1.The Effect of Photodynamic Therapy in BALB/-c Mice Adenocarcinoma in Homograft Model.
Korean Journal of Pathology 2000;34(7):481-487
Among the efficient cancer treatments, photodynamic therapy (PDT) is one of the therapies inducing rapid apoptosis of cancer cells while causing minimal damage to surrounding normal tissue. We studied the effect of PDT on the adenocarcinoma in BALB/-c mice of homograft model, and the following results were obtained. Apoptosis occurred up to 3 mm in depth from the surface in the first 1 hour after PDT applied, and subsequently the counts were increased in the deeper portion. A remarkable apoptosis observed up to 6 mm in depth shows that the light in use could not penetrate more than 6 mm of tissue. Tissue necrosis was identified in the deeper area of the tumor 6 hours later or thereafter. This necrosis seemed to occur as an indirect effect of vascular obstruction resulting from the damage of endothelial cells which was induced by selective collection of photosensitizer in the endothelial cells of newly forming vessels as well as in the cancer cells. These results indicate that the effective depth of PDT is greater than the depth of light penetration.
Adenocarcinoma*
;
Allografts*
;
Animals
;
Apoptosis
;
Endothelial Cells
;
Mice*
;
Necrosis
;
Photochemotherapy*
2.A Clinical Study of Fractures and Dislocations of the Carpus
Jun Dong CHANG ; Sung Il SHIN ; Kyun Ho CHANG
The Journal of the Korean Orthopaedic Association 1989;24(5):1406-1418
In the fractures and dislocations of the carpus, prompt and accurate diagnosis is the prime prerequisite for restoring function to this most complicated joint in the body. And then, early precise reduction and continuous maintenance of the reduced position until ligamentous and bone healing is complete provide the best chance of achieving a satisfactory restoration of function. We analysed forty five cases of fractures and dislocations of the carpus which were treated for 5 years from Jan. 1984 to Dec. 1988 at the Department of Orthopedic Surgery, College of Medicine, Hallym University. The following results were obtained; l. Of the total 45 injuries, scaphoid fractures were seen in 32(71.1%), other carpal bone fractures except scaphoid in 13 patients(28.9%), and carpal bone dislocation and fracture- dislocations in 11 patients(24.4%). 2. Carpal scaphoid fracture 1) 19 of the 32 patients(59.4%) had an associated ipsilateral upper extremity injury. 2) This fracture was common in the young male. 3) A union rate(95.6%) was achieved using a usual conservative treatment for undisplaced racture(14), operative treatment for displaced(18). 4) The mean time to radiological union for all fractures was 11.1 weeks. Old fracture by SotoHall classification took the longest time to union(18.2 weeks), subacute fracture 13 weeks, and acute fracture 9 weeks. 5) 10 cases were treated for nonunion, 5 of 10 nonunions were classified as type (50%). 2 cases showed ultimately nonunion in spite of various sorts of treatment, which belonged to waist fracture. 3. Other carpal bone fractures except scaphoid were seen in 13(15 bones) of 45 injuries, and pisiform(4) and triquetrum(4) fractures were common. 4. Carpal dislocation and fracture-dislocations were seen in 11 of the 45 injuries and dorsal transscaphoid perilunate dislocations(4) were common. These were treated by C.R. and cast immobilization or O.R. and K-wire fixation relatively good results were obtained.
Carpal Bones
;
Classification
;
Clinical Study
;
Diagnosis
;
Dislocations
;
Humans
;
Immobilization
;
Joints
;
Ligaments
;
Male
;
Orthopedics
;
Upper Extremity
3.A clinical investigation of tuberous sclerosis in children.
Byoung Ho CHA ; Jun Soo LEE ; Chang Jun COE
Journal of the Korean Child Neurology Society 1993;1(2):33-39
No abstract available.
Child*
;
Humans
;
Tuberous Sclerosis*
4.Very Long Island Pedicled Sole - fillet Flap for Below - Knee Amputation Stump Reconstruction: 2 Cases Report.
Guen Chang HO ; Dong Chang JUN ; Chang Ju LEE ; Soo Jung CHOI ; Chang Kyun LIM
The Journal of the Korean Orthopaedic Association 1997;32(7):1675-1680
The pedicled fillet flap concept has been successfully applied in both the upper and lower extremities for the treatment of difficult wound. In cases of inevitable extremity amputation, the transfer of pedicled flap from the amputed part is possible. In such substance, it is possible to obtain the pedicled fillet flap from the amputed limb to provide stump coverage. We experienced two cases of below-knee amputation due to severe flame burn which the stump was covered with island pedicled sole-fillet flap.
Amputation Stumps*
;
Amputation*
;
Burns
;
Extremities
;
Knee*
;
Lower Extremity
;
Surgical Flaps
;
Wounds and Injuries
5.Reconstruction of ankle using free vascularized flap from amputated hand: A case report.
Soo Joong CHOI ; Chang Kyun LIM ; Ho Guen CHANG ; Jun Dong CHANG ; Chang Ju LEE
The Journal of the Korean Orthopaedic Association 1998;33(2):484-489
It is indispensable to cover the skin defect when bone or tendon is exposed. In case of inevitable amputation of an extremity, it is possible to harvest a free flap from the amputed limb for providing coverage of the other wound. This technique allows immediate wound coverage without the morbidity of an additional donor site. We experienced an electrical burn case with inevitahle wrist disarticulation and successfully treated soft tissue defect of ankle using free vascularized flap.
Amputation
;
Ankle*
;
Burns
;
Disarticulation
;
Extremities
;
Free Tissue Flaps
;
Hand*
;
Humans
;
Skin
;
Tendons
;
Tissue Donors
;
Wounds and Injuries
;
Wrist
6.Cementless Total Hip Arthroplasty for Avascular Necrosis of the Femoral Head: The influence of the extent of involvement in outcome.
Jun Dong CHANG ; Young Ho LEE ; Soo Jung CHOI ; Ho Guen CHANG ; Won Ho CHO ; Chang Ju LEE
The Journal of the Korean Orthopaedic Association 1997;32(2):243-254
The purpose of this study is to evaluate the influence of the extent of involvement in the results of cementless THA in patients with idiopathic AVN of the femoral head. We reviewed 70 hips (52 patients) who had undergone cementless THA for idiopathic AVN of the femoral head. Anatomic femoral components were used in 43 hips and Harris Galante porous prosthesis were employed in 27 cases. The hips were classified according to International Classification (Association Research Circulation Osseous). The length of the follow-up period ranged from 3 to 5 years (average 53.5 months). Preoperative and postoperative clinical documentation and radiographs were evaluated. Statistical analysis was performed on the results of three analysis groups (Group A, comparison of results among Stage IIIA, IIIB, IIIC, and IV; Group B, between stage III and IV; Group C, between IIIA+IIIB and IIIC + IV). Of the 70 hips in the present study, there were 47 hips in stage III (IIIA, 15; IIIB, 19; IIIC, 13) and 23 hips in stage IV. The average postoperative Harris hip score at the time of study was 91.5 (Analysis Group C, p=.009). Femoral subsidence of more than 5 mm occurred in 5 hips (7.1%). Two hips were in Stage IIIC and three hips were in Stage IV (Group C, p=.024). The hips lower than -10 on Engh's index were present in one hip in Stage IIIC and three hips in Stage IV (Group C, p=.011). This study demonstrated that the clinical and radiological results of cementless THA were poor when the extent of involvement was greater or in the case of late stage subjects, particularly those above IIIC (p<05), with avascular necrosis of the femoral head.
Arthroplasty, Replacement, Hip*
;
Classification
;
Follow-Up Studies
;
Head*
;
Hip
;
Humans
;
Necrosis*
;
Prostheses and Implants
7.Visual Motor Integration Abilities of Children with Learning Disorders.
Chang Jun COE ; Young Hyuk LEE ; Jung Keun KIM ; Ho Taek KIM ; Chang Ho HONG
Journal of the Korean Pediatric Society 1988;31(3):339-347
No abstract available.
Child*
;
Humans
;
Learning Disorders*
;
Learning*
8.Lateral Supramalleolar Free Flap.
Soo Jong CHOI ; Young Ho LEE ; Eung Joo LEE ; Ho Guen CHANG ; Jun Dung CHANG
The Journal of the Korean Orthopaedic Association 1999;34(1):237-245
To cover soft tissue defect, various types of flaps have been used. Although lateral supramalleolar flap has been used as rotation flaps or reversed island flaps to cover defects around the foot and ankle, there has been no report about its application as a free flap. The lateral supramalleolar island flap has proves to be supplied constantly by the terminal branch of the peroneal arterys perforating branch. The free lateral supramalleolar flap has the same skin territory. Its vascular pedicle can be extended to the main peroneal artery and vena comitans, which can be obtained by dissecting the peroneal vessels between the distal tibia and fibula through the interosseous membrane. We have successfully transferred this free flap in eight patients from April 1994 to February 1995. All of the patients had full thickness skin defects which were caused by contact thermal burn, electrical burn, flame burn or traffic accident. There were no complications. From our experience, we feel that this new free flap have some advantages, induding vascular anatomy and long pedicle with large diameter and a relatively thin flap with minimal morbidity of donor site.
Accidents, Traffic
;
Ankle
;
Arteries
;
Burns
;
Fibula
;
Foot
;
Free Tissue Flaps*
;
Humans
;
Membranes
;
Skin
;
Surgical Flaps
;
Tibia
;
Tissue Donors
9.Immunohistochemical studies on neuroendocrine cell changes in disease of uterine cervix.
Sei Jun HAN ; Kyung Sig CHANG ; Ho Jong JEON
Korean Journal of Obstetrics and Gynecology 1992;35(8):1144-1153
No abstract available.
Cervix Uteri*
;
Female
;
Neuroendocrine Cells*
10.The Cytologic Features of Desmoplastic Small Round Cell Tumor with Intranuclear Inclusions : A Case Report .
Ho Chang LEE ; Hye Suk HAN ; Ok Jun LEE
Korean Journal of Pathology 2009;43(3):279-284
Desmoplastic small round cell tumor (DSRCT) is a rare neoplasm of young adults and it is characterized by polyphenotypic differentiation. We experienced a case of abdominal DSRCT that occurred in a 19-year-old female who presented with painful swelling of her right forearm. The tumor was cytokeratin-negative and it exhibited some tumor cells with intranuclear inclusions. Molecular demonstration of EWS-WT1 fusion transcripts is particularly useful to confirm the diagnosis of DSRCT without epithelial differentiation. We report here on a case of cytokeratin-negative DSRCT that showed an unusual feature of intranuclear inclusions.
Desmoplastic Small Round Cell Tumor
;
Female
;
Forearm
;
Humans
;
Intranuclear Inclusion Bodies
;
Keratins
;
Young Adult