Letterer-Siwe disease is a non-lipid reticuloendotheliosis of unknown etiology and usually grouped with Hand-Schuller-Christian disease and eosinophilic granuloma as components of histiocytosis-X. It occurs mostly in infancy and, clinically it is the most generalliaed and serious. In recent years, the prognosis of infants with Letterer-Siwe disease has improved, primarily due to more aggressive therapy with corticosteroids and antimetabolic agents. The 14 months old male patient was admitted into the Severance Hospital on 15th, July 1974 for evaluation of a chronic and refractory skin eruptions, abdominal distension with diarrhea and edema on extremities. He had been well until 3 months old age when he developed seborrhea-like skin eruptions which did not improve on treatment for seborrhea. Vigorous treatment was started for the baby from the beginning of admission day. Routine laboratory tests, skin biopsy, bone marrow aspiration and radiologic studies for bony structures wer done. All those studies had showed severe anemia, thrombocytopenia, multiple bony defects in skull and numerous non-lipid histiocytic infiltration in skin and bone marrow all those were consist with Letterer-Siwe disease.
Adrenal Cortex Hormones ; Anemia ; Biopsy ; Bone Marrow ; Dermatitis, Seborrheic ; Diarrhea ; Edema ; Eosinophilic Granuloma ; Extremities ; Histiocytosis, Langerhans-Cell* ; Humans ; Infant ; Male ; Prognosis ; Skin ; Skin Tests ; Skull ; Thrombocytopenia

Dyskeratosis congsnita is a rare congenital disorder characterized by the triad of reticular pigmentation of the skin. dystrophic naila, and leukoplakia of the mucous membrane, and is often associated with severe pancytopenia. A 9-year-old boy had reticular pigmentation of the skin, dystropbic changes of the finger and toe nails, white patches of the buccal mucosa, mild hyperkeratosia of the palms and soles, excesaive lacrimation, dysphagia and severe pancytopenia, Bone marrow showed hypoplastic anemia and decreased cell mediated immunity was noticed.
Anemia, Aplastic ; Bone Marrow ; Child ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Deglutition Disorders ; Dyskeratosis Congenita* ; Fingers ; Humans ; Immunity, Cellular ; Leukoplakia ; Male ; Mouth Mucosa ; Mucous Membrane ; Pancytopenia ; Pigmentation ; Skin ; Toes

The present study evaluates the type, frequency and location of basal cell epithelioma, as well as the age and sex distribution of patients and the recurrence rate of basal cell epithelioma. In this study 116 patients, who visited Severance hospital during the last 15 years from Jan. 1, 1967 to Dec. 31, 1981 and were diagnosed histopathologically as having basal cell epithelioma, were analysed. (countinued..)
Carcinoma, Basal Cell* ; Humans ; Recurrence ; Sex Distribution

The cutaneous metastaaes from carcinoma of breast produce four definite clinical types: inflammatory carcinoma, telangiectatic carcinoma, nodular carcinoma, and carcinoma en cuirasse. We present a case of 51-year-old woman who had purpuric, hard, sclerotic plaque with ulceration, crust and. several pea-sized hemorrhagic papulovesicular eruptions on the right chest wall for one year. Histopathological findings show metastatic ductal carcinoma but, the primary focus was not determined.
Breast ; Carcinoma, Ductal ; Female ; Humans ; Middle Aged ; Thoracic Wall ; Ulcer

We described a 65-year-old woman with a papule on the left temple area of } year duration. The lesion showed typical findings of atypical fibroxanthoma and was located on the lesion of solar keratosis, So sunlight may be the most important one among the various insults to atypical fibroxanthoma of the skin.
Aged ; Female ; Humans ; Keratosis ; Skin ; Sunlight

Finger print patterns were studied in a series of 99 male schizophrenics who met with the diagnostic criterias of International Pilot Study of schizophrenia except items associated with chronicity in exclusion criteria, As controls, the autbors used 400 Korean men who were free of congenital, dermatological, neurological and psychiatric disorders, The frequency distribution of the finger print patterns in the 99 s'chizophrenics were whorls 52.45%, loops 49.09% and arches 3.46%. and that of controls were vrhorls 49.65%, loops 46.38% and arches 3.97%, The diffeence in pattern frequency was statistically significant (P<0.05). However, the striking differences were found in the frequency of the ridge dissociation. The observed frequency was very significantly high (p<0.005) in the schizophrenics (16.16%) compared to controls (6.25%). This findings supported the rcport of the Raphael (18%) but the frequency of our controls(6.25%) were not matched with previous study of Abel (The frequency for his 4,000 control was negative. No plausible explanation is not found for the extraordinary high frequency of ridge clissociat,ions in the controls of tbis study. Although rnore extensive investigation in needed for the explanation of significantly high frequency of ridge dissociation in thes chizophrenics, the findings of the present study give us another evidence of the constitutional factors in schizophrenics.
Fingers* ; Humans ; Male ; Pilot Projects ; Schizophrenia* ; Strikes, Employee

Characteristic dermatoglyphic patterns are found on the volar aspect of the skin of the primates including, man, apes, monkeys and some kinds of marsupiaIs. It is the delieate continuous or discontinuous and sometimes interrupted or branched, variable shaped configuration of ridged skin patterns, which is composed of the unit pattern of arch, loop and whorl. It is characteristically unique for any individuals so it has been used popularly as a convenient method of personal ideatification or for use in studies of inheritance epecially i the field of Iegal medicine. Besides that, there are statistieal differences between left and right finger, males and femals and different races. Of particular interest is the fct the distortion of the dermatoglypbic patterns occur in relation to cbromosomal aberrations, for exarnple, in mongolism,Klinefelter's syndrome and Turner'e syndrome. In addition to that, dermatoglyphic features may prove and aid to diagnree in dermatology, such as, in alopecia areata, psoriasis and leprosy. Thus, authors studied on the dermatoglyphic pattern types in the 234 cases of healthy normal males, 44 male psoriatic patients and 58 male alopecia areata patients during the period of 10 months from Novernber, 1977 to August, 1978, The resulta are as follows: A. Psoriasis 1. In the analysis of the total fingertip ridges, there are significant differences (p<0.01) between the alopecia areata (141.66+/-8.36) and the control group (152.93+/-9.50). 2. A significant statistical difference between the psoriasis and the control group does not exist with respect to the pattern intensity. 3. In the incidence of simian lines, the psoriatic patients (15.91%) showed more incidence rate than those of control group (8.98%). 4. With respect to the proportional distance (mm.) between the distal flexion crease of the wrist to the base of the middle finger with the distance (mm.) of the same point of the wrist to the axial triradius, a significant statistical difference (p<0.05) between the left hands of the control gorup (15.24+/-0.37%) and, those of psoriasis (17.35+/-1.01%) was existed. 5. As for the and angle, there is no significant differences between the control and psoriasis group. 6. There is no statistical differences in view point the pattern types between the psoriasis and the control group, however in psoriasis group, double whorls are decreased than those of control gorup (6.8%). B. Alopecia areata 1. In the analysis of the total fingertip ridges, there is significant difference (P<0.01) between the Alopecia areata (138.40+/-5.03) and the control group (152.93+/-9.50). 2. A significant statistical differences (P<0.005) between the alopecia areata (14.193+/-0.487) and the control group (14.728+/-0.182) exist with respect to the pattern intensity. 3. In the incidence of simian lines, the alopecia areata patients (3.44%) showed lower incidence rate than those of control group (8.98%). 4. With respect to the proportional distance (mm.) between the distal flexion crease of the wrist to the base of the middle finger with the distance (mm.) of the same point of the wrist to tbe axial triradius, a significant statistical difference(p<0.05) between the left hands of the control group (15.24+/-0.37%) and those of alopecia areata (16.66+/-0.70%) was existed. 5. As for the and angle, it is increased significantly (P<0.01) in both hands of alopecia areata, especially in the right hands of alopecia areata, it is increased about twice that of control group. 6. There is no statistical differences in the pattern types between alopecia areata and control group, however in alopecia areata patients, whorls in the right index finger are decreased (39.66%) than those of control gorup (50.16%), Whereas loops in the right index finger are more freguently found (50%) than those of control group (37.44%).
Alopecia Areata* ; Alopecia* ; Continental Population Groups ; Dermatoglyphics* ; Dermatology ; Fingers ; Hand ; Haplorhini ; Hominidae ; Humans ; Incidence ; Leprosy ; Male ; Primates ; Psoriasis* ; Skin ; Wills ; Wrist

Stasis eczema is one of the important skin manifestations caused by venous stasia. dueto vascular disturbances. Until now a few casses of stasis eczema accornpanied with inferior vena cava obstruction were reported in the literatures. The patient, 31-year old barber, has been suffered from right upper guadrant abdominal pain and tenderness for 6 years, and had dark brownish mottled scaly eczematoid patches of both lower extremitiea for 6 yrs. Inferiorvenacavogram through the right fernoral vein showed complete obstruction of inferior vena cava above the level of T10, and well developed several collateraI veins. Findings of skin biopsy on the right ankle joint area revealed moderate acanthosis, increased pigrnentation of the basal cell layer in the epidermis, capillary proliferation and hemosiderin granules in the dermis, that is consistent with stasis eczema. Possible etiological factor of inferior vena cava obstruction waa discussed and also reviewed with literatvre.
Abdominal Pain ; Adult ; Ankle Joint ; Biopsy ; Capillaries ; Dermis ; Eczema* ; Epidermis ; Hemosiderin ; Humans ; Skin ; Skin Manifestations ; Veins ; Vena Cava, Inferior

Riboflavine tetrabutyrate is a fat soluble riboflavine derivative. It was synthesized by esterification of riboflavine with fatty acid chloride or by esterification of riboflavine with fatty acid anbydride. The advantage of riboflavine tetrabutyrate is prolongation of its biologic half life and as a result enhancing effectivity of riboflavine, This riboflavine tetrabutyrate has been used for treatment of various dermatoses of which Pathogenesis are believed to be related with abnorma1 Iipid rnetabolism. Receatty, there were many case reports showing markedly improved clinical synptoms ofpsoriatic patients who had been administered oral riboflavine tetrabutyrate for more than one month in Japan. In this clinical trial, we have also experienced effectiveness in 4 of 7 psoriatic pztients who was given oral riboflavine t trabutyrate for more than 3 months.
Esterification ; Half-Life ; Humans ; Japan ; Psoriasis* ; Riboflavin* ; Skin Diseases

Kaposi's sarcorna is a tumor-like condition which characterized by a mixed proliferation of fibroblastic components and vascular structures. The authors report a case of nodular type of Kaposis sarcoma in 54 year-old male who had an eroded hemorrhagic nodule and few papular lesions. These lesions involved only both hands and feet without systemic involvement.
Cytochrome P-450 CYP1A1 ; Fibroblasts ; Foot ; Hand ; Humans ; Male ; Middle Aged ; Sarcoma* ; Sarcoma, Kaposi