1.A Case of Extramammary Paget's Disease and Candidiasis of the Vulvar Area.
Chang Min KIM ; Bo Young KIM ; Seung Hyun CHUN ; Jae Beom PARK ; Hwa Jung RYU
Korean Journal of Dermatology 2017;55(8):541-542
No abstract available.
Candidiasis*
;
Paget Disease, Extramammary*
;
Vulva
2.Magnifying Endoscopy in Upper Gastrointestinal Tract.
Sang Ho LEE ; Chang Beom RYU ; Jae Young JANG ; Joo Young CHO
The Korean Journal of Gastroenterology 2006;48(3):145-155
For the diagnosis of upper gastrointestinal (GI) lesions, magnification method is usually used in conjunction with chromoscopy, enabling the endoscopist to view subtle mucosal patterns in exquisite detail. Recently published datas have shown that magnifying endoscopy might be a valuable adjunct for the diagnosis, detection, and characterization of inflammatory and neoplastic lesions of the upper GI tract. It is also proven to be an useful surveillance protocol in identifying dysplastic epithelium or early cancer within a segment of Barrett's esophagus. Possible indications for magnifying endoscopy in upper GI tract include screening and surveillance of Barrett's esophagus, defining the extent of esophageal and gastric adenocarcinoma, detecting synchronous/metachronous gastric and esophageal cancers, diagnosing Helicobacter pylori infection, and recognizing minimal mucosal changes in gastroesophageal reflux disease. By grading the quality of evidence for the currently published trials, it is clear that the majority are case series, case reports, and/or observational studies without randomization, control, or blinding. Moreover, other evidence-based criteria such as independent, blind comparisons of magnifying endoscopy with a standard method which evaluates this technology in an appropriate spectrum of patients to whom the test may be applicable, and standardizing methodology would be crucial before magnifying endoscopy becomes a standard procedure in clinical practice. In the future, a uniform classification system for staining and magnifying patterns should be devised and observer agreement should be tested. Futher studies then could be performed based upon consistent, validated, and standardized terminologies and criteria.
Diagnosis, Differential
;
Duodenal Diseases/pathology
;
Endoscopy, Gastrointestinal/*methods
;
Esophageal Diseases/pathology
;
Gastrointestinal Diseases/*pathology
;
Humans
;
Image Enhancement/*methods
;
Stomach Diseases/pathology
;
Upper Gastrointestinal Tract/pathology
3.Food poisoning.
Chang Beom RYU ; Moon Sung LEE
Journal of the Korean Medical Association 2011;54(6):617-626
This article aims to help physicians to make a differential diagnosis of food poisoning by introducing the incubation period, clinical symptoms of each causative agent according to the mode of manifestation. Etiologic agents for food poisoning are classified as bacterial, viral, natural toxin, and chemical toxin. Bacterial food poisoning is classified as infectious type, toxin type and other type according to the pathogenesis. Natural toxin food poisoning are classified as plant and animal food poisoning according to causative food. Many of the diagnoses are made clinically, without confirmative laboratory tests. However, some of food poisonings require the confirmative etiologic diagnoses, because they have rapid life-threatening courses and need proper speedy therapies. When incubation period is 1-6 hours, natural toxin type food poisoning should be suspected such as Staphylococcus aureus, Bacillus cereus vomiting type. When it is 7 to 12 hours, Clostridium perfringens and Bacillus cereus diarrheal type should be suspected. When it is 12 to 72 hours, Enterotoxigenic Echerichia coli, Salmonella spp., Vibrio parahemolyticus and Norovirus should be suspected. Before the result of confirmative laboratory test, a probable diagnosis for the etiology of food poisoning should be based upon the combination of their clinical manifestations, food histories, and pathogenic mechanisms.
Animals
;
Bacillus cereus
;
Clostridium perfringens
;
Diagnosis, Differential
;
Foodborne Diseases
;
Norovirus
;
Plants
;
Salmonella
;
Staphylococcus aureus
;
Vibrio
;
Vomiting
4.A case of renal arterial embolization using 99% ethanol and lipiodol mixture for autosomal dominant polycystic kidney disease in a hemodialysis patient.
Taeik CHANG ; Dong Ryeol RYU ; Beom Seok KIM ; Sejin JUNG ; Chi Young SHIM ; Ea Wha KANG ; Sug Kyun SHIN
Korean Journal of Medicine 2004;67(Suppl 3):S776-S780
Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disorder characterized by innumerable bilateral renal cysts. It has an prevalence rate of one in 200~1,000 individuals and is a relatively common cause of renal failure. As renal function deteriorates, overall renal size usually diminish in patients with chronic renal failure. However, renal size of patients with ADPKD usually continues to increase, even after the initiation of dialysis therapy, because numerous cysts replace renal mass. Attempted methods to reduce the size of enlarged kidneys have included needle aspiration and sclerotherapy, cyst decompression surgery, laparoscopic and surgical nephrectomy. The outcome of these therapy frequently has been suboptimal, and there is a need to develop a more effective therapy. We report a case of renal arterial embolization using 99% ethanol and lipiodol mixture for ADPKD in a hemodialysis pathient, which has not been previously reported.
Decompression
;
Dialysis
;
Ethanol*
;
Ethiodized Oil*
;
Humans
;
Kidney
;
Kidney Failure, Chronic
;
Laparoscopy
;
Needles
;
Nephrectomy
;
Polycystic Kidney, Autosomal Dominant*
;
Prevalence
;
Renal Dialysis*
;
Renal Insufficiency
;
Sclerotherapy
5.Self - Expanding EsophaCoilTM Esophageal Prosthesis for Malignant Esophageal Stenosis.
Sung Won CHO ; Chan Sup SHIM ; Joon Seong LEE ; Moon Sung LEE ; Chan Wook PARK ; Dong Wha SONG ; Chang Beom RYU ; Jong Hoon OH ; Kwon Ho LEE
Korean Journal of Gastrointestinal Endoscopy 1995;15(1):63-71
Endoscopic endoprosthesis is well established as a cheap, fast and durable procedure for palliation of malignant dysphagia. But the placement of conventional endoprosthesis is difficult and is associated with significant complications such as hemorrhage, perforation and dysfunction of the prosthesis. Recently, self -expand- able metal prosthesis have also been utilized for malignant esophageal stenosis, and palliation of this modality seems to be more effective than other modalities. However the main problems with these metal stents are tumor ingrowth leading to reobstruction, migration, and eophageal trauma by the distal, hard skirt of the stent. EsophaCoil stent is a simple coil with close loops made from a single flat wire of nickel titanium alloy. The radial force of this material is much stronger than stainless steel, expansion time is faster and the stent is able to dilate even extremely resistant strictures. This new metalic stent seems to have several advantages over the current commnerically available ones. We report our experiences with this EsophaCoil stent and review of literature.
Alloys
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Constriction, Pathologic
;
Deglutition Disorders
;
Esophageal Stenosis*
;
Hemorrhage
;
Nickel
;
Prostheses and Implants*
;
Stainless Steel
;
Stents
;
Titanium
6.Endoscopic Variceal Ligation by Use of Transparent Endoscopic Elastic Band Ligating Device.
Sung Won CHO ; Chan Sup SHIM ; Joon Seong LEE ; Moon Sung LEE ; Chan Wook PARK ; Dong Wha SONG ; Chang Beom RYU ; Cheol Ho PARK
Korean Journal of Gastrointestinal Endoscopy 1994;14(4):430-436
Endoscopic variceal ligation(EVL) is effective in both emergent and elective treatment of esophageal varices and can be used as a safe alternative to sclerotherapy. However, as yet no transparent ligating device is widely available, the endoscopic view through the present commercial ligating device is so narrow that it is often difficult to both approach the target and accurately define and position the bleeding site. To assess the benifit of transparent EVL device, total 143 patients, 632 sessions, underwent EVL treatment. In 545 sessions the non-transparent, conventional-type ligating devices (Stigmann-Goff ligating devices) were used, whereas in 87 sessions the transparent ligating devices used. 35 patients underwent EVL under active bleeding conditions; in 29 patients a conventional ligation devices, whereas in 6 patients a transparent ligating devices were used. The remaining l08 patients were either electively treated by EVL. The visual fields decreased to 20-30% with the conventional devices, but no change of visual fields were noted with the transparent devices. In electively treated cases by EVL, the times need to ligate one band were not significantly different in the conventional devices (average, 18.5 sec) compared with that in the transparent devices (average, 16.7 sec), but in active bleeding conditions it took a significantly longer times in the conventional devices (mean, 30.7 sec) compared with that in the transparent devices (average, 19.4 sec). The hemostatic success rates in active bleeding conditions were 89.7%(26/29) using the conventional devices, 100%(6/6) using the transparent devices. In conclusion this newly developed transparent ligating device provides an improved visual field and shortens ligating time, especially in active bleeding condition. Therefore EVL using transparent device is more effective method in treatment of esophageal varices, especially active bleeding conditions.
Esophageal and Gastric Varices
;
Hemorrhage
;
Humans
;
Ligation*
;
Sclerotherapy
;
Visual Fields
7.Two Cases of Esophageal Pyogenic Granuloma Treated by Endoscopic Mucosal Resection.
Chang Hee HAN ; Youn Soo KIM ; Young Kwan CHO ; Chang Beom RYU ; Kye Won KWON ; So Young JIN ; Joon Seong LEE ; Moon Sung LEE ; Chan Sup SHIM
Korean Journal of Gastrointestinal Endoscopy 2005;30(2):75-79
Pyogenic granulomas are benign in nature and commonly found in the skin and mucosa. They rarely involve the gastrointestinal tract other than oral cavity. There are 30 reports in worldwide and only 4 domestic reports of such matter. Upper gastrointestinal endoscopy revealed the pedunculated masses with various surface changes in a 61-year-old man and a 55-year-old women. Endoscopic ultrasonography and endoscopic mucosal resection using snare were performed for accurate diagnosis and treatment. The tumors were pathologically diagnosed as pyogenic granulomas of the esophagus.
Diagnosis
;
Endoscopy
;
Endoscopy, Gastrointestinal
;
Endosonography
;
Esophagus
;
Female
;
Gastrointestinal Tract
;
Granuloma, Pyogenic*
;
Humans
;
Middle Aged
;
Mouth
;
Mucous Membrane
;
Skin
;
SNARE Proteins
8.Survival outcomes of adjuvant radiotherapy and chemotherapy in women with stage I serous papillary and clear cell carcinoma of the endometrium: a Korean multicenter study
Miseon KIM ; Byung Su KWON ; Ha Kyun CHANG ; Seungmee LEE ; Suk Joon CHANG ; Jin Young CHOI ; Sang Yoon PARK ; Maria LEE ; Hee Sug RYU ; Yong Beom KIM
Journal of Gynecologic Oncology 2019;30(3):e44-
OBJECTIVE: To compare the survival outcomes of adjuvant radiotherapy and chemotherapy in women with uterine-confined endometrial cancer with uterine papillary serous carcinoma (UPSC) or clear cell carcinoma (CCC). METHODS: Medical records of 80 women who underwent surgical staging for endometrial cancer were retrospectively reviewed. Stage I UPSC and CCC were pathologically confirmed after surgery. Survival outcomes were compared between the adjuvant radiotherapy and chemotherapy groups. RESULTS: Fifty-four (67.5%) and 26 (32.5%) women had UPSC and CCC, respectively. Adjuvant therapy was administered to 59/80 (73.8%) women (25 radiotherapy and 34 chemotherapy). High preoperative serum cancer antigen-125 level (25.1±20.2 vs. 11.5±6.5 IU/mL, p < 0.001), open surgery (71.2% vs. 28.6%, p=0.001), myometrial invasion (MI) ≥1/2 (33.9% vs. 0, p=0.002), and lymphovascular space invasion (LVSI; 28.8% vs. 4.8%, p=0.023) were frequent in women who received adjuvant therapy compared to those who did not. However, the histologic type, MI ≥1/2, and LVSI did not differ between women who received adjuvant radiotherapy and those who received chemotherapy. The 5-year progression-free survival (78.9% vs. 80.1%, p>0.999) and overall survival (77.5% vs. 87.8%, p=0.373) rates were similar between the groups. Neither radiotherapy (hazard ratio [HR]=1.810; 95% confidence interval [CI]=0.297–11.027; p=0.520) nor chemotherapy (HR=1.638; 95% CI=0.288–9.321; p=0.578) after surgery was independently associated with disease recurrence. CONCLUSION: Our findings showed similar survival outcomes for adjuvant radiotherapy and chemotherapy in stage I UPSC and CCC of the endometrium. Further large study with analysis stratified by MI or LVSI is required.
Adenocarcinoma, Clear Cell
;
Adenocarcinoma, Papillary
;
Chemotherapy, Adjuvant
;
Disease-Free Survival
;
Drug Therapy
;
Endometrial Neoplasms
;
Endometrium
;
Female
;
Humans
;
Medical Records
;
Radiotherapy
;
Radiotherapy, Adjuvant
;
Recurrence
;
Retrospective Studies
9.Synergistic growth inhibition by combination of adenovirus mediated p53 transfer and cisplatin in ovarian cancer cell lines.
Sang Young RYU ; Kidong KIM ; Woo Sik LEE ; Hee Chung KWON ; Kee Ho LEE ; Chang Min KIM ; Soon Beom KANG
Journal of Gynecologic Oncology 2009;20(1):48-54
OBJECTIVE: This study was to investigate the synergistic growth inhibitory effect by combination of adenovirus mediated p53 gene transfer and cisplatin in ovarian cancer cell lines with different p53 gene mutation patterns. METHODS: Three ovarian cancer cell lines, p53 deleted SKOV3, p53 mutated OVCAR-3, and PA-1 with wild-type p53 were transduced with human adenovirus vectors carrying p53 gene (Ad-p53) and treated with a sublethal concentration of cisplatin before and after Ad-p53. The cell number was counted daily for 5 days after Ad-p53 transduction. Western blotting was used to identify p53 and p21 protein expressions, and flow cytometric analysis was performed to investigate any change of DNA ploidy after Ad-p53 transfer. RESULTS: Ad-p53 transduced cells successfully expressed p53 and p21 proteins after 48 hours of Ad-p53 transduction. Synergistic growth inhibition by combination of Ad-p53 and cisplatin was detected only in SKOV3 and OVCAR-3 cells, but not in PA-1 cells. In p53 deleted SKOV3 cells, cisplatin treatment after Ad-p53 showed higher growth inhibition than the treatment before Ad-p53 transduction, and reverse relationship was observed in p53 mutated OVCAR-3 cells. In SKOV3 cells, the fraction of cells at G2/M phase increased after cisplatin treatment, however, it decreased dramatically with Ad-p53 transduction. CONCLUSION: The synergistic growth inhibition by combination of Ad-p53 and cisplatin may depend on the p53 status and the temporal sequence of cisplatin treatment, suggesting judicious selective application of this strategy in clinical trials.
Adenoviridae
;
Adenoviruses, Human
;
Blotting, Western
;
Cell Count
;
Cell Line
;
Cisplatin
;
DNA
;
Genes, p53
;
Genetic Therapy
;
Lifting
;
Ovarian Neoplasms
;
Ploidies
;
Proteins
10.Feasibility and response of helical tomotherapy in patients with metastatic colorectal cancer.
Sun Hyun BAE ; Seong Kwon MOON ; Yong Ho KIM ; Kwang Hwan CHO ; Eung Jin SHIN ; Moon Sung LEE ; Chang Beom RYU ; Bong Min KO ; Jina YUN
Radiation Oncology Journal 2015;33(4):320-327
PURPOSE: To investigate the treatment outcome and the toxicity of helical tomotherapy (HT) in patients with metastatic colorectal cancer (mCRC). MATERIALS AND METHODS: We retrospectively reviewed 18 patients with 31 lesions from mCRC treated with HT between 2009 and 2013. The liver (9 lesions) and lymph nodes (9 lesions) were the most frequent sites. The planning target volume (PTV) ranged from 12 to 1,110 mL (median, 114 mL). The total doses ranged from 30 to 70 Gy in 10-30 fractions. When the alpha/beta value for the tumor was assumed to be 10 Gy for the biologically equivalent dose (BED), the total doses ranged from 39 to 119 Gy10 (median, 55 Gy10). Nineteen lesions were treated with concurrent chemotherapy (CCRT). RESULTS: With a median follow-up time of 16 months, the median overall survival for 18 patients was 33 months. Eight lesions (26%) achieved complete response. The 1- and 3-year local progression free survival (LPFS) rates for 31 lesions were 45% and 34%, respectively. On univariate analysis, significant parameters influencing LPFS rates were chemotherapy response before HT, aim of HT, CCRT, PTV, BED, and adjuvant chemotherapy. On multivariate analysis, PTV < or =113 mL and BED >48 Gy10 were associated with a statistically significant improvement in LFPS. During HT, four patients experienced grade 3 hematologic toxicities, each of whom had also received CCRT. CONCLUSION: The current study demonstrates the efficacy and tolerability of HT for mCRC. To define optimal RT dose according to tumor size of mCRC, further study should be needed.
Chemotherapy, Adjuvant
;
Colorectal Neoplasms*
;
Disease-Free Survival
;
Drug Therapy
;
Follow-Up Studies
;
Humans
;
Liver
;
Lymph Nodes
;
Multivariate Analysis
;
Neoplasm Metastasis
;
Radiotherapy, Intensity-Modulated*
;
Retrospective Studies
;
Treatment Outcome