Letterer-Siwe disease is a non-lipid reticuloendotheliosis of unknown etiology and usually grouped with Hand-Schuller-Christian disease and eosinophilic granuloma as components of histiocytosis-X. It occurs mostly in infancy and, clinically it is the most generalliaed and serious. In recent years, the prognosis of infants with Letterer-Siwe disease has improved, primarily due to more aggressive therapy with corticosteroids and antimetabolic agents. The 14 months old male patient was admitted into the Severance Hospital on 15th, July 1974 for evaluation of a chronic and refractory skin eruptions, abdominal distension with diarrhea and edema on extremities. He had been well until 3 months old age when he developed seborrhea-like skin eruptions which did not improve on treatment for seborrhea. Vigorous treatment was started for the baby from the beginning of admission day. Routine laboratory tests, skin biopsy, bone marrow aspiration and radiologic studies for bony structures wer done. All those studies had showed severe anemia, thrombocytopenia, multiple bony defects in skull and numerous non-lipid histiocytic infiltration in skin and bone marrow all those were consist with Letterer-Siwe disease.
Adrenal Cortex Hormones ; Anemia ; Biopsy ; Bone Marrow ; Dermatitis, Seborrheic ; Diarrhea ; Edema ; Eosinophilic Granuloma ; Extremities ; Histiocytosis, Langerhans-Cell* ; Humans ; Infant ; Male ; Prognosis ; Skin ; Skin Tests ; Skull ; Thrombocytopenia

Dyskeratosis congsnita is a rare congenital disorder characterized by the triad of reticular pigmentation of the skin. dystrophic naila, and leukoplakia of the mucous membrane, and is often associated with severe pancytopenia. A 9-year-old boy had reticular pigmentation of the skin, dystropbic changes of the finger and toe nails, white patches of the buccal mucosa, mild hyperkeratosia of the palms and soles, excesaive lacrimation, dysphagia and severe pancytopenia, Bone marrow showed hypoplastic anemia and decreased cell mediated immunity was noticed.
Anemia, Aplastic ; Bone Marrow ; Child ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Deglutition Disorders ; Dyskeratosis Congenita* ; Fingers ; Humans ; Immunity, Cellular ; Leukoplakia ; Male ; Mouth Mucosa ; Mucous Membrane ; Pancytopenia ; Pigmentation ; Skin ; Toes

The present study evaluates the type, frequency and location of basal cell epithelioma, as well as the age and sex distribution of patients and the recurrence rate of basal cell epithelioma. In this study 116 patients, who visited Severance hospital during the last 15 years from Jan. 1, 1967 to Dec. 31, 1981 and were diagnosed histopathologically as having basal cell epithelioma, were analysed. (countinued..)
Carcinoma, Basal Cell* ; Humans ; Recurrence ; Sex Distribution

A clinical survey on the condyloma acuminatum in the army was carried out during the period of 16 months from July, 1976 to Dec., 1977 by means of ready-made chart and questionare. This study concems a series of 100 maIe patients treated in the ROK Army Hospital. The result can be summarized as follows: 1. 91% of the patients were between the age of 21 and 25, the commonest age being 24(31%) years. The average age was 23.6 years. 86%. of the patients experienced their first sexual contact between the age of 18 and 22, the commonest age being 20 (22%) and 2l(22%) years. The average age was 20years. 2. Predilection sites of the condyloma acuminatum were coronal sulcus (32%), perianal region(22%), glans penis(7%), urethral meatus(7%) and prepuce(4%) 3. Barmaid (58%) was the most frequently suspected sources of prsent infectian and other suspected sources were the prostitute (15%) and the lover (7%). 4. Among the 100 cases of condyloma acuminatum, 78 cases (78%) faund. their skin lesion 1 to 6 months after sexual contact and 49 cases (49%) found it within 8 months. Average incubation period was 3. 7 months. 5. Thirty two cases (32%) of condyloma acuminatum had a past history of other STD and 18 casea (18%) had other coincidently combined STD which were composed of syphilis (15%), urethritis (2%) and chancroid (1% ).
Chancroid ; Hospitals, Military ; Humans ; Sex Workers ; Skin ; Syphilis ; Urethritis

A clinical survey on the syphilitic cases of the military personnel was carried out during the period of 18 months from July, l976 to December, 1977 by means of ready-made STD chart and questianaire. This survey included 180 cases of syphilitic patients who had been diagnosed and treated in the Dept. of Dermatology of ROK Army Hospital. The results can be summarized as follows: I . Total 180 cases af syphilis were classified as 147 cases (81.7%) of secondary syphilis, 22 cases (12. 2%) of primary syphilis and 11 cases (6. l%) of latent syphilis. The cases of secondary syphilis were camposed of 96 cases (65. 3%) of alopecia syphilitica, 88 cases (60.0%) of condyloma latum, 12 cases (8. 2%) of macular syphilid and 1 case (0. 7%) of mucous patch, each. 3. Among 147 cases of secondary syphilis, 42 cases (28.6%) had a positive history of typical chancre at the genital region. III. 68. 3% of patients had first sexual experience between the age of 18 and 20 and the average age was 19.1 years. 71.7% of total patients of syphilis were between the age of 21 and 23 and the average age was 22.8 years. IV. Fourteen cases(63.6%) of primary syphilis had the chancre on the coronal sulcus, 4 cases(18.2%) on the prepuce, 3 cases(13.6%) on the penile shaft and 1 case(4.5%) on the glans penis. V. To review the number of the lesion of 88 cases of condyloma latum, 45 cases(51.1%) had one to three lesions and the average number of the lesion was 3.7 Predilection sites of condyloma latum were perianal region(90.9%), penile shaft(11.4%), scrotum(6.8%) and corona and coronal sulcus(4.5%). VI. Out of 180 cases, 76 cases(42.2%) had a past history of other STD, and 26 cases(14.4%) had other coincidently combined STD which were composed of condyloma acuminatum(8.9%) urethritis(3.3%), chancroid(1.6%) and pediculosis pubis(0.6%). VII. The most common partners of the first sexual experience was lover(50.0%) and followed by barmaid(25.6%) and prostitute(8.9%). Barmaid(56.7%) was the most frequently suspected source of present infection and other sources were prostitute(18.9%) and lover(.9.4%).
Alopecia ; Chancre ; Dermatology ; Hospitals, Military ; Humans ; Lice Infestations ; Male ; Military Personnel ; Penis ; Syphilis* ; Syphilis, Cutaneous ; Syphilis, Latent

Finger print patterns were studied in a series of 99 male schizophrenics who met with the diagnostic criterias of International Pilot Study of schizophrenia except items associated with chronicity in exclusion criteria, As controls, the autbors used 400 Korean men who were free of congenital, dermatological, neurological and psychiatric disorders, The frequency distribution of the finger print patterns in the 99 s'chizophrenics were whorls 52.45%, loops 49.09% and arches 3.46%. and that of controls were vrhorls 49.65%, loops 46.38% and arches 3.97%, The diffeence in pattern frequency was statistically significant (P<0.05). However, the striking differences were found in the frequency of the ridge dissociation. The observed frequency was very significantly high (p<0.005) in the schizophrenics (16.16%) compared to controls (6.25%). This findings supported the rcport of the Raphael (18%) but the frequency of our controls(6.25%) were not matched with previous study of Abel (The frequency for his 4,000 control was negative. No plausible explanation is not found for the extraordinary high frequency of ridge clissociat,ions in the controls of tbis study. Although rnore extensive investigation in needed for the explanation of significantly high frequency of ridge dissociation in thes chizophrenics, the findings of the present study give us another evidence of the constitutional factors in schizophrenics.
Fingers* ; Humans ; Male ; Pilot Projects ; Schizophrenia* ; Strikes, Employee

Characteristic dermatoglyphic patterns are found on the volar aspect of the skin of the primates including, man, apes, monkeys and some kinds of marsupiaIs. It is the delieate continuous or discontinuous and sometimes interrupted or branched, variable shaped configuration of ridged skin patterns, which is composed of the unit pattern of arch, loop and whorl. It is characteristically unique for any individuals so it has been used popularly as a convenient method of personal ideatification or for use in studies of inheritance epecially i the field of Iegal medicine. Besides that, there are statistieal differences between left and right finger, males and femals and different races. Of particular interest is the fct the distortion of the dermatoglypbic patterns occur in relation to cbromosomal aberrations, for exarnple, in mongolism,Klinefelter's syndrome and Turner'e syndrome. In addition to that, dermatoglyphic features may prove and aid to diagnree in dermatology, such as, in alopecia areata, psoriasis and leprosy. Thus, authors studied on the dermatoglyphic pattern types in the 234 cases of healthy normal males, 44 male psoriatic patients and 58 male alopecia areata patients during the period of 10 months from Novernber, 1977 to August, 1978, The resulta are as follows: A. Psoriasis 1. In the analysis of the total fingertip ridges, there are significant differences (p<0.01) between the alopecia areata (141.66+/-8.36) and the control group (152.93+/-9.50). 2. A significant statistical difference between the psoriasis and the control group does not exist with respect to the pattern intensity. 3. In the incidence of simian lines, the psoriatic patients (15.91%) showed more incidence rate than those of control group (8.98%). 4. With respect to the proportional distance (mm.) between the distal flexion crease of the wrist to the base of the middle finger with the distance (mm.) of the same point of the wrist to the axial triradius, a significant statistical difference (p<0.05) between the left hands of the control gorup (15.24+/-0.37%) and, those of psoriasis (17.35+/-1.01%) was existed. 5. As for the and angle, there is no significant differences between the control and psoriasis group. 6. There is no statistical differences in view point the pattern types between the psoriasis and the control group, however in psoriasis group, double whorls are decreased than those of control gorup (6.8%). B. Alopecia areata 1. In the analysis of the total fingertip ridges, there is significant difference (P<0.01) between the Alopecia areata (138.40+/-5.03) and the control group (152.93+/-9.50). 2. A significant statistical differences (P<0.005) between the alopecia areata (14.193+/-0.487) and the control group (14.728+/-0.182) exist with respect to the pattern intensity. 3. In the incidence of simian lines, the alopecia areata patients (3.44%) showed lower incidence rate than those of control group (8.98%). 4. With respect to the proportional distance (mm.) between the distal flexion crease of the wrist to the base of the middle finger with the distance (mm.) of the same point of the wrist to tbe axial triradius, a significant statistical difference(p<0.05) between the left hands of the control group (15.24+/-0.37%) and those of alopecia areata (16.66+/-0.70%) was existed. 5. As for the and angle, it is increased significantly (P<0.01) in both hands of alopecia areata, especially in the right hands of alopecia areata, it is increased about twice that of control group. 6. There is no statistical differences in the pattern types between alopecia areata and control group, however in alopecia areata patients, whorls in the right index finger are decreased (39.66%) than those of control gorup (50.16%), Whereas loops in the right index finger are more freguently found (50%) than those of control group (37.44%).
Alopecia Areata* ; Alopecia* ; Continental Population Groups ; Dermatoglyphics* ; Dermatology ; Fingers ; Hand ; Haplorhini ; Hominidae ; Humans ; Incidence ; Leprosy ; Male ; Primates ; Psoriasis* ; Skin ; Wills ; Wrist

Stasis eczema is one of the important skin manifestations caused by venous stasia. dueto vascular disturbances. Until now a few casses of stasis eczema accornpanied with inferior vena cava obstruction were reported in the literatures. The patient, 31-year old barber, has been suffered from right upper guadrant abdominal pain and tenderness for 6 years, and had dark brownish mottled scaly eczematoid patches of both lower extremitiea for 6 yrs. Inferiorvenacavogram through the right fernoral vein showed complete obstruction of inferior vena cava above the level of T10, and well developed several collateraI veins. Findings of skin biopsy on the right ankle joint area revealed moderate acanthosis, increased pigrnentation of the basal cell layer in the epidermis, capillary proliferation and hemosiderin granules in the dermis, that is consistent with stasis eczema. Possible etiological factor of inferior vena cava obstruction waa discussed and also reviewed with literatvre.
Abdominal Pain ; Adult ; Ankle Joint ; Biopsy ; Capillaries ; Dermis ; Eczema* ; Epidermis ; Hemosiderin ; Humans ; Skin ; Skin Manifestations ; Veins ; Vena Cava, Inferior

Riboflavine tetrabutyrate is a fat soluble riboflavine derivative. It was synthesized by esterification of riboflavine with fatty acid chloride or by esterification of riboflavine with fatty acid anbydride. The advantage of riboflavine tetrabutyrate is prolongation of its biologic half life and as a result enhancing effectivity of riboflavine, This riboflavine tetrabutyrate has been used for treatment of various dermatoses of which Pathogenesis are believed to be related with abnorma1 Iipid rnetabolism. Receatty, there were many case reports showing markedly improved clinical synptoms ofpsoriatic patients who had been administered oral riboflavine tetrabutyrate for more than one month in Japan. In this clinical trial, we have also experienced effectiveness in 4 of 7 psoriatic pztients who was given oral riboflavine t trabutyrate for more than 3 months.
Esterification ; Half-Life ; Humans ; Japan ; Psoriasis* ; Riboflavin* ; Skin Diseases

The cutaneous metastaaes from carcinoma of breast produce four definite clinical types: inflammatory carcinoma, telangiectatic carcinoma, nodular carcinoma, and carcinoma en cuirasse. We present a case of 51-year-old woman who had purpuric, hard, sclerotic plaque with ulceration, crust and. several pea-sized hemorrhagic papulovesicular eruptions on the right chest wall for one year. Histopathological findings show metastatic ductal carcinoma but, the primary focus was not determined.
Breast ; Carcinoma, Ductal ; Female ; Humans ; Middle Aged ; Thoracic Wall ; Ulcer