2.Hyperplasia, Metaplasia, and Dysplasia of the Gallbladder Correlation to Gallbladder Adenocarcinoma.
Korean Journal of Pathology 1997;31(6):527-537
The correlation of metaplasia to dysplasia and carcinoma in the gallbladder has attracted the attention of many investigators. We mapped and examined a total of 263 cholecystectomized gallbladders to analyze the mucosal changes in the carcinogenesis of the gallbladder. Stones were present in 59.7%, hyperplasia in 28.5%, metaplasia in 55.5% (gastric 37.6%, intestinal 17.9%), dysplasia in 17.1% (low grade 9.1%, high grade 8%) and carcinoma in 7.6%. Metaplasia was more frequently identified in the stone-positive group (62.4%) than in the stone-negative group (45.3%) (P<0.05). Especially, the incidence of intestinal metaplasia was significantly higher in the stone-positive group. Dysplasia and carcinoma were more frequent in the metaplasia-positive group (dysplasia 26.7%, carcinoma 11%) than in the metaplasia-negative group (dysplasia 5.1%, carcinoma 3.4%) (P<0.05). Their incidences were significantly higher in the intestinal metaplasia than in the gastric metaplasia. Forty four percent of the dysplasia-positive cases were associated with carcinoma in the adjacent mucosa but carcinoma was absent in the dysplasia-negative cases. Hyperplasia did not reveal any significant correlation with metaplasia, dysplasia and carcinoma. These results suggest that gallstone is causally related to the metaplasia in the gallbladder and the metaplasia-dysplasia- carcinoma sequence exists in the gallbladder.
Adenocarcinoma*
;
Carcinogenesis
;
Gallbladder*
;
Gallstones
;
Humans
;
Hyperplasia*
;
Incidence
;
Metaplasia*
;
Mucous Membrane
;
Research Personnel
3.Pathologic Analysis of Gallbladder Cancer by the Stage and Intestinal Metaplasia with the Diagnostic Significance of CEA and p53.
Korean Journal of Pathology 1997;31(7):599-607
Twenty cases of gallbladder cancers were examined using 5 mm stepwise tissue sections. We analyzed the clinicopathologic findings of the early (stage 1, II) and advanced carcinoma (stage III, IV, V) and those of carcinoma with or without metaplasia in the tumor. We also performed CEA and p53 immunohistochemical staining and compared their findings with those of normal mucosa and preneoplastic lesions. The results were as follow: 1) All of the early carcinomas (n=5) were incidentally diagnosed after the resection for the gallstone. They were compared to advanced carcinoma (n=15) in the absence of the lymphatic or angioinvasion, recurrence, metastasis and death. 2) Metaplastic and non-metaplastic carcinoma did not reveal any difference of the clinicopathologic findings except age distribution. 3) CEA and p53 were positive in preneoplastic and malignant lesions. The extent of staining was related to the degree of the atypia. From the above results, an early detection of gallbladder cancer is very important for the prognosis of the patients. Since preoperative diagnosis is difficult, thorough pathologic examination of routinely resected gallbladder is necessary for the early diagnosis. CEA and p53 immunohistochemical staining may be helpful in the differential diagnosis of non-neoplastic and neoplastic lesion of the gallbladder.
Age Distribution
;
Diagnosis
;
Diagnosis, Differential
;
Early Diagnosis
;
Gallbladder Neoplasms*
;
Gallbladder*
;
Gallstones
;
Humans
;
Metaplasia*
;
Mucous Membrane
;
Neoplasm Metastasis
;
Prognosis
;
Recurrence
4.A Study of Voiding Pattern and Symptom-Related Quality of Life in a Healthy Female Population.
Korean Journal of Urology 2000;41(11):1365-1372
No abstract available.
Female*
;
Humans
;
Quality of Life*
5.No title.
Hee Chang JUNG ; Tong Choon PARK
Journal of the Korean Continence Society 1998;2(2):71-71
No abstract available.
6.The Recurrent Dislocation of the Patella: Report of 2 Case
Chang Hee CHUNG ; Jung Mo SONN
The Journal of the Korean Orthopaedic Association 1971;6(2):131-134
Surgery is the treatment of choice for recurrent dislocation of the patella and many proposed operations can conveniently be grouped into three headings: transposition medially of the quadriceps pull mechanism (Hauser), installment of medial checkrein, either proximal or distal to the patella (Campbell) and patellectomy (West and Sotto Hall). Two cases of the dislocation observed in the young men are reported here, in which the authors performed an operation consisting of Hauser method and in addition the medial checkrein utilizing semitendinosus tendon. The results were successful in both cases, with complete restoration of the knee function.
Dislocations
;
Head
;
Humans
;
Knee
;
Male
;
Methods
;
Patella
;
Tendons
7.A Study of Nucleolar Organizer Regions in Normal and Neoplastic Epithelial Cells of Stomach.
Hee Jin CHANG ; Kyung Ha KANG ; Jung Hee PARK ; Jin Hee SOHN ; Jung Il SUH
Korean Journal of Pathology 1992;26(5):451-458
Nucleolar organizer regions are DNA loops encoding rihbosomal RNA production and detectable by the argyrophilia of their associated proteins(AgNORs). AgNOR numbers correlate with cellular proliferating activity. Many studies have shown a significnt difference in AgNOR counts between benign and malignant tumors. AgNOR counts were also helpful in differential diagnosis. For the evaluation of its diagnostic utility in gastric lesions, a silver staining technique was carried out in paraffin sections of 5 control cases, 5 benign peptic ulcers, 7 hyperplastic polyps, 10 tubular adenomas, 16 early gastric adenocarcinomas and 15 advanced gastric adenocarcinomas. The results were as follows. The mean numbers of AgNORs in early and advanced gastric adenocarcinomas(1.94 and 2.16) were significantly higher than those of normal foveolar epithelium(1.43) and epithelia of benign gastric ulcers(1.54), hyperplastic polyps(1.64) and tubular adenomas(1.79). In malignancy, there was increased variability in size and shape of AgNORs. There was little differences in mean AgNOR numbers between early and advanced gastric adenocarcinomas. Differentiation of the tumor made no difference in AgNOR numbers. From the above results, the AgNORs count, if its morphologic change are taken into consideration, is helpful in differentiation between malignant and non-malignant lesions.
Diagnosis, Differential
;
Adenocarcinoma
8.A clinical study on patients presenting with upper gastrointestinal symptoms.
Sang Yoo CHANG ; Sang Won JUNG ; Jin Hee CHANG ; Jung Jin CHO
Journal of the Korean Academy of Family Medicine 1993;14(2):88-94
No abstract available.
Humans
9.Right Atrial Myxoma Showing Granulomatous Lesion with Pulmonary Infart: A case report.
Kun Chang SONG ; Soon Hee JUNG ; Dong Hwan SHIN
Korean Journal of Pathology 1993;27(5):501-503
Cardiac myxoma is the most common primary tumor of the heart. The tumor contains a variety of cell types that are thought to arise from a focus of primitive pluripotential mesenchymal cells in the area of the fossa ovalis. Throughout the myxoid stroma, there are variable amounts of reticular fivers, collagen, elastic fibers and smooth muscle cells. A 38-year-old female had right atrial myxoma with multiple pulmonary infarcts. In this case, we experienced an unusual degenerative change in the tumor of granulomatous lesion consisting of hemosiderin pigments, foreign body giant cells and peculiar, spheroid, semilunar or bamboo-shaped degenerated elastic fibers. Microscopically it resembles Gamna-Gandy nodule seen in the spleen of chronic passive congestion.
Female
;
Humans
10.A Clinical Investigation on 10 Patients of Tuberous Sclerosis.
Hee Jung CHUNG ; Myung Jin KIM ; Chang Jun COE
Journal of the Korean Pediatric Society 1983;26(4):373-379
No abstract available.
Humans
;
Tuberous Sclerosis*