The area overlying the ischium is the most frequent site for the development and recurrence of pressure sores in the paraplegic patient. This report describes a newly-designed inferior gluteus maximus myocutaneous island flap that is useful for the repair of ischial pressure sores in paraplegic patients. Sacral sore develops a wide and flat ulcer crater. However, ischial sore seems to develop large and deep bursa with relatively small openings. We have used a newly-designed gluteus maximus myocutaneous island flap according to the specific characteristics of ischial sore. The flap is designed in the fashion of a small skin island with a large muscle flap. This flap with its abundant and constant blood supply had proved very reliable in the surgical management of ischial pressure sore. There is also the possible advantage of cushioning with the bulk of muscle for greater long-term durability. Incision could be extended for a complete bursetomy and partial ischiectomy. The reliability, versatility and low morbidity of the inferior gluteus maximus island flap has been demonstrated by its use in our consecutive series of 7 patients with 8 ischial pressure sores. We conclude that this newly-designed inferior gluteus maximus myocutaneous island flap can be applied in deep, infected ischial sore according to the specific characteristics of ischial sore, and it is a very useful method in comparison to other flaps.
Humans ; Ischium ; Pressure Ulcer ; Recurrence ; Skin ; Ulcer

Breast cancer is the second leading cause of cancer death in women. Unfortunately, the frequency of breast cancer and mastectomy are increasing in Korea. The purpose of the study is to analyze the results of breast reconstruction using free transverse rectus abdominis myocutaneous(TRAM) flap and to suggest the operative technique for more satisfactory results. 19 patients underwent immediate breast reconstruction from 1990 to 1998, and we experienced 2 cases of bilateral immediate reconstruction of breasts following mastectomy. We have performed the free TRAM flaps based on the deep inferior epigastric vessels using microvascular technique. TRAM flap included very small portion of rectus sheath and muscle-so called muscle sparing technique. So it reduced markedly donor site morbidity. The postoperative course of these cases was uneventful with minor complication. The free TRAM flap was an excellent method of immediate breast reconstruction using autogenous tissue and provided satisfactory outcome. The goals of the immediate breast reconstruction after mastectomy are to restore body image, to achieve near normal shape of breast, and to reduce the complications. This paper represents our experience of immediate breast reconstruction using free TRAM flap, and technical options to get more satisfactory result and reduce the complications. We think this method could be regarded as the first choice for immediate breast reconstruction.
Body Image ; Breast Neoplasms ; Breast* ; Female ; Humans ; Korea ; Mammaplasty* ; Mastectomy ; Rectus Abdominis* ; Tissue Donors

No abstract available.
Clone Cells* ; Cloning, Organism* ; Thymidine*

Akabane, Aino and Chuzan virus are arthropod-borne (arbo)viruses mainly associated with reproductive failures in cattle. We investigated apoptosis in Vero cells (C-1586) infected with Akabane, Aino and Chuzan virus. The fragmentation of chromosomal DNA was simultaneously detected with the progress of cytopathic effect from 48 hr to 72 hr post infection, depending on viruses. Although the treatment of cycloheximide blocked apoptosis in Vero cells infected with three viruses, actinomycin D did not prevent DNA oligomerization, thus indicating that de novo viral protein synthesis is critical for viral apoptosis. In addition, the activation of caspase-3 was also detected in Vero cells by indirect fluorescent assay. From the present results, it is of future interest whether apoptotic characteristics of these viruses are related to pathogenecity in vivo.
Animals ; Apoptosis/*physiology ; Bunyaviridae/*physiology ; Caspase 3 ; Caspases/metabolism ; Cercopithecus aethiops ; Cytopathogenic Effect, Viral/*physiology ; DNA Fragmentation/physiology ; Dactinomycin ; Enzyme Activation ; Orbivirus/*physiology ; Vero Cells

Hemifacial microsomia is a common congenital craniofacial deformity involving bone and soft-tissue. Mandibular hypoplasia is the most obvious skeletal manifestation of hemifacial microsomia. In the past, complete realignment of the skeleton was preferred to soft-tissue correction, which was clearly second choice. However, in this study, simultaneous correction of bone and soft tissue deformities were equally important in treatment of hemifacial microsomia. One-stage and simultaneous bone and soft tissue reconstruction is possible and staged operations of the skeleton and soft tissue are no longer necessary, except in special cases. Even in children and adolescents, good results and normal growth potential can be achieved with simultaneous correction of bone and soft tissue.
Adolescent ; Child ; Congenital Abnormalities* ; Goldenhar Syndrome ; Humans ; Skeleton

Diabetic foot is one of the most frequent complications with diabetic nephropathy and diabetic retinopathy in diabetic patient. Ischemia and peripheral neuropathy are the primary pathologic mechanism leading to diabetic foot. Approximately 20% of all diabetic patients admitted for foot problems, and about 80% of these patients need leg amputations. The objective of this article is to analyze the result of strategic treatment for limb salvage and to suggest appropriate surgical management in patients with diabetic foot. This study included 97 cases of treatment of diabetic foot for 6 years since August, 1995. The patients' age ranged from 34 to 83 years. There were 59 males and 38 females. According to the wound grade, extent, and involved site, we classified into 4 groups of diabetic foot. Conservative treatment was accomplished in 53 cases, local flap and/or skin graft in 13 cases, free flaps were in 12 cases, and amputations in 19 cases. The relatively superficial defects were treated with reversed adipofascial flap and split thickness skin graft. The used free flaps were 10 radial forearm free flap, 1 radial forearm osteocutaneous free flap, 1 latissimus dorsi muscle free flap. One flap loss occurred in latissimus dorsi free flap and the patient was treated with below knee amputation. The amputations included 9 toe amputations, 3 Syme amputations, 5 below knee amputations, and 2 above knee amputations. Except one patient, all patients had primary wound healing in operated site without specific complications. We conclude that selection of treatment method is very important for diabetic foot patient. Appropriate surgical treatment for limb salvage consists of infection control, coverage of exposed tendon, joint, and bone, and prevention of recurrence. In case of rapid progression of necrosis, amputations can be considered in order to prevent sepsis and provide early rehabilitation with prosthesis.
Amputation ; Diabetic Foot* ; Diabetic Nephropathies ; Diabetic Retinopathy ; Female ; Foot ; Forearm ; Free Tissue Flaps ; Humans ; Infection Control ; Ischemia ; Joints ; Knee ; Leg ; Limb Salvage ; Lower Extremity* ; Male ; Necrosis ; Peripheral Nervous System Diseases ; Prostheses and Implants ; Recurrence ; Rehabilitation ; Sepsis ; Skin ; Superficial Back Muscles ; Tendons ; Toes ; Transplants ; Wound Healing ; Wounds and Injuries

The free TRAM flap has been accepted as an excellent method of autogenous tissue breast reconstruction. In addition, oncologic surgeons and plastic surgeons are trying to perform skin preserved mastectomy to get more esthetically better result in breast reconstruction. Breast tissue and mass would be removed through circumareolar incision, and axillary lymph node dissection could be carried through separate incision on axilla. This paper represents our experiences and results of immediate breast reconstruction with transverse rectus abdominis myocutaneous free flap after skin-sparing mastectomy. From 1999 to 2001, the flaps were utilized in 15 patients to reconstruct the new breast by free TRAM flap after skin sparing mastectomy. The mean age of the patients were a 42-years-old. Location of cancer was on the right breast in 12 cases, left breast in 2 cases and bilateral breasts in 1 case. We chose the thoracodorsal artery and its venae commitantes as recipient vessels, and deep inferior epigastric vessels as donor vessels.All flaps survived completely. There has been no flap necrosis, hematoma, and seroma. The results have been functionally and esthetically satisfactory. There are several advantages in this technique comparing with similar breast reconstruction of routine modified radical mastectomy. This technique leaves less scar and allows better preservation of sensation, aesthetically more natural shape, and better symmetry in reconstructed breast with free TRAM flap afterskin sparing-mastectomy.
Arteries ; Axilla ; Breast* ; Cicatrix ; Female ; Free Tissue Flaps* ; Hematoma ; Humans ; Lymph Node Excision ; Mammaplasty* ; Mastectomy* ; Mastectomy, Modified Radical ; Necrosis ; Rectus Abdominis* ; Sensation ; Seroma ; Skin* ; Tissue Donors

The free TRAM flap has been accepted as an excellent method of autogenous tissue breast reconstruction. In addition, oncologic surgeons and plastic surgeons are trying to perform skin preserved mastectomy to get more esthetically better result in breast reconstruction. Breast tissue and mass would be removed through circumareolar incision, and axillary lymph node dissection could be carried through separate incision on axilla. This paper represents our experiences and results of immediate breast reconstruction with transverse rectus abdominis myocutaneous free flap after skin-sparing mastectomy. From 1999 to 2001, the flaps were utilized in 15 patients to reconstruct the new breast by free TRAM flap after skin sparing mastectomy. The mean age of the patients were a 42-years-old. Location of cancer was on the right breast in 12 cases, left breast in 2 cases and bilateral breasts in 1 case. We chose the thoracodorsal artery and its venae commitantes as recipient vessels, and deep inferior epigastric vessels as donor vessels.All flaps survived completely. There has been no flap necrosis, hematoma, and seroma. The results have been functionally and esthetically satisfactory. There are several advantages in this technique comparing with similar breast reconstruction of routine modified radical mastectomy. This technique leaves less scar and allows better preservation of sensation, aesthetically more natural shape, and better symmetry in reconstructed breast with free TRAM flap afterskin sparing-mastectomy.
Arteries ; Axilla ; Breast* ; Cicatrix ; Female ; Free Tissue Flaps* ; Hematoma ; Humans ; Lymph Node Excision ; Mammaplasty* ; Mastectomy* ; Mastectomy, Modified Radical ; Necrosis ; Rectus Abdominis* ; Sensation ; Seroma ; Skin* ; Tissue Donors

This paper represents the versatility of buccinator myomucosal flap for intraoral and orbital reconstruction of mild to moderate defect and we introduce recontructive methods are introduced along with our clinical experience. Buccal artery from internal maxillary artery is the main arterial pedicle, and buccal branch from facial artery also can supply blood for the buccinator muscle. The abundant blood flow from interconnected pedicles supports the reliable circulation of the buccal mucosa. So we could reconstruct the eye socket using reversed island buccinator myomucosal flap based on the angular vessel. The motor innervation of the buccinator muscle comes from the facial nerve. The buccinator muscle is considered to be a part of the sphincteric muscular system involving the functions of sucking, whistling, propelling food during mastication and voiding the buccal cavity. From 1990 to 1999, the flap was utilized in 8 patients to reconstruct the small to moderate intraoral defect and 1 patient for orbital mucosal defect. All flaps survived completely. There has been no flap necrosis and fistula. The results have been functionally and esthetically satisfactory. It is very reliable and safe flap with a minimal morbidity of donor site. It doesn't require microsurgical technique. Rapid healing may be achieved with its mucosal nature. We conclude that buccinator myomucosal flap can be widely used with a lot of advantages for intraoral and orbital defect because of its many advantages.
Arteries ; Facial Nerve ; Fistula ; Humans ; Mastication ; Maxillary Artery ; Mouth Mucosa ; Mouth* ; Necrosis ; Orbit* ; Singing ; Tissue Donors

Vector-borne arboviruses produce mild to severe symptoms in domestic animals. Bovine ephemeral fever (BEF), Akabane, Aino, and Chuzan virus have been primarily attributed to reproductive disorders or febrile diseases in cattle, and Japanese encephalitis virus (JEV) is mainly associated with reproductive failures in swine. We investigated antibody titers from domestic swine against four bovine arboviruses (BEF, Akabane, Aino, and Chuzan virus) and from cattle against JEV in Korea. While the positive rates for Akabane and BEF were 37.4% and 15.7%, the positive incidence of Chuzan and Aino were relatively low, with positive rates of 3.04% and 0.4%, respectively, based on a virus neutralization assay. Antibody titers against more than one virus were also frequently detected in domestic swine. The incidence of JEV was 51.3% among domestic cattle. In addition, one positive case was detected in the thoracic fluids from 35 aborted calves, based on the hemagglutination inhibition test. Our results indicate that swine are susceptible hosts of bovine arboviruses without showing clinical symptoms in a natural environment. Moreover, we confirmed that JEV could be associated with reproductive failure in pregnant cattle, as were other vector-borne bovine arboviruses assessed in this study.
Animals ; Antibodies, Viral/blood ; Cattle ; Cattle Diseases/*epidemiology/*virology ; Encephalitis Virus, Japanese/*immunology ; Encephalitis, Japanese/blood/epidemiology/*veterinary/virology ; Ephemeral Fever/blood/*epidemiology/virology ; Ephemeral Fever Virus, Bovine/*immunology ; Hemagglutination Tests ; Incidence ; Korea/epidemiology ; Neutralization Tests ; Swine ; Swine Diseases/*epidemiology/*virology