The author studied 294 cased of childhood thyroid disorder at Pediatrics Department in Pusan National University Hospital from Jan. 1984 to Dec. 1991. The patients with grouped according to thyroid function and disease entity, and were evaluated symptoms and signs, laboratory findings and treatment. The results were summarized as follow 1) The childhood thyroid disorder was the most common in the older children, but congenital hypothyroidism was the most frequent in the early infancy. The ratio of male and female was 1:4.6, but in congenital hypothyroidism, it was 1:1.7. 2) In classification of thyroid disorder according to thyroid function, euthyroidism was the most common with 73% of the patients, hypothyroidism was 15% and hyperthyroidism was 12% in order. in hypothyroidism. the majority was Graves' disease and a few cases were Hashimoto's thyroiditis. In Euthyroidism, simple goiter was the most common with 72%, Hashimoto's thyroiditis was 24%,and 3 cases were thyroid cancer. In hypothyroidism. congenital hypothyroidism was 44% and Hashimoto's thyroiditis was the most common cause of congenital hypothyroidism. 3) The clinical manifestation at first visit hypothyroidism included thyroid enlargement which was seen in all cases, cold sweating,palpitation and nervousness. In Euthyroidism, there was no specific complaints except thyroid enlargement. Growth retardation, constipation and mental retardation were visible in congenital hypothyroidism. In acquired hypothyroidism, the patents complained thyroid enlargement, lethargy, anorexia. The causes of congenital hypothyroidism was ectopic thyroid, aplasia or hypoplasia of thyroid and dyshormonogensis with similar frequency. 4) In most cases of hyperthyroidism, propylthiouracil was administerd. The half of the patients were recovered at 4 weeks after treatment, and 92% of them were recoverd at 3 months later after treatment. The side effects were rare. In a few of them surgical method was underwent. In hypothyroidism. L-thyroxine was adminisetered, and the result was excellent.
Anorexia ; Anxiety ; Busan ; Child ; Classification ; Congenital Hypothyroidism ; Constipation ; Female ; Goiter ; Graves Disease ; Humans ; Hyperthyroidism ; Hypothyroidism ; Intellectual Disability ; Lethargy ; Male ; Pediatrics ; Propylthiouracil ; Thyroid Dysgenesis ; Thyroid Gland* ; Thyroid Neoplasms ; Thyroiditis ; Thyroxine

No abstract available.
Adolescent* ; Humans

No abstract available.
Brain* ; Meningitis* ; Tuberculosis, Meningeal

No abstract available.
Child* ; Humans ; Nephrotic Syndrome*

No abstract available.
Echocardiography* ; Myocarditis*

To evaluate the atlantoaxial instability in children with Down syndrome, the authors analyzed the 97 children with Down syndrome attending to 2 schools for handicaped children in Pusan. The rsults of study were as follows; 1)The incidence of atlantoaxial instability in 97 individuals with Down syndrome was 8(8.3%) in neutral position and in 10(10.3%) in flexion, respectively. 2) The mean atlantoaxial gap was significantly higher in patients with Down syndrome than in the control group(P<0.05). 3) The mean atlantoaxial gaps in patients with Down stydrome according neck position was significantly higher in flexion(3.27 +/-1.08mm)than in neutral(2.63 +/-1.18)(p<0.05). 4) When mean atlantoaxial gaps of patients with Down syndrome were analyzed according to age groups, young age groups were statistically higher than old age groups in flexion position(p<0.05) but no statistically signigican differences were in neutral position. 5) The mean atlantoaxial gap of obese group was slightly higher than those of non-obese group but no statistically significant difference was noted(p<0.05).
Busan ; Child* ; Down Syndrome* ; Humans ; Incidence ; Neck

No abstract available.
Alkaline Phosphatase* ; Child* ; Humans ; Leukocytes* ; Leukocytosis*

No abstract available.
Child* ; Humans

No abstract available.
Child* ; Heart Septal Defects, Ventricular* ; Humans

The auther analysed 29 patients who were treated with prednisolone, including nephrotic syndrome (13 cases), acute leukemia(10 cases), bronchial asthma (2 cases), juvenile rheumatoid arthritis (2 cases) and ulcerative colitis (1 cases) patients in childhood, after remission induction, pro9longed alternate or interrupted treatment was used. The auther observed patterns of height velocity of these patients from 1.6 to 10.3 years. The results were as follow 1) Of the total 29 patients who were treated with prednisolone, most of them showed normal height velocity within the percentile channels, but 4 cases (13.8%) of them showed delay in height velocity. 2) The 4 cases who delayed in height velocity, including 2 cases of bronchial asthma and 2 cases of juvenile rheumatoid arthritis patients, received prednisolone daily about 0.4~1.5mg/kg from 3 to 6 years alternatively or interruptedly. Height velocity was decreased from bet ween 3 and 25 percentile channel at first to below 3 percentile channel at last contiously. 3) In these 4 cases, height velocity was inversely proportion to dosage of prednisolone.
Arthritis, Juvenile ; Asthma ; Colitis, Ulcerative ; Humans ; Nephrotic Syndrome ; Prednisolone ; Remission Induction