No abstract available.
Peptic Ulcer Perforation* ; Peptic Ulcer*

No abstract available.
Appendicitis* ; Child* ; Humans

No abstract available.
Humans

Peroxisome proliferator-activated receptor-gamma (PPARgamma) has been implicated in the growth inhibition of a number of cancer cells. In the present study, we investigated the antitumor effect of the PPARgamma agonist rosiglitazone in U87MG human glioma cells. Rosiglitazone treatment in vitro reduced cell proliferation without induction of cell death in a dose- and time-dependent manner. Rosiglitazone decreased cell migration and mRNA level of MMP-9. Rosiglitazone treatment also induced marked changes in glioma cell morphology. Oral administration of rosiglitazone in animals with subcutaneous U87MG glioma cells reduced tumor volume. Subsequent tumor tissue analysis showed that rosiglitazone decreased the number of PCNA-positive staining cells and MMP-9 expression and induced apoptosis of tumor cells. These data suggest that rosiglitazone exerts antineoplastic effect in U87MG cells and may serve as potential therapeutic agent for malignant human gliomas.
Administration, Oral ; Animals ; Apoptosis ; Cell Death ; Cell Movement ; Cell Proliferation ; Glioma ; Humans ; Peroxisomes ; PPAR gamma ; RNA, Messenger ; Thiazolidinediones ; Tumor Burden

No abstract available.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive*

No abstract available.
Colorectal Neoplasms, Hereditary Nonpolyposis*

OBJECTIVE: Microvascular decompression(MVD) is an effective technique for the patients who have trigeminal neuralgia(TN) and hemifacial spasm(HS). But, the failed MVD cases have been reported in long term follow-up studies. We introduce our unique operative technique in MVD and analyze the effect of MVD through our modified operative technique, offending vessels in operative field, operative complications, and failed cases. PATIENTS AND METHODS: A series of 52 patients with intractable TN(32 cases) or HS(20 cases) were treated by MVD. Other 7 cases of TN were excluded because they were proved to have TNs secondary to other pathologies, such as nasopharyngeal carcionoma, trigeminal schwannoma, epidermoid tumors, postherpetic neuralgia. The follow-up time was from 3 months to 4 years. RESULT: All 52 patients were treated by retromastoid suboccipital approach. 28 patients of TN were treated with MVD only, and the other 4 patients, were treated with selective sensory root squeezing(1 case), partial sensory rhizotomy(PSR)(2 cases), and PSR with MVD(1 case). Among 20 patients of HS were treated with MVD, 3 patients were not relieved after first operation but were free of spasm after reoperation within 1 week. The degree of nerve root compression was classified as compression and contact and the final outcome compared each other. We used our uniquely designed horseshoe-shaped teflon ring to decompress the vessel from the nerve. In TN, the most common offending vessel was superior cerebellar artery(59.4%) and the final outcomes were as follows: excellent, 87.5%(28 cases): good, 3.1%(1 case): poor, 9.4%(3 cases). In HS, the most common offending vessel was anterior inferior cerebellar artery(55%) and the final outcomes were as follows: excellent, 85%(17 cases): good, 5%(1 case): poor, 10%(2 cases). CONCLUSION: In compressed group, the cure rate was 100%. However, in contact group the cure rate were 81.3% in TN and 75% in HS. RESULT: From the review of the literatures in failed MVD, the etiologies most commonly reported were inadequate decompression, new vessel compression, adhesion and lysis of prosthesis. Our specially designed horseshoe-shaped teflon ring has some advantages to prevent recurrence of symptom by dislodging or slippage of prosthesis or recompression by other vessels. The overall result of our unique MVD was excellent in patients with TN(87.5%) and HS(85%).
Decompression ; Follow-Up Studies ; Hemifacial Spasm* ; Humans ; Microvascular Decompression Surgery* ; Neuralgia, Postherpetic ; Neurilemmoma ; Pathology ; Polytetrafluoroethylene ; Prostheses and Implants ; Radiculopathy ; Recurrence ; Reoperation ; Spasm ; Trigeminal Neuralgia*

Malignant tumors of the small bowel are uncommon by comparison with those in other parts of the gastrointestinal tract. Adenocarcinomas account for about half of the malignant tumors of the small intestine, which account for 1% to 2% of the gastrointestinal neoplasma. Small-bowel tumors are often asymptomatic and without clinical significance, and later became symptomatic and are eventually fatal. Patient's with regional enteritis, especially those who have had segments of the intestine surgically by passed, have an increased incidence of small-bowel cancer. The author experienced a case of an adenocarcinoma at the jejunostomy site (Braun anastomosis) which was treated by using a B II type subtotal gastrectomy for stomach cancer. That case of a jejunostomy site adenocarcinoma is reported and the literature on small-bowel malignancy is reviewed.
Adenocarcinoma* ; Crohn Disease ; Gastrectomy ; Gastrointestinal Tract ; Incidence ; Intestine, Small ; Intestines ; Jejunostomy ; Stomach Neoplasms

There were many methods to treat spondylolisthesis since the past but completely satisfiable method was not developed until now. Recently, many spinal instruments were introduced and used worldwidely to treat spondylolisthesis. The author reports the experience of nine patients of transpedicular screw instrumentation of obtain reduction and fixation of the spondylolisthesis. Follow-up period was between 7 to 33 months after operation with average 19 months. The result was as follows: The age of the patients was 46 years in average ranging from 29 to 61 years. 2) Types of spondylolisthesis were isthmic type in 6 cases and degenerative type in 3 cases. The level of lesion were L4-5 in 5 cases. L5-S1 in 3 cases and L3-4 in 1 case. 3) Preoperative clinical feature include low back pain(100%), sensory disturbance(78%), radiating pain(67%), neurologic claudication(56%). 4) The amount of displacement measured by Boxall was 22.6% preoperatively to 7.3% postoperatively and the amount of angle by Meschan was from 12.7 degree preoperatively to 4 degree postoperatively. 5) Postoperative complications were urinary tract infection(3 cases), screw loosening(1 case), superficial wound infection(1 case), deep wound infection(1 case), and meralgia paresthetica(1 case). 6) The overall result was satisfactory except 1 case due to screw loosening, and satisfiable bony fusion was obtained except 1 case.
Follow-Up Studies ; Humans ; Postoperative Complications ; Spondylolisthesis* ; Urinary Tract ; Wounds and Injuries

This study was undertaken to identify acute changes and mechanism of traumatic brain edema in the rabit by measuring the regional specific gravities and water content with Evans blue dye staining. After delivery of brain injury on the frontal area, animals were sacrificed at 30 minutes, 2, 4 and 6 hours. Specific gravity data collection of regional brain tissue was taken in the serial copper sulfate gravity solution. The regions tested included frontal lobe, occipital lobe, basal ganglia, cerebellum, pons and medulla. Specific gravity data and Evans blue dye staining with spread were compared with those from similar areas in the uninjured anesthetized rabbits to test for brain edema. The results obtained were as follows: 1) Immediately following brain impact, almost all animals in this study demonstrated temporary respiratory arrest. The mean duration of respiratory arrest in experimental animals was 15+/-3 seconds. There was no correlation between length of respiratory arrest and either gross intracranial pathology or brain edema data. 2) The specific gravities in both hemispheres were same in control animals and were not affected by the duration of anesthesia. 3) Significant decrease of specific gravity was identified in the both supratentorial regions at 30 minutes, 2 and 4 hours after trauma. This finding was more prominent in the contused side. No significant changes occurred in the cerebellum but significant decrease of specific gravity occurred in medulla at 6 hours. 4) Almost brain water content was increased as the time course and arrived on peak value at 4 hours and decreased at 6 hours after trauma in the supratentorial regions. 5) Evans blue dye staining occurred in the contusion area at 30 minutes after trauma and spread to surrounding cortex and subcortex but dye density was decreased with time. These results suggest that traumatic brain edema may originate from vasogenic mechanism due to dysfunction of blood-brain barrier and this edema may spread to both cerebral hemispheres and brain stem.
Anesthesia ; Animals ; Basal Ganglia ; Blood-Brain Barrier ; Brain Edema* ; Brain Injuries* ; Brain Stem ; Brain* ; Cerebellum ; Cerebrum ; Contusions ; Copper Sulfate ; Data Collection ; Edema ; Evans Blue ; Frontal Lobe ; Gravitation ; Occipital Lobe ; Pathology ; Pons ; Rabbits ; Specific Gravity