Light therapy (also called light treatment or phototherapy) involves scheduled exposure to bright artificial light. Evidence-based treatments for sleep disorders especially for circadian rhythm sleep disorders include light therapy and pharmacotherapy. In clinical practice, many of patients with sleep problems tend to impair circadian rhythmicity. Considering that light is the most potent entraining agent of circadian rhythm, careful use of light therapy can be recommended for patients with several kinds of sleep disorders. I briefly review the possible therapeutic mechanisms and clinical applications of light therapy, focusing on circadian sleep disorders.
Circadian Rhythm ; Humans ; Light ; Phototherapy ; Sleep Wake Disorders ; Sleep Wake Disorders, Circadian Rhythm

The authors studied the lung injury induced by endotoxemia and the effects of proteolytic agent on the lung changed by endotoxemia. Sprague-Dawley rats were intraperitoneally administrated with a single dose of endotoxin (4 mg/kg, E. coli 025 : B6 lipopolysaccharide) or with endotoxin and gabexate mesilate (200 mg/kg), a proteolytic agent, concomitantly. Rats of each group were scarificed at 9, 18, and 27 hours after injection. Light and electron microscopic examination were done. The results obtained were summarized as follows: Light microscopic exmination revealed congested capillaries and neutrophilic infiltration in both groups. Electron microscopic findings were interstitial and alveolar neutrophilic infiltration, endothelial swelling with increased pinocytotic vesicles and cytoplasmic process formation, and interstitial edema. Decrease of osmiophilic bodies in the type II pneumocytes had appeared at 9 hours after endotoxin injection. These changes were increased in severity at 18 hours and 27 hours after endotoxin injection. In the group of concomitant treatment of gabexate mesilated and endotoxin, there was no edema at 9 hours after injection. After 18 hours welling of endothelial cell and interstitial edema had appeared. However, the severity of the edema was markedly decreased. Type II pneumocytes showed well preserved osmiophilic bodies. According to these results, it is considered that administration of gabexate mesilate can significantly redeced the lung injury induced by endotoxemia.
Rats ; Animals

No abstract available.
Humans ; Infant, Newborn* ; Leukocytes*

No abstract available.

No abstract available.
Child* ; Humans

No abstract available.
Humans

The search for tumor-avid agents for use in nuclear medicine imaging is an ongoing field of importance. The purpose of this study was to determine the affinity for radiolabeled vitamin B12 by a wide histologic variety of tumor types in mice. Seventeen different types of tumor were grown subcutaneously in female Balb/C or Balb nu/nu(nude) mice. When the tumors reached about 1 cm in diameter, mice were injected intraperitoneally with 57Co-vitamin B12. Twenty-foul hours later, the mice were sacrificed. Organs and tissues were removed, weighed, and activity per mg determined by gamma counter. Values represented cpm/mg tissue that was normalized to 20 grams body weight for each mouse. A wide variety of tumor types showed significant uptake and concentration of 57Co-vitamin B12, as evidenced by tumor:tissue activity ratios. For many tissues of great importance in terms of background(bone, muscle, blood), the tumor:tissue activity ratios of uptake were high. These data strongly suggest that further efforts to evaluate the utility of radiolabeled adducts of vitamin B12 for clinical use in oncologic imaging are warranted.
Animals ; Body Weight ; Female ; Humans ; Mice* ; Nuclear Medicine ; Vitamin B 12

No abstract available.
Anti-Bacterial Agents* ; Dysentery, Bacillary*

No abstract available.
Ileus* ; Lymph Nodes*

Dysfunction of autonomic nervous system had been reported in a number of neurologic and medical diseases, but acquired primary dysautonomia is uncommon and usually tends to show a chronic progressive pattern. Acute panautonomic neuropathy characterized by selective involvement of sympathetic and parasympathetic nerves with complete or relative sparing of somatic motor and sensory functions was first described by Young et. Al, in 1969 and since then, about 26 additional cases had been reported in the literatures, but there have been no such reports in Korea. The present report describes a 22 year-old female patient who had been admitted to Severance hospital because of abruptly developed fever, generalized myalgia, hyperesthesia and difficulties in swallowing and voiding. On admission, physical and neurological examinations revealed orthostatic hypotension, unreactive pupils to light and accomodation, dereased gag reflex, and decreased sensation of pain and temperature on the face and neck. A few days following admission, progressive loss of deep tendon reflew was noticed, followed by distal muscle weakness and atrophy. The serial electrophysiologic studies revealed progressive peripheral axonal polyneuropathy. Autonomic function tests suggested pandysautonomia of postganglionic lesion. Spinal fluid protein was 16mg/dl on admission, but was increased up to 80mg/dl without pleocytosis on the twenty first hospital day. Recovery was poor over a four -month period and she died of disseminated pneumonia.
Atrophy ; Autonomic Nervous System ; Axons ; Deglutition ; Female ; Fever ; Humans ; Hyperesthesia ; Hypotension, Orthostatic ; Korea ; Leukocytosis ; Muscle Weakness ; Myalgia ; Neck ; Neurologic Examination ; Pneumonia ; Polyneuropathies ; Primary Dysautonomias ; Pupil ; Reflex ; Sensation ; Tendons ; Young Adult