1.A novel robust nomogram based on peripheral monocyte counts for predicting lymph node metastasis of prostate cancer.
Jia-Wei ZHOU ; Yun-Hua MAO ; Yang LIU ; Hai-Tao LIANG ; Chandni Chandur SAMTANI ; Yue-Wu FU ; Yun-Lin YE ; Gang XIAO ; Zi-Ke QIN ; Cun-Dong LIU ; Jian-Kun YANG ; Qi-Zhao ZHOU ; Wen-Bin GUO ; Kang-Yi XUE ; Shan-Chao ZHAO ; Ming-Kun CHEN
Asian Journal of Andrology 2021;23(4):409-414
Accurate methods for identifying pelvic lymph node metastasis (LNM) of prostate cancer (PCa) prior to surgery are still lacking. We aimed to investigate the predictive value of peripheral monocyte count (PMC) for LNM of PCa in this study. Two hundred and ninety-eight patients from three centers were divided into a training set (n = 125) and a validation set (n = 173). In the training set, the independent predictors of LNM were analyzed using univariate and multivariate logistic regression analyses, and the optimal cutoff value was calculated by the receiver operating characteristic (ROC) curve. The sensitivity and specificity of the optimal cutoff were authenticated in the validation cohort. Finally, a nomogram based on the PMC was constructed for predicting LNM. Multivariate analyses of the training cohort demonstrated that clinical T stage, preoperative Gleason score, and PMC were independent risk factors for LNM. The subsequent ROC analysis showed that the optimal cutoff value of PMC for diagnosing LNM was 0.405 × 109 l
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