased. The roentgenograms revealed normal appearnce, and radioactive bne scan showed increased uptake at the affected level. Discitis should be considered in any child with limping gait or leg pain, refusal to walk, or abdominal pain. Early recognition may avoid unnecessary diagnotic and treatment procedures.
Abdominal Pain ; Child* ; Discitis* ; Disulfiram ; Erythrocytes ; Female ; Fever ; Gait ; Humans ; Leg

Clinical investigation of 20 cases of brain abscess has been done at the dept of Pediatric Yonsei Medical Center, who had been treated during the period of 8 years from January 1977 through Jun 1985. Following results has been obtained: 1. Of 20 patients, 14 patient was male and the rest 6 was female rating M:F ratio 2.3:1 and the youngest patient was undler 1 year, the oldest one was 15 years old. 2. The chief complaints at admission were headache, fever, vomiting in order of frequency, while neurologic signs were neck stiffiness, hemiparesis, papilledema etc. 3. The preceeding causative diseases of brain abscess were diseases involving ENT 15%, congenital heart disease 20%, head trauma 35% and the rest 20% the etiology of brain abscess was not determined. The abscess tended to occure at temporoparietal area in the cases associated with otitis media while abscess originating from congenital heart diseases tended to occure multiple area. 4. 10 cases out of 20 had lumbar puncture under the suspision of meningitis, 2 cases manifested normal CSF finding. Patients who has focal neurologic finding associated with OMPC or congenital heart disease should suspect for brain abscess, which can be easily conform by brain C-T scan as well as patient who manifested unusual clinical course. 5. Factor relating prognosis were mental state and duriation between onset of clinical symptom and time starting treatment; clear mental state and short duration reflect better prognosis. 6. The motality rate was 33%, and the neurologic sequelas were hemiparesis (36.4%), mental deficit (18.2), dysarthria, epilepsy, hydrocephalus and blindness.
Abscess ; Adolescent ; Blindness ; Brain Abscess* ; Brain* ; Child* ; Craniocerebral Trauma ; Dysarthria ; Epilepsy ; Female ; Fever ; Headache ; Heart Defects, Congenital ; Heart Diseases ; Humans ; Hydrocephalus ; Male ; Meningitis ; Neck ; Neurologic Manifestations ; Otitis Media ; Papilledema ; Paresis ; Prognosis ; Spinal Puncture ; Vomiting

No abstract available.
Seasonal Affective Disorder* ; Seasons*

PURPOSE: H. pylori infection was recently reported to be associated with unexplained iron-deficiency anemia(IDA) in children and adolescents. H. pylori-related IDA was thought to occur due to GI blood loss, scavenging of iron by H. pylori and iron malabsorption. The aim of this study was to examine how the status of H. pylori infection and age of children affected RBC indices, serum iron level and TIBC. METHODS: We performed esophagogastroduodenoscopy, and examined RBC indices, serum iron and TIBC on 178 pediatric patients with recurrent abdominal pain. H. pylori infection was assessed by CLO test and silver stain of gastric biopsy specimen. RESULTS: H. pylori infection was found in 42 of 178 patients(23.6%). In children with H. pylori infection, the prevalence of iron deficiency(ID) and IDA(39.0% and 10.3%, respectively) was higher than in children without H. pylori infection(29.6% and 4.1%, respectively), but there was no statistically significant difference. Serum iron level was lower(69.5+/-32.7 vs 77.3+/-34.1g/dL; P= 0.08) and TIBC was higher(380.8+/-50.4 vs 366.9+/-47.0g/dL; P=0.09) in children with H. pylori infection than in children without H. pylori infection. All RBC indices and iron saturation were lower in children with H. pylori infection than in children without H. pylori infection, but there was no significant difference between the two groups. In correlation analysis, serum iron, Hgb, Hct, MCV and MCH were significantly increased by age in children without H. pylori infection (P<0.05), but MCH and MCHC were decreased significantly(P<0.05) by age in children with H. pylori infection. In multiple regression analysis, the change of serum iron, MCH and MCHC by age was significantly influenced by the status of H. pylori infection(P<0.05). CONCLUSION: H. pylori infection decreases RBC indices and serum iron and increases TIBC in children. These changes become prominent as age increases. This age effect rnay be related to the duration of H. pylori infection. (J Korean Pediatr Soc 2000;43:755-762)
Abdominal Pain ; Adolescent ; Anemia, Iron-Deficiency ; Biopsy ; Child* ; Endoscopy, Digestive System ; Erythrocytes* ; Helicobacter pylori* ; Helicobacter* ; Humans ; Iron* ; Prevalence ; Silver

We present a case of pemphigus vulgaris developed during pregnancy. The clinical features of this patient were similar to those of hetpes gestationis. By immunofluorescence studies we found that the patient's serum contained autoantibodies to intercellular substance of epidermis. Direct immunofluorescence microscopy of a perilesional skin also demontrated immunoglobulin deposition in the intercellular areas. Additionally we did in vitro C3 staining for further confirmation of the diagnosis but it was negative in basement membrane zone. This patient was initially treated with corticosteroid and azathioprine. Several months later gold compound was given instead of azathioprine and corticosteroid with good therapeutic response.
Autoantibodies ; Azathioprine ; Basement Membrane ; Diagnosis ; Epidermis ; Fluorescent Antibody Technique ; Fluorescent Antibody Technique, Direct ; Humans ; Immunoglobulins ; Microscopy ; Pemphigus* ; Pregnancy* ; Skin

No abstract available.
Antibodies, Monoclonal* ; Blood Cells*

No abstract available.
Child* ; Humans