No abstract available.
Aged* ; Antihypertensive Agents* ; Humans ; Hypertension*

No abstract available.
Disease Management* ; Hypertension*

No abstract available.
Cardiovascular Diseases* ; Obesity*

No abstract available.
Peptic Ulcer Perforation* ; Peptic Ulcer*

Adolescence is the period in which physical, mental and social maturation occurs and it is an important transit stage, changing from childhood to adulthood. This is a period in which important changes occur physically such as rapid growth in height and weight gain but significant differences in growth may occur for the same age. Therfore, the degree of sexual maturation may be an important indicator in evaluating growth in adolescence. Six thousand five hundred and eighty six male and female students from grade 4 to senior high from Seoul, district town and countryside were evaluated for sexual maturity using Tanner staging, weight, height and body mass index and compared for growth. There was a rapid growth in height of 6.7cm in boys between the ages of 11 and 14 years and 6.3 cm in height for girls between the ages of 10 and 12 years, showing earlier growth in height for girls. Growth in height according to sexual maturation showed the greatest growth during stages 2~3 for boys and girls. Boys grew an average of 18.94 cm and girls an average of 18.03 cm in height during the whole sexual maturation period. There was an increase of 5.5 kg in weight for boys during the same age as for growth in height, that is between 11 and 14 years of age. In girls, an average weight gain of 5.1 kg occurred between 11 and 13 years of age, slightly later than that of growth in height. Rapid gain in weight occurred during Tanner stages 2~3 for girls. Total gain of 20.70 kg for boys occurred during the whole sexual maturation period while girls gained total 19.73 kg. Body mass index increased gradually during the whole adolescent period. It was greater in boys during the ages of 9 and 12 years and greater in girls the age of 13 years and again in boys after 17 years of age. During the whole maturation period, boys gained 3.24 and girls, 4.05 of body mass index showing more gain in girls. Height, weight and body mass index showed normal variations during the sexual maturation index showed normal variations during the sexual maturation period and the results may bring an increased understanding that adolescent physical growth was closely related to sexual maturation.
Adolescent* ; Body Mass Index ; Female ; Humans ; Male ; Seoul ; Sexual Maturation* ; Weight Gain

No abstract available.
Thromboangiitis Obliterans

No abstract available.
Antibodies, Monoclonal* ; Glycoproteins* ; Humans*

The amlodipine/atorvastatin single tablet has been shown to improve patients' achievement of national guideline recommended blood pressure and lipid target levels and exhibits a safety profile consistent with the parent com-pounds. The single tablet formulation has the potential to improve adherence and decrease prescription costs. These potential benefits are associated with important implications because hypertensive patients with additional risk factors represent a large proportion of those at risk for cardiovascular events. Combination low-dose drug treatment increases efficacy and reduces adverse effects. Fixed low-dose combination drug treatment increases efficacy and reduces adverse effects. This combination has greater potency and a similar side effect profile to monotherapy and represents a highly effective approach for attaining goal blood pressure levels using a therapeutic strategy that very effectively lowers blood pressure, is well-tolerated, and minimizes increasing doses of monotherapy-induced metabolic effects.
Achievement ; Amlodipine ; Antihypertensive Agents ; Blood Pressure ; Drug Therapy, Combination ; Heptanoic Acids ; Humans ; Parents ; Prescriptions ; Pyrroles ; Risk Factors ; Risk Reduction Behavior ; Atorvastatin Calcium

BACKGROUND/AIMS: Despite the clinical importance and widespread use of pulse wave velocity (PWV), there are no standards for pulse sensors or for system requirements to ensure accurate pulse wave measurement. We assessed the reproducibility of PWV values using a newly developed PWV measurement system. METHODS: The system used in this study was the PP-1000, which simultaneously provides regional PWV values from arteries at four different sites (carotid, femoral, radial, and dorsalis pedis). Seventeen healthy male subjects without any cardiovascular disease participated in this study. Two observers performed two consecutive measurements in the same subject in random order. To evaluate the reproducibility of the system, two sets of analyses (within-observer and between-observer) were performed. RESULTS: The means+/-SD of PWV for the aorta, arm, and leg were 7.0+/-1.48, 8.43+/-1.14, and 8.09+/-0.98 m/s as measured by observer A and 6.76+/-1.00, 7.97+/-0.80, and 7.97+/-0.72 m/s by observer B, respectively. Betweenobserver differences for the aorta, arm, and leg were 0.14+/-0.62, 0.18+/-0.84, and 0.07+/-0.86 m/s, respectively, and the correlation coefficients were high, especially for aortic PWV (r=0.93). All the measurements showed significant correlation coefficients, ranging from 0.94 to 0.99. CONCLUSIONS: The PWV measurement system used in this study provides accurate analysis results with high reproducibility. It is necessary to provide an accurate algorithm for the detection of additional features such as flow wave, reflection wave, and dicrotic notch from a pulse waveform.
Adult ; Blood Flow Velocity/*physiology ; Carotid Arteries/*physiology ; Femoral Artery/*physiology ; Foot/*blood supply ; Humans ; Male ; Middle Aged ; Radial Artery/*physiology ; Reference Values ; Regional Blood Flow/*physiology ; Reproducibility of Results ; Vascular Diseases/diagnosis ; Vascular Resistance/physiology ; Young Adult

The majority of hypertensive patients do not achieve target blood pressure for a variety of reasons, including insufficient medication, drug resistance, and noncompliance. There remains a significant need to develop new agents to better control hypertension. Nebivolol is a third-generation beta-adrenergic receptor blocker which is very highly cardioselective and has direct vasodilator properties via stimulation of endothelial nitric oxide synthase activity. Aliskiren is the first orally active inhibitor of renin as an antihypertensive agent. It is associated with dose-related falls in blood pressure comparable to other major classes of antihypertensive drugs with a placebo level of side effects. Endothelin is a powerful vasoconstrictor peptide. An endothelin-receptor antagonist such as bosentan significantly lowered blood pressure in patients with essential hypertension. Vasopeptidase inhibitors inhibit neutral endopeptidase and angiotensin converting enzymes, but side-effects such as angio-oedema and cough remain to be overcome. AngQb vaccine in hypertensive patients showed a marked reduction in early morning blood pressure without serious adverse events.
Amides ; Angiotensins ; Antihypertensive Agents ; Benzopyrans ; Blood Pressure ; Cough ; Drug Resistance ; Endothelins ; Ethanolamines ; Fumarates ; Humans ; Hypertension ; Nebivolol ; Neprilysin ; Nitric Oxide Synthase Type III ; Renin ; Sulfonamides