1.Degenerative Cervical Myelopathy: Pathophysiology and Current Treatment Strategies
Sung Hoon CHOI ; Chang-Nam KANG
Asian Spine Journal 2020;14(5):710-720
Chronic compression or ischemia of the spinal cord in the cervical spine causes a clinical syndrome known as cervical myelopathy. Recently, a new term “degenerative cervical myelopathy (DCM)” was introduced. DCM encompasses spondylosis, intervertebral disk herniation, facet arthrosis, ligamentous hypertrophy, calcification, and ossification. The pathophysiology of DCM includes structural and functional abnormalities of the spinal cord caused by static and dynamic factors. In nonoperative patients, cervical myelopathy has a poor prognosis. Surgical treatments, such as anterior or posterior decompression accompanying arthrodesis, arthroplasty, or laminoplasty, should be considered for patients with chronic progressive cervical myelopathy. Surgical decompression can prevent the progression of myelopathy and improve the neurologic status, functional outcomes, and quality of life, irrespective of differences in medical systems and sociocultural determinants of health. The anterior surgical approach to the cervical spine has the advantage of removing or floating the intervertebral disk, osteophytes, and ossification of the posterior longitudinal ligament that compress the spinal cord directly. The posterior surgical approach to the cervical spine is mainly used for multisegment spinal cord compression in patients with cervical lordosis. In this review article, we addressed the pathophysiology, clinical manifestations, differential diagnosis, and treatment options for DCM.
2.Comparative study of survival rate of gastric cancer patients according to TNM classification.
Chang Hoon LEE ; Kyung Hoon CHOI ; Jae Kwan SEO
Journal of the Korean Cancer Association 1993;25(2):170-175
No abstract available.
Classification*
;
Humans
;
Stomach Neoplasms*
;
Survival Rate*
3.Effect of Extracorporeal Shock Wave Lithotripsy of Caliceal Stone according to the Location of the Stone .
Chang Hoon CHOI ; Ho Cheol SEO ; Jong Sung KIM
Korean Journal of Urology 1998;39(2):138-140
PURPOSE: Lower caliceal stones treated with ESWL do fail to pass more frequently than middle or upper caliceal stones. We analyzed the results of ESWL of renal caliceal stones according to the location of calix. MATERIALS AND METHODS: We reviewed the stone-free rate in 119 caliceal stone patients treated with 3rd generation lithotriptor, EDAP LT-02 according to the caliceal location of the stone. Location of the stones were upper calix in 30, middle calix in 30, and lower calix in 59 patients. RESULTS: Stone-free rate was 90.0%(27/30 patients) in middle caliceal stones, 74.6%(44/59 patients) in lower caliceal stones, and 66.7%(20/30 patients) in upper caliceal stones. CONCLUSIONS: Stone-free rate of lower caliceal stones is higher than upper caliceal stones.
Humans
;
Lithotripsy*
;
Shock*
4.Cutaneous Manifestations of Carbon Monoxide Poisoning.
Jung Bock LEE ; Kyung Hoon CHANG ; Il Saing CHOI
Korean Journal of Dermatology 1983;21(3):279-286
Carbon monoxide is colorless, oolorless, tasteless and non-irritating gas produced by the incomplete combustion of carbonaceous rnaterial. It combines with hemoglobin and displaces oxygen because the affinity of hemoglobin for carbon monoxide is two hundred times greater than oxygen. Symptoma and signs of carbon monoxide poisoning include headache, nausea, vomiting, dizziness, collapse, unconsciousness, blindness, convulsion, coma and skin lesions. Recently we have observed seven patients with carbon monoxide poisoning who expressed cutaneous syrnptoms. In this work we investigated the pathogenesis of cutaneous manifestations of carbon monoxide poisoning through clinical, histologic and electronmicroscopic study. The results are summarized as follows: 1. Mental states of the patients were comatose in two, Semicomatcse in two, stuporous in two, and drowsy in one patient. In routine laboratory tests, we observed elevated blood sugar in six, elevated sorum creatinine phosphokinase in four and abnormal findings in urinalysis in all patients. 2. Cutaneous lesions were vesicobullae, plaque or swelling, erythema, gangrene and 'ulceration in order of frequency and located in the dependent areas in six caies. 3. Histopathologically, the sites of the bullae were subepidermal in four cases and intraepidermal in. one case and there was one case with ulceration. 4. In electronmicroscopic findings, secretory and ductal cells showed degenerative
Blindness
;
Blood Glucose
;
Carbon Monoxide Poisoning*
;
Carbon Monoxide*
;
Carbon*
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Coma
;
Creatinine
;
Dizziness
;
Erythema
;
Gangrene
;
Headache
;
Humans
;
Nausea
;
Oxygen
;
Seizures
;
Skin
;
Stupor
;
Ulcer
;
Unconsciousness
;
Urinalysis
;
Vomiting
5.Serum and urine potassium changes during, and after extracorporeal circulation in open heart surgery.
Chang Hoon JO ; Sae Young CHOI ; Chang Kwon PARK ; Kwang Sook LEE ; Young Sun YOO
The Korean Journal of Thoracic and Cardiovascular Surgery 1992;25(1):17-22
No abstract available.
Extracorporeal Circulation*
;
Heart*
;
Potassium*
;
Thoracic Surgery*
6.Clinical experience of multiple valve replacement.
Chang Hoon CHO ; Sae Young CHOI ; Chang Kwon PARK ; Kwang Sook LEE ; Young Sun YOO
The Korean Journal of Thoracic and Cardiovascular Surgery 1992;25(11):1346-1353
No abstract available.
7.Coronary Intervention of Cardiogenic Shock in Acute Myocardial Infarction.
Jae Woong CHOI ; Chang Sup SONG ; Chin Woo IMM ; Tae Hoon AHN ; In Seog CHOI ; Ik Kyun SHIN ; Young Hoon PARK
Korean Circulation Journal 1996;26(2):449-454
BACKGROUND: Despite improvement of mortality in acute myocardial infarcrtion, high mortality rate associated with cardiogenic shock remains essentially unchanged. We have reviewed our result of coronary intervention in 15 patients and found relative survival advantage. METHODS: Between Sep. 1992 and Aug. 1995, 15 consecutive patients(M. 10, F. 5) with cardiogenic shock in acute myocardial infarction were treated with coronary intervention using ballon PTCA. IABP was inserted in all patients prior to PTCA. RESULTS: 1) Most commonly found infarct related artery was left anterior descending artery(11) followed by right coronary artery(3) and left main coronary artery(1). 2) Successful reperfusion rate was 86.7%(13/15), and in-hospital mortality rate was 26.7%(4/15). 3) In-hospital mortality was higher in elderly patients compared with less than 70yaer old patients(0%(0/11)vs. 75.0%(3/4)(P < 0.05). 4) Mortality rate was lower in single vessel disease than multivessel disease(11.1%(1/9) vs. 50%(3/6) p<0.05). CONCLUSION: Although this study is uncontrolled, the date suggest that urgent coronary intervention for improving coronary perfusion may reduce mortality of acute myocardial infarction complicated by cardiogenic shock, particularly with single vessel disease and young age group.
Aged
;
Arteries
;
Hospital Mortality
;
Humans
;
Mortality
;
Myocardial Infarction*
;
Perfusion
;
Reperfusion
;
Shock, Cardiogenic*
8.Tracheal homografts in the canine.
Hong Shik CHOI ; Eun Chang CHOI ; Kwang Moon KIM ; Nam Hoon CHO ; Kee Hyun PARK
Korean Journal of Otolaryngology - Head and Neck Surgery 1991;34(2):304-315
No abstract available.
Allografts*
9.Reference Values of Cadmium in Kidney and Liver in Korean.
Jung Duck PARK ; Byung Sun CHOI ; Il Hoon KWEON ; Yeon Pyo HONG ; Im Won CHANG
Korean Journal of Occupational and Environmental Medicine 2000;12(3):346-355
OBJECTIVES: Cadmium (Cd), a toxic and non-essential metal, is recognized as a human carcinogen, which has a tendency to accumulate in the human body. The levels of Cd in renal cortex and liver are good indicators as an index of Cd exposure in the general population. In this study, we present an estimation of reference Cd levels in tissue (renal cortex and liver) and total body burden in the general population of Korea. MEDTHODS: Cd and zinc (Zn) were analyzed in renal cortex and liver from 254 autopsies (male : 188 cases, female : 66 cases) aged 0 to 87 years. RESULTS: Geometric mean concentration of Cd was 27.4 and 3.1 ua/g wet weight in renal cortex and liver, respectively. The level of Zn in renal cortex and liver was 35.4 and 42. 6 v/g wet weight, respectively. The result suggests that kidney is the target organ for Cd accumulation. The accumulation of Cd in renal cortex was age-dependent with a biphasic pattern. The level of Cd in renal cortex increased with age up to the fifties, and then leveled off thereafter. Based on the data, the regression model for Cd accumulation in renal cortex by age is predicted by : Log KCd = 0. 2325 + 0. 0553 Age 0. 0005 Age. The highest Cd accumulation in renal cortex of Koreans was estimated at 43. 3 ua/g wet weight at 50. 8 years old. In addition, the total Cd body burden by age was estimated by the following equation: Total Cd Body Burden = -4. 5948 + l. 2278 Age - 0. 0121 Age. The highest body burden of Cd was estimated at 26. 5 mg at age 50. 7 years in the Korean general population. The positive correlation between Zn and Cd was observed in renal cortex and liver. CONCLUSIONS: The level of Cd exposure in Korean was found to be lower than in Japanese, but same as or higher than in American and Europeans.
Asian Continental Ancestry Group
;
Autopsy
;
Body Burden
;
Cadmium*
;
Child
;
Female
;
Human Body
;
Humans
;
Kidney Cortex
;
Kidney*
;
Korea
;
Liver*
;
Reference Values*
;
Zinc
10.Detection of human CTLA-4 by using anti-peptide antibody.
Yong Hoon CHUNG ; Yang Ja CHO ; Seog Won LEEM ; Chang Hwan PARK ; Yong CHOI ; Dupont BO
Journal of the Korean Society for Microbiology 1993;28(3):229-237
No abstract available.
Humans*