1.Paget's disease of bone: one case report.
Woon Sik CHOY ; Chang Hyun BAEK ; Dong Hoo KOH
The Journal of the Korean Orthopaedic Association 1991;26(3):970-974
No abstract available.
Osteitis Deformans*
2.Congenital absence of the thenar muscles, bilateral: a case report.
Won Sik CHOY ; Chang Hyun BAEK ; Hyun Jin JANG ; Keun Hong PARK
The Journal of the Korean Orthopaedic Association 1991;26(3):991-994
No abstract available.
Muscles*
3.A case of 7q-syndrome.
Ja Hyun PAK ; Baek Gil LEE ; Il Kyung KIM ; Jung Sik MIN ; Chang Hee CHOI
Journal of the Korean Pediatric Society 1992;35(3):422-427
No abstract available.
4.Rectal Leiomyosarcoma: Report of Two Cases.
On Koo CHO ; Hyun Chul RHIM ; Byung Hee KOH ; Chang Kok HAHM ; Jung Hwan BAEK
Journal of the Korean Radiological Society 1994;31(3):511-514
PURPOSE: To evaluate the radiologic manifestations of the rectal leiomyosarcoma. MATERIALS AND METHODS: We reviewed CT and barium study of 2 cases of rectal leiomyosarcoma, which were operated and pathologically proved. RESULTS: In both cases colon studies showed a huge smooth marginated filling defect in the rectum. Precontrast CT scans showed a well-circumscribed, slightly Iobulated, inhomogeneous mass without calcification. Postcontrast scans showed minimal enhancement with internal low-density areas. In pathologic specimens there were large areas of necrosis and hemorrhage in the masses. Pericolic fat infiltration, lymph node metastasis, or distant metastasis were not detected. CONCLUSION: Leiomyosarcoma is rarely developed in the rectum, but general radiologic findings are similar to that of other part of the gastrointestinal tracts except for the tendency of intraluminal growth due to narrow pelvic space.
Barium
;
Colon
;
Gastrointestinal Tract
;
Hemorrhage
;
Leiomyosarcoma*
;
Lymph Nodes
;
Necrosis
;
Neoplasm Metastasis
;
Rectum
;
Tomography, X-Ray Computed
5.Pathogenetic factors involved in recurrent pregnancy loss from multiple aspects
Chang Zhu PEI ; Young Ju KIM ; Kwang Hyun BAEK
Obstetrics & Gynecology Science 2019;62(4):212-223
Recurrent pregnancy loss (RPL) is a common complication in obstetrics, affecting about 5% of women of childbearing age. An increase in the number of abortions results in escalation in the risk of miscarriage. Although concentrated research has identified numerous causes for RPL, about 50% of them remain unexplained. Pregnancy is a complex process, comprising fertilization, implantation, organ and tissue differentiation, and fetal growth, which is effectively controlled by a number of both maternal and fetal factors. An example is the immune response, in which T cells and natural killer cells participate, and inflammation mediated by tumor necrosis factor or colony-stimulating factor, which hinders embryo implantation. Furthermore, vitamin D affects glucose metabolism and inhibits embryonic development, whereas microRNA has a negative effect on the gene expression of embryo implantation and development. This review examines the causes of RPL from multiple perspectives, and focuses on the numerous factors that may result in RPL.
Abortion, Habitual
;
Abortion, Spontaneous
;
Colony-Stimulating Factors
;
Embryo Implantation
;
Embryonic Development
;
Female
;
Fertilization
;
Fetal Development
;
Gene Expression
;
Glucose
;
Humans
;
Inflammation
;
Killer Cells, Natural
;
Metabolism
;
MicroRNAs
;
Obstetrics
;
Pregnancy
;
Proteomics
;
T-Lymphocytes
;
Tumor Necrosis Factor-alpha
;
Vitamin D
6.Sensitivity, Specificity, and Predictive Value of Optic Disc Parameters in Primary Open-Angle Glaucoma.
Ki Bang UHM ; Chul HONG ; Joon Hyun KIM ; Chang Eun BAEK
Journal of the Korean Ophthalmological Society 1997;38(10):1819-1826
Attempts to quantify the parameters of optic nerve head structure have been made to recognize the earliest structural abnormalities in glaucoma, and to efficiently monitor the structural changes of the optic nerve head with advancing disease. Optic disc parameters were measured in 88 normal subjects and 149 primary open-angle glaucoma patients using a computer graphic program (Adobe photoshopTM) and the photographic magnification was corrected according to Littmanns method. The sensitivity, specificity, and predictive value of optic disc parameters were calculated to discriminate between normal and glaucomatous eyes at different stages of glaucoma. Receiver operating characteristics curves were used for comparisons of different disc parameters. In the group with mild glaucomatous visual field (VF) defects (mean deviation (MD); better than -5dB, group 1), optic disc parameters did not provide greater sensitivity and specificity enough to detect early glaucomatous optic nerve head damage. In the group with moderate VF defects (MD; -6~-10dB, group 2) and advanced VF defects (MD; worse than -11dB, group 3), the minimum rim width within the 60 sector across the vertical meridian (predictive value; 84.4%, 95.9%, respectively), vertical cup to disc ratio (83.7%, 95.2%, respectively), and rim area to disc area ratio (83.7%, 95.1%, respectively) were helpful to identify the glaucomatous eyes, whereas horizontal cup to disc ratio (77.3%, 90.3%, respectively) and cup area (75.2%, 89.0%, respectively) were less helpful in this regard.
Computer Graphics
;
Glaucoma
;
Glaucoma, Open-Angle*
;
Humans
;
Optic Disk
;
ROC Curve
;
Sensitivity and Specificity*
;
Visual Fields
7.Study on Clinical Efficacy of Pixoicam Pathch ( Trast(r) ) in Patients with Rheumatoid Arthritis.
Chang Wan HAN ; Hyun Ah KIM ; Yong Sung LIM ; Eun Bong LEE ; Han Joo BAEK ; Yeong Wok SONG
The Journal of the Korean Rheumatism Association 1998;5(1):56-63
OBJECTIVE: To evaluate the effects of piroxicam patch(Trast) in rheumatoid arthritis patients with knee joint pain and swelling and to determine the concentration of plasma and synovial fluid following patch application. METHODS: Twenty-two patients with rheumatoid arthritis participated in a double-blind, placebo-controlled study. The patients were instructed to apply piroxicam or placebo patch at one knee and re-apply it every other day for 2 weeks. They had washout period for 2 weeks and then applied the other patch for 2 weeks at the same joint. The patients recorded knee joint pain using visual analog scale. Knee joint swelling and tenderness were assessed before and after application of piroxicam and placebo patch. Complete blood count, AST, ALT, BUN, creatinine, joint fluid analysis were also done. Piroxicam concentration in plasma and synovial fluid were measured by high performance liquid chromatography(HPLC) after 2 weeks of piroxicam patch application. RESULTS: Knee joint pain improved significantly after the application of piroxicam patch for 2 weeks(visual analog scale, 56. 2+5. 9m vs 48. 2+5. 7mm, p=0. 03 by Wilcoxon signed rank test). There was no significant change in white cell count of synovial fluid, peripheral blood cell count, chemistry, C-reactive protein and erythrocyte sedimentation rate. In terms of adverse effects, mild gastrointesti nal disturbance(8/21 cases, 38%) and local side effects such as pruritus and ery thema(3/21 cases, 14%) were developed, which were insignificant compared with control groups(30%, 15% respectively). Piroxicam concentrations in plasma and synovial fluid after the application of piroxicam patch were 0. 129+0. 04ug/ ml (mean+SE) and 0. 644+0. 202ug/ml respectively. CONCLUSIONS: Piroxicam patch is a safe and effective therapeutic modality for knee joint pain in patients with rheumatoid arthritis. Mild adverse effects such as gastrointestinal disturbance and local side effects were noted. Piroxicam concentration was higher in synovial fluid than in plasma following the application of piroxicam patch.
Arthritis, Rheumatoid*
;
Blood Cell Count
;
Blood Sedimentation
;
C-Reactive Protein
;
Cell Count
;
Chemistry
;
Creatinine
;
Humans
;
Joints
;
Knee
;
Knee Joint
;
Piroxicam
;
Plasma
;
Pruritus
;
Synovial Fluid
;
Visual Analog Scale
8.Effects of Subconjunctival Mitomycin C on Glaucoma Triple Procedure, as Compared with Trabeculectomy alone.
Chang Eun BAEK ; Joon Hyun KIM ; Yong Ho SOH ; Ki Bang UHM ; Chul HONG
Journal of the Korean Ophthalmological Society 1997;38(1):94-104
Mitomycin C (MMC) trabeculectomy combined with extracapsular cataract extraction and posteor chamber intraocular lens implantation (glaucoma triple procedure, 30 eyes) was clinically compared with MMC trabeculectomy alone (30 eyes). The age, type of glaucoma, and preoperative number of medications were matched with the previous group (P>0.05). The mean preoperative intraocular pressures (IOPs) were 30.2+/-8.3mmHg (range, 22~56mmHg) in the glaucoma triple procedure group and 31.6+/-8.9mmHg (range, 22~57mmHg) in the trabeculectomy alone group (p=0.55). The mean postoperative IOPs were significantly higher in the glaucoma triple procedure group compared with the trabeculectomy alone group at all postoperative vistis (one month to nine months) (p<0.05). However, there were no statistically significant differences in the mean number of postoperative rise exceeding 30 mmHg within the postoperative one month tended to occur more frequently in the glaucoma triple procedure group (7 eyes (23%)) than the trabeculectomy alone group (2 eyes(7%)) (p=0.13). Conjunctival filtering blebs were significantly frequently observed in the trabeculectomy alone group than the glaucoma triple procedure group (28 eyes (93%), 20 eyes (67%), respectively, P=0.02) at 6 months postoperatively. The common postoperative complications were hyphema (4 eyes) and posterior capsular opacification (4 eyes) in the glaucoma triple procedure group and shallow anterior chamber(4 statistical difference was noted between these two groups (p>0.05). Although hypotensive effect of MMC on the glaucoma triple procedure was less than on the trabeculectomy alone, glaucoma triple procedure using MMC could be recommended to be safe and effective on controlling the high IOP for treating glaucoma patients with coexisting cataract.
Blister
;
Cataract
;
Cataract Extraction
;
Glaucoma*
;
Humans
;
Hyphema
;
Intraocular Pressure
;
Lens Implantation, Intraocular
;
Mitomycin*
;
Postoperative Complications
;
Trabeculectomy*
9.Punctoplasty Using a Radiofrequency Surgical Unit for Punctal Stenosis.
Jun Ki KWON ; Min Wook CHANG ; Se Hyun BAEK ; Tae Soo LEE
Journal of the Korean Ophthalmological Society 2012;53(12):1727-1731
PURPOSE: To introduce and assess the results of punctoplasty using a radiofrequency surgical unit for punctal stenosis. METHODS: Patients who complained of epiphora, had an intact lacrimal pathway below puncti, and underwent punctoplasty with the Ellman Surgitron F.F.P.F were evaluated in the present study. RESULTS: A total of 19 patients (31 eyes) were included in the study. The average age was 55 years (+/-15.7 years). At the last follow-up visit, 27 eyes (87%) had patent puncti, 1 eye became stenotic again, and 3 eyes were completely obstructed. Twenty-two eyes (71%) showed almost complete disappearance of dye on the fluorescein dye-disappearance test (FDDT). Twenty-five eyes (81%) had symptomatic improvement. No significant complication was reported postoperatively. CONCLUSIONS: Punctoplasty with a radiofrequency surgical unit is a simple and effective method for punctal stenosis.
Constriction, Pathologic
;
Eye
;
Fluorescein
;
Follow-Up Studies
;
Humans
;
Lacrimal Apparatus Diseases
10.Acute-Onset Chronic Inflammatory Demyelinating Polyradiculoneuropathy Mimicking Miller-Fisher Syndrome.
Hyun Seok BAEK ; Chang Hun BIN ; Min Su PARK
Journal of the Korean Neurological Association 2015;33(3):196-200
A 77-year-old man developed diplopia, gait ataxia, and paresthesia. A clinical examination also revealed ophthalmoplegia, facial palsy, ataxia of the limbs and trunk, and reduced deep tender reflexes. Laboratory and electrophysiological studies revealed albuminocytological dissociation and demyelination. He was diagnosed as Miller-Fisher syndrome and received intravenous immunoglobulin therapy. His clinical symptoms deteriorated at 12 weeks after onset. We diagnosed acute-onset chronic inflammatory demyelinating polyradiculoneuropathy, and which the patient recovered from following corticosteroid therapy.
Aged
;
Ataxia
;
Demyelinating Diseases
;
Diplopia
;
Extremities
;
Facial Paralysis
;
Gait Ataxia
;
Guillain-Barre Syndrome
;
Humans
;
Immunization, Passive
;
Miller Fisher Syndrome*
;
Ophthalmoplegia
;
Paresthesia
;
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating*
;
Reflex