1.Expression of Fragile Histidine Triad (FHIT) Gene Product in the Uterine Cervical Carcinoma.
Korean Journal of Gynecologic Oncology and Colposcopy 1999;10(3):217-223
To investigate the involvement of expression of the Fragile Histidine Triad(FH1T) gene product in the process of carcinogenesis and progression in cervical carcinoma, we examined its expression by immunohistochemical method in 15 cervical invasive carcinomas, 10 low grade cervical intraepithelial neoplasias(CINs) and 30 high grade CINs(CMI and III). We detected expression of FHIT gene product in 4 of 15(27%) of invasive carcinomas, 3 of 10(30%) low grade CIN and 7 of 30(23%) of high grade CIN, while we detected expression of FHIT gene product in 28 of 45(62%) normal and metaplastic epithelium near the tumor. Thesc data indicate that loss of expression of FH1T gene product has some role in the early tumorigenesis of uterine cervical carcinoma, but not the consequence of the pregression of the tumor.
Carcinogenesis
;
Epithelium
;
Histidine*
;
Immunohistochemistry
3.Free jejunal graft for cervical esophageal reconstruction.
The Korean Journal of Thoracic and Cardiovascular Surgery 1991;24(5):515-521
No abstract available.
Transplants*
4.The Capacity of 2 mm Matriderm(R) as a Dermal Substitute in Single Stage Skin Resurfacing.
Chang Ryul YI ; Joon Hyon KIM ; Young Joon KIM
Journal of Korean Burn Society 2015;18(1):19-23
PURPOSE: Matriderm(R) is a highly porous dermal substitute consisting of a collagen matrix (collagen type I, III, and V) cross-linked to an elastin hydrolysate. The 1 mm thickness Matriderm(R) is used in a one-stage procedure. On the other hand, 2 mm thickness Matriderm(R) has been used in two-stage procedures in combination with split thickness skin grafts (STSG) for reconstruction as dermal substitute. To the best our knowledge, there is no case that reports the single stage procedure with 2 mm thickness Matriderm(R). There are many expected advantages if a two-stage surgery could be performed by one-stage procedure as long as the result is guaranteed. The purpose of this study is to present capacity of 2 mm thickness Matriderm(R) as a dermal substitute in single stage skin grafting by the successful results of six cases. METHODS: We performed this one-stage procedure in five patients instead of soft tissue reconstruction. Those patients were required soft tissue reconstruction after trauma injuries or radial forearm harvest as a donor site in the period between 2011 and 2012. Five Patients were treated with a combination of STSG and 2 mm thickness Matriderm(R) solely. Three out of five patients who were injured by trauma got transplanted splint thickness skin that were range from 4/1000~8/1000 inches (Table 1). Patients' data were analyzed retrospectively by chart review and patients interviews. Each patient's chart was reviewed for age, gender, type of injury, complications, final outcome and successful rates. RESULTS: The patient group consisted of 4 men and 1 woman between ages of 5 and 70. The clinical results of these five treated patients concerning skin-quality and coverage of exposed soft tissue were very good. Using 2 mm thickness Matriderm(R) the wound could gain more dermal substitute compare to 1 mm thickness Matriderm(R). CONCLUSION: Matriderm(R) is a single-use three-dimensional matrix composed of native, structurally intact collagen fibrils and elastin for supporting dermal regeneration. In this study five patients with trauma injuries or radial forearm harvest as a donor site were treated with 2 mm thickness Matriderm(R) as a dermal substitute and STSG as a single-stage procedure to cover exposed structures. Compare to 1 mm Matriderm(R), 2 mm thickness Matriderm(R) provide more dermal collagen and enhance skin-elastisity. Achieving single stage STSG with 2 mm thickness Matriderm(R), patient's hospital days were reduced in half and infection chances were also decreased. In conclusion, single skin grafting with 2 mm thickness Matriderm(R) is feasible and it is time-effient and cost effective procedure.
Collagen
;
Elastin
;
Female
;
Forearm
;
Hand
;
Humans
;
Male
;
Regeneration
;
Retrospective Studies
;
Skin Transplantation
;
Skin*
;
Splints
;
Tissue Donors
;
Transplants
;
Wounds and Injuries
5.A Case of Congentital Leukemia.
Joon Sik KIM ; Chang Ik LEE ; Dong Hak SHIN
Journal of the Korean Pediatric Society 1984;27(8):802-807
No abstract available.
Leukemia*
6.Positive rate of anti-HCV in patients with abnormal liver function test.
Ho Sun CHANG ; Joon Suh SONG ; Young Sik KIM
Journal of the Korean Academy of Family Medicine 1992;13(1):49-56
No abstract available.
Humans
;
Liver Function Tests*
;
Liver*
7.Pemphigus Vulgaris Developed During Pregnancy.
Chang Woo LEE ; Seon Hoon KIM ; Hee Joon YU
Korean Journal of Dermatology 1981;19(1):99-103
We present a case of pemphigus vulgaris developed during pregnancy. The clinical features of this patient were similar to those of hetpes gestationis. By immunofluorescence studies we found that the patient's serum contained autoantibodies to intercellular substance of epidermis. Direct immunofluorescence microscopy of a perilesional skin also demontrated immunoglobulin deposition in the intercellular areas. Additionally we did in vitro C3 staining for further confirmation of the diagnosis but it was negative in basement membrane zone. This patient was initially treated with corticosteroid and azathioprine. Several months later gold compound was given instead of azathioprine and corticosteroid with good therapeutic response.
Autoantibodies
;
Azathioprine
;
Basement Membrane
;
Diagnosis
;
Epidermis
;
Fluorescent Antibody Technique
;
Fluorescent Antibody Technique, Direct
;
Humans
;
Immunoglobulins
;
Microscopy
;
Pemphigus*
;
Pregnancy*
;
Skin
8.Monoclonal antibodies specific to rickettsia typhi.
Myong Joon HAHN ; Ik Sang KIM ; Woo Hyun CHANG
Journal of the Korean Society for Microbiology 1992;27(1):29-34
No abstract available.
Antibodies, Monoclonal*
;
Rickettsia typhi*
;
Rickettsia*
9.Monoclonal antibodies specific to rickettsia typhi.
Myong Joon HAHN ; Ik Sang KIM ; Woo Hyun CHANG
Journal of the Korean Society for Microbiology 1992;27(1):29-34
No abstract available.
Antibodies, Monoclonal*
;
Rickettsia typhi*
;
Rickettsia*
10.Management of atrial septal defect in patients ages 35 years or older.
Chul Hyun PARK ; Sang Joon OH ; Chang Ho KIM
The Korean Journal of Thoracic and Cardiovascular Surgery 1991;24(12):1161-1166
No abstract available.
Heart Septal Defects, Atrial*
;
Humans