1.A Comparative Study of PCNA Immunostaining, AgNOR Scores Hormone Receptors and Histology in Human Breast Cancer.
Eun Sook CHANG ; Kwan Kyu PARK
Korean Journal of Pathology 1993;27(6):605-617
This study was performed on 50 cases of primary breast cancer removed surgically during the period 1990~1991 and compared the results of four morphologic methods developed for the detection of estrogen receptors, progesterone receptors, monoclonal antibody PCNA immunoreactivity, and the mean number of argyrophilic nucleolar organizer regions(mAgNORs) to ascertain the prognostic significance and also to detect highly malignant heterogenous cancer. To determine the validity of these measurements, a variance analysis was done with Kruskal-Wallis 1-way ANOVA. The results showed that the significant correlation between histologic grade and ER/PR status(P=0.005/P=0.015), the borderline significant correlation between mAgNORs and ER/PR status(P=0.08), and between AgNORs and stage(P=0.07), PCNA has no correlation with ER/PR status(P=0.25), clinical stage and histologic grade. In follow up, four cases of invasive ductal carcinoma with ER/PR, developed early and rapid metastasis within 2 years, three of them were classified as histologic grade 3 and another case was grade 2, whereas two of them were classified ans stage III(+) and the rest were in stage IIB(+) and stage IIA(-). The mAgNOR count of these four cases were ranged from 3.32 to 4.29 which were in the aneuploid category most likely. One of them had rather stormy rapid course with multiple organ metastases resulting death within one year. These results indicated that ductal carcinoma(>2cm size) with ER-/PR- and high mAgNOR level or high PCNA grade, and hihg histologic grade had h highly malignant course, marked by rapidly developing metastases. Thus we concluded that the status of ER/PR alone in tumor tissue is an important information for selecting hormone treatment btu, for the ultimate prognosis, is a weak indicator. Therefore for early detection of such heterogenous tumor, besides ER/PR, AgNORs or PCNA, histologic grade and tumor size are very useful as biological indicators of prognosis. The status ER/PR in combination with these indicators are more accurate and provide better basis on which to base a decision for early implementation of chemotherapy from which to give probably benefit by inhibition of rapid progress.
Humans
;
Neoplasm Metastasis
;
Breast Neoplasms
3.The effectiveness of selective posterior rhizotomy in cerebral palsy.
Chang Il PARK ; Eun Sook PARK ; Dong Soo LEE ; Jong Eun CHOI
Journal of the Korean Academy of Rehabilitation Medicine 1993;17(1):105-111
No abstract available.
Cerebral Palsy*
;
Rhizotomy*
4.Gross motor changes following selective posterior rhyzotomy in children with cerebral palsy.
Young Rok KIM ; Chang Il PARK ; Eun Sook PARK ; June Eun CHOI
Journal of the Korean Academy of Rehabilitation Medicine 1993;17(3):330-338
No abstract available.
Cerebral Palsy*
;
Child*
;
Humans
5.Factors Associated with Cancer Screening Rates of Manufacturing Workers.
Su Ho PARK ; Chang Hee KIM ; Eun Kyung KIM
Korean Journal of Occupational Health Nursing 2013;22(3):179-190
PURPOSE: Regular cancer screening for workers can help prevent cancer or allow early treatment, and is thus beneficial in improving health, reducing costs, and increasing companies' productivity. However, there has been little research on cancer screening rates of workers and related factors. The purpose of this study was to identify cancer screening rates and relevant factors among manufacturing workers. METHODS: Using a questionnaire, data were collected from 335 workers aged over 40 years recruited from seven manufacturing companies. The collected information included cancer screenings (stomach, colorectal, breast, and cervical), attitude towards cancer screening, and demographic and job characteristics. RESULTS: 72.5% of workers received stomach cancer screening (SCS), and 43% received colorectal cancer screening (CRCS). Among 86 women, 68.6% received breast cancer screening and cervical cancer screening. The attitude towards cancer screening was 29.5+/-3.78. Workers aged over 51, married, and those working in mobile manufacturing were more likely to have undergone SCS. Workers aged over 51, married, those working in mobile manufacturing, those in workplaces with more than 1,001 employees, and those with more positive attitudes toward cancer screening were more likely to have undergone CRCS. Finally, attitude affected cervical cancer screening. CONCLUSION: Workers in small-sized workplaces had lower cancer screening rates. Thus, follow-up research should assess the health environment of workplaces and develop educational programs on cancer screening that reflect attitudes towards screening.
Aged
;
Breast Neoplasms
;
Colorectal Neoplasms
;
Early Detection of Cancer
;
Efficiency
;
Female
;
Follow-Up Studies
;
Humans
;
Mass Screening
;
Surveys and Questionnaires
;
Stomach Neoplasms
;
Uterine Cervical Neoplasms
6.A Study on Free Fatty Acid and Albumin Levels in Breast Milk.
Eun Young KWAK ; Sang Kee PARK ; Chang Soo RA
Journal of the Korean Pediatric Society 1990;33(3):291-298
No abstract available.
Breast*
;
Milk, Human*
7.Expression of Surfactant-D Protein and TNF-alpha in the Interaction of Pneumocystis Carinii and Alveolar Macrophages in Pneumocystis Carinii Pneumonia.
Kun Young KWON ; Kwan Kyu PARK ; Chang Kwon PARK ; Young June JEON ; Eun Sook CHANG
Korean Journal of Pathology 1999;33(9):684-694
Alveolar macrophages participate in the host defense against P. carinii, but the mechanisms in degradation and clearance of the organism from lung has not been well established. We observed the transmission and scanning electron microscopic features and evaluated the expression of TNF-alpha and Surfactant-D in the interaction of P. carinii with alveolar macrophages. Expression of TNF-alpha and Surfactant-D in the experimentally induced P. carinii pneumonia in rat was examined by immunohistochemistry and immunoelectron microscopy. Electron microscopically, the alveolar macrophages phagocytized trophozoites and cysts of P. carinii micro-organisms. Immunohistochemically TNF-alpha was strongly expressed in the cytoplasms of alveolar macrophages. Postembedding immunogold labeling for Surfactant-D protein was expressed on the pellicles of trophozoites and cysts, P. carinii micro-organisms in the cytoplasms of macrophages, free floating surfactant materials and multilamellar bodies of type II epithelial cells. We conclude that alveolar macrophages interacted with P. carinii micro-organisms respond with increased expression of TNF-alpha. TNF-alpha may bind to P. carinii and exert a direct toxic effect upon the micro-organisms. Surfactant-D protein may augment binding of P. carinii to the alveolar macrophages and enhance the clearance of the micro-organisms.
Animals
;
Cytoplasm
;
Epithelial Cells
;
Immunohistochemistry
;
Lung
;
Macrophages
;
Macrophages, Alveolar*
;
Microscopy, Immunoelectron
;
Pneumocystis carinii*
;
Pneumocystis*
;
Pneumonia
;
Pneumonia, Pneumocystis*
;
Rats
;
Trophozoites
;
Tumor Necrosis Factor-alpha*
8.A study of physical growth in infants with delayed development or with risk factors for celebral palsy.
Mee Kyung PARK ; Chang Il PARK ; Eun Sook PARK ; Mi Hee LEE
Journal of the Korean Academy of Rehabilitation Medicine 1993;17(2):177-186
No abstract available.
Humans
;
Infant*
;
Paralysis*
;
Risk Factors*
9.Predictive value of postural reactions and neurological examinations for early diagnosis of cerebral palsy.
Chang Il PARK ; Jung Soon SHIN ; Eun Sook PARK ; Bum Suk LEE ; Ran NAMGUNG ; Kook In PARK
Journal of the Korean Academy of Rehabilitation Medicine 1991;15(2):22-32
No abstract available.
Cerebral Palsy*
;
Early Diagnosis*
;
Neurologic Examination*
10.Pseudolymphoma Induced by Ear Piercing.
Chang Hun HUH ; Je Young PARK ; Chong Hyun WON ; Hee Chul EUN ; Sang Eun MOON
Annals of Dermatology 2004;16(1):9-12
We present a patient who developed a pseudolymphoma after ear piercing. A patch test showed gold sensitivity. Therefore, long standing dermal exposure to gold from a pierced-type earring might have produced the patient's disease. This patient did not respond to an intralesional steroid injection and was finally treated with a complete resection of the lesion. It is proposed that every patient with a hyperplastic lesion in the ear lobe should be taken a biopsy in order to rule out the possibility of a pseudolymphoma. When a pseudolymphoma develops in the ear lobe, a complete surgical excision could be the treatment of choice, especially for the prevention of recurrence.
Biopsy
;
Body Piercing*
;
Ear*
;
Humans
;
Patch Tests
;
Pseudolymphoma*
;
Recurrence