Objective To explore the construction, application advantages and values of the ECG network system under Wise Information Technology.Methods A total of 240 patients enrolled in Department of Neurology, the First Affiliated Hospital of Wenzhou Medical University from March 2016 to May 2016 were randomly divided into two groups: conventional ECG group (control group) and network ECG group (experimental group), with 120 cases respectively. The ECG test time and satisfaction of patients and nurses were compared between two groups.Results Compared with the conventional ECG group, patients in network ECG group took less time to have an ECG examination, which decreased from an average of 33.32 min to 9.59 min. And the time required for nurses decreased from an average of 10.27 min to 4.82 min. The differences were statistically significant (P<0.001). Patients' satisfaction increased from 89.8% to 99.5%, while medical staff's satisfaction increased from 91.5% to 99.3%. The differences were statistically significant (P<0.001). Conclusions Network ECG examination greatly reduces the waste of human resources and saves operating costs, enhances the health care staff satisfaction and is worth further promotion in the clinical application.