1.A case of pompe disease associated with wpw syndrome.
Woo Sung CHUN ; Moon Sung PARK ; Se Wook OH ; Chang Joon KO ; Tai Seung KIM
Journal of the Korean Child Neurology Society 1993;1(1):179-185
No abstract available.
Glycogen Storage Disease Type II*
;
Wolff-Parkinson-White Syndrome*
2.Tow Cases of Cerebral Cavernous Hemangiomas in Children.
Jung Keun KIM ; Kwang Kil LEE ; Dong Ik KIM ; Chang Joon KO
Journal of the Korean Neurological Association 1985;3(2):285-290
Recently we experienced two cases of cerebral cavernous hemangioma in children at Pediatric Department of Yonsei Medical School. We are reporting these two cases with literature review.
Child*
;
Hemangioma, Cavernous, Central Nervous System*
;
Humans
;
Schools, Medical
3.A Case of Myotonia Dystrophy.
Yong Baek KWON ; Seung Kyue LEE ; Chang Joon KO ; Kyue Rae KIM
Journal of the Korean Neurological Association 1983;1(1):76-80
Recently, we experienced a case of myotonia dystrophy at Pediatric department of Yonsei Medical School. And we are presenting the case we experienced with reviewing the literatures.
Myotonia*
;
Schools, Medical
4.Clinical Utility of Bronchial Washing PCR for IS6110 and Amplicor for the Rapid Diagnosis of Active Pulmonary Tuberculosis in Smear Negative Patients.
Jungu LEE ; Youngsam KIM ; Jaemin PARK ; Wonki KO ; Donggoo YANG ; Sekyu KIM ; Joon CHANG ; Sungkyu KIM ; Jongrak CHOI
Tuberculosis and Respiratory Diseases 2001;50(2):213-221
BACKGROUND: There is a well recognized interlaboratory variation in the results using the polymerase chain reaction(PCR) to detect the IS6110 sequence. The clinical utility of a commercially developed PCR test(Amplicor) in bronchial washings for detecting pulmonary tuberculosis in smear negative patients was evaluated. The sensitivity and specificity of Amplicor was compared with that of an in-house PCR test used for detecting the IS6110 sequence of Mycobacterium tuberculosis(M.tbc) in the bronchial washing fluid. METHODS: 66 patients whose sputum smear for M.tbc were negative or who could not produce any sputum were recruited from January 1999 to July 1999. They all had a bronchoscopy performed to determine if there were signs of hemoptysis, patients who could not cough up sputum, lung lesion that exclude pulmonary tuberculosis. Pulmonary tuberculosis was diagnosed on the basis of a positive culture or a response to anti-tuberculosis therapy. RESULTS: 19 patients with tuberculosis were identified and samples from 16 patients were later confirmed by culture. Bronchial washing for Amplicor PCR revealed a sensitivity, specificity, positive and negative predictive values of 94.7%, 97.9%, 94.7%, 97.9%, respectively. Using IS6110 based PCR, the sensitivity, specificity, positive and negative predictive values were of 73.7%, 87.2%, 70%, 89.1% respectively. CONCLUSION: Bronchial washing for Amplicor PCR proved to be more useful than IS6110 based PCR in rapidly diagnosing smear negative pulmonary pulmoary tuberculosis in patients where tuberculosis was likely to be differential and rapid diagnosis was essential for optimal treatment.
Bronchoscopy
;
Cough
;
Diagnosis*
;
Hemoptysis
;
Humans
;
Lung
;
Mycobacterium
;
Polymerase Chain Reaction*
;
Sensitivity and Specificity
;
Sputum
;
Tuberculosis
;
Tuberculosis, Pulmonary*
5.Surgical Treatment of Spondylolisthesis Using Transpedicular Fixation System
Ki Soo KIM ; Kwang Joon KIM ; Seung Hee KO ; Hyeong Seong KIM ; Chang Moon SEO ; In Kyu BAIK
The Journal of the Korean Orthopaedic Association 1994;29(1):261-272
We have analyzed clinical results of forty-five patients who had spondylolisthesis which were operated using transpedicular screw fixation devices (CD or Steffee VSP system) between June, 1987 and March, 1992 at the department of Orthopedic Surgery of Kwang-ju Christian Hospital. Simultaneously we compared the postoperative results between two groups. The results were as follows: 1. The ratio of man and woman was 1: 2.2 and mean age was 44.3 years (44.8 years in degenerative type and 42.5 years in isthmic type). 2. The most common level was L4 on L5 and two-third of all cases were isthmic type. 3. The clinical results were satisfactory in 91% (41 cases) according to anthors modified evaluation system. There was no significant difference between degenerative and isthmic type. 4. The mean % of slip was improved from 23.3% preoperatively to 7.4% postoperatively and the mean slip angle was improved from 3.5 degrees preoperatively to-5.4 degrees postoperatively. 5. The devices which were used for operation were C-D instrument in 21 cases and Steffee VSP system in 23 cases. There was no difference in radiographic examinaton and clinical result between two groups. 6. The anterior fusion was done for 9 active young patients. The results were significantly satisfactory. 7. We consider the transpedicular fixation system is the most recommandable method of treatment for spondylolisthesis in providing excellent reduction of slippage and maintenance of reduction with rigid fixation device.
Female
;
Gwangju
;
Humans
;
Methods
;
Orthopedics
;
Spondylolisthesis
6.Anatomical Study of the Variations of Motor Branches of Tibial Nerve to Gastrocnemius Muscle.
Jai Koo CHOI ; Chang Kyung KANG ; Ki Suk KO ; Joon Buhm KIM ; Dong Hyuk SINN ; Sun Heum KIM
Journal of the Korean Society of Aesthetic Plastic Surgery 2001;7(2):140-145
No abstract available.
Muscle, Skeletal*
;
Tibial Nerve*
7.Effect of Ga2 gene mutation on the Expression of Thyrotropin-Releasing Hormone ( TRH ) Receptor Gene in GH3 Cells.
Seung Joon PARK ; In Myung YANG ; Jeong Hwa RYU ; Joo Ho CHUNG ; Jee Chang JUNG ; Kye Chang KO ; Young Seol KIM ; Young Kil CHOI
Journal of Korean Society of Endocrinology 1997;12(3):357-363
8.Clinical Features and Predilection Sites of the Lesions Observed in Chronic Cutaneous Lupus Erythematosus.
Ji Goo OH ; Joo Yeon KO ; Hee Joon YU ; Chang Woo LEE
The Journal of the Korean Rheumatism Association 2005;12(2):67-72
OBJECTIVE: The typical clinical feature of chronic cutaneous lupus erythematosus (CCLE) is 'discoid erythema'; however, several different clinical variants exist such as hypertrophic LE, LE profundus, chilblain LE, tumid LE and so on. The heterogeneity-spectrum of the lesional morphology of the cutaneous lesions and the predilection sites of the lesions of twenty Korean patients with CCLE were examined and tried to compare to those of CCLE patients of Caucasian origin. METHODS: Clinical examinations of twenty patients with CCLE were carried out by dermatologists to define the morphologic characteristics of cutaneous lesions and the anatomic predilection sites of the lesions. RESULTS: The most common cutaneous lesion-morphology noted in Korean patients with CCLE was classic discoid erythema. Three cases had concurrent cutaneous lesions of other clinical variants of CCLE. The predilection sites of all lesions were the face (cheeks) and head (frontal area). These clinical findings observed among this group of patients are similar to those features seen in people of Caucasian origin. CONCLUSION: The most frequent clinical feature of CCLE was discoid erythema and the predilections sites of the lesions found were the face and the scalp; indicating that the morphological heterogeneity-spectrum of cutaneous lesions and the predilection sites observed in Korean patients of CCLE seem to have no remarkable differences when compared with Caucasian cases with the same diagnoses.
Chilblains
;
Diagnosis
;
Erythema
;
Head
;
Humans
;
Lupus Erythematosus, Cutaneous*
;
Scalp
9.Aggressive Surgical Treatment for Intrahepatic Cholangiocarcinoma and Prognostic factors.
Hong Jin KIM ; Sung Su YUN ; Juong Uuk KO ; Joon Hyuk CHOI ; Jay Chun CHANG ; Koing Bo KWUN
Korean Journal of Hepato-Biliary-Pancreatic Surgery 1999;3(1):27-36
BACKGROUND/AIMS: To review the cases of surgically-treated intrahepatic cholangiocarcinoma, and to evaluate the clinical and pathologic features of intrahepatic cholangiocarcinoma that may affect longterm survival among Korean patients. MATERIALS AND METHODS: From 1990 to 1997, 28 patients with intrahepatic cholangiocarcinoma underwent laparotomy. Among them, resection was performed in 25 patients and wedge resection in only 3 patients. The liver resections included: 5 right lobectomies, 1 right trisegmentectomy, 7 left lobectomies, 3 extended left lobectomies, 2 hepatopancreatoduodenectomies and 7 segmentectomies. Curative resection was performed on 15 patients. The histological sections of all resected specimens were immunohistochemically stained with p53 and Ki-67 monoclonal antibodies to assess biological behavior of the tumor cells. The cumulative survival rate and clinicopathological factors, including biological markers (p53, Ki-67), that may influence prognosis were analyzed stastistically. RESULTS: The patients undergoing curative resection survived significantly longer than the patients undergoing noncurative resection. The median survival time for patients with curative resection was 24 months (mean, 34+/-8 months) with 1-, 2-, and 3-year survival rates of 66.6%, 44.4%, and 35.6%, respectively. The median survival time for patients with noncurative resection was 3 months (mean, 8+/-3 months) with 1- and 2-year survival rates of 26.7% and 13.4%, respectively. Univariate analysis showed that positive regional lymph node significantly correlated with poor prognosis (p=0.004); and that curative resection significantly correlated with better prognosis (p=0.001). Age, sex, tumor size, the degree of cell differentiation, gross type of tumor, and p53 and Ki-67 labeling index had no significant correlation with prognosis. CONCLUSION: Our results support the idea that an aggressive liver resection along with regional lymph node dissection is recommended for long-term survival. The validity of the molecular biologic tumor markers (p53, Ki -67) as a prognostic factor is not yet clearly defined.
Antibodies, Monoclonal
;
Biomarkers
;
Cell Differentiation
;
Cholangiocarcinoma*
;
Fibrinogen
;
Hepatectomy
;
Humans
;
Laparotomy
;
Liver
;
Lymph Node Excision
;
Lymph Nodes
;
Mastectomy, Segmental
;
Prognosis
;
Survival Rate
;
Biomarkers, Tumor
10.Immediate Breast Reconstruction Following Mastectomy for the Treatment of Advanced Breast Cancer Patients.
Ho Sung YOON ; Chang Dae KO ; Hee Joon KANG ; Sei Hyun AHN ; Taik Jong LEE ; Sang Hoon HAN
Journal of the Korean Surgical Society 2002;62(2):127-132
PURPOSE: To elucidate whether there is a delay of adjuvant treatment or detection of recurrences, or an increasing of the recurrence of tumorsin clinically advanced breast cancer patients. METHODS: The study group included 55 patients underwent mastectomy with immediate reconstruction (IBR), and 563 patients who received the mastectomy without reconstruction (non-IBR), and who were stage IIB and IIIA breast cancer patients, at Asan Medical Center between Jun 1993 and December 2000. We retrospectively assessed the comparative outcomes through using follow-up data. RESULTS: Out of 2,057 patients who had undergone the mastectomy on during the period, 175 (8.5%) underwent immediate reconstruction. 55 of them (31.6%) were stage IIB and IIIA patients, a similar portion (29.9%) was seen in the 563 patients of same stages without reconstruction. The mean ages of these groups were 37.1 and 46.9 years, that is, the reconstruction group was about 10 years younger. All these patients voluntarily underwent immediate reconstruction. For the patients who were followed up, the local recurrence was 3.6% (2/55) for the IBR group and 5.2% (29/563) for the non-IBR group. On the other hand, the distant relapse rates were 12.7% and 13.9%. The administration of adjuvant chemotherapy was not delayed and radiotherapy was used as an adjuvant treatment after reconstruction in nine of the cases (16.4%). Chemotherapy was also conducted in 98.2% of the IBR group and 77.3% of the non-IBR group. While radiotherapy was used in the IBR group less frequently, there was no statistical difference between the two groups (P=0.63). CONCLUSION: Immediate reconstruction following mastectomy for the treatment of breast cancer is now more frequently performed. IBR can be done in clinically advanced breast cancer without increasing the risk of treatment failure or modification.
Breast Neoplasms*
;
Breast*
;
Chemotherapy, Adjuvant
;
Chungcheongnam-do
;
Drug Therapy
;
Female
;
Follow-Up Studies
;
Hand
;
Humans
;
Mammaplasty*
;
Mastectomy*
;
Radiotherapy
;
Recurrence
;
Retrospective Studies
;
Treatment Failure