1.Effects of long-term anticonvulsant therapy of thyroid function.
Sei Joong KO ; Duk Hi KIM ; Chang Jun COE
Journal of the Korean Pediatric Society 1989;32(11):1533-1539
No abstract available.
Thyroid Gland*
2.Physical Gowth According to Sexual Maturation of Korean Adolescents.
Hwan Gyu PARK ; Chang Ho HONG ; Duk Hi KIM
Journal of the Korean Pediatric Society 1994;37(9):1187-1195
Adolescence is the period in which physical, mental and social maturation occurs and it is an important transit stage, changing from childhood to adulthood. This is a period in which important changes occur physically such as rapid growth in height and weight gain but significant differences in growth may occur for the same age. Therfore, the degree of sexual maturation may be an important indicator in evaluating growth in adolescence. Six thousand five hundred and eighty six male and female students from grade 4 to senior high from Seoul, district town and countryside were evaluated for sexual maturity using Tanner staging, weight, height and body mass index and compared for growth. There was a rapid growth in height of 6.7cm in boys between the ages of 11 and 14 years and 6.3 cm in height for girls between the ages of 10 and 12 years, showing earlier growth in height for girls. Growth in height according to sexual maturation showed the greatest growth during stages 2~3 for boys and girls. Boys grew an average of 18.94 cm and girls an average of 18.03 cm in height during the whole sexual maturation period. There was an increase of 5.5 kg in weight for boys during the same age as for growth in height, that is between 11 and 14 years of age. In girls, an average weight gain of 5.1 kg occurred between 11 and 13 years of age, slightly later than that of growth in height. Rapid gain in weight occurred during Tanner stages 2~3 for girls. Total gain of 20.70 kg for boys occurred during the whole sexual maturation period while girls gained total 19.73 kg. Body mass index increased gradually during the whole adolescent period. It was greater in boys during the ages of 9 and 12 years and greater in girls the age of 13 years and again in boys after 17 years of age. During the whole maturation period, boys gained 3.24 and girls, 4.05 of body mass index showing more gain in girls. Height, weight and body mass index showed normal variations during the sexual maturation index showed normal variations during the sexual maturation period and the results may bring an increased understanding that adolescent physical growth was closely related to sexual maturation.
Adolescent*
;
Body Mass Index
;
Female
;
Humans
;
Male
;
Seoul
;
Sexual Maturation*
;
Weight Gain
3.The serum levels of estradiol, progesterone, and ?hCG in ectopic pregnancy.
Hi Young CHANG ; Young Soo KANG ; Young Ju KIM ; Eun Hee YOO ; Cheong Il KIM ; Bock Hi WOO
Korean Journal of Obstetrics and Gynecology 1993;36(7):1444-1451
No abstract available.
Estradiol*
;
Female
;
Pregnancy
;
Pregnancy, Ectopic*
;
Progesterone*
4.Quantification of human urinary growth hormone and its clinical significance in the diagnosis of growth hormone deficiency.
Seung Ryul LEE ; Ho Seong KIM ; Duk Hi KIM ; Chang Mi KIM
Journal of the Korean Pediatric Society 1992;35(5):595-601
No abstract available.
Diagnosis*
;
Growth Hormone*
;
Humans*
5.The effects of testosterone on the pituitary growth hormone secretion.
Ho Seong KIM ; Duk Hi KIM ; Kyung Za RYU ; Chang Mee KIM ; Deok Bae PARK
Journal of the Korean Pediatric Society 1992;35(2):174-181
No abstract available.
Growth Hormone*
;
Testosterone*
6.Characteristics of Childhood Diabetes.
Mi Jung PARK ; Wook CHANG ; Hyun Chul LEE ; Duk Hi KIM ; Ho Seoung KIM
Journal of the Korean Pediatric Society 1995;38(8):1116-1123
No abstract available.
7.A Clinical Studies in Patients with Turner's Syndrome.
Chang Hyun YANG ; Duk Hi KIM ; Kir Young KIM ; Young Ho YANG
Journal of the Korean Pediatric Society 1987;30(10):1143-1151
No abstract available.
Humans
;
Turner Syndrome*
8.Argyrophilic Nucleolar Organizer Region and Expression of Ki-67 in Malignant Lymphoma.
Hee Jung LEE ; An Hi LEE ; Kyo Young LEE ; Chang Suk KANG ; Sang In SHIM ; Byung Kee KIM
Korean Journal of Pathology 2000;34(4):257-263
Nucleolar organizer regions (NORs) are loops of DNA which occur in the nucleoli of cells which possess ribosomal RNA genes. The numbers and areas of NORs have been thought to be related to cellular activities. We aimed to investigate the direct relationship between the parameters of AgNORs and cellular proliferative activity using immunohistochemical method with the monoclonal antibody Ki-67, which demonstrates proliferating nuclei. The sequential technique for the simultaneous Ki-67 immunostaining and NOR staining was applied to the same slides of a series of non-Hodgkin's lymphomas (NHL) of the low, intermediate, and high grade type. The number of AgNOR per cell was counted and mean NOR percentage nuclear area (NPNA) was measured by morphometry in both the Ki-67 positive and Ki-67 negative nuclei. The increased immunoreactivity for Ki-67 was found in the high grade than in the low grade non-Hodgkin's lymphoma. This was reflected in the two areas of the palatine tonsils and lymph nodes, the positive cell counts being higher in the follicle center nuclei than in those in the interfollicular compartment. In general the numbers and NPNA of AgNORs were higher in the Ki-67 positive nuclei than in those lacking the antigen in malignant lymphomas as well as in control. The AgNORs numbers and NPNA in controls were the highest in the Ki-67 positive cells in the follicular area and the lowest in the Ki-67 negative cells in the perifollicular area. In malignant lymphomas the numbers and NPNA of AgNORs tended to increase in proportion to their grade in both the Ki-67 positive and negative cells. The numbers of AgNORs of the high grade and the NPNA of the intermediate and the high grade were significantly higher in Ki-67 positive cells than in Ki-67 negative ones. With this double staining method it was now possible to confirm that numbers and NPNA of AgNORs were directly related to the cellular proliferative activity. In maligant lymphoma, among the several parameters of the AgNORs, NPNA in Ki-67 positive cells is proposed to be the most useful marker in determining the prognosis of the patient.
Cell Count
;
DNA
;
Genes, rRNA
;
Humans
;
Lymph Nodes
;
Lymphoma*
;
Lymphoma, Non-Hodgkin
;
Nucleolus Organizer Region*
;
Palatine Tonsil
;
Prognosis
9.Expression of Matrix Metalloproteinase and Tissue Inhibitors of Matrix Metalloproteinase in Malignant Lymphoma.
Ah Won LEE ; An Hi LEE ; Chang Suk KANG ; Byung Kee KIM
Korean Journal of Pathology 2000;34(4):249-256
Matrix metalloproteinases (MMPs) and their inhibitors (tissue inhibitors of matrix metalloproteinases, TIMPs) play essential roles in the remodelling of the extracellular matrix. The balance between MMPs and TIMPs is altered in neoplasia, contributing to the invasive and metastatic properties of malignant tumors. Although MMP and TIMP are believed to play an important role in invasion and metastasis in malignant solid tumors, little is known about their involvement in malignant lymphoma. Immunohistochemical stains for MMP-1, MMP-2, MMP-9, TIMP-1 and TIMP-2 were performed using 56 paraffin blocks of the malignant lymphoma and the results were analyzed by using the tumor grade by Working Formulation. The expression of MMP-9 was noted in 45.5% of low grade, 86.1% of intermediate grade, and 100% of high grade malignant lymphoma. The incidence of MMP-9 expression in tumor cells was positively correlated with the grade of the malignant lymphoma (P<0.025). In nodal lymphomas, the incidence of the MMP-9 expression of the tumor cells was higher in malignant lymphoma with extracapsular invasion than those without extracapsular invasion (P=0.008). The incidence of TIMP-1 expression in the tumor cells and fibroblasts was positively correlated with the grade of the malignant lymphoma (P<0.025). In nodal lymphoma, the incidence of the TIMP-1 expression of the tumor cells was higher in malignant lymphoma with extracapsular invasion than those without extracapsular invasion (P=0.009). The incidences of the MMP-1, MMP-2, and TIMP-2 expression in malignant lymphoma were neither increased in the malignant lymphoma with extracapsular tumor invasion nor correlated with the grade by working formulation. There was no significant difference in the expression rate of MMP-1, MMP-2, MMP-9, TIMP-1, and TIMP-2 in nodal- and extra-nodal malignant lymphoma. The above results suggest that the expressions of MMP-9 and TIMP-1 are positively correlated with the grade and the presence of extranodal tumor invasion in malignant lymphomas.
Coloring Agents
;
Extracellular Matrix
;
Fibroblasts
;
Incidence
;
Lymphoma*
;
Matrix Metalloproteinases
;
Neoplasm Metastasis
;
Paraffin
;
Tissue Inhibitor of Metalloproteinase-1
;
Tissue Inhibitor of Metalloproteinase-2
10.Effects of Dimethylpiperazinium on the Renal Function of Rabbits.
Korean Journal of Urology 1982;23(1):1-5
In this study, effects of the intraventricular and intravenous dimethylphenylpiperazinium (DMPP) on the renal function of rabbits were investigated. Intraventricular DMPP (100 microgram) elicited diuresis following antidiuresis concomitant with the changes in renal blood flow, glomerular filtration rate and urinary excretory amount of electrolytes (Na and K). The changes in urine flow correlated with the changes in renal blood flow, glomerular filtration rate and excretory rates of electrolytes in urine. Intravenous DMPP (50 microgram/kg) did not affect the renal function.
Dimethylphenylpiperazinium Iodide
;
Diuresis
;
Electrolytes
;
Glomerular Filtration Rate
;
Rabbits*
;
Renal Circulation