Twenty-nail dystrophy is a distinctive pattern of nail changes, in which all 20 nails are uniformly affected with excessive longitudinal ridging and loss of luster. It occurs at any age ranging from children to adulthood, however, it is most commonly diagnosed in children. It can be idiopathic or caused by other inflammatory dermatoses, but the exact cause and pathogenesis of these changes are so far unknown. Several treatment modalities have been employed for treatment of twenty-nail dystrophy, such as topical steroid, intralesional steroids injection, and topical PUVA, however, without much success. We herein report a case of an adults, patient with twenty-nail dystrophy which was successfully treated with topical 0.025% Tretinoin cream.
Adult ; Child ; Humans ; Skin Diseases ; Steroids ; Tretinoin*

Reconstruction of partial ear defects presents a unique and notable challenge to the dermatologist. This is due to the complex architecture of the external ear which is difficult to duplicate surgically. Several procedures are available for correction of defects to the external ear. However, the diversity of external ear shapes shows how difficult it is to achieve a certain solution to this problem. We report a case of auricular squamous cell carcinoma in which the skin defect is reconstructed by a staged supra-auricular interpolation pedicle flap.
Carcinoma, Squamous Cell ; Ear* ; Ear, External ; Skin

No abstract available.
Animals ; Fibronectins* ; Macrophages* ; Mycobacterium bovis* ; Nitric Oxide Synthase* ; Nitric Oxide* ; Rats* ; Urinary Bladder*

STUDY DESIGN: A retrospective study. PURPOSE: To comparatively investigated the rate of the adjacent segment degeneration and the clinical outcomes in patients with spondylolytic spondylolisthesis, spinal stenosis or degenerative spondylolisthesis. OVERVIEW OF LITERATURE: There have been few studies reported on the adjacent segment degeneration following posterior lumbar interbody fusion(PLIF). Many risk factors for the adjacent segment degeneration following PLIF have been proposed. The range of decompression has been presented as one of the risk factors, yet controversial. METHODS: This study enrolled sixty-three patients who had been treated with single-level PLIF and who were followed up for more than two years. The patients were divided into 3 groups based on the preoperative diagnosis. We analyzed the difference between the preoperative and postoperative intervertebral disc heights of the superior adjacent segments. The incidence rates of instability and the clinical outcomes were comparatively analyzed between each group. RESULTS: The average age of the patients was 55.8 years in the spondylolytic spondylolisthesis group, 65.9 years in the degenerative spondylolisthesis group and 60.4 years in the spinal stenosis group. The average follow-up period was 44 months, 43 months and 42 months, respectively. At the last follow-up, compared to the preoperative period, the intervertebral disc height decreased in all three groups. A statistically significant decrease (p < 0.01) was observed only in the spondylolytic spondylolisthesis group and no significant difference was observed between each group (p = 0.41). The incidence rate of instability and the clinical outcome were not significantly different between each group. CONCLUSIONS: Spondylolytic spondylolisthesis with total laminectomy and single-level PLIF showed no significant difference in the superior adjacent segment degeneration and instability, and the clinical outcome as compared to that of partial laminectomy with single-level PLIF for treating degenerative spondylolisthesis or spinal stenosis.
Decompression ; Follow-Up Studies ; Humans ; Incidence ; Intervertebral Disc ; Laminectomy ; Preoperative Period ; Retrospective Studies ; Risk Factors ; Spinal Stenosis ; Spondylolisthesis

Lumbosacral fixation or spinopelvic fixation is frequently required for the surgical treatment of neuromuscular scoliosis and degenerative lesions, trauma and tumor in the lumbosacral vertebrae. However, the establishment of stable fixation with these procedures is difficult due to the anatomic characteristics of the sacrum and this is even more problematic for the cases with long segmental fixation, severe instability and bone defects. Although the emergence of pedicle screws makes spinal fixation easier and more rigid, S1 pedicle screws alone do not provide enough stability for lumbosacral fixation. For the purposes of reinforcing lumbosacral fixation, procedures using rods or screws can be used: the procedures using rods include the Galveston method, the McCarthy S-rod and the Jackson intrasacral rod, and the procedures using screws include sacral alar screws, transdiscal screws and iliac screws. The purpose of this study was to ascertain the proper fixation methods, according to each indication, for spinopelvic fixation and we analyzed the advantages and drawbacks of each fixation method. In addition, the fixation method of iliac screws, which has recently become more popular, is presented in detail to enhance the availability and reduce the complication of this technique.
Sacrum ; Scoliosis ; Spine ; Succinates

OBJECTIVES: The present study was designed to assess the reliability and validity of Korean version of Family Questionnaire (FQ-K), a brief questionnaire measuring expressed emotion (EE). METHODS: A sample of 84 first-order relatives of schizophrenics completed the FQ-K and the data were analyzed for internal consistency and factor structure. Additionally non-random subset of participants (n=34) refilled FQ-K after two weeks for testretest reliability and naturalistic follow-up data of 36 were obtained for any re-hospitalization events to assess predictive validity. RESULTS: Internal consistency of FQ-K was good (Cronbach's alpha=.819) and principal component factor analysis revealed the two-factor structure (criticism and emotional overinvolvement) identical to previously reported for the FQ. The FQ-K also showed reasonable test-retest reliability and excellent predictive validity was indicated in that outcome of re-hospitalization was superior for low expressed emotion patients at six-month naturalistic follow-up. CONCLUSION: The Korean version of FQ proved to be a reliable and valid instrument measuring expressed emotion in relatives of Korean patients with schizophrenia.
Expressed Emotion* ; Follow-Up Studies ; Humans ; Surveys and Questionnaires* ; Reproducibility of Results* ; Schizophrenia

PURPOSE: Recently, a new animal model for permanent focal brain ischemia using macrospheres was developed wherein the hypothalamic area was free from ischemic injury. The purpose of this study was to evaluate spatiotemporal changes in the expressions of cFos, pERK, and pAkt proteins in the macrosphere model. METHOD: Three or four macrospheres were injected into the internal carotid artery after ligation of the external carotid artery to induce permanent focal brain ischemic injury. RESULT: Twenty-four hours after macrosphere injection, 2,3,5-Triphenyltetrazlium (TTC) staining showed a marked ischemic injury in the blood supply territory of the middle cerebral artery, for example, the cerebral cortex and striatum. Furthermore, TUNEL staining revealed apoptotic cell death in the ischemic injury region of the cerebral cortex and striatum. Expression of the cFos protein was significant in the penumbral zone, but not in the ischemic core of the cortex and striatum, two and six hours after ischemic insult. A transient prominent expression of the pERK1/2 protein was noted in the penumbral zone of the cortex and striatum two hours after injection of macrospheres. In contrast, there was a strong immunoreactivity for the pAkt protein in the ischemic core, but not in the penumbral zone of the cortex and striatum, six hours after ischemic injury. CONCLUSION: The above results suggest that early expressions of cFos, pERK1/2, and pAkt proteins take part in different signaling cascades for cell survival or death in macrosphere animal model of permanent focal brain ischemic injury.
Animals* ; Brain Ischemia ; Brain* ; Carotid Artery, External ; Carotid Artery, Internal ; Cell Death ; Cell Survival ; Cerebral Cortex ; In Situ Nick-End Labeling ; Ligation ; Middle Cerebral Artery ; Models, Animal*

Ovarian granulosa cell tumor is a uncommon low-grade feminizing malignancy. Its natural history shows slow growth without pain. It often reveals to be very large sized mass when diagnosed, and is confined to the involved ovary in many cases. Complete surgical removal is primary treatment and recurrences thereafter are relatively common. Postoperative adjuvant therapy including reoperation, chemotherapy, radiation therapy or a combination therapy has been used with various degrees of success. We experienced a case of huge ovarian granulosa cell tumor occupying whole abdominal cavity by rapid growth, which is presented with a brief review of corresponding literatures.
Abdominal Cavity ; Drug Therapy ; Female ; Granulosa Cell Tumor* ; Granulosa Cells* ; Natural History ; Ovary* ; Recurrence ; Reoperation

PURPOSE: More than 80% of colorectal cancers are known to occur from adenomas, but only a subset of adenomas undergoes malignant transformation. The aim of this retrospective study was to assess clinicopathologic characteristics of synchronous adenomas associated with metachronous malignant neoplasms in colorectal cancer patients. METHODS: Three hundred sixty-eight colorectal cancer patients with synchronous adenomas who underwent a complete polypectomy were consecutively enrolled between 1995 and 2002. The patients with familial adenomatous polyposis (FAP), hereditary nonpolyposis colorectal cancer (HNPCC), and synchronous colorectal cancers with invasion beyond the submucosa, and patients who underwent a total colectomy were excluded. RESULTS: The mean age were 60 years (range, 27~83), and the male- to-female ratio was 2.6:1. The mean number of synchronous adenomos was 2.4 (1~22). The incidence of metachronous adenomas was 44.3% (163 patients), and that of metachronous malignant neoplasms was 5.2% (19 patients), consisting of 9 carcinomas and 10 malignant polyps (or adenomas with malignant change). In the multivariate analysis, the variables associated a metachronous adenoma were sex (male), location of the primary tumor, and multiple synchronous adenomas. The independent risk factors of metachronous malignant neoplasms were synchronous neoplastic adenomas (OR, 3.8; 95% CI, 1.24~11.83) and large adenomas (OR, 3.64; 95% CI, 1.17~11.27). The mean free-inverval of matachronous malignant neoplasms was 24 months (range, 12~52). CONCLUSIONS: Colorectal cancer patients with synchronous adenomas are prone to be at risk for recurrent adenomas and malignant tumors. High- risk patients for metachnonous malignant neoplasms should be considered for frequent colonoscopy follow-up.
Adenoma* ; Adenomatous Polyposis Coli ; Colectomy ; Colonoscopy ; Colorectal Neoplasms* ; Colorectal Neoplasms, Hereditary Nonpolyposis ; Follow-Up Studies ; Humans ; Incidence ; Multivariate Analysis ; Polyps ; Retrospective Studies ; Risk Factors*

PURPOSE: To evaluate the results of simple keratectomy for limbal dermoids. METHODS: We reviewed the ocular records of 29 consecutive patients with limbal dermoids who had undergone simple keratectomy in Seoul National University Children's hospital from 1989 to 2006. The preoperative and postoperative visual acuity and astigmatism levels as well as the cosmetic outcomes were measured. RESULTS: The mean age at surgery was 28 months (range, 6~70 months), and the mean follow-up period was 56 months (range, 18~168 months). The mean visual acuity at the last follow-up was 20/30. The mean preoperative and postoperative cylinder was -2.64D and -2.12D, respectively, in the affected eye (p=0.064); and -0.79D and -0.43D, respectively, in the fellow eye (p=0.149). There was a significant correlation between preoperative astigmatism and the final visual acuity in the involved eye. No opaque lesions were visible at a distance of 1 meter in 16 of the 29 eyes (55.2%), and there were no significant complications related to the surgery. CONCLUSIONS: Simple keratectomy of limbal dermoids can be a good surgical technique to get a cosmetically acceptable corneal clarity without complication.
Astigmatism ; Cosmetics ; Dermoid Cyst ; Eye ; Follow-Up Studies ; Humans ; Visual Acuity