Since Duhamel (1739), numerous experimental studies on the longitudinal growth of growing long bone have been reported. In Hales(1747) experience, growing long bone showed overgrowth after drilling in the tibia of chickens. David(1924) observed the fact that various degrees of shortening disappeared within 15 months after fracture of the femur in children and he concluded that fractures in children should be treated with the caution that the growing long bone has a tendency to increase in length after injury. Bisgard(1936) concluded that shortening from overriding of fragments in fractured extremities of children will frequently, but not invariablly, become partially or totally eliminated by the acceleration of growth which incidentaIly results from the inflammatory process, incited by trauma and fracture repair. Hass(1926) reported that interstitial proliferation of osseous tissue plays no part in the elongation of a growing bone, either in the mature bone or the young osteoid tissue bordering on the epiphyseal cartilage plate, and length growth of bone is entirely dependant on the purposeful multiplication of cartilage cells of the epiphyseal cartilage plate. Ham(1952) reported that the growth of long bone depends upon the interstitial growth of cartilage. This study was initiated to investigate the effects of fractures in the longitudinal bone growth of growing bone. Artificial fractures were made at two different sites in the diaphysis of the tibia in young rabbits. The operation for artificial fracture was performed under general anesthesia with ether. The type of fracture was an incomplete one, leaving a part of the posterior cortex of the tibia, in order to prevent the displacement of fractured fragments. In all of the cases, no cast immobilization was applied. After the fractures, follow up observations were made weekly till the 4th week, and thereafter at two week intervals, with roentgenographic, lethal measurement and histological examination. The results were as follows; 1) Longitudinal bone growth was increased from fracture of the diaphysis of growing long bone. 2) Compared with the control limb, tendency to overgrowth of growing bone was noted from the first week after the operation. 3) In follow up measurements, no growth inhibition was observed till the 10th week after the operation, but, thereafter, a tendency to reduce the proliferation of cartilage cells was noted. 4) In cases of fracture of the mid 1/3, the gorwing activity in the epiphyseal plate was increased more than from proximal 1/3 fractures. 5) The bony growth, accelerated by fractures in diaphysis of growing long bone without displacement was transient, and the prolonged overgrowth was compensated by the reduction of growing activity and premature closure of the epiphysis.
Acceleration ; Anesthesia, General ; Bone Development ; Cartilage ; Chickens ; Child ; Diaphyses ; Epiphyses ; Ether ; Extremities ; Femur ; Follow-Up Studies ; Growth Plate ; Humans ; Immobilization ; Rabbits ; Tibia

No abstract available.
Animals ; Cats* ; Neurons* ; Visual Cortex*

No abstract available.
Animals ; Brain* ; Corpus Striatum* ; Neurons* ; Neuropeptides* ; Rats*

No abstract available.
Immunohistochemistry* ; Sciuridae*

No abstract available.
Endocrine Cells* ; Immunohistochemistry* ; Sciuridae*

Renal papillary necrosis is rare. It usually occurs in association with diabetes mellitus, pyelonephritis, urinary tract obstruction, analgesic abuse and sickle cell hemoglobinopathies. The basic pathophysiologic process in renal papillary necrosis appears to be ischemic necrosis. We experienced a case of renal papillary necrosis associated with diabetes mellitus. This 59 years old female was diabetic for 10 years and had persistent pyuria, not controlled with antibiotics. The excretory urography showed nonvisualized left kidney and retrograde pyelography showed multiple irregular filling defect in pelvis and ureter. The nephrectomized kidney showed typical findings of papillary necrosis, grossly and microscopically.
Anti-Bacterial Agents ; Diabetes Mellitus* ; Female ; Hemoglobinopathies ; Humans ; Kidney ; Middle Aged ; Necrosis* ; Pelvis ; Pyelonephritis ; Pyuria ; Ureter ; Urinary Tract ; Urography

No abstract available.
Animals ; Antibody Formation* ; Cattle ; Enzootic Bovine Leukosis* ; Giant Cells* ; Goats* ; Leukemia Virus, Bovine*

Complete decompression is very important for the surgical treatment of the spinal stenosis. But it may produce the segmental instability or spondylolisthesis as postoperative complications. So rigid internal fixation is mandatory to reduce this problem. Authors treated 16 cases of spinal stenosis by complete decompression and pedicale screw fixation and posterolateral fusion, analyzed 11 cases which were followed more than 9 months. The results were as follows: 1. Among the 11 cases, the mean age was 49 years old and there were 5 males and 6 females. 2. The most common cause was degenerative type, 7 cases. The most frequent level of involvement was L4–L5, 10 cases and two level involvement was 3 cases. 3. Among the 11 cases, 6 cases were excellent and 4 cases were good, and 1 case was fair, in Hanley's criteria. 4. In spondylolisthetic stenosis, the average percentage of slippage was changed from 22% pre-operatively to 2.7% postoperatively and 3.8% after 9 months follow up. 5. The complications were relatively few(1 case of hematoma and 3 cases of pain on the bone graft donor site).
Constriction, Pathologic ; Decompression ; Female ; Follow-Up Studies ; Hematoma ; Humans ; Male ; Pedicle Screws ; Postoperative Complications ; Spinal Stenosis ; Spondylolisthesis ; Tissue Donors ; Transplants

The talus is a bone with unique biomechanical features and vascular supply. Although fractures of the talus are not common, the complications of the displaced fractures or dislocation are frequent and resulting disabilities are so severe that the importance of proper management is emphasized. Authors analyzed 17 cases of fracture-dislocation of the talus, treated at Soon Chun Hyang University Hospital from January 1983 to December 1988. The results were as follows:l. Among the 17 cases, there were 15 males and 2 females and the average age was 28 years old, ranged from 21 years to 58 years. 2. The causes were fall from height in 10 cases, traffic accident in 6 and others in one. 3. According to Marti-Weber classification, 2 cases were type I, 5 in type II, 7 in type III and 3 type IV. 4. Among the 17 cases, 9 cases in type I and II were treated conservatively, and 8 cases in thpe III and IV were treated operatively. 5. Complications were avascular necrosis in 3 cases, degenerative arthritis in 4 and nonunion in 1. 6. Final results, evaluated by the criteria of Mindell et al., were as follows: excellent in 7 cases, good in 5, fair in 3 and poor in 2.
Accidents, Traffic ; Classification ; Clinical Study ; Dislocations ; Female ; Humans ; Male ; Necrosis ; Osteoarthritis ; Talus

This is a case of synovial chondromatosis involving the left knee joint of a forty one year old man. Chief complaints were gradual development of pain and limitation of knee joint motion of about 10 years duration. K-ray study revealed a single radio-opaque loose body filling the joint cavity. This body, measuring about 3×2×2cm, was removed surgically and found to have a pedicle from the synovial membrane, consisting of fat and fibrous tissue. The diagnosis of synovial chondromatosis was confirmed by pathological study. The postoperative course was uneventful and three months after the operation, the range of motion of the affected knee joint was good.
Chondromatosis, Synovial ; Diagnosis ; Joints ; Knee Joint ; Knee ; Range of Motion, Articular ; Synovial Membrane