No abstract available.

The radiological findings of various cervical spine fractures were analized on the basis of J.Harrisclassification. It appears to be important for the radiologist to be familiar with radiographic findings ofcervical spine fractures, particularly those of unstable fractures which can result in serious medical problems ifimproperly handled in the department of radiology. 68 cases of cervial spine fracures were analized. The resultsare as follows; 1. Stable and unstable fracures were about equal in incedence. 2. Anterior subluxation accountsfor 43.4% of stable fractures, 19% of all fractures. 3. Bilateral interfacetal dislocation accounts for 51.1% ofunstable fractures, 255 of all fractures. 4. Associated fracture were involved in skull, scapula, mandible andfemur. 5. About 80% of the patients is in third through fifth decade.
Dislocations ; Humans ; Mandible ; Scapula ; Skull ; Spine

BACKGROUND: The inactivation of the cyclin dependent kinase 4 inhibitor p16INK4A may be caused by deletion, mutations or promoter hyper-methylation. Recently, DNA methylation of p16INK4A promoter has been shown to suppress of p16INK4A gene transcription in various tumors. OBJECTIVE: We analyzed the gene status of p16INK4A in squamous cell carcinoma (SCC) and basal call carcinoma (BCC) of the Korean skin to investigate whether the inactivation of the gene participated in carcinogenesis. METHODS: We examined 12 SCC and 3 BCC cell lines using PCR to detect homozygous deletion of chromosome 9p21 region and methylation-specific PCR. RESULTS: Deletion of the p16INK4A gene were not, but methylation of the p16INK4A promoter region was common in SCC of the skin. CONCLUSION: These results suggest that de novo methylation of the p16INK4A promoter region seems to play an important role in the pathogenesis of SCC.

Cysticercosis infestation is a cosmopolitan disease. Recently we experienced six cases of intracranial cysticercosis in childhood, three of them were male and their age distributed from 2 to 15 years. Their main clinical manifestations were symptoms of increased intracranial pressure signs and other neurological sings as well, In diagnostic procedures, brain C-T scan was performed in all cases and Conray ventriculography was very helpful in cases of intra-ventricular location of cysticerci. By surgical exploration, single cysticerci were removed from 4 th ventricle in five cases, and cysticercus racemosus was found in subdural space in one cases. Five cases were successfully cured and one case was died of persistent brain swelling after surgical manipulation.
Brain ; Brain Edema ; Cysticercosis* ; Cysticercus ; Humans ; Intracranial Pressure ; Male ; Subdural Space

Seizure is the frequent disorder in childhood and detection of organic lesions is very important for both the determination of a therapeutic plan and the prognosis of the patient. Computerized transverse axial tomographic examination of 106 patients with seizure in Severance Hospital, Yonsei University from Dec. '77 to Dec. '79 was reviewed and analysed the following results were obtained. 1. The studies were abnormal in 51(48.1%) among 106 patients and decreasing numbers of abnormal findings were detected in the order age group. 2. Those with focal seizures showed more findings(55.6%) than generlized seizure(47.6%). Especially patients with increased intracranial pressure or focal neurologic signs revealed considerably increased abnormality. 3. In the various types of the organic lesion, mass lesion and inflammatory lesion were common and subdural hygroma, hydrocephalus, cortical atrophy were followed. In patients with seizure, computerized transverse axial tomography gave accurate informations about the frequency, topography, and severity of morphologic abnormalities. Therefore, when organic lesion of the brain is suspected, computerized transverse axial tomography should be used for the deternination of prognosis and therapeutic plan in seizure patients.
Atrophy ; Brain ; Epilepsy* ; Humans ; Hydrocephalus ; Intracranial Pressure ; Neurologic Manifestations ; Prognosis ; Seizures* ; Subdural Effusion

Primary carcinoma of the seminal vesicle is a very rare neoplasm that can imitate tumors in adjacent organs in its clinical presentation, including bladder, rectal, and most frequently, prostate carcinoma. We report a case of primary adenocarcinoma of the seminal vesicle with terminal gross hematuria in a 50-year-old man, who was treated with surgery and radiotherapy.
Adenocarcinoma* ; Hematuria ; Humans ; Middle Aged ; Prostate ; Radiotherapy ; Seminal Vesicles* ; Urinary Bladder

No abstract available.
Hyperuricemia* ; Kidney Transplantation*

No abstract available.
Hyperuricemia* ; Kidney Transplantation*

Intravenous succinylcholine is often associated with adverse effects, including muscle fasciculation, postoperative myalgia, increased intraocular and intragastric pressure, along with potassium and creatinine phosphokinase, myoglobinuria, and disturbances in cardiac rate and rhythm. Several methods have been used to modify these side effects, the most popular of which has been the of subparalyzing doses of nondepolarizining relaxants prior to injection of succinylcholine. With such pretreatment however satisfactory muscular relaxation is often not achieve, necessitaing use of larger doses of succinylcholine becauses pretreatment renders the endplateless sensitive to succinylcholine; hence large doses of succinylcholine are necessary to ensure adquate degress of relaxation. The present investigation was undertaken to determine the effects of flunitrazepam on the adverse effects of succinylcholine. This paper covers the period from March, 1981 to March, 1982 in the Department of Anesthesiology, Hanyang University Hospital. The 45 subjects were divided into 3 groups: 1) propanidid (8mg/kg) with succinylcholine 2) flunitrazepam(0.03mg/kg) with succinylcholine 3) flunitrazepam(0.06mg/kg) with succinylcholine. None had existing neuromuscular disease nor were any patients receiving diazepam or any drug known to influence myoneural blocking agent. Patients with burns, muscle injury of muscle atrophy were excluded. In each group, the plasma concentration of potassium and creatinie phosphokinase was observed before and 10 minutes after use of succinylcholine. Also succinylcholine in duced myalgia, fasciculation, onset of loss of eyelid reflex and relaxation were observed and compared. The conclusions are as follows: 1) There were no significant changes of plasma concentration of potassium and creatinine phosphokinase in presuccinylcholine and 10 minutes postsuccinylcholine. Also any statistically significant changes were not observed in the comparison of the propanidid group and the flunitrazepam groups. 2) Flunitrazepam significantly diminished the incidence of postoperative muscle pain and it was shown that the degree of fasciculation has no relationship with succinylcholine induced muscle pain. 3) In the propanidid group, the onset of loss of eyelid reflex was most rapid(22+/-13 second). In the flunitrasepam 0.03mg/kg group, the onset of loss of eyelid reflex was statistically significant (p<0.05), as compared with the 0.06mg/kg group(42+/-27 second). 4) In all groups, excellent conditions of intubation were observed. Propanidid and flunitrazepam did not affect the magnitude nor duration of the succinylcholine neuromuscular block.
Anesthesiology ; Burns ; Creatinine ; Diazepam ; Eyelids ; Fasciculation ; Flunitrazepam* ; Humans ; Incidence ; Intubation ; Muscular Atrophy ; Myalgia ; Myoglobinuria ; Neuromuscular Blockade ; Neuromuscular Diseases ; Plasma ; Potassium ; Propanidid ; Reflex ; Relaxation ; Succinylcholine*

We report a 52-yr-old Korean woman with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) whose diagnosis was confirmed by skin biopsy and the presence of a novel mutation in the NOTCH3 gene. The patient's clinical features were rather unusual in that 1) clinical presentations were only two episodes of stroke and mild dementia unaccompanied by mood disturbances or migraine, and 2) there was no family history. Brain MRI showed T2 hyperintensities in both temporal pole areas in line with the recent suggestion by O'Sullivan et al. that the abnormality could be a radiologic marker of CADASIL. FDG-PET also showed a hypometabolism in the temporal pole areas with an abnormal finding on MRI in addition to the hypometabolism in cortical and subcortical regions. We could learn from this case that CADASIL may be included in the differential diagnoses in patients with vascular dementia associated with a small vessel disease, even in the absence of a family history, especially when there are no known stroke risk factors and when the MRI shows T2 hyperintensity in the temporal pole regions.
Amino Acid Substitution ; Biopsy ; Brain/pathology ; Codon/genetics ; Dementia, Multi-Infarct/diagnosis ; Dementia, Multi-Infarct/genetics* ; Dementia, Multi-Infarct/pathology ; Dementia, Multi-Infarct/radionuclide imaging ; Female ; Human ; Korea ; Magnetic Resonance Imaging ; Middle Aged ; Mutation, Missense* ; Neuropsychological Tests ; Point Mutation* ; Proto-Oncogene Proteins/genetics* ; Skin/pathology ; Tomography, Emission-Computed